@article{MTMT:35707139,
	title = {Development and Characterization of In Situ Gelling Nasal Cilostazol Spanlastics},
	url = {https://m2.mtmt.hu/api/publication/35707139},
	author = {Salamah, Maryana and Budai-Szűcs, Mária and Sipos, Bence and Volk, Balázs and Katona, Gábor and Balogh, György Tibor and Pannonhalminé Csóka, Ildikó},
	doi = {10.3390/gels11020082},
	journal-iso = {GELS-BASEL},
	journal = {GELS (BASEL)},
	volume = {11},
	unique-id = {35707139},
	year = {2025},
	eissn = {2310-2861},
	orcid-numbers = {Budai-Szűcs, Mária/0000-0001-5187-5702; Sipos, Bence/0000-0002-0131-4728; Volk, Balázs/0000-0002-2019-1874; Katona, Gábor/0000-0003-1564-4813; Balogh, György Tibor/0000-0003-3347-1880; Pannonhalminé Csóka, Ildikó/0000-0003-0807-2781}
}

@misc{MTMT:35719027,
	title = {Természetes és mesterséges oxazol és tiazol heterociklusokat tartalmazó indolszármazékok szintézise},
	url = {https://m2.mtmt.hu/api/publication/35719027},
	author = {Pollák, Patrik and Milen, Mátyás and Volk, Balázs},
	unique-id = {35719027},
	year = {2025},
	orcid-numbers = {Volk, Balázs/0000-0002-2019-1874}
}

@misc{MTMT:35771068,
	title = {Synthesis and Structure-Activity Relationship Studies of Novel Oxazolyl- and Thiazolyl-indoles as Selective Antiproliferative Agents Against Leukemia and Glioma Cell Lines},
	url = {https://m2.mtmt.hu/api/publication/35771068},
	author = {Pollák, Patrik and Szele, Boglárka and Varga, Máté and Paszternák, Alexandra and Varga, Kamilla and Dancsó, András and Simig, Gyula and Volk, Balázs and Tábi, Tamás and Milen, Mátyás},
	unique-id = {35771068},
	abstract = {Poszter prezentáció},
	year = {2025},
	orcid-numbers = {Dancsó, András/0000-0001-8460-217X; Simig, Gyula/0000-0002-2569-6476; Volk, Balázs/0000-0002-2019-1874; Tábi, Tamás/0000-0001-5343-0205}
}

@article{MTMT:36052939,
	title = {Design, Synthesis, and Evaluation of a New Fluorescent Ligand for the M 2 Muscarinic Acetylcholine Receptor},
	url = {https://m2.mtmt.hu/api/publication/36052939},
	author = {Szabó, Renáta and Szepesi Kovács, Dénes and Kiss, Dóra Judit and Yazdi, Zeinab Nezafat and Tóth, András and Brea, Jose and Loza, María Isabel and Meszéna, Domokos and Wittner, Lucia and Ulbert, István and Volk, Balázs and Hunyady, László and Keserű, György Miklós},
	doi = {10.1021/acsmedchemlett.4c00592},
	journal-iso = {ACS MED CHEM LETT},
	journal = {ACS MEDICINAL CHEMISTRY LETTERS},
	volume = {16},
	unique-id = {36052939},
	issn = {1948-5875},
	abstract = {The M2 muscarinic acetylcholine receptor (M2R) is a G protein-coupled receptor involved in regulating cardiovascular functions and mediation of central muscarinic effects, such as movement, temperature control, and antinociceptive responses. Molecular probes targeting this receptor are therefore important in exploring its pathophysiological role at a molecular level. Herein, we report the design, synthesis, and evaluation of a new fluorescent probe for M2R based on an anthranilamide ligand. In radioligand binding experiments, the presented Oregon Green 488-labeled conjugate (33) exhibited high M2R affinity (Ki = 2.4 nM), a moderate preference for the M2R over the M4 receptor, and excellent to pronounced M2R selectivity compared to the M1, M3, and M5 receptors. The utility of the probe was demonstrated in confocal, two-photon, and stimulated emission depletion nanoscopy (STED) imaging to specifically label the receptors in human embryonic kidney (HEK) 293T cells. These properties suggest that our probe may be utilized in advanced microscopy to study the pharmacology of the M2R.},
	year = {2025},
	pages = {552-559},
	orcid-numbers = {Tóth, András/0000-0003-2746-9370; Loza, María Isabel/0000-0003-4730-0863; Meszéna, Domokos/0000-0003-4042-2542; Wittner, Lucia/0000-0001-6800-0953; Ulbert, István/0000-0001-9941-9159; Volk, Balázs/0000-0002-2019-1874; Hunyady, László/0000-0002-8438-7251}
}

@article{MTMT:36133236,
	title = {Comparative Computational Study on the Robinson–Gabriel Synthesis and Bischler–Napieralski Reaction: Density Functional Theory Investigation of T3P-Mediated Ring Closure},
	url = {https://m2.mtmt.hu/api/publication/36133236},
	author = {Pollák, Patrik and Milen, Mátyás and Volk, Balázs and Ábrányi-Balogh, Péter},
	doi = {10.1002/ejoc.202400679},
	journal-iso = {EUR J ORG CHEM},
	journal = {EUROPEAN JOURNAL OF ORGANIC CHEMISTRY},
	volume = {28},
	unique-id = {36133236},
	issn = {1434-193X},
	abstract = {Previously, this study reported novel and efficient methods for the Bischler–Napieralski and Robinson–Gabriel reactions of tryptamides under microwave conditions using propylphosphonic anhydride (T3P). Furthermore, it presents the first computational study on Bischler–Napieralski reaction of Nb-benzoyltryptamine with T3P leading to 1-phenyl-3,4-dihydro-β-carboline. Here, it provides the detailed comparison of both T3P promoted reactions that actually lead to different products in case of a small change in the substrate. To reveal the effect of the substrate structure, density functional theory (DFT) computations have been performed on the two model tryptamides leading to three different product molecules. The computed mechanistic pathways correspond to the experimental observations and explain why the oxoalkyl tryptamide derivative selectively reacts in a Robinson–Gabriel cyclization (highest activation Gibbs free energy is 194.9 kJ mol−1) and does not give any Bischler–Napieralski product (highest activation Gibbs free energy of the pathway is 269.4 kJ mol−1). It can also be understood why high temperature is required for both reactions. It is the first occasion in the literature that these two reactions are compared by DFT calculations. © 2025 The Author(s). European Journal of Organic Chemistry published by Wiley-VCH GmbH.},
	year = {2025},
	eissn = {1099-0690},
	orcid-numbers = {Volk, Balázs/0000-0002-2019-1874}
}

@article{MTMT:36152714,
	title = {Studies on the syntheses of β-carboline alkaloids brevicarine and brevicolline},
	url = {https://m2.mtmt.hu/api/publication/36152714},
	author = {Batizi, Benedek and Pollák, Patrik and Dancsó, András and Keglevich, Péter and Simig, Gyula and Volk, Balázs and Milen, Mátyás},
	doi = {10.3762/bjoc.21.79},
	journal-iso = {BEILSTEIN J ORG CHEM},
	journal = {BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY},
	volume = {21},
	unique-id = {36152714},
	issn = {1860-5397},
	abstract = {A new total synthesis of the β-carboline alkaloid brevicarine is disclosed. The synthesis was carried out starting from an aromatic triflate key intermediate, allowing the introduction of various substituents into position 4 of β-carboline by cross-coupling reactions. Thanks to its scalability, this novel approach ensures a broad accessibility to the target compound for potential pharmacological measurements. Using detailed NMR studies, the NMR signals have been assigned for both the base and its dihydrochloride salt for further confirming their structures. A new synthesis of the related alkaloid brevicolline was also attempted from the same intermediate. However, after successful coupling of β-carboline with N-methylpyrrole, the trials to saturate the pyrrole ring under various conditions led to unexpected reactions: reduction of ring A of the β-carboline skeleton or trifluoroethylation of the pyrrole moiety occurred, leading to interesting and potentially useful derivatives.},
	year = {2025},
	eissn = {1860-5397},
	pages = {955-963},
	orcid-numbers = {Dancsó, András/0000-0001-8460-217X; Simig, Gyula/0000-0002-2569-6476; Volk, Balázs/0000-0002-2019-1874}
}

@article{MTMT:36153807,
	title = {Measurement of Diketene Using In Situ Derivatization-Headspace-Gas Chromatography},
	url = {https://m2.mtmt.hu/api/publication/36153807},
	author = {Göröcs, Noémi and Volk, Balázs},
	doi = {10.1007/s10337-025-04398-4},
	journal-iso = {CHROMATOGRAPHIA},
	journal = {CHROMATOGRAPHIA},
	volume = {88},
	unique-id = {36153807},
	issn = {0009-5893},
	year = {2025},
	eissn = {1612-1112},
	pages = {279-285},
	orcid-numbers = {Volk, Balázs/0000-0002-2019-1874}
}

@article{MTMT:36158616,
	title = {Preparation, and ex vivo and in vivo Characterization of Favipiravir-Loaded Aspasomes and Niosomes for Nose-to-Brain Administration},
	url = {https://m2.mtmt.hu/api/publication/36158616},
	author = {Salamah, Maryana and Volk, Balázs and Lekli, István and Bak, István and Gyöngyösi, Alexandra and Kozma, Gábor and Kónya, Zoltán and Szalenko-Tőkés, Ágnes and Kiricsi, Ágnes and Rovó, László and Balogh Weiser, Diána and Zupkó, István and Pannonhalminé Csóka, Ildikó and Katona, Gábor and Balogh, György Tibor},
	doi = {10.2147/IJN.S518486},
	journal-iso = {INT J NANOMED},
	journal = {INTERNATIONAL JOURNAL OF NANOMEDICINE},
	volume = {20},
	unique-id = {36158616},
	issn = {1176-9114},
	abstract = {Purpose: The present study aimed to develop and compare the intranasal applicability of favipiravir-loaded aspasomes (FAV-ASPs) using film hydration method, and favipiravir-loaded niosomes (FAV-NIOs) using ethanol injection method.
		Methods: The FAV-ASP and FAV-NIO formulations were characterized according to nanoparticulate characteristics (DLS, drug loading, drug encapsulation efficacy, droplet size distribution), drug release and permeability behavior.
		Results: The optimized FAV-ASP formulation (FAV-ASP8) consisted of FAV, ascorbyl palmitate, Span® 60 and cholesterol (30:25:25:50 w/w) with nano-scale size range (292.06 ± 2.10 nm), narrow polydispersity index (PDI) value (0.36 ± 0.03), adequate zeta potential (− 74.73 ± 3.28 mV) and acceptable encapsulation efficiency (55.33 ± 0.41%). The optimized FAV-NIO formulation (FAV-NIO9) contained FAV, Span® 60 and cholesterol (30:30:40 w/w) with nano-scale size range (167.13 ± 1.60 nm), narrow PDI value (0.07 ± 0.01), adequate zeta potential (− 27.1 ± 1.24 mV) and acceptable encapsulation efficiency (51.30 ± 0.69%). FAV-ASP8 and FAV-NIO9 were suitable for spraying into the nasal cavity (droplet size distribution < 200 μm). In vitro drug release and permeability studies demonstrated enhanced solubility and increased blood–brain barrier (BBB) permeability of FAV formulations, respectively. The ex vivo human nasal permeability study revealed that FAV diffusion from FAV-ASP8 was higher than from FAV-NIO9 or initial FAV. Furthermore, the in vivo animal study showed that FAV-ASP8 had a higher BBB penetration compared to FAV-NIO9 and pure FAV. The in vitro–in vivo correlation study showed good correlation between the in vitro and the in vivo pharmacokinetic data.
		Conclusion: FAV-ASP8 for nose-to-brain delivery system could be a promising formulation to improve FAV bioavailability compared to FAV-NIO9.},
	year = {2025},
	eissn = {1178-2013},
	pages = {6489-6514},
	orcid-numbers = {Volk, Balázs/0000-0002-2019-1874; Kozma, Gábor/0000-0003-2033-0720; Kónya, Zoltán/0000-0002-9406-8596; Rovó, László/0000-0003-1782-1756; Balogh Weiser, Diána/0000-0002-9957-1203; Zupkó, István/0000-0003-3243-5300; Pannonhalminé Csóka, Ildikó/0000-0003-0807-2781; Katona, Gábor/0000-0003-1564-4813; Balogh, György Tibor/0000-0003-3347-1880}
}

@article{MTMT:36161634,
	title = {Synthesis and SAR Studies of Novel Oxazolyl‐ and Thiazolyl‐indoles and Their Intermediates as Selective Antiproliferative Agents Against HL‐60 Leukemia and C6 Glioma Cell Lines},
	url = {https://m2.mtmt.hu/api/publication/36161634},
	author = {Pollák, Patrik and Szele, Boglárka and Varga, Máté and Paszternák, Alexandra and Varga, Kamilla and Dancsó, András and Simig, Gyula and Volk, Balázs and Tábi, Tamás and Milen, Mátyás},
	doi = {10.1002/cmdc.202500030},
	journal-iso = {CHEMMEDCHEM},
	journal = {CHEMMEDCHEM},
	unique-id = {36161634},
	issn = {1860-7179},
	year = {2025},
	eissn = {1860-7187},
	orcid-numbers = {Dancsó, András/0000-0001-8460-217X; Simig, Gyula/0000-0002-2569-6476; Volk, Balázs/0000-0002-2019-1874; Tábi, Tamás/0000-0001-5343-0205}
}

@misc{MTMT:36211581,
	title = {Oxazolil- és tiazolil-indolok szintézise és antiproliferatív szerkezet-hatás vizsgálata leukémia és glióma sejtvonalakon},
	url = {https://m2.mtmt.hu/api/publication/36211581},
	author = {Pollák, Patrik and Volk, Balázs and Simig, Gyula and Milen, Mátyás},
	unique-id = {36211581},
	year = {2025},
	orcid-numbers = {Volk, Balázs/0000-0002-2019-1874; Simig, Gyula/0000-0002-2569-6476}
}