@article{MTMT:34753868,
	title = {Nitrogen-containing andrographolide derivatives with multidrug resistance reversal effects in cancer cells},
	url = {https://m2.mtmt.hu/api/publication/34753868},
	author = {Ribeiro, Joana R. L. and Szemerédi, Nikoletta and Gonçalves, Bruno M. F. and Spengler, Gabriella and Afonso, Carlos A. M. and Ferreira, Maria-José U.},
	doi = {10.1039/D3MD00711A},
	journal-iso = {RSC MED CHEM},
	journal = {RSC MEDICINAL CHEMISTRY},
	volume = {15},
	unique-id = {34753868},
	abstract = {A set of twenty-three new andrographolide derivatives, bearing a nitrogen-containing moiety, is reported. Several derivatives were found to be promising leads for reversing cancer multidrug resistance.},
	year = {2024},
	eissn = {2632-8682},
	pages = {1348-1361},
	orcid-numbers = {Gonçalves, Bruno M. F./0000-0002-3137-5329; Spengler, Gabriella/0000-0001-8085-0950; Afonso, Carlos A. M./0000-0002-7284-5948; Ferreira, Maria-José U./0000-0002-8742-1486}
}

@article{MTMT:34746290,
	title = {Antibacterial Potential of Symmetrical Twin-Drug 3,6-Diaminoxanthones},
	url = {https://m2.mtmt.hu/api/publication/34746290},
	author = {Resende, D.I.S.P. and Durães, F. and Zubarioglu, S. and Freitas-Silva, J. and Szemerédi, Nikoletta and Pinto, M. and Pinto, E. and Martins, da Costa P. and Spengler, Gabriella and Sousa, E.},
	doi = {10.3390/ph17020209},
	journal-iso = {PHARMACEUTICALS-BASE},
	journal = {PHARMACEUTICALS},
	volume = {17},
	unique-id = {34746290},
	abstract = {Global health faces a significant issue with the rise of infectious diseases caused by bacteria, fungi, viruses, and parasites. The increasing number of multi-drug resistant microbial pathogens severely threatens public health worldwide. Antibiotic-resistant pathogenic bacteria, in particular, present a significant challenge. Therefore, there is an urgent need to identify new potential antimicrobial targets and discover new chemical entities that can potentially reverse bacterial resistance. The main goal of this research work was to create and develop a library of 3,6-disubstituted xanthones based on twin drugs and molecular extension approaches to inhibit the activity of efflux pumps. The process involved synthesizing 3,6-diaminoxanthones through the reaction of 9-oxo-9H-xanthene-3,6-diyl bis(trifluoromethanesulfonate) with various primary and secondary amines. The resulting 3,6-disubstituted xanthone derivatives were then tested for their in vitro antimicrobial properties against a range of pathogenic strains and their efficacy in inhibiting the activity of efflux pumps, biofilm formation, and quorum-sensing. Several compounds have exhibited effective antibacterial properties against the Gram-positive bacterial species tested. Xanthone 16, in particular, has demonstrated exceptional efficacy with a remarkable MIC of 11 µM (4 µg/mL) against reference strains Staphylococcus aureus ATCC 25923 and Enterococcus faecalis ATCC 29212, and 25 µM (9 µg/mL) against methicillin-resistant S. aureus 272123. Furthermore, some derivatives have shown potential as antibiofilm agents in a crystal violet assay. The ethidium bromide accumulation assay pinpointed certain compounds inhibiting bacterial efflux pumps. The cytotoxic effect of the most promising compounds was examined in mouse fibroblast cell line NIH/3T3, and two monoamine substituted xanthone derivatives with a hydroxyl substituent did not exhibit any cytotoxicity. Overall, the nature of the substituent was critical in determining the antimicrobial spectra of aminated xanthones. © 2024 by the authors.},
	keywords = {ARTICLE; MOUSE; CYTOTOXICITY; human; high performance liquid chromatography; controlled study; nonhuman; enzyme linked immunosorbent assay; quality control; Fluorometry; human cell; unclassified drug; minimum inhibitory concentration; crystal structure; particle size; chemical structure; CYCLIZATION; multidrug resistance; multidrug resistance; protein purification; Staphylococcus aureus; Serratia marcescens; Antifungal activity; antibacterial activity; antibacterial activity; Biofilm; Pseudomonas aeruginosa; Enterococcus faecalis; bacterial virulence; drug synthesis; Column chromatography; XANTHONES; efflux pump; chemical compound; Molecular docking; heteronuclear single quantum coherence; quadrupole mass spectrometry; quorum sensing; quorum sensing; xanthone derivative; cytotoxicity assay; Biofilm inhibition; 3,6 diaminoxanthone},
	year = {2024},
	eissn = {1424-8247},
	orcid-numbers = {Spengler, Gabriella/0000-0001-8085-0950}
}

@article{MTMT:34729015,
	title = {Új minimálinvazív kezelési lehetőségek jó- és rosszindulatú fül-orr-gégészeti betegségekben nanoszerkezetű hatóanyag-leadó rendszerek alkalmazásával = New minimally invasive treatment options in benign and malignant otorhinolaryngological diseases using nanostructured drug delivery systems},
	url = {https://m2.mtmt.hu/api/publication/34729015},
	author = {Szabó, Diána and Janovák, László and Abdelghafour, Mohamed M. and Takács, Tamás and Csanády, Miklós ifj. and Spengler, Gabriella and Szakács, László and Csanády, Miklós and Rovó, László},
	doi = {10.1556/650.2024.32978},
	journal-iso = {ORV HETIL},
	journal = {ORVOSI HETILAP},
	volume = {165},
	unique-id = {34729015},
	issn = {0030-6002},
	year = {2024},
	eissn = {1788-6120},
	pages = {370-378},
	orcid-numbers = {Janovák, László/0000-0002-2066-319X; Abdelghafour, Mohamed M./0000-0002-7895-4555; Spengler, Gabriella/0000-0001-8085-0950; Rovó, László/0000-0003-1782-1756}
}

@article{MTMT:34715381,
	title = {Cyclic Amines Coupled to Indole Derivatives With Improved Efflux Pump Inhibiting Activity in Bacteria and Cancer Cells},
	url = {https://m2.mtmt.hu/api/publication/34715381},
	author = {Hegedűs, Dóra and Szemerédi, Nikoletta and Gábor, Maja and Sas, Judit and Belasri, Khadija and Szatmári, István and Spengler, Gabriella},
	doi = {10.21873/anticanres.16910},
	journal-iso = {ANTICANCER RES},
	journal = {ANTICANCER RESEARCH},
	volume = {44},
	unique-id = {34715381},
	issn = {0250-7005},
	year = {2024},
	eissn = {1791-7530},
	pages = {1149-1160},
	orcid-numbers = {Szatmári, István/0000-0002-8571-5229; Spengler, Gabriella/0000-0001-8085-0950}
}

@article{MTMT:34601216,
	title = {Organometallic Ru(II), Rh(III) and Re(I) complexes of sterane-based bidentate ligands: Synthesis, solution speciation, interaction with biomolecules and anticancer activity},
	url = {https://m2.mtmt.hu/api/publication/34601216},
	author = {Pivarcsik, Tamás and Kiss, Márton Attila and Rapuš, Uroš and Kljun, Jakob and Spengler, Gabriella and Nagyné Frank, Éva and Turel, Iztok and Enyedy, Éva Anna},
	doi = {10.1039/D3DT04138G},
	journal-iso = {DALTON T},
	journal = {DALTON TRANSACTIONS},
	volume = {53},
	unique-id = {34601216},
	issn = {1477-9226},
	abstract = {In this study, we present the synthesis, characterization and in vitro cytotoxicity of six organometallic [Ru(II)(η6-p-cymene)(N,N)Cl]Cl, [Rh(III)(η5-C5Me5)(N,N)Cl]Cl and [Re(I)(CO)3(N,N)Cl] complexes, in which the (N,N) ligands are sterane-based 2,2’-bipyridine derivatives (4-Me-bpy-St-OH,...},
	year = {2024},
	eissn = {1477-9234},
	pages = {4984-5000},
	orcid-numbers = {Spengler, Gabriella/0000-0001-8085-0950; Nagyné Frank, Éva/0000-0002-1332-0551; Enyedy, Éva Anna/0000-0002-8058-8128}
}

@article{MTMT:34556458,
	title = {Comparative Solution Equilibrium Studies on Anticancer Estradiol-Based Conjugates and Their Copper Complexes},
	url = {https://m2.mtmt.hu/api/publication/34556458},
	author = {Enyedy, Éva Anna and Giricz, Anett and Petrasheuskaya, Tatsiana and Mészáros, János Péter and May, Nóra Veronika and Spengler, Gabriella and Kovács, Ferenc and Molnár, Barnabás and Nagyné Frank, Éva},
	doi = {10.3390/inorganics12020049},
	journal-iso = {INORGANICS},
	journal = {INORGANICS},
	volume = {12},
	unique-id = {34556458},
	abstract = {Steroids are often considered valuable molecular tools for the development of anticancer agents with improved pharmacological properties. Conjugation of metal chelating moieties with a lipophilic sterane backbone is a viable option to obtain novel anticancer compounds. In this work, two estradiol-based hybrid molecules (PMA-E2 and DMA-E2) with an (N,N,O) binding motif and their Cu(II) complexes were developed. The lipophilicity, solubility, and acid-base properties of the novel ligands were determined by the combined use of UV-visible spectrophotometry, pH-potentiometry, and 1H NMR spectroscopy. The solution speciation and redox activity of the Cu(II) complexes were also investigated by means of UV-visible and electron paramagnetic resonance spectroscopy. Two structurally analogous ligands (PMAP and DMAP) were also included in the studies for better interpretation of the solution chemical data obtained. Three pKa values were determined for all ligands, revealing the order of the deprotonation steps: pyridinium-NH+ or NH(CH3)2+, secondary NH2+, and OH. The dimethylamine derivatives (DMA-E2, DMAP) are found in their H2L+ forms in solution at pH 7.4, whereas the fraction of the neutral HL species is significant (34–37%) in the case of the pyridine nitrogen-containing derivatives (PMA-E2, PMAP). Both estradiol derivatives were moderately cytotoxic in human breast (MCF-7) and colon adenocarcinoma (Colo-205) cells (IC50 = 30–63 μM). They form highly stable complexes with Cu(II) ions capable of oxidizing ascorbate and glutathione. These Cu(II) complexes are somewhat more cytotoxic (IC50 = 15–45 μM) than their corresponding ligands and show a better selectivity profile.},
	year = {2024},
	eissn = {2304-6740},
	orcid-numbers = {Enyedy, Éva Anna/0000-0002-8058-8128; Mészáros, János Péter/0000-0001-6301-5259; May, Nóra Veronika/0000-0003-4770-4681; Spengler, Gabriella/0000-0001-8085-0950; Nagyné Frank, Éva/0000-0002-1332-0551}
}

@article{MTMT:34536068,
	title = {A Comparative Study on the Complexation of the Anticancer Iron Chelator VLX600 with Essential Metal Ions},
	url = {https://m2.mtmt.hu/api/publication/34536068},
	author = {Pósa, Vivien and Federa, Anja and Cseh, Klaudia and Wenisch, Dominik and Spengler, Gabriella and May, Nóra Veronika and Lihi, Norbert and Samu, Gergely Ferenc and Jakupec, Michael A. and Keppler, Bernhard K. and Kowol, Christian R. and Enyedy, Éva Anna},
	doi = {10.1021/acs.inorgchem.3c03259},
	journal-iso = {INORG CHEM},
	journal = {INORGANIC CHEMISTRY},
	volume = {63},
	unique-id = {34536068},
	issn = {0020-1669},
	year = {2024},
	eissn = {1520-510X},
	pages = {2401-2417},
	orcid-numbers = {Spengler, Gabriella/0000-0001-8085-0950; May, Nóra Veronika/0000-0003-4770-4681; Lihi, Norbert/0000-0003-2986-2395; Samu, Gergely Ferenc/0000-0002-3239-9154; Jakupec, Michael A./0000-0001-7945-1426; Kowol, Christian R./0000-0002-8311-1632; Enyedy, Éva Anna/0000-0002-8058-8128}
}

@article{MTMT:34501021,
	title = {Chemical composition, antimicrobial and antiproliferative activity of the essential oil from Ambrosia artemisiifolia L},
	url = {https://m2.mtmt.hu/api/publication/34501021},
	author = {Kovács, Balázs and Szemerédi, Nikoletta and Csikós, Orsolya and Kiss, Tivadar and Veres, Katalin and Spengler, Gabriella and Csupor-Löffler, Boglárka and Csupor, Dezső},
	doi = {10.1080/10412905.2024.2303449},
	journal-iso = {J ESSENT OIL RES},
	journal = {JOURNAL OF ESSENTIAL OIL RESEARCH},
	volume = {36},
	unique-id = {34501021},
	issn = {1041-2905},
	year = {2024},
	eissn = {2163-8152},
	pages = {30-42},
	orcid-numbers = {Kiss, Tivadar/0000-0003-3538-377X; Veres, Katalin/0000-0001-7108-3622; Spengler, Gabriella/0000-0001-8085-0950; Csupor, Dezső/0000-0002-4088-3333}
}

@book{MTMT:34747796,
	title = {MEDICAL MICROBIOLOGY. Practical classes},
	url = {https://m2.mtmt.hu/api/publication/34747796},
	isbn = {9789633069325},
	author = {Burián, Katalin and Endrész, Valéria and Megyeri, Klára and Mosolygó, Tímea and Orosz, László and Somogyvári, Ferenc and Spengler, Gabriella and Bogdanov, Anita and Virók, Dezső},
	editor = {Burián, Katalin},
	publisher = {SZTE SZAOK Orvosi Mikrobiológiai Intézet},
	unique-id = {34747796},
	year = {2023},
	orcid-numbers = {Burián, Katalin/0000-0003-1300-2374; Endrész, Valéria/0000-0002-9402-3857; Mosolygó, Tímea/0000-0002-4499-388X; Spengler, Gabriella/0000-0001-8085-0950; Bogdanov, Anita/0000-0003-3067-8835; Burián, Katalin/0000-0003-1300-2374}
}

@book{MTMT:34747744,
	title = {ORVOSI MIKROBIOLÓGIA. Gyakorlati jegyzet I-II. kötet},
	url = {https://m2.mtmt.hu/api/publication/34747744},
	isbn = {9789633069332},
	author = {Burián, Katalin and Endrész, Valéria and Megyeri, Klára and Mosolygó, Tímea and Orosz, László and Somogyvári, Ferenc and Spengler, Gabriella and Bogdanov, Anita and Virók, Dezső},
	editor = {Burián, Katalin},
	publisher = {SZTE SZAOK Orvosi Mikrobiológiai Intézet},
	unique-id = {34747744},
	year = {2023},
	orcid-numbers = {Burián, Katalin/0000-0003-1300-2374; Endrész, Valéria/0000-0002-9402-3857; Mosolygó, Tímea/0000-0002-4499-388X; Spengler, Gabriella/0000-0001-8085-0950; Bogdanov, Anita/0000-0003-3067-8835; Burián, Katalin/0000-0003-1300-2374}
}