@{MTMT:34715613,
	title = {Az öregedés},
	url = {https://m2.mtmt.hu/api/publication/34715613},
	author = {Sőti, Csaba},
	booktitle = {Orvosi patobiokémia},
	unique-id = {34715613},
	year = {2023},
	pages = {405-419},
	orcid-numbers = {Sőti, Csaba/0000-0002-4057-7678}
}

@article{MTMT:34144416,
	title = {Lysosome-related organelles promote stress and immune responses in C. elegans},
	url = {https://m2.mtmt.hu/api/publication/34144416},
	author = {Hajdú, Gábor and Somogyvári, Milán and Csermely, Péter and Sőti, Csaba},
	doi = {10.1038/s42003-023-05246-7},
	journal-iso = {COMMUN BIOL},
	journal = {COMMUNICATIONS BIOLOGY},
	volume = {6},
	unique-id = {34144416},
	abstract = {Lysosome-related organelles (LROs) play diverse roles and their dysfunction causes immunodeficiency. However, their primordial functions remain unclear. Here, we report that C. elegans LROs (gut granules) promote organismal defenses against various stresses. We find that toxic benzaldehyde exposure induces LRO autofluorescence, stimulates the expression of LRO-specific genes and enhances LRO transport capacity as well as increases tolerance to benzaldehyde, heat and oxidative stresses, while these responses are impaired in glo-1 /Rab32 and pgp- 2 ABC transporter LRO biogenesis mutants. Benzaldehyde upregulates glo-1 - and pgp-2- dependent expression of heat shock, detoxification and antimicrobial effector genes, which requires daf-16 /FOXO and/or pmk-1 /p38MAPK. Finally, benzaldehyde preconditioning increases resistance against Pseudomonas aeruginosa PA14 in a glo-1 - and pgp-2 -dependent manner, and PA14 infection leads to the deposition of fluorescent metabolites in LROs and induction of LRO genes. Our study suggests that LROs may play a role in systemic responses to stresses and in pathogen resistance.},
	year = {2023},
	eissn = {2399-3642},
	orcid-numbers = {Somogyvári, Milán/0000-0002-6257-4849; Csermely, Péter/0000-0001-9234-0659; Sőti, Csaba/0000-0002-4057-7678}
}

@article{MTMT:33541689,
	title = {Protein Kinase D3 (PKD3) Requires Hsp90 for Stability and Promotion of Prostate Cancer Cell Migration},
	url = {https://m2.mtmt.hu/api/publication/33541689},
	author = {Varga, Attila and Nguyen, Minh Tu and Pénzes, Kinga and Bátai, Bence and Gyulavári, Pál and Gurbi, Bianka and Murányi, József and Csermely, Péter and Csala, Miklós and Vántus, Tibor and Sőti, Csaba},
	doi = {10.3390/cells12020212},
	journal-iso = {CELLS-BASEL},
	journal = {CELLS},
	volume = {12},
	unique-id = {33541689},
	abstract = {Prostate cancer metastasis is a significant cause of mortality in men. PKD3 facilitates tumor growth and metastasis, however, its regulation is largely unclear. The Hsp90 chaperone stabilizes an array of signaling client proteins, thus is an enabler of the malignant phenotype. Here, using different prostate cancer cell lines, we report that Hsp90 ensures PKD3 conformational stability and function to promote cancer cell migration. We found that pharmacological inhibition of either PKDs or Hsp90 dose-dependently abrogated the migration of DU145 and PC3 metastatic prostate cancer cells. Hsp90 inhibition by ganetespib caused a dose-dependent depletion of PKD2, PKD3, and Akt, which are all involved in metastasis formation. Proximity ligation assay and immunoprecipitation experiments demonstrated a physical interaction between Hsp90 and PKD3. Inhibition of the chaperone–client interaction induced misfolding and proteasomal degradation of PKD3. PKD3 siRNA combined with ganetespib treatment demonstrated a specific involvement of PKD3 in DU145 and PC3 cell migration, which was entirely dependent on Hsp90. Finally, ectopic expression of PKD3 enhanced migration of non-metastatic LNCaP cells in an Hsp90-dependent manner. Altogether, our findings identify PKD3 as an Hsp90 client and uncover a potential mechanism of Hsp90 in prostate cancer metastasis. The molecular interaction revealed here may regulate other biological and pathological functions.},
	year = {2023},
	eissn = {2073-4409},
	orcid-numbers = {Nguyen, Minh Tu/0000-0003-1653-8377; Gyulavári, Pál/0000-0002-5850-0441; Gurbi, Bianka/0000-0002-5635-6255; Csermely, Péter/0000-0001-9234-0659; Csala, Miklós/0000-0002-3829-4361; Vántus, Tibor/0000-0002-7894-017X; Sőti, Csaba/0000-0002-4057-7678}
}

@article{MTMT:33061712,
	title = {Hsp90: From Cellular to Organismal Proteostasis},
	url = {https://m2.mtmt.hu/api/publication/33061712},
	author = {Somogyvári, Milán and Khatatneh, Saba and Sőti, Csaba},
	doi = {10.3390/cells11162479},
	journal-iso = {CELLS-BASEL},
	journal = {CELLS},
	volume = {11},
	unique-id = {33061712},
	abstract = {Assuring a healthy proteome is indispensable for survival and organismal health. Proteome disbalance and the loss of the proteostasis buffer are hallmarks of various diseases. The essential molecular chaperone Hsp90 is a regulator of the heat shock response via HSF1 and a stabilizer of a plethora of signaling proteins. In this review, we summarize the role of Hsp90 in the cellular and organismal regulation of proteome maintenance.},
	year = {2022},
	eissn = {2073-4409},
	orcid-numbers = {Somogyvári, Milán/0000-0002-6257-4849; Sőti, Csaba/0000-0002-4057-7678}
}

@article{MTMT:31847732,
	title = {The pleiotropic neuroprotective effects of resveratrol in cognitive decline and Alzheimer’s disease pathology: from antioxidant to epigenetic therapy.},
	url = {https://m2.mtmt.hu/api/publication/31847732},
	author = {Griñán-Ferré, Christian and Bellver-Sanchis, Aina and Izquierdo, Vanessa and Corpas, Rubén and Roig-Soriano, Joan and Chillón, Miguel and Andres-Lacueva, Cristina and Somogyvári, Milán and Sőti, Csaba and Sanfeliu, C and Mercè, Pallàs},
	doi = {10.1016/j.arr.2021.101271},
	journal-iso = {AGEING RES REV},
	journal = {AGEING RESEARCH REVIEWS},
	volume = {67},
	unique-id = {31847732},
	issn = {1568-1637},
	year = {2021},
	eissn = {1872-9649},
	orcid-numbers = {Somogyvári, Milán/0000-0002-6257-4849; Sőti, Csaba/0000-0002-4057-7678}
}

@article{MTMT:31781703,
	title = {Reaction Kinetics Modeling of eHsp70 Induced by Norepinephrine in Response to Exercise Stress},
	url = {https://m2.mtmt.hu/api/publication/31781703},
	author = {Lovas, Attila and Szilágyi, Brigitta and Bosnyák, Edit and Ács, Pongrác and Oláh, András and Komka, Zsolt and Tóth, Miklós and Merkely, Béla Péter and Németh, Endre and Gilányi, Beatrix and Krepuska, Miklós and Sőti, Csaba and Sótonyi, Péter},
	doi = {10.1055/a-1224-3792},
	journal-iso = {INT J SPORTS MED},
	journal = {INTERNATIONAL JOURNAL OF SPORTS MEDICINE},
	volume = {42},
	unique-id = {31781703},
	issn = {0172-4622},
	year = {2021},
	eissn = {1439-3964},
	pages = {506-512},
	orcid-numbers = {Ács, Pongrác/0000-0002-4999-7345; Merkely, Béla Péter/0000-0001-6514-0723; Sőti, Csaba/0000-0002-4057-7678; Sótonyi, Péter/0000-0002-2216-4298}
}

@article{MTMT:31206109,
	title = {Toxic stress-specific cytoprotective responses regulate learned behavioral decisions in C. elegans},
	url = {https://m2.mtmt.hu/api/publication/31206109},
	author = {Hajdú, Gábor and Gecse, Eszter and Taisz, István and Móra , István András and Sőti, Csaba},
	doi = {10.1186/s12915-021-00956-y},
	journal-iso = {BMC BIOL},
	journal = {BMC BIOLOGY},
	volume = {19},
	unique-id = {31206109},
	issn = {1741-7007},
	year = {2021},
	eissn = {1741-7007},
	orcid-numbers = {Gecse, Eszter/0000-0003-1174-4219; Sőti, Csaba/0000-0002-4057-7678}
}

@article{MTMT:31790902,
	title = {Synaptic polarity and sign-balance prediction using gene expression data in the Caenorhabditis elegans chemical synapse neuronal connectome network},
	url = {https://m2.mtmt.hu/api/publication/31790902},
	author = {Fenyves, Bánk and Szilágyi, Gábor S. and Vassy, Zsolt and Sőti, Csaba and Csermely, Péter},
	doi = {10.1371/journal.pcbi.1007974},
	journal-iso = {PLOS COMPUT BIOL},
	journal = {PLOS COMPUTATIONAL BIOLOGY},
	volume = {16},
	unique-id = {31790902},
	issn = {1553-734X},
	abstract = {Graph theoretical analyses of nervous systems usually omit the aspect of connection polarity, due to data insufficiency. The chemical synapse network of Caenorhabditis elegans is a well-reconstructed directed network, but the signs of its connections are yet to be elucidated. Here, we present the gene expression-based sign prediction of the ionotropic chemical synapse connectome of C. elegans (3,638 connections and 20,589 synapses total), incorporating available presynaptic neurotransmitter and postsynaptic receptor gene expression data for three major neurotransmitter systems. We made predictions for more than two-thirds of these chemical synapses and observed an excitatory-inhibitory (E:I) ratio close to 4:1 which was found similar to that observed in many real-world networks. Our open source tool (http://EleganSign.linkgroup.hu) is simple but efficient in predicting polarities by integrating neuronal connectome and gene expression data.},
	year = {2020},
	eissn = {1553-7358},
	orcid-numbers = {Fenyves, Bánk/0000-0003-2374-7513; Szilágyi, Gábor S./0000-0003-0205-5796; Vassy, Zsolt/0000-0003-1370-0877; Sőti, Csaba/0000-0002-4057-7678; Csermely, Péter/0000-0001-9234-0659}
}

@article{MTMT:31356446,
	title = {Az integratív medicina képzésének hazai koncepciója nemzetközi minták alapján},
	url = {https://m2.mtmt.hu/api/publication/31356446},
	author = {Eőry, Ajándék and Szabó, János and Csik, Ivett and Csupor, Dezső and Sőti, Csaba and Kalabay, László and Varsányi, Péter and Komsa, Ildikó and Eőry, Ajándok and Torzsa, Péter},
	doi = {10.1556/650.2020.31754},
	journal-iso = {ORV HETIL},
	journal = {ORVOSI HETILAP},
	volume = {161},
	unique-id = {31356446},
	issn = {0030-6002},
	year = {2020},
	eissn = {1788-6120},
	pages = {1122-1130},
	orcid-numbers = {Eőry, Ajándék/0000-0002-4434-1339; Csupor, Dezső/0000-0002-4088-3333; Sőti, Csaba/0000-0002-4057-7678; Kalabay, László/0000-0002-8329-3755; Torzsa, Péter/0000-0002-8148-4961}
}

@misc{MTMT:31173629,
	title = {Toxic stress-pecific molecular cytoprotective responses determine behavioural adaptation in C. elegans},
	url = {https://m2.mtmt.hu/api/publication/31173629},
	author = {Hajdú, Gábor and Taisz, I and Móra, I and Sőti, Csaba},
	unique-id = {31173629},
	year = {2019},
	orcid-numbers = {Sőti, Csaba/0000-0002-4057-7678}
}