TY - JOUR AU - Dvorácskó, Szabolcs AU - Lázár, László AU - Fülöp, Ferenc AU - Palkó, Márta AU - Zalán, Zita AU - Penke, Botond AU - Fülöp, Lívia AU - Tömböly, Csaba AU - Bogár, Ferenc TI - Novel High Affinity Sigma-1 Receptor Ligands from Minimal Ensemble Docking-Based Virtual Screening JF - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES J2 - INT J MOL SCI VL - 22 PY - 2021 IS - 15 PG - 17 SN - 1661-6596 DO - 10.3390/ijms22158112 UR - https://m2.mtmt.hu/api/publication/32123857 ID - 32123857 LA - English DB - MTMT ER - TY - BOOK AU - Lázár, László AU - Miklós, Ferenc AU - Palkó, Márta AU - Szakonyi, Zsolt AU - Zalán, Zita ED - Fülöp, Ferenc ED - Lázár, László ED - Szakonyi, Zsolt TI - Laboratory investigations in pharmaceutical chemistry ET - 0 PB - Szegedi Tudományegyetem (SZTE) CY - Szeged PY - 2015 UR - https://m2.mtmt.hu/api/publication/3123383 ID - 3123383 LA - English DB - MTMT ER - TY - BOOK AU - Lázár, László AU - Miklós, Ferenc AU - Palkó, Márta AU - Szakonyi, Zsolt AU - Zalán, Zita ED - Lázár, László ED - Fülöp, Ferenc TI - Gyógyszerészi kémia gyakorlatok ET - 0 PB - Szegedi Tudományegyetem (SZTE) CY - Szeged PY - 2015 UR - https://m2.mtmt.hu/api/publication/3123382 ID - 3123382 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Henri, Kivelä AU - Olli, Martiskainen AU - Kalevi, Pihlaja AU - Zalán, Zita AU - Lázár, László TI - Stereoselective synthesis and structural analysis of polycyclic lactams derived from tetrahydroisoquinoline 1,2- and 1,3-diamines JF - ARKIVOC J2 - ARKIVOC VL - 2012 PY - 2012 IS - 5 SP - 244 EP - 264 PG - 21 SN - 1551-7012 DO - 10.3998/ark.5550190.0013.521 UR - https://m2.mtmt.hu/api/publication/2275877 ID - 2275877 N1 - Funding Agency and Grant Number: [TAMOP-4.2.1/B-09/1/KONV-2010-0005] Funding text: ZZ and LL thank TAMOP-4.2.1/B-09/1/KONV-2010-0005 for financial support. Part number: 5 LA - English DB - MTMT ER - TY - JOUR AU - Martinek, Tamás AU - Szolnoki, Éva Tünde AU - Zalán, Zita AU - Fülöp, Ferenc TI - Synthesis And Steric Structure of Pyrrolidine- And Piperidine-fused 1,3,4,2-oxadiazaphosphinanes JF - ARKIVOC J2 - ARKIVOC VL - 2007 PY - 2007 IS - 5 SP - 202 EP - 209 PG - 8 SN - 1551-7012 DO - 10.3998/ark.5550190.0008.516 UR - https://m2.mtmt.hu/api/publication/1085086 ID - 1085086 N1 - Part number: 5 AB - Pyrrolidine- and piperidine-fused 1,3,4,2-oxadiazaphosphinane 2-oxides were prepared by cyclization of the corresponding pyrrolidine-and piperidine-hydrazino alcohols by using phosphorus-containing reagents. Stereochemical and conformational analyses were carried out in order to determine the effect of the ring size on the conformational behavior of the nitrogen-bridged bicyclic system. It was found that the chair conformation in the pyrrolidine-fused 1,3,4,2-oxadiazaphosphinane 2-oxides can be shifted toward twisted or distorted conformations. LA - English DB - MTMT ER - TY - THES AU - Zalán, Zita TI - Syntheses and ring-closures of difunctional tetrahydroisoquinolines PB - Szegedi Tudományegyetem (SZTE) PY - 2006 SP - 56 UR - https://m2.mtmt.hu/api/publication/31156393 ID - 31156393 LA - English DB - MTMT ER - TY - JOUR AU - Zalán, Zita TI - Tetrahidroizokinolinvázas difunkciós vegyületek szintézise és gyűrűzárásai [Syntheses and ring-closures of difunctional tetrahydroisoquinolines] JF - ACTA PHARMACEUTICA HUNGARICA J2 - ACTA PHARM HUNG VL - 76 PY - 2006 IS - 3 SP - 155 EP - 164 PG - 10 SN - 0001-6659 UR - https://m2.mtmt.hu/api/publication/20316698 ID - 20316698 N1 - Admin megjegyzés-24893122 tblsubtype: (name,DocTypeID) ('Tetrahidroizokinolinvázas difunkciós vegyületek szintézise és gyuruzárásai',24) #Besorolás LA - Hungarian DB - MTMT ER - TY - JOUR AU - Juhasz, M AU - Zalán, Zita AU - Fülöp, Ferenc AU - Pihlaja, K TI - Electron ionization mass spectra of phosphorus-containing heterocycles. III. 1,3,4,2-Oxadiazaphosphinane 2-oxides JF - RAPID COMMUNICATIONS IN MASS SPECTROMETRY J2 - RAPID COMMUN MASS SPECTR VL - 20 PY - 2006 IS - 23 SP - 3595 EP - 3604 PG - 10 SN - 0951-4198 DO - 10.1002/rcm.2771 UR - https://m2.mtmt.hu/api/publication/1078936 ID - 1078936 N1 - Turku Univ, Dept Chem, FI-20014 Turku, Finland. Univ Szeged, Inst Pharmaceut Chem, H-6701 Szeged, Hungary. AB - The 1,3,4,2-oxadiazaphosphinane 2-oxides differ not only in the relative configuration of the P atom (R* or S*) but also in many other ways such as the ring size, ring fusion, P substitution and bridgehead N atom whose effects on their fragmentations have been studied. Some fragmentations resembled those of 3,1,2-oxazaphosphinane 2-oxides and 1,3,2-diazaphosphinane-2-oxides, but new routes were also found, initiated by ionization at the bridgehead N atom. The relative abundances of the molecular ions and some fragment ions allowed the differentiation of cis-trans epimers. Compounds with n = 2 and R=N(CH2CH2Cl)(2), and linearly or angularly isoquinoline-fused isomers in most cases, gave more numerous ions with lower relative abundances than the other compounds in this series. Only the isoquinoline derivatives provided fragments resulting from ionization of the aromatic part of the molecule. Copyright (c) 2006 John Wiley & Sons, Ltd. LA - English DB - MTMT ER - TY - JOUR AU - Juhasz, M AU - Martiskainen, O AU - Zalán, Zita AU - Fülöp, Ferenc AU - Pihlaja, K TI - Electron ionization mass spectra of phosphorus-containing heterocycles. I. 1,4,4a,5,6,7,8,8a-octahydro-2H-3,1,2-benzoxazaphosphinine 2-oxides JF - RAPID COMMUNICATIONS IN MASS SPECTROMETRY J2 - RAPID COMMUN MASS SPECTR VL - 20 PY - 2006 SP - 433 EP - 437 PG - 5 SN - 0951-4198 DO - 10.1002/rcm.2319 UR - https://m2.mtmt.hu/api/publication/1012941 ID - 1012941 N1 - Institute of Pharmaceutical Chemistry, University of Szeged, POB 121, H-6701 Szeged, Hungary Department of Chemistry, University of Turku, FIN-20014 Turku, Finland Cited By :7 Export Date: 15 February 2023 CODEN: RCMSE Correspondence Address: Pihlaja, K.; Department of Chemistry, , FIN-20014 Turku, Finland; email: kpihlaja@utu.fi AB - The electron ionization mass spectra of 27 cis- and trans-annelated 1,4,4a,5,6,7,8,8a-octahydro-2H-3,1,2-benzoxazaphosphinine 2-oxides were recorded to clarify the effects of the ring heteroatom (O or N), ring annelation, the P configuration and the substituents attached to the ring or to the N and P atoms. For compounds 1-12 different alkyl radical and alkene losses and the cleavage of the P-heteroatom bonds, instead of the P-C bonds, were representative and dependent mainly on the substitution on the N and P atoms. The replacement of Ph and OPh by N(CH2CH2Cl)(2) on the P atom had a dramatic influence on the fragmentation process: new fragment ions were obtained and very little W (1-3%) was formed. Only slight differences were found between some of the corresponding isomers, but interestingly the compounds formed clear groups on the basis of the differences in their fragmentation, depending on the ring-N and ring-P substituents. Copyright (c) 2006 John Wiley & Sons, Ltd. LA - English DB - MTMT ER - TY - JOUR AU - Zalán, Zita AU - Martinek, Tamás AU - Lázár, László AU - Sillanpaa, R AU - Fülöp, Ferenc TI - Synthesis and conformational analysis of tetrahydroisoquinoline and piperidine-fused 1,3,4,2-oxadiazaphosphinanes, new ring systems JF - TETRAHEDRON J2 - TETRAHEDRON VL - 62 PY - 2006 IS - 12 SP - 2883 EP - 2891 PG - 9 SN - 0040-4020 DO - 10.1016/j.tet.2006.01.018 UR - https://m2.mtmt.hu/api/publication/1012939 ID - 1012939 N1 - Institute of Pharmaceutical Chemistry, University of Szeged, PO Box 121, H-6701 Szeged, Hungary Department of Chemistry, University of Jyväskylä, PO Box 35, 40351 Jyväskylä, Finland Cited By :27 Export Date: 15 February 2023 CODEN: TETRA Correspondence Address: Fülöp, F.; Institute of Pharmaceutical Chemistry, PO Box 121, H-6701 Szeged, Hungary; email: fulop@pharm.u-szeged.hu Funding details: Hungarian Scientific Research Fund, OTKA, T049407 Funding text 1: The authors' thanks are due to the Hungarian Research Foundation (OTKA No. T049407) for financial support. AB - Through cyclization of tetrahydroisoquinoline and piperidine 1,2-hydrazino alcohols with phenylphosphonic dichloride and phenyl dichlorophosphate, P-epimeric diastereomers of 1,6,7,11b-tetrahydro-4H-1,3,4,2-oxidiazaphosphino[5,4-a]isoquinoline-3-o xides (13 and 14). 1,6,11,11a-tetrahydro-4H-1,3,4,2-oxadiazaphosphino[4,5-b]isoquinoline-3- oxides (15 and 16) and 1,6,7,8,9,9a-hexahydro-4H-pyrido[1,2-d][1,3,4,2]oxadiazaphosphinane-3-ox ides (17 and 18), the first representatives of these ring systems, were prepared. NMR and X-ray diffraction studies revealed that, independently of the P-substituent and the relative configuration of the phosphorus atom, 13, 14, 17 and 18 could be characterized by trans-connected hetero rings and the chair conformation of the 1,3,4,2-oxadiazaphosphinane moiety, while the stereochemistry of the connection of the hetero rings in the 1,3,4,2-oxidiazaphosphinanes linearly fused to tetrahydroisoquinoline (15 and 16) was found to be dependent on the P-configuration relative to that of the carbon at the annelation. (c) 2006 Elsevier Ltd. All rights reserved. LA - English DB - MTMT ER -