@article{MTMT:34804165,
	title = {Ammonium chloride-induced hypothermia is attenuated by transient receptor potential channel vanilloid-1, but augmented by ankyrin-1 in rodents},
	url = {https://m2.mtmt.hu/api/publication/34804165},
	author = {Rumbus, Zoltán and Fekete, Kata and Kelava, Leonardo and Gardos, Bibor and Klonfar, Krisztian and Kéringer, Patrik and Pintér, Erika and Pákai, Eszter and Garami, András},
	doi = {10.1016/j.lfs.2024.122633},
	journal-iso = {LIFE SCI},
	journal = {LIFE SCIENCES},
	volume = {346},
	unique-id = {34804165},
	issn = {0024-3205},
	abstract = {Systemic administration of ammonium chloride (NH4Cl), an acidifying agent used in human patients and experimental conditions, causes hypothermia in mice, however, the mechanisms of the thermoregulatory response to NH4Cl and whether it develops in other species remained unknown.We studied body temperature (Tb) changes in rats and mice induced by intraperitoneal administration of NH4Cl after blockade of transient receptor potential vanilloid-1 (TRPV1) or ankyrin-1 (TRPA1) channels.In rats, NH4Cl decreased Tb by 0.4-0.8°C (p < 0.05). The NH4Cl-induced hypothermia also developed in Trpv1 knockout (Trpv1-/-) and wild-type (Trpv1+/+) mice, however, the Tb drop was exaggerated in Trpv1-/- mice compared to Trpv1+/+ controls with maximal decreases of 4.0 vs. 2.1°C, respectively (p < 0.05). Pharmacological blockade of TRPV1 channels with AMG 517 augmented the hypothermic response to NH4Cl in genetically unmodified mice and rats (p < 0.05 for both). In contrast, when NH4Cl was infused to mice genetically lacking the TRPA1 channel, the hypothermic response was significantly attenuated compared to wild-type controls with maximal mean Tb difference of 1.0°C between the genotypes (p = 0.008). Pretreatment of rats with a TRPA1 antagonist (A967079) also attenuated the NH4Cl-induced Tb drop with a maximal difference of 0.7°C between the pretreatment groups (p = 0.003).TRPV1 channels limit, whereas TRPA1 channels exaggerate the development of NH4Cl-induced hypothermia in rats and mice, but other mechanisms are also involved. Our results warrant for regular Tb control and careful consideration of NH4Cl treatment in patients with TRPA1 and TRPV1 channel dysfunctions.},
	keywords = {THERMOREGULATION; TRPV1; hypothermia; TRPA1; thermophysiology; NH(4)Cl},
	year = {2024},
	eissn = {1879-0631},
	orcid-numbers = {Pintér, Erika/0000-0001-9898-632X; Garami, András/0000-0003-2493-0571}
}

@misc{MTMT:34794536,
	title = {A Viable Concept to Support Gifted Medical Students to Accelerate Their Development: The Romhányi György College for Advanced Studies},
	url = {https://m2.mtmt.hu/api/publication/34794536},
	author = {Filipánits, Kristóf and László, Kristóf and Horváth-Sarródi, Andrea and Pintér, Erika and Duga, Zsófia and Németh, Timea and Czopf, László and Tamás, Andrea and Reglődi, Dóra},
	unique-id = {34794536},
	year = {2024},
	orcid-numbers = {Pintér, Erika/0000-0001-9898-632X; Czopf, László/0000-0001-9565-0732}
}

@{MTMT:34792101,
	title = {Low-dose, stable-release transdermal preparation and patch, and method for their production},
	url = {https://m2.mtmt.hu/api/publication/34792101},
	author = {Pintér, Erika and Botz, Lajos and Pozsgai, Gábor and László, Szabolcs and Wagner, Ödön},
	unique-id = {34792101},
	year = {2024},
	orcid-numbers = {Pintér, Erika/0000-0001-9898-632X}
}

@article{MTMT:34574198,
	title = {The Lack of TRPA1 Ion Channel Does Not Affect the Chronic Stress-Induced Activation of the Locus Ceruleus},
	url = {https://m2.mtmt.hu/api/publication/34574198},
	author = {Milicic, Milica and Gaszner, Balázs and Berta, Gergely and Pintér, Erika and Kormos, Viktória},
	doi = {10.3390/ijms25031765},
	journal-iso = {INT J MOL SCI},
	journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES},
	volume = {25},
	unique-id = {34574198},
	issn = {1661-6596},
	abstract = {We have previously proven the involvement of transient receptor potential ankyrin 1 (TRPA1) in stress adaptation. A lack of TRPA1 affects both urocortin 1 (member of the corticotropin-releasing hormone (CRH) family) content of the Edinger-Westphal nucleus. The noradrenergic locus ceruleus (LC) is also an important player in mood control. We aimed at investigating whether the TRPA1 is expressed in the LC, and to test if the response to chronic variable mild stress (CVMS) is affected by a lack of TRPA1. The TRPA1 expression was examined via RNAscope in situ hybridization. We investigated TRPA1 knockout and wildtype mice using the CVMS model of depression. Tyrosine hydroxylase (TH) and FOSB double immunofluorescence were used to test the functional neuromorphological changes in the LC. No TRPA1 expression was detected in the LC. The TH content was not affected by CVMS exposure. The CVMS-induced FOSB immunosignal did not co-localize with the TH neurons. TRPA1 is not expressed in the LC. A lack of functional TRPA1 receptor neither directly nor indirectly affects the TH content of LC neurons under CVMS.},
	keywords = {STRESS; DEPRESSION; TRPA1; CVMS},
	year = {2024},
	eissn = {1422-0067},
	orcid-numbers = {Gaszner, Balázs/0000-0003-2830-2732; Pintér, Erika/0000-0001-9898-632X}
}

@article{MTMT:34505194,
	title = {TRPA1 Receptor Expressed by the Edinger-Westphal Nucleus (EWcp) is Involved in Stress Adaptation},
	url = {https://m2.mtmt.hu/api/publication/34505194},
	author = {Pintér, Erika and Kormos, Viktoria and Zelena, Dóra and Konkoly, János and Gaszner, Balazs and Kecskes, Miklos},
	doi = {10.1124/jpet.122.167950},
	journal-iso = {J PHARMACOL EXP THER},
	journal = {JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS},
	volume = {385},
	unique-id = {34505194},
	issn = {0022-3565},
	year = {2023},
	eissn = {1521-0103},
	orcid-numbers = {Pintér, Erika/0000-0001-9898-632X}
}

@article{MTMT:34424543,
	title = {The Epigenetics of Neuropathic Pain: A Systematic Update},
	url = {https://m2.mtmt.hu/api/publication/34424543},
	author = {Pethő, Gábor and Kántás, Boglárka and Horváth, Ádám and Pintér, Erika},
	doi = {10.3390/ijms242417143},
	journal-iso = {INT J MOL SCI},
	journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES},
	volume = {24},
	unique-id = {34424543},
	issn = {1661-6596},
	abstract = {Epigenetics deals with alterations to the gene expression that occur without change in the nucleotide sequence in the DNA. Various covalent modifications of the DNA and/or the surrounding histone proteins have been revealed, including DNA methylation, histone acetylation, and methylation, which can either stimulate or inhibit protein expression at the transcriptional level. In the past decade, an exponentially increasing amount of data has been published on the association between epigenetic changes and the pathomechanism of pain, including its most challenging form, neuropathic pain. Epigenetic regulation of the chromatin by writer, reader, and eraser proteins has been revealed for diverse protein targets involved in the pathomechanism of neuropathic pain. They include receptors, ion channels, transporters, enzymes, cytokines, chemokines, growth factors, inflammasome proteins, etc. Most work has been invested in clarifying the epigenetic downregulation of mu opioid receptors and various K+ channels, two types of structures mediating neuronal inhibition. Conversely, epigenetic upregulation has been revealed for glutamate receptors, growth factors, and lymphokines involved in neuronal excitation. All these data cannot only help better understand the development of neuropathic pain but outline epigenetic writers, readers, and erasers whose pharmacological inhibition may represent a novel option in the treatment of pain.},
	year = {2023},
	eissn = {1422-0067},
	orcid-numbers = {Pintér, Erika/0000-0001-9898-632X}
}

@article{MTMT:34324931,
	title = {A kénhidrogén és a nitrogén-monoxid által vezérelt jelátviteli útvonalak összefonódása},
	url = {https://m2.mtmt.hu/api/publication/34324931},
	author = {Bogdándi, Virág and Ditrói, Tamás and Bátai, István Zoárd and Sándor, Zoltán and Minnion, Magdalena and Varga-Vasas, Anita and Galambos, Klaudia and Buglyó, Péter and Pintér, Erika and Feelisch, Martin and Nagy, Péter},
	journal-iso = {MAGYAR ONKOLÓGIA},
	journal = {MAGYAR ONKOLÓGIA},
	volume = {67},
	unique-id = {34324931},
	issn = {0025-0244},
	year = {2023},
	eissn = {2060-0399},
	pages = {14-14},
	orcid-numbers = {Buglyó, Péter/0000-0002-6714-7598; Pintér, Erika/0000-0001-9898-632X; Nagy, Péter/0000-0003-3393-235X}
}

@article{MTMT:34212246,
	title = {The lack of transient receptor potential ankyrin 1 (TRPA1) alters the behavioural responses as well as the urocortin1 expression of the Edinger-Westphal nucleus in the mouse model of posttraumatic stress disorder},
	url = {https://m2.mtmt.hu/api/publication/34212246},
	author = {Konkoly, Janos and Kormos, Viktoria and Gaszner, Balazs and Zelena, Dora and Pintér, Erika},
	journal-iso = {BR J PHARMACOL},
	journal = {BRITISH JOURNAL OF PHARMACOLOGY},
	volume = {180},
	unique-id = {34212246},
	issn = {0007-1188},
	year = {2023},
	eissn = {1476-5381},
	pages = {984-985},
	orcid-numbers = {Pintér, Erika/0000-0001-9898-632X}
}

@article{MTMT:34183455,
	title = {The anti-inflammatory effect of dimethyl trisulfide in experimental acute pancreatitis},
	url = {https://m2.mtmt.hu/api/publication/34183455},
	author = {Orján, Erik Márk and Kormányos, Eszter Sára and Fűr, Gabriella and Dombi, Ágnes and Bálint, Emese Réka and Balla, Zsolt and Balog, Beáta Adél and Dágó, Ágnes and Totonji, Ahmad and Bátai, István Zoárd and Jurányi, Eszter Petra and Ditrói, Tamás and Al-omari, Ammar and Pozsgai, Gábor and Kormos, Viktória and Nagy, Péter and Pintér, Erika and Rakonczay, Zoltán and Kiss, Lóránd},
	doi = {10.1038/s41598-023-43692-9},
	journal-iso = {SCI REP},
	journal = {SCIENTIFIC REPORTS},
	volume = {13},
	unique-id = {34183455},
	issn = {2045-2322},
	abstract = {Various organosulfur compounds, such as dimethyl trisulfide (DMTS), display anti-inflammatory properties. We aimed to examine the effects of DMTS on acute pancreatitis (AP) and its mechanism of action in both in vivo and in vitro studies. AP was induced in FVB/n mice or Wistar rats by caerulein, ethanol-palmitoleic acid, or L-ornithine-HCl. DMTS treatments were administered subcutaneously. AP severity was assessed by pancreatic histological scoring, pancreatic water content, and myeloperoxidase activity measurements. The behaviour of animals was followed. Pancreatic heat shock protein 72 (HSP72) expression, sulfide, and protein persulfidation were measured. In vitro acinar viability, intracellular Ca 2+ concentration, and reactive oxygen species production were determined. DMTS dose-dependently decreased the severity of AP. It declined the pancreatic infiltration of leukocytes and cellular damage in mice. DMTS upregulated the HSP72 expression during AP and elevated serum sulfide and low molecular weight persulfide levels. DMTS exhibited cytoprotection against hydrogen peroxide and AP-inducing agents. It has antioxidant properties and modulates physiological but not pathophysiological Ca 2+ signalling. Generally, DMTS ameliorated AP severity and protected pancreatic acinar cells. Our findings indicate that DMTS is a sulfur donor with anti-inflammatory and antioxidant effects, and organosulfur compounds require further investigation into this potentially lethal disease.},
	year = {2023},
	eissn = {2045-2322},
	orcid-numbers = {Orján, Erik Márk/0000-0003-4176-0834; Balog, Beáta Adél/0009-0008-3568-4090; Jurányi, Eszter Petra/0000-0002-0563-4876; Nagy, Péter/0000-0003-3393-235X; Pintér, Erika/0000-0001-9898-632X; Rakonczay, Zoltán/0000-0002-1499-3416}
}

@article{MTMT:34084348,
	title = {Plasma Somatostatin Levels Increase during Scoliosis Surgery, but Not Herniated Disc Operations: Results of a Pilot Study},
	url = {https://m2.mtmt.hu/api/publication/34084348},
	author = {Sütő, Balázs and Kolumbán, Bálint and Szabó, Éva and Pásztor, Sára and Németh, Timea and Bagoly, Teréz and Botz, Bálint and Pintér, Erika and Helyes, Zsuzsanna},
	doi = {10.3390/biomedicines11082154},
	journal-iso = {BIOMEDICINES},
	journal = {BIOMEDICINES},
	volume = {11},
	unique-id = {34084348},
	abstract = {Somatostatin (SST) released from capsaicin-sensitive sensory nerves in response to stimulation exerts systemic anti-inflammatory, analgesic actions. Its elevation correlates with the extent of tissue injury. We measured plasma SST alterations during spine operations (scoliosis and herniated disc) to determine whether its release might be a general protective mechanism during painful conditions. Sampling timepoints were baseline (1), after: soft tissue retraction (2), osteotomy (3), skin closure (4), the following morning (5). Plasma SST-like immunoreactivity (SST-LI) determined by radioimmunoassay was correlated with pain intensity and the correction angle (Cobb angle). In scoliosis surgery, postoperative pain intensity (VAS 2.) 1 day after surgery significantly increased (from 1.44 SEM ± 0.68 to 6.77 SEM ± 0.82, p = 0.0028) and positively correlated with the Cobb angle (p = 0.0235). The baseline Cobb degree negatively correlated (p = 0.0459) with the preoperative SST-LI. The plasma SST-LI significantly increased in fraction 3 compared to the baseline (p < 0.05), and significantly decreased thereafter (p < 0.001). In contrast, in herniated disc operations no SST-LI changes were observed in either group. The VAS decreased after surgery both in the traditional (mean 6.83 to 2.29, p = 0.0005) and microdiscectomy groups (mean 7.22 to 2.11, p = 0.0009). More extensive and destructive scoliosis surgery might cause greater tissue damage with greater pain (inflammation), which results in a significant SST release into the plasma from the sensory nerves. SST is suggested to be involved in an endogenous postoperative analgesic (anti-inflammatory) mechanism.},
	year = {2023},
	eissn = {2227-9059},
	orcid-numbers = {Pintér, Erika/0000-0001-9898-632X}
}