TY - JOUR AU - Leone, M.A. AU - Helbok, R. AU - Bianchi, E. AU - Yasuda, C.L. AU - Konti, M. AU - Ramankulov, D. AU - Lolich, M. AU - Lovrencic-Huzjan, A. AU - Kovács, Tibor AU - Armon, C. AU - Cotelli, M.S. AU - Cavallieri, F. AU - Grosu, O. AU - Kiteva-Trenchevska, G. AU - Rodriguez-Leyva, I. AU - Boldingh, M. AU - Brola, W. AU - Maia, L.F. AU - de, Seabra M.M.L. AU - Davidescu, E.I. AU - Popescu, B.O. AU - Kopishinskaia, S. AU - Bassetti, C.L.A. AU - Moro, E. ED - Bereczki, Dániel / Collaborator TI - Outcome predictors of post-COVID conditions in the European Academy of Neurology COVID-19 registry JF - JOURNAL OF NEUROLOGY J2 - J NEUROL PY - 2024 SN - 0340-5354 DO - 10.1007/s00415-024-12212-8 UR - https://m2.mtmt.hu/api/publication/34772248 ID - 34772248 LA - English DB - MTMT ER - TY - JOUR AU - Bankó, Éva Mária AU - Weiss, Béla AU - Hevesi, István AU - Manga, Annamária Eszter AU - Vakli, Pál AU - Havadi-Nagy, Menta AU - Kelemen, Rebeka AU - Somogyi, Eszter AU - Homolya, István AU - Bihari, Adél AU - Simon, Ádám AU - Nárai, Ádám AU - Tóth, Krisztina AU - Báthori, Noémi AU - Tomacsek, Vivien AU - Horváth, András Attila AU - Kamondi, Anita AU - Racsmány, Mihály AU - Dénes, Ádám AU - Simor, Péter AU - Kovács, Tibor AU - Hermann, Petra AU - Vidnyánszky, Zoltán TI - Study protocol of the Hungarian Longitudinal Study of Healthy Brain Aging (HuBA). JF - IDEGGYOGYASZATI SZEMLE / CLINICAL NEUROSCIENCE J2 - IDEGGYOGY SZEMLE VL - 77 PY - 2024 IS - 1-2 SP - 51 EP - 59 PG - 9 SN - 0019-1442 DO - 10.18071/isz.77.0051 UR - https://m2.mtmt.hu/api/publication/34568140 ID - 34568140 N1 - Funding Agency and Grant Number: Hungarian National Research, Development and Innovation Office [2019-2.1.7-ERANET-2020-00008]; European Union [RRF-2.3.1-21-202200015]; HUN-REN [0708-21 515 AT]; Ministry of Culture and Innovation of Hungary from the National-Research, Development, and Innovation Fund Funding text: This research was supported by the Hungarian National Research, Development and Innovation Office (grant number 2019-2.1.7-ERANET-2020-00008) and Project no. RRF-2.3.1-21-202200015, which has been implemented with the support provided by the European Union. This work was also supported by a grant from HUN-REN (0708-21 515 AT) to MR and ZV. NB was supported by the Ministry of Culture and Innovation of Hungary from the National-Research, Development, and Innovation Fund, financed under the TKP2021EGA funding scheme. We thank Szandra Pancsusak and Emilia Nagy for managing patient logistics and are very grateful to all participants for their time and participation in this study. AB - Neuro­cog­nitive aging and the associated brain diseases impose a major social and economic burden. Therefore, substantial efforts have been put into revealing the lifestyle, the neurobiological and the genetic underpinnings of healthy neurocognitive aging. However, these studies take place almost exclusively in a limited number of highly-developed countries. Thus, it is an important open question to what extent their findings may generalize to neurocognitive aging in other, not yet investigated regions. The purpose of the Hungarian Longitudinal Study of Healthy Brain Aging (HuBA) is to collect multi-modal longitudinal data on healthy neurocognitive aging to address the data gap in this field in Central and Eastern Europe..We adapted the Australian Ima­ging, Biomarkers and Lifestyle (AIBL) study of aging study protocol to local circumstances and collected demographic, lifestyle, men­tal and physical health, medication and medical history related information as well as re­cor­ded a series of magnetic resonance imaging (MRI) data. In addition, participants were al­so offered to participate in the collection of blood samples to assess circulating in­flam­matory biomarkers as well as a sleep study aimed at evaluating the general sleep quality based on multi-day collection of subjective sleep questionnaires and whole-night elec­troencephalographic (EEG) data..Baseline data collection has al­ready been accomplished for more than a hundred participants and data collection in the se­condsession is on the way. The collected data might reveal specific local trends or could also indicate the generalizability of previous findings. Moreover, as the HuBA protocol al­so offers a sleep study designed for tho­rough characterization of participants’ sleep quality and related factors, our extended multi-modal dataset might provide a base for incorporating these measures into healthy and clinical aging research. .Besides its straightforward na­tional benefits in terms of health ex­pen­di­ture, we hope that this Hungarian initiative could provide results valid for the whole Cent­ral and Eastern European region and could also promote aging and Alzheimer’s disease research in these countries.. LA - English DB - MTMT ER - TY - JOUR AU - Kollai, Sarolta AU - Bereczki, Dániel AU - Glasz, Tibor AU - Hortobágyi, Tibor AU - Kovács, Tibor TI - Early histopathological changes of secondary degeneration in the spinal cord after total MCA territory stroke JF - SCIENTIFIC REPORTS J2 - SCI REP VL - 13 PY - 2023 IS - 1 PG - 9 SN - 2045-2322 DO - 10.1038/s41598-023-49230-x UR - https://m2.mtmt.hu/api/publication/34441451 ID - 34441451 LA - English DB - MTMT ER - TY - JOUR AU - Bateman, Randall J. AU - Smith, Janice AU - Donohue, Michael C. AU - Delmar, Paul AU - Abbas, Rachid AU - Salloway, Stephen AU - Wojtowicz, Jakub AU - Blennow, Kaj AU - Bittner, Tobias AU - Black, Sandra E. AU - Klein, Gregory AU - Boada, Mercè AU - Grimmer, Timo AU - Tamaoka, Akira AU - Perry, Richard J. AU - Turner, R. Scott AU - Watson, David AU - Woodward, Michael AU - Thanasopoulou, Angeliki AU - Lane, Christopher AU - Baudler, Monika AU - Fox, Nick C. AU - Cummings, Jeffrey L. AU - Fontoura, Paulo AU - Doody, Rachelle S. ED - Kovács, Tibor / Collaborator ED - Balázs, Nóra / Collaborator ED - Farsang, Marianna / Collaborator ED - Hornyák, Csilla / Collaborator TI - Two Phase 3 Trials of Gantenerumab in Early Alzheimer’s Disease JF - NEW ENGLAND JOURNAL OF MEDICINE J2 - NEW ENGL J MED VL - 389 PY - 2023 IS - 20 SP - 1862 EP - 1876 PG - 15 SN - 0028-4793 DO - 10.1056/NEJMoa2304430 UR - https://m2.mtmt.hu/api/publication/34425210 ID - 34425210 LA - English DB - MTMT ER - TY - JOUR AU - Beghi, Ettore AU - Moro, Elena AU - Irene Davidescu, Eugenia AU - Ovidiu Popescu, Bogdan AU - Grosu, Oxana AU - Valzania, Franco AU - Sofia Cotelli, Maria AU - Kiteva-Trenchevska, Gordana AU - Zakharova, Maria AU - Kovács, Tibor AU - Armon, Carmel AU - Brola, Waldemar AU - Lin Yasuda, Clarissa AU - F. Maia, Luís AU - Lovrencic-Huzjan, Arijana AU - Maria Laracho de Seabra, Mafalda AU - Avalos-Pavon, Rafael AU - Hege Aamodt, Anne AU - Meoni, Sara AU - Gryb, Victoria AU - Krehan, Ingomar AU - A. Leone, Maurizio AU - Lolich, Maria AU - Bianchi, Elisa AU - Rass, Verena AU - Helbok, Raimund AU - L. A. Bassetti, Claudio ED - Bereczki, Dániel / Collaborator ED - Dobronyi, Levente / Collaborator ED - Dénes, Kitti Csilla / Collaborator TI - Comparative features and outcomes of major neurological complications of COVID-19 JF - EUROPEAN JOURNAL OF NEUROLOGY J2 - EUR J NEUROL VL - 30 PY - 2023 IS - 2 SP - 413 EP - 433 PG - 21 SN - 1351-5101 DO - 10.1111/ene.15617 UR - https://m2.mtmt.hu/api/publication/33268141 ID - 33268141 N1 - Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy Centre Hospitalier Universitaire de Grenoble, Service de Neurologie, Grenoble Institute of Neurosciences, Grenoble Alpes University, Grenoble, France Neurology Department, Colentina Clinical Hospital, Bucharest, Romania and Department of Clinical Neurosciences, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania Diomid Gherman Institute of Neurology and Neurosurgery, Chișinău, Moldova Neurology Unit, Neuromotor and Rehabilitation Department, Azienda USL-IRCCS di Reggio Emilia, Reggio Emilia, Italy Neurology Unit ASST Valcamonica, Brescia, Italy University Clinic for Neurology, Medical Faculty, University "Ss. Cyril and Methodius", Skopje, North Macedonia Department of the Research Centre of Neurology, Moscow, Russian Federation Semmelweis University Budapest, Budapest, Hungary Tel Aviv University School of Medicine and Shamir (Assaf Harofeh) Medical Center, Tel Aviv, Israel Department of Neurology, Specialist Hospital Konskie, Collegium Medicum, Jan Kochanowski University, Kielce, Poland CEPID BRAINN - Brazilian Institute of Neuroscience and Neurotechnology and University of Campinas, Campinas, Brazil Neurology Department Hospital Santo António – CHUP, Porto, Portugal Department of Neurology, UHC Sestre milosrdnice, Zagreb, Croatia Department of Neurology, Centro Hospitalar Universitário de São João, E.P.E, Porto, Spain Cardiovascular I&D Unit, Portugal Department of Clinical Neurosciences and Mental Health, Faculty of Medicine University of Porto, Porto, Portugal Neurology Service, Facultad de Medicina, Universidad Autonoma de San Luis Potosi. Hospital Central, San Luis Potosi, Mexico Department of Neurology, Oslo University Hospital, Oslo, Norway Department of Neurology and Neurosurgery, Ivano-Frankivsk National Medical University, Ivano-Frankivsk, Ukraine Selcuk University Faculty of Medicine, Department of Neurology, Konya, Turkey University of Health Science, Gulhane School of Medicine, Neurology Department, Ankara, Turkey Department of Neurology, Kepler University Hospital, Linz, Austria European Acadmey of Neurology, Vienna, Austria Neurocritical Care Unit, Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria Department of Neurology, University Hospital of Bern, Bern, Switzerland Cited By :6 Export Date: 9 April 2024 CODEN: EJNEF Correspondence Address: Bassetti, C.L.A.; Department of Neurology, Switzerland; email: claudio.bassetti@unibe.ch LA - English DB - MTMT ER - TY - JOUR AU - Csabán, Dóra AU - Illés, Anett AU - Tóth-Bencsik, Renáta AU - Balicza, Péter AU - Pentelényi, Klára AU - Molnár, Viktor AU - Gézsi, András AU - Grosz, Zoltán AU - Gál, Anikó AU - Kovács, Tibor AU - Klivényi, Péter AU - Molnár, Mária Judit TI - Genetic landscape of early-onset dementia in Hungary JF - NEUROLOGICAL SCIENCES J2 - NEUROL SCI VL - 43 PY - 2022 IS - 9 SP - 5289 EP - 5300 PG - 12 SN - 1590-1874 DO - 10.1007/s10072-022-06168-8 UR - https://m2.mtmt.hu/api/publication/32918455 ID - 32918455 N1 - Funding Agency and Grant Number: Semmelweis University; Hungarian National Brain Research Program [KTIA_13_NAP-A-III/6]; National Research, Development, and Innovation Office (NKFIH) [OTKA139010]; Janos Bolyai Research Scholarship of the Hungarian Academy of Sciences; National Research, Development and Innovation Office (NKFIH) [OTKA PD 134449]; National Research, Development, and Innovation Fund of Hungary [TKP2021-EGA-02]; Hungarian Brain Research Program NAP 2.0 (Nemzeti Agykutatasi Program) [2017-1.2.1-NKP-2017-00002]; Ministry of Innovation and Technology of Hungary from the National Research, Development and Innovation Fund under the TKP2021-EGA funding scheme [TKP2021-EGA-32]; [TKP2021-EGA-25]; [TKP2021-NVA-15] Funding text: Open access funding provided by Semmelweis University. This study was supported by the Hungarian National Brain Research Program KTIA_13_NAP-A-III/6 project; the National Research, Development, and Innovation Office (NKFIH, Grant No. OTKA139010); and by the TKP2021-EGA-25, TKP2021-NVA-15. A. G. was supported by the Janos Bolyai Research Scholarship of the Hungarian Academy of Sciences; the National Research, Development and Innovation Office (NKFIH, Grant No. OTKA PD 134449); and by the National Research, Development, and Innovation Fund of Hungary under Grant TKP2021-EGA-02. T. K. was supported by the Hungarian Brain Research Program NAP 2.0 (Nemzeti Agykutatasi Program 2017-1.2.1-NKP-2017-00002). Project no. TKP2021-EGA-32 has been implemented with the support provided by the Ministry of Innovation and Technology of Hungary from the National Research, Development and Innovation Fund, financed under the TKP2021-EGA funding scheme. AB - Introduction Early-onset dementias (EOD) are predominantly genetically determined, but the underlying disease-causing alterations are often unknown. The most frequent forms of EODs are early-onset Alzheimer's disease (EOAD) and frontotemporal dementia (FTD). Patients This study included 120 Hungarian patients with EOD (48 familial and 72 sporadic) which had a diagnosis of EOAD (n = 49), FTD (n = 49), or atypical dementia (n = 22). Results Monogenic dementia was detected in 15.8% of the patients. A pathogenic hexanucleotide repeat expansion in the C9ORF72 gene was present in 6.7% of cases and disease-causing variants were detected in other known AD or FTD genes in 6.7% of cases (APP, PSEN1, PSEN2, GRN). A compound heterozygous alteration of the TREM2 gene was identified in one patient and heterozygous damaging variants in the CSF1R and PRNP genes were detected in two other cases. In two patients, the coexistence of several heterozygous damaging rare variants associated with neurodegeneration was detected (1.7%). The APOE genotype had a high odds ratio for both the APOE e4/3 and the e4/4 genotype (OR = 2.7 (95%CI = 1.3-5.9) and OR = 6.5 (95%CI = 1.4-29.2), respectively). In TREM2, SORL1, and ABCA7 genes, 5 different rare damaging variants were detected as genetic risk factors. These alterations were not present in the control group. Conclusion Based on our observations, a comprehensive, targeted panel of next-generation sequencing (NGS) testing investigating several neurodegeneration-associated genes may accelerate the path to achieve the proper genetic diagnosis since phenotypes are present on a spectrum. This can also reveal hidden correlations and overlaps in neurodegenerative diseases that would remain concealed in separated genetic testing. LA - English DB - MTMT ER - TY - JOUR AU - Beghi, E AU - Helbok, R AU - Ozturk, S AU - Karadas, O AU - Lisnic, V AU - Grosu, O AU - Kovács, Tibor AU - Dobronyi, Levente AU - Bereczki, Dániel AU - Cotelli, MS AU - Turla, M AU - Davidescu, EI AU - Popescu, BO AU - Valzania, F AU - Cavallieri, F AU - Ulmer, H AU - Maia, LF AU - Amodt, AH AU - Armon, C AU - Brola, W AU - Victoria, G AU - Riahi, A AU - Krehan, I AU - von Oertzen, T AU - Azab, MA AU - Crean, M AU - Lolich, M AU - Lima, MJ AU - Sellner, J AU - Perneczky, J AU - Jenkins, T AU - Meoni, S AU - Bianchi, E AU - Moro, E AU - Bassetti, CLA TI - Short- and long-term outcome and predictors in an international cohort of patients with neuro-COVID-19 JF - EUROPEAN JOURNAL OF NEUROLOGY J2 - EUR J NEUROL VL - 29 PY - 2022 IS - 6 SP - 1663 EP - 1684 PG - 22 SN - 1351-5101 DO - 10.1111/ene.15293 UR - https://m2.mtmt.hu/api/publication/32763914 ID - 32763914 N1 - ENERGY Study Group LA - English DB - MTMT ER - TY - JOUR AU - Balázs, Nóra AU - Bereczki, Dániel AU - Ajtay, András AU - Oberfrank, Ferenc AU - Kovács, Tibor TI - Cholinesterase inhibitors for the treatment of dementia: real-life data in Hungary JF - GEROSCIENCE: OFFICIAL JOURNAL OF THE AMERICAN AGING ASSOCIATION (AGE) J2 - GEROSCIENCE VL - 44 PY - 2022 IS - 1 SP - 253 EP - 263 PG - 11 SN - 2509-2715 DO - 10.1007/s11357-021-00470-7 UR - https://m2.mtmt.hu/api/publication/32469191 ID - 32469191 N1 - Department of Neurology, Semmelweis University, Balassa utca 6., Budapest, H-1083, Hungary MTA-SE, Neuroepidemiological Research Group ELKH, Balassa utca 6., Budapest, H-1083, Hungary Institute of Experimental Medicine, Szigony utca 43., Budapest, H-1083, Hungary Cited By :2 Export Date: 6 November 2023 Correspondence Address: Kovács, T.; Department of Neurology, Balassa utca 6., Hungary; email: kovacs.tibor@med.semmelweis-univ.hu Chemicals/CAS: donepezil, 120011-70-3, 120014-06-4, 142057-77-0; memantine, 19982-08-2, 41100-52-1, 51052-62-1; nicergoline, 27848-84-6; piracetam, 7491-74-9; rivastigmine, 129101-54-8, 123441-03-2; vinpocetine, 42971-09-5; Cholinesterase Inhibitors; Rivastigmine Funding text 1: The authors are grateful to Kornél Jahn PhD for his generous help with the analysis. The study was supported by the Hungarian Brain Research Program NAP2.0 (Nemzeti Agykutatási Program 2017-1.2.1-NKP-2017-00002). Funding text 2: This work was supported by the Hungarian Brain Research Program NAP2.0 (Nemzeti Agykutatási Program 2017–1.2.1-NKP-2017–00002 – Tibor Kovács). LA - English DB - MTMT ER - TY - JOUR AU - Balázs, Nóra AU - Bereczki, Dániel AU - Kovács, Tibor TI - Cholinesterase inhibitors and memantine for the treatment of Alzheimer and non-Alzheimer dementias JF - IDEGGYOGYASZATI SZEMLE / CLINICAL NEUROSCIENCE J2 - IDEGGYOGY SZEMLE VL - 74 PY - 2021 IS - 11-12 SP - 379 EP - 387 PG - 9 SN - 0019-1442 DO - 10.18071/isz.74.0379 UR - https://m2.mtmt.hu/api/publication/32505341 ID - 32505341 LA - English DB - MTMT ER - TY - JOUR AU - Lambertus, Iván Tamás AU - Dobronyi, Levente AU - Bereczki, Dániel AU - Kovács, Tibor TI - A Covid-19 neurológiai szövődményei JF - LEGE ARTIS MEDICINAE J2 - LEGE ART MED VL - 31 PY - 2021 IS - 7 SP - 259 EP - 264 PG - 6 SN - 0866-4811 DO - 10.33616/lam.31.018 UR - https://m2.mtmt.hu/api/publication/32179711 ID - 32179711 AB - The SARS-CoV-2 virus of COVID-19 is present in all countries of the world by 2021 causing primarily respiratory symptoms by penumonia with severe respiratory failure. Since the early stages of the pandemic, there were published case reports and comprehensive clinical studies about the neurological symptoms and complications of the infection (e.g. myalgia, anosmia, ageusia, encephalitis, encephalopathy, cerebrovascular conditions, Guillain-Barré syndrome and specific neuropathies). As it is well known, drugs used in therapeutic research may also have neurological adverse effects. Our summary aims to provide a practical overview of domestic and international literature about the already known neurological complications of SARS-CoV-2 infection. © 2021 Literatura Medica Publishing House. All rights reserved. LA - Hungarian DB - MTMT ER -