@article{MTMT:34568140, title = {Study protocol of the Hungarian Longitudinal Study of Healthy Brain Aging (HuBA).}, url = {https://m2.mtmt.hu/api/publication/34568140}, author = {Bankó, Éva Mária and Weiss, Béla and Hevesi, István and Manga, Annamária Eszter and Vakli, Pál and Havadi-Nagy, Menta and Kelemen, Rebeka and Somogyi, Eszter and Homolya, István and Bihari, Adél and Simon, Ádám and Nárai, Ádám and Tóth, Krisztina and Báthori, Noémi and Tomacsek, Vivien and Horváth, András Attila and Kamondi, Anita and Racsmány, Mihály and Dénes, Ádám and Simor, Péter and Kovács, Tibor and Hermann, Petra and Vidnyánszky, Zoltán}, doi = {10.18071/isz.77.0051}, journal-iso = {IDEGGYOGY SZEMLE}, journal = {IDEGGYOGYASZATI SZEMLE / CLINICAL NEUROSCIENCE}, volume = {77}, unique-id = {34568140}, issn = {0019-1442}, abstract = {Neuro­cog­nitive aging and the associated brain diseases impose a major social and economic burden. Therefore, substantial efforts have been put into revealing the lifestyle, the neurobiological and the genetic underpinnings of healthy neurocognitive aging. However, these studies take place almost exclusively in a limited number of highly-developed countries. Thus, it is an important open question to what extent their findings may generalize to neurocognitive aging in other, not yet investigated regions. The purpose of the Hungarian Longitudinal Study of Healthy Brain Aging (HuBA) is to collect multi-modal longitudinal data on healthy neurocognitive aging to address the data gap in this field in Central and Eastern Europe..We adapted the Australian Ima­ging, Biomarkers and Lifestyle (AIBL) study of aging study protocol to local circumstances and collected demographic, lifestyle, men­tal and physical health, medication and medical history related information as well as re­cor­ded a series of magnetic resonance imaging (MRI) data. In addition, participants were al­so offered to participate in the collection of blood samples to assess circulating in­flam­matory biomarkers as well as a sleep study aimed at evaluating the general sleep quality based on multi-day collection of subjective sleep questionnaires and whole-night elec­troencephalographic (EEG) data..Baseline data collection has al­ready been accomplished for more than a hundred participants and data collection in the se­condsession is on the way. The collected data might reveal specific local trends or could also indicate the generalizability of previous findings. Moreover, as the HuBA protocol al­so offers a sleep study designed for tho­rough characterization of participants’ sleep quality and related factors, our extended multi-modal dataset might provide a base for incorporating these measures into healthy and clinical aging research. .Besides its straightforward na­tional benefits in terms of health ex­pen­di­ture, we hope that this Hungarian initiative could provide results valid for the whole Cent­ral and Eastern European region and could also promote aging and Alzheimer’s disease research in these countries..}, keywords = {sleep; Magnetic resonance imaging (MRI); neurocognitive aging; neuro­in­flam­mation}, year = {2024}, eissn = {2498-6208}, pages = {51-59}, orcid-numbers = {Bankó, Éva Mária/0009-0001-5354-5077; Weiss, Béla/0000-0003-1031-0283; Nárai, Ádám/0000-0001-5972-6509; Báthori, Noémi/0000-0003-3971-4441; Kamondi, Anita/0000-0001-9860-730X; Kovács, Tibor/0000-0002-8603-8848} } @article{MTMT:34441451, title = {Early histopathological changes of secondary degeneration in the spinal cord after total MCA territory stroke}, url = {https://m2.mtmt.hu/api/publication/34441451}, author = {Kollai, Sarolta and Bereczki, Dániel and Glasz, Tibor and Hortobágyi, Tibor and Kovács, Tibor}, doi = {10.1038/s41598-023-49230-x}, journal-iso = {SCI REP}, journal = {SCIENTIFIC REPORTS}, volume = {13}, unique-id = {34441451}, issn = {2045-2322}, year = {2023}, eissn = {2045-2322}, orcid-numbers = {Kollai, Sarolta/0000-0002-5045-4794; Bereczki, Dániel/0000-0002-8374-0500; Glasz, Tibor/0000-0003-2947-2733; Hortobágyi, Tibor/0000-0001-5732-7942; Kovács, Tibor/0000-0002-8603-8848} } @article{MTMT:34425210, title = {Two Phase 3 Trials of Gantenerumab in Early Alzheimer’s Disease}, url = {https://m2.mtmt.hu/api/publication/34425210}, author = {Bateman, Randall J. and Smith, Janice and Donohue, Michael C. and Delmar, Paul and Abbas, Rachid and Salloway, Stephen and Wojtowicz, Jakub and Blennow, Kaj and Bittner, Tobias and Black, Sandra E. and Klein, Gregory and Boada, Mercè and Grimmer, Timo and Tamaoka, Akira and Perry, Richard J. and Turner, R. Scott and Watson, David and Woodward, Michael and Thanasopoulou, Angeliki and Lane, Christopher and Baudler, Monika and Fox, Nick C. and Cummings, Jeffrey L. and Fontoura, Paulo and Doody, Rachelle S.}, doi = {10.1056/NEJMoa2304430}, journal-iso = {NEW ENGL J MED}, journal = {NEW ENGLAND JOURNAL OF MEDICINE}, volume = {389}, unique-id = {34425210}, issn = {0028-4793}, year = {2023}, eissn = {1533-4406}, pages = {1862-1876}, orcid-numbers = {Abbas, Rachid/0000-0002-9737-4548; Kovács, Tibor/0000-0002-8603-8848; Balázs, Nóra/0000-0003-3030-2563; Farsang, Marianna/0000-0002-6490-7985; Hornyák, Csilla/0000-0003-1273-5883} } @article{MTMT:33268141, title = {Comparative features and outcomes of major neurological complications of COVID-19}, url = {https://m2.mtmt.hu/api/publication/33268141}, author = {Beghi, Ettore and Moro, Elena and Irene Davidescu, Eugenia and Ovidiu Popescu, Bogdan and Grosu, Oxana and Valzania, Franco and Sofia Cotelli, Maria and Kiteva-Trenchevska, Gordana and Zakharova, Maria and Kovács, Tibor and Armon, Carmel and Brola, Waldemar and Lin Yasuda, Clarissa and F. Maia, Luís and Lovrencic-Huzjan, Arijana and Maria Laracho de Seabra, Mafalda and Avalos-Pavon, Rafael and Hege Aamodt, Anne and Meoni, Sara and Gryb, Victoria and Krehan, Ingomar and A. Leone, Maurizio and Lolich, Maria and Bianchi, Elisa and Rass, Verena and Helbok, Raimund and L. A. Bassetti, Claudio}, doi = {10.1111/ene.15617}, journal-iso = {EUR J NEUROL}, journal = {EUROPEAN JOURNAL OF NEUROLOGY}, volume = {30}, unique-id = {33268141}, issn = {1351-5101}, year = {2023}, eissn = {1468-1331}, pages = {413-433}, orcid-numbers = {Kovács, Tibor/0000-0002-8603-8848; Bereczki, Dániel/0000-0002-8374-0500; Dobronyi, Levente/0000-0002-5313-8076; Dénes, Kitti Csilla/0000-0001-8331-0028} } @article{MTMT:32918455, title = {Genetic landscape of early-onset dementia in Hungary}, url = {https://m2.mtmt.hu/api/publication/32918455}, author = {Csabán, Dóra and Illés, Anett and Tóth-Bencsik, Renáta and Balicza, Péter and Pentelényi, Klára and Molnár, Viktor and Gézsi, András and Grosz, Zoltán and Gál, Anikó and Kovács, Tibor and Klivényi, Péter and Molnár, Mária Judit}, doi = {10.1007/s10072-022-06168-8}, journal-iso = {NEUROL SCI}, journal = {NEUROLOGICAL SCIENCES}, volume = {43}, unique-id = {32918455}, issn = {1590-1874}, abstract = {Introduction Early-onset dementias (EOD) are predominantly genetically determined, but the underlying disease-causing alterations are often unknown. The most frequent forms of EODs are early-onset Alzheimer's disease (EOAD) and frontotemporal dementia (FTD). Patients This study included 120 Hungarian patients with EOD (48 familial and 72 sporadic) which had a diagnosis of EOAD (n = 49), FTD (n = 49), or atypical dementia (n = 22). Results Monogenic dementia was detected in 15.8% of the patients. A pathogenic hexanucleotide repeat expansion in the C9ORF72 gene was present in 6.7% of cases and disease-causing variants were detected in other known AD or FTD genes in 6.7% of cases (APP, PSEN1, PSEN2, GRN). A compound heterozygous alteration of the TREM2 gene was identified in one patient and heterozygous damaging variants in the CSF1R and PRNP genes were detected in two other cases. In two patients, the coexistence of several heterozygous damaging rare variants associated with neurodegeneration was detected (1.7%). The APOE genotype had a high odds ratio for both the APOE e4/3 and the e4/4 genotype (OR = 2.7 (95%CI = 1.3-5.9) and OR = 6.5 (95%CI = 1.4-29.2), respectively). In TREM2, SORL1, and ABCA7 genes, 5 different rare damaging variants were detected as genetic risk factors. These alterations were not present in the control group. Conclusion Based on our observations, a comprehensive, targeted panel of next-generation sequencing (NGS) testing investigating several neurodegeneration-associated genes may accelerate the path to achieve the proper genetic diagnosis since phenotypes are present on a spectrum. This can also reveal hidden correlations and overlaps in neurodegenerative diseases that would remain concealed in separated genetic testing.}, keywords = {MUTATION; ALZHEIMERS-DISEASE; FAMILY; VARIANTS; genetic risk; Alzheimer's disease; FRONTOTEMPORAL DEMENTIA; Next-generation sequencing; Clinical Neurology; EARLY-ONSET DEMENTIA; clinical phenotype}, year = {2022}, eissn = {1590-3478}, pages = {5289-5300}, orcid-numbers = {Csabán, Dóra/0000-0003-4602-6639; Illés, Anett/0000-0001-5351-9015; Tóth-Bencsik, Renáta/0000-0003-0527-8979; Balicza, Péter/0000-0001-8555-5467; Pentelényi, Klára/0000-0003-2034-5869; Molnár, Viktor/0000-0002-4156-9987; Gézsi, András/0000-0003-1022-6356; Grosz, Zoltán/0000-0001-7353-1214; Gál, Anikó/0000-0002-2059-5748; Kovács, Tibor/0000-0002-8603-8848; Klivényi, Péter/0000-0002-5389-3266; Molnár, Mária Judit/0000-0001-9350-1864} } @article{MTMT:32763914, title = {Short- and long-term outcome and predictors in an international cohort of patients with neuro-COVID-19}, url = {https://m2.mtmt.hu/api/publication/32763914}, author = {Beghi, E and Helbok, R and Ozturk, S and Karadas, O and Lisnic, V and Grosu, O and Kovács, Tibor and Dobronyi, Levente and Bereczki, Dániel and Cotelli, MS and Turla, M and Davidescu, EI and Popescu, BO and Valzania, F and Cavallieri, F and Ulmer, H and Maia, LF and Amodt, AH and Armon, C and Brola, W and Victoria, G and Riahi, A and Krehan, I and von Oertzen, T and Azab, MA and Crean, M and Lolich, M and Lima, MJ and Sellner, J and Perneczky, J and Jenkins, T and Meoni, S and Bianchi, E and Moro, E and Bassetti, CLA}, doi = {10.1111/ene.15293}, journal-iso = {EUR J NEUROL}, journal = {EUROPEAN JOURNAL OF NEUROLOGY}, volume = {29}, unique-id = {32763914}, issn = {1351-5101}, year = {2022}, eissn = {1468-1331}, pages = {1663-1684}, orcid-numbers = {Kovács, Tibor/0000-0002-8603-8848; Dobronyi, Levente/0000-0002-5313-8076; Bereczki, Dániel/0000-0002-8374-0500} } @article{MTMT:32469191, title = {Cholinesterase inhibitors for the treatment of dementia: real-life data in Hungary}, url = {https://m2.mtmt.hu/api/publication/32469191}, author = {Balázs, Nóra and Bereczki, Dániel and Ajtay, András and Oberfrank, Ferenc and Kovács, Tibor}, doi = {10.1007/s11357-021-00470-7}, journal-iso = {GEROSCIENCE}, journal = {GEROSCIENCE: OFFICIAL JOURNAL OF THE AMERICAN AGING ASSOCIATION (AGE)}, volume = {44}, unique-id = {32469191}, issn = {2509-2715}, year = {2022}, eissn = {2509-2723}, pages = {253-263}, orcid-numbers = {Balázs, Nóra/0000-0003-3030-2563; Bereczki, Dániel/0000-0002-8374-0500; Ajtay, András/0000-0003-0194-2596; Kovács, Tibor/0000-0002-8603-8848} } @article{MTMT:32505341, title = {Cholinesterase inhibitors and memantine for the treatment of Alzheimer and non-Alzheimer dementias}, url = {https://m2.mtmt.hu/api/publication/32505341}, author = {Balázs, Nóra and Bereczki, Dániel and Kovács, Tibor}, doi = {10.18071/isz.74.0379}, journal-iso = {IDEGGYOGY SZEMLE}, journal = {IDEGGYOGYASZATI SZEMLE / CLINICAL NEUROSCIENCE}, volume = {74}, unique-id = {32505341}, issn = {0019-1442}, year = {2021}, eissn = {2498-6208}, pages = {379-387}, orcid-numbers = {Balázs, Nóra/0000-0003-3030-2563; Bereczki, Dániel/0000-0002-8374-0500; Kovács, Tibor/0000-0002-8603-8848} } @article{MTMT:32179711, title = {A Covid-19 neurológiai szövődményei}, url = {https://m2.mtmt.hu/api/publication/32179711}, author = {Lambertus, Iván Tamás and Dobronyi, Levente and Bereczki, Dániel and Kovács, Tibor}, doi = {10.33616/lam.31.018}, journal-iso = {LEGE ART MED}, journal = {LEGE ARTIS MEDICINAE}, volume = {31}, unique-id = {32179711}, issn = {0866-4811}, abstract = {The SARS-CoV-2 virus of COVID-19 is present in all countries of the world by 2021 causing primarily respiratory symptoms by penumonia with severe respiratory failure. Since the early stages of the pandemic, there were published case reports and comprehensive clinical studies about the neurological symptoms and complications of the infection (e.g. myalgia, anosmia, ageusia, encephalitis, encephalopathy, cerebrovascular conditions, Guillain-Barré syndrome and specific neuropathies). As it is well known, drugs used in therapeutic research may also have neurological adverse effects. Our summary aims to provide a practical overview of domestic and international literature about the already known neurological complications of SARS-CoV-2 infection. © 2021 Literatura Medica Publishing House. All rights reserved.}, keywords = {ENCEPHALITIS; stroke; neurology; COVID-19; SARS COV-2}, year = {2021}, eissn = {2063-4161}, pages = {259-264}, orcid-numbers = {Lambertus, Iván Tamás/0000-0001-6936-1777; Dobronyi, Levente/0000-0002-5313-8076; Bereczki, Dániel/0000-0002-8374-0500; Kovács, Tibor/0000-0002-8603-8848} } @article{MTMT:32077071, title = {Az Alzheimer-kór heterogenitása}, url = {https://m2.mtmt.hu/api/publication/32077071}, author = {Balázs, Nóra and Kovács, Tibor}, doi = {10.1556/650.2021.32130}, journal-iso = {ORV HETIL}, journal = {ORVOSI HETILAP}, volume = {162}, unique-id = {32077071}, issn = {0030-6002}, year = {2021}, eissn = {1788-6120}, pages = {970-977}, orcid-numbers = {Balázs, Nóra/0000-0003-3030-2563; Kovács, Tibor/0000-0002-8603-8848} }