TY - JOUR AU - Bajusz, Csaba AU - Kristó, Ildikó AU - Abonyi, Csilla AU - Venit, Tomáš AU - Vedelek, Viktor AU - Lukácsovich, Tamás AU - Farkas, Attila AU - Borkúti, Péter AU - Kovács, Zoltán AU - Bajusz, Izabella AU - Marton, Annamária AU - Vizler, Csaba AU - Lipinszki, Zoltán AU - Sinka, Rita AU - Percipalle, Piergiorgio AU - Vilmos, Péter TI - The nuclear activity of the actin‐binding Moesin protein is necessary for gene expression in Drosophila JF - FEBS JOURNAL J2 - FEBS J VL - 288 PY - 2021 IS - 16 SP - 4812 EP - 4832 PG - 21 SN - 1742-464X DO - 10.1111/febs.15779 UR - https://m2.mtmt.hu/api/publication/31909117 ID - 31909117 N1 - Eötvös Loránd Research Network (ELKH), Biological Research Centre, Szeged, Hungary Doctoral School of Biology, University of Szeged, Hungary Department of Genetics, University of Szeged, Hungary Doctoral School of Multidisciplinary Medical Science, University of Szeged, Hungary Lendület Laboratory of Cell Cycle Regulation, ELKH, Biological Research Centre, Szeged, Hungary LA - English DB - MTMT ER - TY - CONF AU - Bajusz, Izabella AU - Kúthy-Sutus, Enikő AU - Szabó, Viktória AU - Henry, Surya AU - Kovács, Gergő AU - Pirity, Melinda TI - Germ cells unleashed: The role of Ring1 and YY1 binding protein in regulating germ cell determinants. T2 - Straub-napok (2019) C1 - Szeged PY - 2019 SP - 1 UR - https://m2.mtmt.hu/api/publication/34645620 ID - 34645620 LA - English DB - MTMT ER - TY - JOUR AU - Borkúti, Péter AU - Bajusz, Izabella AU - Bajusz, Csaba AU - Kristó, Ildikó AU - Kovács, Zoltán AU - Vilmos, Péter TI - Testing the biological significance of the nuclear localization of actin JF - BIOPOLYMERS AND CELL J2 - BIOPOLYMERS CELL VL - 35 PY - 2019 IS - 3 SP - 204 EP - 204 PG - 1 SN - 0233-7657 DO - 10.7124/bc.000A06 UR - https://m2.mtmt.hu/api/publication/31305572 ID - 31305572 LA - English DB - MTMT ER - TY - JOUR AU - Bajusz, Izabella AU - Henry, Surya AU - Kúthy-Sutus, Enikő AU - Kovács, Gergő AU - Pirity, Melinda TI - Evolving Role of RING1 and YY1 Binding Protein in the Regulation of Germ-Cell-Specific Transcription. JF - GENES J2 - GENES-BASEL VL - 10 PY - 2019 IS - 11 PG - 33 SN - 2073-4425 DO - 10.3390/genes10110941 UR - https://m2.mtmt.hu/api/publication/31015725 ID - 31015725 N1 - Journal Article; Review; Research Support, Non-U.S. Gov't Biological Research Centre, Temesvári krt. 62, Szeged, H-6726, Hungary School of Biology, Faculty of Science and Informatics, University of Szeged, Dugonics tér 13, Szeged, H-6720, Hungary Export Date: 22 January 2020 Correspondence Address: Bajusz, I.; Biological Research Centre, Temesvári krt. 62, Hungary; email: bajusz.izabella@brc.hu Biological Research Centre, Temesvári krt. 62, Szeged, H-6726, Hungary School of Biology, Faculty of Science and Informatics, University of Szeged, Dugonics tér 13, Szeged, H-6720, Hungary Cited By :1 Export Date: 13 February 2020 Correspondence Address: Bajusz, I.; Biological Research Centre, Temesvári krt. 62, Hungary; email: bajusz.izabella@brc.hu Biological Research Centre, Temesvári krt. 62, Szeged, H-6726, Hungary School of Biology, Faculty of Science and Informatics, University of Szeged, Dugonics tér 13, Szeged, H-6720, Hungary Cited By :5 Export Date: 18 February 2021 Correspondence Address: Bajusz, I.; Biological Research Centre, Temesvári krt. 62, Hungary; email: bajusz.izabella@brc.hu AB - Separation of germline cells from somatic lineages is one of the earliest decisions of embryogenesis. Genes expressed in germline cells include apoptotic and meiotic factors, which are not transcribed in the soma normally, but a number of testis-specific genes are active in numerous cancer types. During germ cell development, germ-cell-specific genes can be regulated by specific transcription factors, retinoic acid signaling and multimeric protein complexes. Non-canonical polycomb repressive complexes, like ncPRC1.6, play a critical role in the regulation of the activity of germ-cell-specific genes. RING1 and YY1 binding protein (RYBP) is one of the core members of the ncPRC1.6. Surprisingly, the role of Rybp in germ cell differentiation has not been defined yet. This review is focusing on the possible role of Rybp in this process. By analyzing whole-genome transcriptome alterations of the Rybp-/- embryonic stem (ES) cells and correlating this data with experimentally identified binding sites of ncPRC1.6 subunits and retinoic acid receptors in ES cells, we propose a model how germ-cell-specific transcription can be governed by an RYBP centered regulatory network, underlining the possible role of RYBP in germ cell differentiation and tumorigenesis. LA - English DB - MTMT ER - TY - CONF AU - Bajusz, Izabella AU - Kúthy-Sutus, Enikő AU - Szabó, Viktória AU - Kovács, Gergő AU - Surya, Henry AU - Pirity, Melinda TI - A good reason to shut up: The role of RYBP in germ cell specific gene silencing. T2 - Straub-napok (2018) C1 - Szeged PY - 2018 SP - 1 UR - https://m2.mtmt.hu/api/publication/34645271 ID - 34645271 LA - English DB - MTMT ER - TY - JOUR AU - Bajusz, Izabella AU - Kovács, Gergő AU - Pirity, Melinda TI - From Flies to Mice: The Emerging Role of Non-Canonical PRC1 Members in Mammalian Development. The Emerging Role of Non-Canonical PRC1 Members in Mammalian Development TS - The Emerging Role of Non-Canonical PRC1 Members in Mammalian Development JF - EPIGENOMES J2 - EPIGENOMES VL - 2 PY - 2018 IS - 1 PG - 50 SN - 2075-4655 DO - 10.3390/epigenomes2010004 UR - https://m2.mtmt.hu/api/publication/3329269 ID - 3329269 N1 - Funding Agency and Grant Number: National Research, Development and Innovation Office [GINOP-2.3.2-15-2016-00001, GINOP-2.3.2-15-2016-00039] Funding text: We thank Eva Monostori and Gabriella Tick as well as members of the Pirity laboratory, for stimulating discussions and critical reading of the manuscript. This work was supported by National Research, Development and Innovation Office GINOP-2.3.2-15-2016-00001 and GINOP-2.3.2-15-2016-00039. LA - English DB - MTMT ER - TY - JOUR AU - Kristó, Ildikó AU - Bajusz, Izabella AU - Bajusz, Csaba AU - Borkúti, Péter AU - Vilmos, Péter TI - Actin, actin-binding proteins, and actin-related proteins in the nucleus. JF - HISTOCHEMISTRY AND CELL BIOLOGY J2 - HISTOCHEM CELL BIOL VL - 145 PY - 2016 IS - 4 SP - 373 EP - 388 PG - 16 SN - 0948-6143 DO - 10.1007/s00418-015-1400-9 UR - https://m2.mtmt.hu/api/publication/3016419 ID - 3016419 AB - Extensive research in the past decade has significantly broadened our view about the role actin plays in the life of the cell and added novel aspects to actin research. One of these new aspects is the discovery of the existence of nuclear actin which became evident only recently. Nuclear activities including transcriptional activation in the case of all three RNA polymerases, editing and nuclear export of mRNAs, and chromatin remodeling all depend on actin. It also became clear that there is a fine-tuned equilibrium between cytoplasmic and nuclear actin pools and that this balance is ensured by an export-import system dedicated to actin. After over half a century of research on conventional actin and its organizing partners in the cytoplasm, it was also an unexpected finding that the nucleus contains more than 30 actin-binding proteins and new classes of actin-related proteins which are not able to form filaments but had evolved nuclear-specific functions. The actin-binding and actin-related proteins in the nucleus have been linked to RNA transcription and processing, nuclear transport, and chromatin remodeling. In this paper, we attempt to provide an overview of the wide range of information that is now available about actin, actin-binding, and actin-related proteins in the nucleus. LA - English DB - MTMT ER - TY - CHAP AU - Bajusz, Izabella AU - Farkas, Dávid AU - Sipos, László Attila ED - Vágvölgyi, Csaba ED - Siklós, László TI - Epigenetic regulation of differential gene expression T2 - Selected Topics from Contemporary Experimental Biology, Volume 2 PB - MTA Szegedi Biológiai Központ CY - Szeged PY - 2015 SP - 83 EP - 101 PG - 19 UR - https://m2.mtmt.hu/api/publication/3003028 ID - 3003028 LA - English DB - MTMT ER - TY - CHAP AU - Farkas, D AU - Kozma, G AU - Bajusz, Izabella AU - Jankovics, F AU - Gyurkovics, H ED - Róbert, Hohol ED - Zsuzsanna, Heiszler ED - Nóra, Éles-Etele TI - Revealing the in Situ Function of the BXD TRE in Maintaining the Active State of the BXD Cis-Regulatory Region of Drosophila T2 - Hungarian Molecular Life Sciences 2015 PB - Diamond Congress Kft. CY - Budapest SN - 9786155270154 PY - 2015 SP - 226 EP - 226 PG - 1 UR - https://m2.mtmt.hu/api/publication/2983777 ID - 2983777 LA - English DB - MTMT ER - TY - CHAP AU - Bajusz, Izabella AU - Gyurkovics, H AU - Mihaly, J AU - Cléard-Karch, F AU - Karch, F AU - Sipos, L ED - Róbert, Hohol ED - Zsuzsanna, Heiszler ED - Nóra, Éles-Etele TI - Some Polycomb-Group Proteins Can Modulate the Regulatory Capacity of Active Cis-Regulators T2 - Hungarian Molecular Life Sciences 2015 PB - Diamond Congress Kft. CY - Budapest SN - 9786155270154 PY - 2015 SP - 94 EP - 95 PG - 2 UR - https://m2.mtmt.hu/api/publication/2983774 ID - 2983774 LA - English DB - MTMT ER -