TY - JOUR AU - Bäck, Magnus AU - Topouchian, Jirar AU - Labat, Carlos AU - Gautier, Sylvie AU - Blacher, Jacques AU - Cwynar, Marcin AU - de la Sierra, Alejandro AU - Páll, Dénes AU - Duarte, Kevin AU - Fantin, Francesco AU - Farkas, Katalin AU - Garcia-Ortiz, Luis AU - Hakobyan, Zoya AU - Jankowski, Piotr AU - Jelakovic, Ana AU - Kotsani, Marina AU - Konradi, Alexandra AU - Mikhailova, Oksana AU - Mintale, Iveta AU - Plunde, Oscar AU - Ramos, Rafael AU - Rogoza, Anatoly AU - Sirenko, Yuriy AU - Tasic, Nebojsa AU - Rudyk, Iurii AU - Urazalina, Saule AU - Wohlfahrt, Peter AU - Zelveian, Parounak AU - Asmar, Roland AU - Benetos, Athanase TI - Cardio-ankle vascular index for predicting cardiovascular morbimortality and determinants for its progression in the prospective advanced approach to arterial stiffness (TRIPLE-A-Stiffness) study JF - EBIOMEDICINE J2 - EBIOMEDICINE PY - 2024 SN - 2352-3964 DO - 10.1016/j.ebiom.2024.105107 UR - https://m2.mtmt.hu/api/publication/34821280 ID - 34821280 LA - English DB - MTMT ER - TY - JOUR AU - Gaudet, Daniel AU - Páll, Dénes AU - Watts, Gerald F. AU - Nicholls, Stephen J. AU - Rosenson, Robert S. AU - Modesto, Karen AU - San Martin, Javier AU - Hellawell, Jennifer AU - Ballantyne, Christie M. TI - Plozasiran (ARO-APOC3) for Severe Hypertriglyceridemia JF - JAMA CARDIOLOGY J2 - JAMA CARDIOL PY - 2024 SN - 2380-6583 DO - 10.1001/jamacardio.2024.0959 UR - https://m2.mtmt.hu/api/publication/34817593 ID - 34817593 LA - English DB - MTMT ER - TY - JOUR AU - Nemcsik, János AU - Takács, Johanna AU - Pásztor, Dorottya Tímea AU - Farsang, Csaba AU - Simon, Attila AU - Páll, Dénes AU - Torzsa, Péter AU - Dolgos, Szilveszter AU - Koller, Ákos AU - Habony, Norbert AU - Járai, Zoltán TI - Frequency of office blood pressure measurements and the seasonal variability of blood pressure: results of the Hungarian Hypertension Registry JF - BLOOD PRESSURE J2 - BLOOD PRESSURE VL - 33 PY - 2024 IS - 1 PG - 7 SN - 0803-7051 DO - 10.1080/08037051.2024.2337170 UR - https://m2.mtmt.hu/api/publication/34775499 ID - 34775499 LA - English DB - MTMT ER - TY - JOUR AU - Kovács, Beáta AU - Németh, Ákos AU - Daróczy, Bálint AU - Karányi, Zsolt AU - Maroda, László AU - Diószegi, Ágnes AU - Páll, Dénes AU - Harangi, Mariann TI - A lipidanyagcsere eltéréseinek vizsgálata felnőtt hypertoniás betegek esetén adatbányászati módszerrel JF - HYPERTONIA ÉS NEPHROLOGIA J2 - HYPERTONIA NEPHROLOGIA VL - 28 PY - 2024 IS - 1 SP - 13 EP - 18 PG - 6 SN - 1418-477X DO - 10.33668/hn.28.002 UR - https://m2.mtmt.hu/api/publication/34732888 ID - 34732888 AB - A hypertonia és a hyperlipidaemia együttes előfordulása gyakori, és közös jelenlétük fokozza a cardiovascularis megbetegedések kialakulásának kockázatát. Célul tűztük ki a lipidanyagcsere eltéréseinek vizsgálatát és annak összefüggését a testtömegindexszel (BMI) egy nagyméretű, felnőtt hypertoniás betegpopuláción adatbányászati módszerek alkalmazásával. LA - Hungarian DB - MTMT ER - TY - JOUR AU - Járai, Zoltán AU - Farsang, Csaba AU - Nemcsik, János AU - Páll, Dénes TI - Melyek az Európai Hypertonia Társaság 2023. évi irányelvének legfontosabb újdonságai? JF - HYPERTONIA ÉS NEPHROLOGIA J2 - HYPERTONIA NEPHROLOGIA VL - 27 PY - 2023 IS - 4 SP - 180 EP - 184 PG - 5 SN - 1418-477X UR - https://m2.mtmt.hu/api/publication/34147505 ID - 34147505 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Nemcsik, János AU - Páll, Dénes AU - Takács, Johanna AU - Koller, Ákos AU - Jarai, Zoltan TI - DETERMINANTS OF ELASTIC AND STIFFENING PULSE PRESSURE COMPONENTS: RESULTS OF THE NEW HUNGARIAN ABPM REGISTRY JF - JOURNAL OF HYPERTENSION J2 - J HYPERTENSION VL - 41 PY - 2023 IS - Suppl 3 SP - E245 EP - E245 PG - 1 SN - 0263-6352 DO - 10.1097/01.hjh.0000941500.22031.09 UR - https://m2.mtmt.hu/api/publication/34134459 ID - 34134459 AB - Objective: Pulse pressure (PP) received relative less attention in the guidelines regarding its potential role in the hypertension-mediated target organ damage. Recently it has been proposed that PP can be divided into two components: elastic PP (elPP) and stiffening PP (stPP). Thus the aim of our study was to explore the determinants of 24-hour, daytime and nighttime elPP and stPP in a new national ambulatory blood pressure monitoring (ABPM) database. Design and method: ABPM data were collected from the Hungarian ABPM Registry between February 2021 and August 2022. The Hungarian ABPM Registry is a an ongoing multicenter, open-label, observational non-interventional study. Meditech ABPM-06 monitors were used for ABPM measurements. Basic patients’ data were documented in electronic case report forms and were later analyzed together with ABPM data. elPP and stPP were calculated according to Gavish et al (DOI:10.1097/HJH.0000000000003258). Results: 14817 ABPM data were analyzed. The average age of the subjects was 55.29 ± 15.1 years, 7845 (48.9%) of them were men. 24h, daytime and nighttime elPP were 47.42 ± 8.89, 46.45 ± 9.34 and 45.93 ± 10.94 mmHg, respectively. 24h, daytime and nighttime stPP were 8.51 ± 5.86, 9.15 ±6.56 and 8.62 ± 7.81 mmHg, respectively. Under the age of 50 years all elPPs were significantly lower in women compared to men, while all stPPs were lower in both sexes in age under 50 (p<0.05). Independently from age and sex, obesity increased all elPPs, while under the age of 50 years nighttime stPP was elevated only in obese women (p<0.05). The independent determinants of daytime and nighttime elPPs were age, systolic blood pressure (sBP), obesity and diabetes with adding ischemic heart disease in case of 24h elPP. The independent determinants of 24h and daytime stPPs were age, sBP and diabetes, while in case of nighttime stPP age, sBP and sex. Conclusions: The new Hungarian ABPM Registry underline the importance of PP and its elastic and stiffening components. The evaluation of their determinants can help to better understand the pathomechanisms responsible for the development of hypertension-mediated target organ damage. Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved. LA - English DB - MTMT ER - TY - JOUR AU - Kovács, Beáta AU - Németh, Ákos AU - Daróczy, Bálint Zoltán AU - Karányi, Zsolt AU - Maroda, László AU - Diószegi, Ágnes AU - Harangi, Mariann AU - Páll, Dénes TI - Assessment of Hypertensive Patients’ Complex Metabolic Status Using Data Mining Methods JF - JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE J2 - J CARDIOVASC DEV DIS VL - 10 PY - 2023 IS - 8 SP - 345 PG - 14 SN - 2308-3425 DO - 10.3390/jcdd10080345 UR - https://m2.mtmt.hu/api/publication/34119117 ID - 34119117 N1 - Division of Metabolic Diseases, Department of Internal Medicine, Faculty of Medicine, University of Debrecen, Debrecen, H-4032, Hungary Institute for Computer Science and Control (SZTAKI), Hungarian Research Network, Budapest, H-1111, Hungary Department of Mathematical Engineering (INMA/ICTEAM), Université Catholique de Louvain, Louvain-la-Neuve, 1348, Belgium Department of Medical Clinical Pharmacology, Faculty of Medicine, University of Debrecen, Debrecen, H-4032, Hungary Institute of Health Studies, Faculty of Health Sciences, University of Debrecen, Debrecen, H-4032, Hungary Export Date: 2 October 2023 Correspondence Address: Páll, D.; Department of Medical Clinical Pharmacology, Hungary; email: pall.denes@unideb.hu AB - Cardiovascular diseases are among the leading causes of mortality worldwide. Hypertension is a preventable risk factor leading to major cardiovascular events. We have not found a comprehensive study investigating Central and Eastern European hypertensive patients’ complex metabolic status. Therefore, our goal was to calculate the prevalence of hypertension and associated metabolic abnormalities using data-mining methods in our region. We assessed the data of adults who visited the University of Debrecen Clinical Center’s hospital (n = 937,249). The study encompassed data from a period of 20 years (2001–2021). We detected 292,561 hypertensive patients. The calculated prevalence of hypertension was altogether 32.2%. Markedly higher body mass index values were found in hypertensive patients as compared to non-hypertensives. Significantly higher triglyceride and lower HDL-C levels were found in adults from 18 to 80 years old. Furthermore, significantly higher serum glucose and uric acid levels were measured in hypertensive subjects. Our study confirms that the calculated prevalence of hypertension is akin to international findings and highlights the extensive association of metabolic alterations. These findings emphasize the role of early recognition and immediate treatment of cardiometabolic abnormalities to improve the quality of life and life expectancy of hypertensive patients. LA - English DB - MTMT ER - TY - JOUR AU - Járai, Zoltán AU - Nemcsik, János AU - Páll, Dénes AU - Takács, Johanna AU - Koller, Ákos TI - PATIENT CHARACTERISTICS OF A REAL WORLD REGISTRY OF AMBULATORY BLOOD PRESSURE MONITORING: DATA FROM THE NEW HUNGARIAN ABPM REGISTRY JF - JOURNAL OF HYPERTENSION J2 - J HYPERTENSION VL - 41 PY - 2023 IS - Suppl 3 SN - 0263-6352 DO - 10.1097/01.hjh.0000939872.07588.ad UR - https://m2.mtmt.hu/api/publication/34073421 ID - 34073421 AB - Objective: Current European guidelines recommend ambulatory blood pressure (BP) monitoring (ABPM) for the diagnosis and follow-up of patients with known or suspected hypertension. Thus in 2021 the Hungarian Society of Hypertension initiated a nationwide registry in order to evaluate ABPM indications and patient characteristics. Design and method: This is an ongoing, multicenter, open-label, observational study. Data collection to an electronic case report form is performed by GPs, internists and cardiologists. For ABPM measurements Meditech-ABPM-06 monitors are used. Data of the current analysis were collected between 21.02.2021-5.10.2022. 15 835 ABPMs were performed; due to missing data or protocol deviation 1018 patients were excluded from the analysis. Results: 10 212 patients were known and treated hypertensives (HT), and 4 571 were newly diagnosed or suspected hypertensives (nHT) (69% and 31%, respectively; females: 51.1%, males 48.9%). 76% of the nHTs were untreated. They were 12 years younger than HT patients (46.7 ± 13.9 and 59.1 ± 13.9 years old, respectively p<0.001). Besides high BP, other atherosclerotic risk factors and comorbidities were less frequent in nHT patients than in HT patients: dyslipidemia was known only in 11.8% vs. 28.7%, obesity (BMI > 30 kg/m2) in 32.2% vs. 40.3%, diabetes 2.7% vs. 13.1%, coronary heart disease in 0.8% vs. 9.6% of patients, respectively. In the HT group compared to the nHT group there were more cerebrovascular (3.3% vs 0.8%, p<0.001) and peripheral arterial diseases (1.8% vs 0.4%, p<0.001). In both groups the main indication of ABPM was high (62%) or labile (39.5%) home BP values. More ABPMs were performed in the nHT group because of the suspicion of white-coat- (19.2% vs. 9.0%, p<0.001), or masked hypertension (3.9% vs. 0.9%, p<0.001). Hypertension was diagnosed by the largest percentage in patients with suspected resistant hypertension (83%) and by the lowest percentage with suspected nocturnal hypertension (57%). Conclusions: The major indications for ABPM are the high or labile home BP values. Among nHTs suspected white coat hypertension is the third most important indication for ABPM, while in HT patients the follow up of therapies. Additional risk factors and comorbidities are less known in nHTs. Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved. LA - English DB - MTMT ER - TY - JOUR AU - Járai, Zoltán AU - Nemcsik, János AU - Páll, Dénes AU - Takács, Johanna AU - Koller, Ákos TI - HUNGARIAN AMBULATORY BLOOD PRESSURE MONITORING REGISTRY REVEALED THAT HYPERTENSION IS HIGHLY PREVALENT BOTH IN ALREADY DIAGNOSED AND TREATED PATIENTS AND IN SUSPECTED HYPERTENSIVES JF - JOURNAL OF HYPERTENSION J2 - J HYPERTENSION VL - 41 PY - 2023 IS - Suppl 3 SP - e111 SN - 0263-6352 DO - 10.1097/01.hjh.0000939868.21767.ef UR - https://m2.mtmt.hu/api/publication/34073367 ID - 34073367 AB - Objective: In 2021 the Hungarian Society of Hypertension initiated a program to promote the nationwide use of ambulatory blood pressure (BP) monitoring (ABPM) (Hungarian ABPM Registry) aiming to increase the awareness of high BP and to monitor the efficacy of therapies. The goal was to collect and analyze the ABPM values of treated hypertensive (HT) and newly diagnosed patients (nHT) and assess the influence of other risk factors, comorbidities and patient characteristics. Design and method: Adults (18-100 years old) can be included into this ongoing, multicenter, open-label, observational study. Data collection to an electronic case report form is performed by GPs, internists, and cardiologists. Meditech ABPM-06 monitors are used. Data of the current analysis were collected between 21.02.2021-5.10.2022. 15 835 ABPMs were performed; due to missing data or protocol deviation 1018 patients were excluded from the analysis. Results: 10212 patients were HTs, 4571 were nHTs (69% and 31%, respectively). 76% of nHT patients were untreated during ABPM. Mean 24-hour systolic and diastolic BP was 134.03±14.6 mmHg and 79.3±10.1 mmHg, respectively. There was no difference in the 24-hour mean systolic BP between nHT and HT patients (134.08±14.9 mmHg vs. 133.91±14.6 mmHg, respectively, p = NS). Two-third of the patients (all: 68.2%, HT: 68.5%, nHT: 67.6%) were hypertensive according to ABPM measurements. Obesity (BMI>30 kg/m2) doubled the risk of hypertension in both groups (OR = 2.18 [2.03;2.34] for 24-hour average), but it had a higher impact in nHTs (OR = 2.57[2.22;2.98] for 24-hour average in nHT and OR = 2.12[1.94;2.30] for 24-hour average in HT patients). Snoring increased the risk of hypertension in both group of patients (OR = 1.45[1.34;1.56] for 24-hour average) irrespectively of gender, and – interestingly – it had a greater impact on the daily values of BP (day: OR = 1.51[1.40;1.62] and night: OR = 1.32[1.22;1.42]). Conclusions: The new ABPM Hungary Registry revealed hypertension in the majority of screened individuals, regardless of gender or treatment. In addition, in both gender, obesity, snoring, increased the risk of hypertension. These data underline the importance of ABPM in the screening for and treatment of hypertension leading to the earlier and more effective treatment. Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved. LA - English DB - MTMT ER - TY - JOUR AU - Lurbe, Empar AU - Mancia, Giuseppe AU - Calpe, Javier AU - Drozdz, Dorota AU - Erdine, Serap AU - Fernandez-Aranda, Fernando AU - Hadjipanayis, Adamos AU - Hoyer, Peter F. AU - Jankauskiene, Augustina AU - Jimenez-Murcia, Susana AU - Litwin, Mieczyslaw AU - Mazur, Artur AU - Páll, Dénes AU - Seeman, Tomas AU - Sinha, Manish D. AU - Simonetti, Giacomo AU - Stabouli, Stella AU - Wuehl, Elke TI - Joint statement for assessing and managing high blood pressure in children and adolescents: Chapter 1. How to correctly measure blood pressure in children and adolescents JF - FRONTIERS IN PEDIATRICS J2 - FRONT PEDIATR VL - 11 PY - 2023 PG - 9 SN - 2296-2360 DO - 10.3389/fped.2023.1140357 UR - https://m2.mtmt.hu/api/publication/33866764 ID - 33866764 AB - The joint statement is a synergistic action between HyperChildNET and the European Academy of Pediatrics about the diagnosis and management of hypertension in youth, based on the European Society of Hypertension Guidelines published in 2016 with the aim to improve its implementation. The first and most important requirement for the diagnosis and management of hypertension is an accurate measurement of office blood pressure that is currently recommended for screening, diagnosis, and management of high blood pressure in children and adolescents. Blood pressure levels should be screened in all children starting from the age of 3 years. In those children with risk factors for high blood pressure, it should be measured at each medical visit and may start before the age of 3 years. Twenty-four-hour ambulatory blood pressure monitoring is increasingly recognized as an important source of information as it can detect alterations in circadian and short-term blood pressure variations and identify specific phenotypes such as nocturnal hypertension or non-dipping pattern, morning blood pressure surge, white coat and masked hypertension with prognostic significance. At present, home BP measurements are generally regarded as useful and complementary to office and 24-h ambulatory blood pressure for the evaluation of the effectiveness and safety of antihypertensive treatment and furthermore remains more accessible in primary care than 24-h ambulatory blood pressure. A grading system of the clinical evidence is included. LA - English DB - MTMT ER -