@article{MTMT:34821280, title = {Cardio-ankle vascular index for predicting cardiovascular morbimortality and determinants for its progression in the prospective advanced approach to arterial stiffness (TRIPLE-A-Stiffness) study}, url = {https://m2.mtmt.hu/api/publication/34821280}, author = {Bäck, Magnus and Topouchian, Jirar and Labat, Carlos and Gautier, Sylvie and Blacher, Jacques and Cwynar, Marcin and de la Sierra, Alejandro and Páll, Dénes and Duarte, Kevin and Fantin, Francesco and Farkas, Katalin and Garcia-Ortiz, Luis and Hakobyan, Zoya and Jankowski, Piotr and Jelakovic, Ana and Kotsani, Marina and Konradi, Alexandra and Mikhailova, Oksana and Mintale, Iveta and Plunde, Oscar and Ramos, Rafael and Rogoza, Anatoly and Sirenko, Yuriy and Tasic, Nebojsa and Rudyk, Iurii and Urazalina, Saule and Wohlfahrt, Peter and Zelveian, Parounak and Asmar, Roland and Benetos, Athanase}, doi = {10.1016/j.ebiom.2024.105107}, journal-iso = {EBIOMEDICINE}, journal = {EBIOMEDICINE}, unique-id = {34821280}, issn = {2352-3964}, year = {2024}, eissn = {2352-3964}, orcid-numbers = {Bäck, Magnus/0000-0003-0853-5141; Topouchian, Jirar/0009-0006-4297-9810} } @article{MTMT:34817593, title = {Plozasiran (ARO-APOC3) for Severe Hypertriglyceridemia}, url = {https://m2.mtmt.hu/api/publication/34817593}, author = {Gaudet, Daniel and Páll, Dénes and Watts, Gerald F. and Nicholls, Stephen J. and Rosenson, Robert S. and Modesto, Karen and San Martin, Javier and Hellawell, Jennifer and Ballantyne, Christie M.}, doi = {10.1001/jamacardio.2024.0959}, journal-iso = {JAMA CARDIOL}, journal = {JAMA CARDIOLOGY}, unique-id = {34817593}, issn = {2380-6583}, year = {2024}, eissn = {2380-6591} } @article{MTMT:34775499, title = {Frequency of office blood pressure measurements and the seasonal variability of blood pressure: results of the Hungarian Hypertension Registry}, url = {https://m2.mtmt.hu/api/publication/34775499}, author = {Nemcsik, János and Takács, Johanna and Pásztor, Dorottya Tímea and Farsang, Csaba and Simon, Attila and Páll, Dénes and Torzsa, Péter and Dolgos, Szilveszter and Koller, Ákos and Habony, Norbert and Járai, Zoltán}, doi = {10.1080/08037051.2024.2337170}, journal-iso = {BLOOD PRESSURE}, journal = {BLOOD PRESSURE}, volume = {33}, unique-id = {34775499}, issn = {0803-7051}, year = {2024}, eissn = {1651-1999}, orcid-numbers = {Nemcsik, János/0000-0002-3573-0287; Takács, Johanna/0000-0002-8709-8826; Pásztor, Dorottya Tímea/0009-0001-8399-1019; Torzsa, Péter/0000-0002-8148-4961; Koller, Ákos/0000-0003-3256-8701} } @article{MTMT:34732888, title = {A lipidanyagcsere eltéréseinek vizsgálata felnőtt hypertoniás betegek esetén adatbányászati módszerrel}, url = {https://m2.mtmt.hu/api/publication/34732888}, author = {Kovács, Beáta and Németh, Ákos and Daróczy, Bálint and Karányi, Zsolt and Maroda, László and Diószegi, Ágnes and Páll, Dénes and Harangi, Mariann}, doi = {10.33668/hn.28.002}, journal-iso = {HYPERTONIA NEPHROLOGIA}, journal = {HYPERTONIA ÉS NEPHROLOGIA}, volume = {28}, unique-id = {34732888}, issn = {1418-477X}, abstract = {A hypertonia és a hyperlipidaemia együttes előfordulása gyakori, és közös jelenlétük fokozza a cardiovascularis megbetegedések kialakulásának kockázatát. Célul tűztük ki a lipidanyagcsere eltéréseinek vizsgálatát és annak összefüggését a testtömegindexszel (BMI) egy nagyméretű, felnőtt hypertoniás betegpopuláción adatbányászati módszerek alkalmazásával.}, year = {2024}, eissn = {2498-6259}, pages = {13-18} } @article{MTMT:34147505, title = {Melyek az Európai Hypertonia Társaság 2023. évi irányelvének legfontosabb újdonságai?}, url = {https://m2.mtmt.hu/api/publication/34147505}, author = {Járai, Zoltán and Farsang, Csaba and Nemcsik, János and Páll, Dénes}, journal-iso = {HYPERTONIA NEPHROLOGIA}, journal = {HYPERTONIA ÉS NEPHROLOGIA}, volume = {27}, unique-id = {34147505}, issn = {1418-477X}, year = {2023}, eissn = {2498-6259}, pages = {180-184}, orcid-numbers = {Nemcsik, János/0000-0002-3573-0287} } @article{MTMT:34134459, title = {DETERMINANTS OF ELASTIC AND STIFFENING PULSE PRESSURE COMPONENTS: RESULTS OF THE NEW HUNGARIAN ABPM REGISTRY}, url = {https://m2.mtmt.hu/api/publication/34134459}, author = {Nemcsik, János and Páll, Dénes and Takács, Johanna and Koller, Ákos and Jarai, Zoltan}, doi = {10.1097/01.hjh.0000941500.22031.09}, journal-iso = {J HYPERTENSION}, journal = {JOURNAL OF HYPERTENSION}, volume = {41}, unique-id = {34134459}, issn = {0263-6352}, abstract = {Objective: Pulse pressure (PP) received relative less attention in the guidelines regarding its potential role in the hypertension-mediated target organ damage. Recently it has been proposed that PP can be divided into two components: elastic PP (elPP) and stiffening PP (stPP). Thus the aim of our study was to explore the determinants of 24-hour, daytime and nighttime elPP and stPP in a new national ambulatory blood pressure monitoring (ABPM) database. Design and method: ABPM data were collected from the Hungarian ABPM Registry between February 2021 and August 2022. The Hungarian ABPM Registry is a an ongoing multicenter, open-label, observational non-interventional study. Meditech ABPM-06 monitors were used for ABPM measurements. Basic patients’ data were documented in electronic case report forms and were later analyzed together with ABPM data. elPP and stPP were calculated according to Gavish et al (DOI:10.1097/HJH.0000000000003258). Results: 14817 ABPM data were analyzed. The average age of the subjects was 55.29 ± 15.1 years, 7845 (48.9%) of them were men. 24h, daytime and nighttime elPP were 47.42 ± 8.89, 46.45 ± 9.34 and 45.93 ± 10.94 mmHg, respectively. 24h, daytime and nighttime stPP were 8.51 ± 5.86, 9.15 ±6.56 and 8.62 ± 7.81 mmHg, respectively. Under the age of 50 years all elPPs were significantly lower in women compared to men, while all stPPs were lower in both sexes in age under 50 (p<0.05). Independently from age and sex, obesity increased all elPPs, while under the age of 50 years nighttime stPP was elevated only in obese women (p<0.05). The independent determinants of daytime and nighttime elPPs were age, systolic blood pressure (sBP), obesity and diabetes with adding ischemic heart disease in case of 24h elPP. The independent determinants of 24h and daytime stPPs were age, sBP and diabetes, while in case of nighttime stPP age, sBP and sex. Conclusions: The new Hungarian ABPM Registry underline the importance of PP and its elastic and stiffening components. The evaluation of their determinants can help to better understand the pathomechanisms responsible for the development of hypertension-mediated target organ damage. Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.}, year = {2023}, eissn = {1473-5598}, pages = {E245-E245}, orcid-numbers = {Nemcsik, János/0000-0002-3573-0287; Takács, Johanna/0000-0002-8709-8826; Koller, Ákos/0000-0003-3256-8701} } @article{MTMT:34119117, title = {Assessment of Hypertensive Patients’ Complex Metabolic Status Using Data Mining Methods}, url = {https://m2.mtmt.hu/api/publication/34119117}, author = {Kovács, Beáta and Németh, Ákos and Daróczy, Bálint Zoltán and Karányi, Zsolt and Maroda, László and Diószegi, Ágnes and Harangi, Mariann and Páll, Dénes}, doi = {10.3390/jcdd10080345}, journal-iso = {J CARDIOVASC DEV DIS}, journal = {JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE}, volume = {10}, unique-id = {34119117}, issn = {2308-3425}, abstract = {Cardiovascular diseases are among the leading causes of mortality worldwide. Hypertension is a preventable risk factor leading to major cardiovascular events. We have not found a comprehensive study investigating Central and Eastern European hypertensive patients’ complex metabolic status. Therefore, our goal was to calculate the prevalence of hypertension and associated metabolic abnormalities using data-mining methods in our region. We assessed the data of adults who visited the University of Debrecen Clinical Center’s hospital (n = 937,249). The study encompassed data from a period of 20 years (2001–2021). We detected 292,561 hypertensive patients. The calculated prevalence of hypertension was altogether 32.2%. Markedly higher body mass index values were found in hypertensive patients as compared to non-hypertensives. Significantly higher triglyceride and lower HDL-C levels were found in adults from 18 to 80 years old. Furthermore, significantly higher serum glucose and uric acid levels were measured in hypertensive subjects. Our study confirms that the calculated prevalence of hypertension is akin to international findings and highlights the extensive association of metabolic alterations. These findings emphasize the role of early recognition and immediate treatment of cardiometabolic abnormalities to improve the quality of life and life expectancy of hypertensive patients.}, year = {2023}, eissn = {2308-3425}, pages = {345-359}, orcid-numbers = {Daróczy, Bálint Zoltán/0000-0001-6233-3490} } @article{MTMT:34073421, title = {PATIENT CHARACTERISTICS OF A REAL WORLD REGISTRY OF AMBULATORY BLOOD PRESSURE MONITORING: DATA FROM THE NEW HUNGARIAN ABPM REGISTRY}, url = {https://m2.mtmt.hu/api/publication/34073421}, author = {Járai, Zoltán and Nemcsik, János and Páll, Dénes and Takács, Johanna and Koller, Ákos}, doi = {10.1097/01.hjh.0000939872.07588.ad}, journal-iso = {J HYPERTENSION}, journal = {JOURNAL OF HYPERTENSION}, volume = {41}, unique-id = {34073421}, issn = {0263-6352}, abstract = {Objective: Current European guidelines recommend ambulatory blood pressure (BP) monitoring (ABPM) for the diagnosis and follow-up of patients with known or suspected hypertension. Thus in 2021 the Hungarian Society of Hypertension initiated a nationwide registry in order to evaluate ABPM indications and patient characteristics. Design and method: This is an ongoing, multicenter, open-label, observational study. Data collection to an electronic case report form is performed by GPs, internists and cardiologists. For ABPM measurements Meditech-ABPM-06 monitors are used. Data of the current analysis were collected between 21.02.2021-5.10.2022. 15 835 ABPMs were performed; due to missing data or protocol deviation 1018 patients were excluded from the analysis. Results: 10 212 patients were known and treated hypertensives (HT), and 4 571 were newly diagnosed or suspected hypertensives (nHT) (69% and 31%, respectively; females: 51.1%, males 48.9%). 76% of the nHTs were untreated. They were 12 years younger than HT patients (46.7 ± 13.9 and 59.1 ± 13.9 years old, respectively p<0.001). Besides high BP, other atherosclerotic risk factors and comorbidities were less frequent in nHT patients than in HT patients: dyslipidemia was known only in 11.8% vs. 28.7%, obesity (BMI > 30 kg/m2) in 32.2% vs. 40.3%, diabetes 2.7% vs. 13.1%, coronary heart disease in 0.8% vs. 9.6% of patients, respectively. In the HT group compared to the nHT group there were more cerebrovascular (3.3% vs 0.8%, p<0.001) and peripheral arterial diseases (1.8% vs 0.4%, p<0.001). In both groups the main indication of ABPM was high (62%) or labile (39.5%) home BP values. More ABPMs were performed in the nHT group because of the suspicion of white-coat- (19.2% vs. 9.0%, p<0.001), or masked hypertension (3.9% vs. 0.9%, p<0.001). Hypertension was diagnosed by the largest percentage in patients with suspected resistant hypertension (83%) and by the lowest percentage with suspected nocturnal hypertension (57%). Conclusions: The major indications for ABPM are the high or labile home BP values. Among nHTs suspected white coat hypertension is the third most important indication for ABPM, while in HT patients the follow up of therapies. Additional risk factors and comorbidities are less known in nHTs. Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.}, year = {2023}, eissn = {1473-5598}, orcid-numbers = {Nemcsik, János/0000-0002-3573-0287; Takács, Johanna/0000-0002-8709-8826; Koller, Ákos/0000-0003-3256-8701} } @article{MTMT:34073367, title = {HUNGARIAN AMBULATORY BLOOD PRESSURE MONITORING REGISTRY REVEALED THAT HYPERTENSION IS HIGHLY PREVALENT BOTH IN ALREADY DIAGNOSED AND TREATED PATIENTS AND IN SUSPECTED HYPERTENSIVES}, url = {https://m2.mtmt.hu/api/publication/34073367}, author = {Járai, Zoltán and Nemcsik, János and Páll, Dénes and Takács, Johanna and Koller, Ákos}, doi = {10.1097/01.hjh.0000939868.21767.ef}, journal-iso = {J HYPERTENSION}, journal = {JOURNAL OF HYPERTENSION}, volume = {41}, unique-id = {34073367}, issn = {0263-6352}, abstract = {Objective: In 2021 the Hungarian Society of Hypertension initiated a program to promote the nationwide use of ambulatory blood pressure (BP) monitoring (ABPM) (Hungarian ABPM Registry) aiming to increase the awareness of high BP and to monitor the efficacy of therapies. The goal was to collect and analyze the ABPM values of treated hypertensive (HT) and newly diagnosed patients (nHT) and assess the influence of other risk factors, comorbidities and patient characteristics. Design and method: Adults (18-100 years old) can be included into this ongoing, multicenter, open-label, observational study. Data collection to an electronic case report form is performed by GPs, internists, and cardiologists. Meditech ABPM-06 monitors are used. Data of the current analysis were collected between 21.02.2021-5.10.2022. 15 835 ABPMs were performed; due to missing data or protocol deviation 1018 patients were excluded from the analysis. Results: 10212 patients were HTs, 4571 were nHTs (69% and 31%, respectively). 76% of nHT patients were untreated during ABPM. Mean 24-hour systolic and diastolic BP was 134.03±14.6 mmHg and 79.3±10.1 mmHg, respectively. There was no difference in the 24-hour mean systolic BP between nHT and HT patients (134.08±14.9 mmHg vs. 133.91±14.6 mmHg, respectively, p = NS). Two-third of the patients (all: 68.2%, HT: 68.5%, nHT: 67.6%) were hypertensive according to ABPM measurements. Obesity (BMI>30 kg/m2) doubled the risk of hypertension in both groups (OR = 2.18 [2.03;2.34] for 24-hour average), but it had a higher impact in nHTs (OR = 2.57[2.22;2.98] for 24-hour average in nHT and OR = 2.12[1.94;2.30] for 24-hour average in HT patients). Snoring increased the risk of hypertension in both group of patients (OR = 1.45[1.34;1.56] for 24-hour average) irrespectively of gender, and – interestingly – it had a greater impact on the daily values of BP (day: OR = 1.51[1.40;1.62] and night: OR = 1.32[1.22;1.42]). Conclusions: The new ABPM Hungary Registry revealed hypertension in the majority of screened individuals, regardless of gender or treatment. In addition, in both gender, obesity, snoring, increased the risk of hypertension. These data underline the importance of ABPM in the screening for and treatment of hypertension leading to the earlier and more effective treatment. Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.}, year = {2023}, eissn = {1473-5598}, pages = {e111}, orcid-numbers = {Nemcsik, János/0000-0002-3573-0287; Takács, Johanna/0000-0002-8709-8826; Koller, Ákos/0000-0003-3256-8701} } @article{MTMT:33866764, title = {Joint statement for assessing and managing high blood pressure in children and adolescents: Chapter 1. How to correctly measure blood pressure in children and adolescents}, url = {https://m2.mtmt.hu/api/publication/33866764}, author = {Lurbe, Empar and Mancia, Giuseppe and Calpe, Javier and Drozdz, Dorota and Erdine, Serap and Fernandez-Aranda, Fernando and Hadjipanayis, Adamos and Hoyer, Peter F. and Jankauskiene, Augustina and Jimenez-Murcia, Susana and Litwin, Mieczyslaw and Mazur, Artur and Páll, Dénes and Seeman, Tomas and Sinha, Manish D. and Simonetti, Giacomo and Stabouli, Stella and Wuehl, Elke}, doi = {10.3389/fped.2023.1140357}, journal-iso = {FRONT PEDIATR}, journal = {FRONTIERS IN PEDIATRICS}, volume = {11}, unique-id = {33866764}, issn = {2296-2360}, abstract = {The joint statement is a synergistic action between HyperChildNET and the European Academy of Pediatrics about the diagnosis and management of hypertension in youth, based on the European Society of Hypertension Guidelines published in 2016 with the aim to improve its implementation. The first and most important requirement for the diagnosis and management of hypertension is an accurate measurement of office blood pressure that is currently recommended for screening, diagnosis, and management of high blood pressure in children and adolescents. Blood pressure levels should be screened in all children starting from the age of 3 years. In those children with risk factors for high blood pressure, it should be measured at each medical visit and may start before the age of 3 years. Twenty-four-hour ambulatory blood pressure monitoring is increasingly recognized as an important source of information as it can detect alterations in circadian and short-term blood pressure variations and identify specific phenotypes such as nocturnal hypertension or non-dipping pattern, morning blood pressure surge, white coat and masked hypertension with prognostic significance. At present, home BP measurements are generally regarded as useful and complementary to office and 24-h ambulatory blood pressure for the evaluation of the effectiveness and safety of antihypertensive treatment and furthermore remains more accessible in primary care than 24-h ambulatory blood pressure. A grading system of the clinical evidence is included.}, keywords = {Blood Pressure; CHILDREN; HYPERTENSION; MONITORING; Adolescents}, year = {2023}, eissn = {2296-2360}, orcid-numbers = {Lurbe, Empar/0000-0002-3748-5529} }