TY - JOUR AU - Saif-alnasr H, Mohammed AU - Mirdamadi, Seyedmohsen AU - Szűcs, Kálmán Ferenc AU - Gáspár, Róbert TI - Non-genomic actions of steroid hormones on the contractility of non-vascular smooth muscles JF - BIOCHEMICAL PHARMACOLOGY J2 - BIOCHEMIC PHARMACOL VL - 222 PY - 2024 PG - 10 SN - 0006-2952 DO - 10.1016/j.bcp.2024.116063 UR - https://m2.mtmt.hu/api/publication/34656993 ID - 34656993 N1 - Export Date: 22 March 2024 CODEN: BCPCA Correspondence Address: Gaspar, R.; Department of Pharmacology and Pharmacotherapy, Hungary; email: gaspar.robert@med.u-szeged.hu Funding details: Nemzeti Kutatási, Fejlesztési és Innovaciós Alap, NKFIA Funding text 1: Project No. TKP2021-EGA-32 was implemented with the support provided by the Ministry of Innovation and Technology of Hungary from the National Research, Development, and Innovation Fund , financed under the TKP2021-EGA funding scheme. This work was also supported by the Stipendium Hungaricum Scholarship. AB - Steroid hormones play an important role in physiological processes. The classical pathway of steroid actions is mediated by nuclear receptors, which regulate genes to modify biological processes. Non-genomic pathways of steroid actions are also known, mediated by cell membrane-located seven transmembrane domain receptors. Sex steroids and glucocorticoids have several membrane receptors already identified to mediate their rapid actions. However, mineralocorticoids have no identified membrane receptors, although their rapid actions are also measurable. In non-vascular smooth muscles (bronchial, uterine, gastrointestinal, and urinary), the rapid actions of steroids are mediated through the modification of the intracellular Ca2+ level by various Ca-channels and the cAMP and IP3 system. The non-genomic action can be converted into a genomic one, suggesting that these distinct pathways may interconnect, resulting in convergence between them. Sex steroids mostly relax all the non-vascular smooth muscles, except androgens and progesterone, which contract colonic and urinary bladder smooth muscles, respectively. Corticosteroids also induce relaxation in bronchial and uterine tissues, but their actions on gastrointestinal and urinary bladder smooth muscles have not been investigated yet. Bile acids also contribute to the smooth muscle contractility. Although the therapeutic application of the rapid effects of steroid hormones and their analogues for smooth muscle contractility disorders seems remote, the actions and mechanism discovered so far are promising. Further research is needed to expand our knowledge in this field by using existing experience. One of the greatest challenges is to separate genomic and non-genomic effects, but model molecules are available to start this line of research. LA - English DB - MTMT ER - TY - CHAP AU - Köteles, Dávid AU - Baccouri, Wissem AU - Tóth, Violetta AU - Gáspár, Róbert AU - Csaba, Utasi AU - Mikó, Edit ED - Denis, Kučević TI - Comparison of different thermometric instruments and their potential applications in stress and noncontact production by testing parameters of intensive breeding pigs T2 - The International Symposium on Animal Science PB - University of Novi Sad, Faculty of Agriculture CY - Novi Sad SN - 9788675205937 PY - 2023 SP - 41 UR - https://m2.mtmt.hu/api/publication/34434798 ID - 34434798 LA - English DB - MTMT ER - TY - JOUR AU - Kékesi, Gabriella AU - Plesz, Szonja AU - Adlan, Leatitia AU - Horváth, Gyöngyi AU - Szűcs, Kálmán Ferenc AU - Gáspár, Róbert TI - GASTROINTESTINAL ACTIVITY IN AWAKE SCHIZOPHRENIA-LIKE WISKET RATS JF - IBRO NEUROSCIENCE REPORTS J2 - IBRO NEUROSCI REP VL - 15 PY - 2023 SP - S589 SN - 2667-2421 DO - 10.1016/j.ibneur.2023.08.1167 UR - https://m2.mtmt.hu/api/publication/34407637 ID - 34407637 LA - English DB - MTMT ER - TY - JOUR AU - Barna, Tamara AU - Szűcs, Kálmán Ferenc AU - Mirdamadi, Seyedmohsen AU - Gáspár, Róbert TI - The combined uterorelaxant effect of sildenafil and terbutalin in the rat: The potential benefit of co-administration of low doses JF - HELIYON J2 - HELIYON VL - 9 PY - 2023 IS - 12 PG - 13 SN - 2405-8440 DO - 10.1016/j.heliyon.2023.e22488 UR - https://m2.mtmt.hu/api/publication/34396514 ID - 34396514 N1 - Funding Agency and Grant Number: New National Excellence Program of the Ministry for Culture and Innovation from the source of the National Research, Development and Innovation Fund; Ministry of Innovation and Technology of Hungary from the National Research, Development, and Innovation Fund [6401]; Research Fund of Albert Szent-Gyorgyi Medical School, University of Szeged, Hungary; University of Szeged Open Access Fund; [TKP2021-EGA-32]; [UNKP-22-3-SZTE-237] Funding text: Supported by the UNKP-22-3-SZTE-237, 2022 New National Excellence Program of the Ministry for Culture and Innovation from the source of the National Research, Development and Innovation Fund. Project No. TKP2021-EGA-32 was implemented with the support provided by the Ministry of Innovation and Technology of Hungary from the National Research, Development, and Innovation Fund, financed under the TKP2021-EGA funding scheme. The work was also funded by the Research Fund of Albert Szent-Gyorgyi Medical School, University of Szeged, Hungary and University of Szeged Open Access Fund (Grant number 6401) . LA - English DB - MTMT ER - TY - CHAP AU - Gillay, Zoltán AU - Kovács, Zoltán AU - Bázár, György AU - Roszkos, Róbert AU - Csavajda, Éva AU - Hingyi, Hajnalka AU - Henrik, Baranyay AU - Gáspár, Róbert AU - Szűcs, Kálmán Ferenc AU - Tóth, Tamás TI - Estrus detection in pigs based on testing urine with aquaphotomics T2 - 3rd Aquaphotomics European Conference: Book of Abstracts PB - International Aquaphotomics Society C1 - Roma PY - 2023 SP - 21 UR - https://m2.mtmt.hu/api/publication/34378798 ID - 34378798 LA - English DB - MTMT ER - TY - JOUR AU - Ivić, Vedrana AU - Zjalić, Milorad AU - Blažetić, Senka AU - Fenrich, Matija AU - Labak, Irena AU - Scitovski, Rudolf AU - Szűcs, Kálmán Ferenc AU - Ducza, Eszter AU - Tábi, Tamás AU - Bagaméry, Fruzsina AU - Szökő, Éva AU - Vuković, Rosemary AU - Rončević, Alen AU - Mandić, Dario AU - Debeljak, Željko AU - Berecki, Monika AU - Balog, Marta AU - Seres, Adrienn AU - Sztojkov-Ivanov, Anita AU - Hajagos-Tóth, Judit AU - Gajović, Srećko AU - Imširović, Alen AU - Bakula, Marina AU - Mahiiovych, Solomiia AU - Gáspár, Róbert AU - G. Vari, Sandor AU - Heffer, Marija TI - Elderly rats fed with a high-fat high-sucrose diet developed sex-dependent metabolic syndrome regardless of long-term metformin and liraglutide treatment JF - FRONTIERS IN ENDOCRINOLOGY J2 - FRONT ENDOCRINOL VL - 14 PY - 2023 PG - 22 SN - 1664-2392 DO - 10.3389/fendo.2023.1181064 UR - https://m2.mtmt.hu/api/publication/34207754 ID - 34207754 N1 - Funding Agency and Grant Number: This study was supported by the RECOOP-CSMC Fusion Research Grant No. 029 2015-2021 "Obesity and Diabetes", and by the Ministry of Human Capacities [Hungary grant 20391-3/2018/FEKUSTRAT]. This study was supported in part with the following grants: Croatian [029 2015-2021]; Ministry of Human Capacities [Hungary] [20391-3/2018/FEKUSTRAT]; Croatian Science Foundation [IP-2014-09-2324, IP-2016-06-6545, IP-06-2016-1892]; Josip Juraj Strossmayer University of Osijek, Faculty of Medicine institutional grant [IP9-2019]; Josip Juraj Strossmayer University of Osijek [INGI-2015-35, UNIOS-ZUP 2018-44]; European Union through the European Regional Development Fund [KK.01.1.1.01.0007, KK.01.1.1.02.0015]; diagnostics of malignant, infectious and rare metabolic diseases based on MALDI TOF technology" Funding text: We would like to extend our sincere gratitude to the reviewers for their invaluable contributions in reviewing this manuscript. Their thoughtful comments and suggestions significantly improved the quality of our work.r This study was supported by the RECOOP-CSMC Fusion Research Grant No. 029 2015-2021 "Obesity and Diabetes", and by the Ministry of Human Capacities [Hungary grant 20391-3/2018/FEKUSTRAT]. This study was supported in part with the following grants: Croatian Science Foundation grants to MH (Raft tuning, IP-2014-09-2324), RS (IP-2016-06-6545), and SG (RepairStroke, IP-06-2016-1892); Josip Juraj Strossmayer University of Osijek, Faculty of Medicine institutional grant to MH (Lipid profile of metabolic stress, IP9-2019); Josip Juraj Strossmayer University of Osijek grant to MH (INGI-2015-35) and VI (UNIOS-ZUP 2018-44); and European Union through the European Regional Development Fund, Operational Programme "Competitiveness and Cohesion 2014-2020", grant agreement No. KK.01.1.1.01.0007, CoRE - Neuro, and grant agreement No. KK.01.1.1.02.0015, "Research and diagnostics of malignant, infectious and rare metabolic diseases based on MALDI TOF technology". LA - English DB - MTMT ER - TY - CONF AU - Kemény, Kata Kira AU - Seres, Adrienn AU - Gáspár, Róbert AU - Barna, Tamara AU - Mirdamadi, Seyedmohsen AU - Surányi, Andrea AU - Németh, Gábor László AU - Altorjay, Ábel Tamás AU - Molnár, András AU - Ducza, Eszter TI - Role of aquaporin 5 in the regulation of pregnant uterus contraction T2 - 4th European Spontaneous Preterm Birth Congress Abstract Book PY - 2023 SP - 1 UR - https://m2.mtmt.hu/api/publication/34170498 ID - 34170498 LA - English DB - MTMT ER - TY - CONF AU - Kékesi, Gabriella AU - Plesz, Szonja Bianka AU - Adlan, Leatitia Gabriella AU - Horváth, Gyöngyi AU - Szűcs, Kálmán Ferenc AU - Gáspár, Róbert AU - Ligeti, Balázs AU - Zádori, Zoltán Sándor TI - GUT MICROBIOME COMPOSITION AND GASTROINTESTINAL ACTIVITY IN THE WISKET RAT MODEL OF SCHIZOPHRENIA T2 - FAMÉ 2023 PY - 2023 SP - 124 EP - 124 PG - 1 UR - https://m2.mtmt.hu/api/publication/34152373 ID - 34152373 LA - English DB - MTMT ER - TY - JOUR AU - Vari, S. G. AU - Shevchuk, O. AU - Boychuk, A. AU - Kramar, S. AU - Nebesna, Z. AU - Yakymchuk, Y. AU - Kobylinska, L. AU - Chernyshenko, V. AU - Korolova, D. AU - Surányi, Andrea AU - Altorjay, Ábel Tamás AU - Gáspár, Róbert TI - Common mechanisms of placental dysfunction in preeclampsia, gestational diabetes, and COVID-19 in pregnant women JF - UKRAINIAN BIOCHEMICAL JOURNAL J2 - UKRAINIAN BIOCHEMICAL JOURNAL VL - 95 PY - 2023 IS - 3 SP - 5 EP - 11 PG - 7 SN - 2409-4943 DO - 10.15407/ubj95.03.005 UR - https://m2.mtmt.hu/api/publication/34105139 ID - 34105139 AB - COVID-19 infection, preeclampsia and gestational diabetes mellitus in pregnancy cause similar changes in the placenta and influence development of the fetus between conception and birth in gestation. Proper uterine and placental vascularization is essential for normal fetal development. The transplacental exchange is regulated and maintained by the placental endothelium. During placental implantation, the trophoblast differentiates into two distinct layers, the inner cytotrophoblast and outer syncytiotrophoblast, which are key elements of the human placental barrier. Proinflammatory cytokines exacerbate ischemic events and create an upward spiral of an inflammatory reaction in the placenta. Placental pathology in gestational COVID-19 shows desquamation and damage of trophoblast and chronic histiocytic intervillositis. Similar lesions also occur in gestational diabetes mellitus and preeclampsia. The systemic inflammatory response of the mother, the increased inflammation in the placenta and cytokine production by placental trophoblasts should be monitored throughout pregnancy. Placental angiogenesis can be evaluated by serum vascular endothelial growth factor, Annexin A2, placental growth factor or sclerostin. Tissue damage can be assessed by measuring levels of serum lactate dehydrogenase and myeloperoxidase. Blood flow can be monitored with three-dimensional Doppler and pathological changes can be documented with paraffin-embedded tissue sections stained with hematoxylin and eosin, and electron microscope images as well as immunohistochemistry tests for vascular endothelial growth factor, placental growth factor, sclerostin and Annexin A2. The damage of maternal and fetal vascular perfusion (villitis and fibrin deposition) is a common mechanism of gestational diseases. The placenta lesions liberate anti-endothelial factors that lead to anti-angiogenic conditions and are the common mechanism of maternal placental vascular malperfusion in gestational diseases. Keywords: dysfunction, inflammation, pathology, placenta, pregnancy, vascularization LA - English DB - MTMT ER - TY - JOUR AU - Nagy, Anikó AU - Szűcs, Kálmán Ferenc AU - Grosz, György AU - Süle, Miklós AU - Fekete, Ferenc AU - Karoliny, Anna AU - Borsos, Mariann AU - Papp, Zsuzsanna AU - Vigh, Dóra AU - Gáspár, Róbert TI - Prediction of gastroesophageal reflux episodes by smooth muscle electromyography: A translational study in rats and adolescents JF - HELIYON J2 - HELIYON VL - 9 PY - 2023 IS - 8 PG - 14 SN - 2405-8440 DO - 10.1016/j.heliyon.2023.e18859 UR - https://m2.mtmt.hu/api/publication/34105120 ID - 34105120 N1 - Heim Pal National Pediatric Institute, Budapest, Hungary Department of Pharmacology and Pharmacotherapy, Albert-Szent-Györgyi Medical School, Faculty of Medicine, University of Szeged, Szeged, Hungary MSB-MET Ltd, Balatonfüred, Hungary Adware Research Ltd, Balatonfüred, Hungary Export Date: 21 August 2023 Correspondence Address: Gáspár, R.; Department of Pharmacology and Pharmacotherapy, Hungary; email: gaspar.robert@med.u-szeged.hu Correspondence Address: Vigh, D.; Department of Pharmacology and Pharmacotherapy, Hungary; email: vigh.dora@med.u-szeged.hu LA - English DB - MTMT ER -