@article{MTMT:34656993, title = {Non-genomic actions of steroid hormones on the contractility of non-vascular smooth muscles}, url = {https://m2.mtmt.hu/api/publication/34656993}, author = {Saif-alnasr H, Mohammed and Mirdamadi, Seyedmohsen and Szűcs, Kálmán Ferenc and Gáspár, Róbert}, doi = {10.1016/j.bcp.2024.116063}, journal-iso = {BIOCHEMIC PHARMACOL}, journal = {BIOCHEMICAL PHARMACOLOGY}, volume = {222}, unique-id = {34656993}, issn = {0006-2952}, abstract = {Steroid hormones play an important role in physiological processes. The classical pathway of steroid actions is mediated by nuclear receptors, which regulate genes to modify biological processes. Non-genomic pathways of steroid actions are also known, mediated by cell membrane-located seven transmembrane domain receptors. Sex steroids and glucocorticoids have several membrane receptors already identified to mediate their rapid actions. However, mineralocorticoids have no identified membrane receptors, although their rapid actions are also measurable. In non-vascular smooth muscles (bronchial, uterine, gastrointestinal, and urinary), the rapid actions of steroids are mediated through the modification of the intracellular Ca2+ level by various Ca-channels and the cAMP and IP3 system. The non-genomic action can be converted into a genomic one, suggesting that these distinct pathways may interconnect, resulting in convergence between them. Sex steroids mostly relax all the non-vascular smooth muscles, except androgens and progesterone, which contract colonic and urinary bladder smooth muscles, respectively. Corticosteroids also induce relaxation in bronchial and uterine tissues, but their actions on gastrointestinal and urinary bladder smooth muscles have not been investigated yet. Bile acids also contribute to the smooth muscle contractility. Although the therapeutic application of the rapid effects of steroid hormones and their analogues for smooth muscle contractility disorders seems remote, the actions and mechanism discovered so far are promising. Further research is needed to expand our knowledge in this field by using existing experience. One of the greatest challenges is to separate genomic and non-genomic effects, but model molecules are available to start this line of research.}, keywords = {human; uterus; gastrointestinal tract; CORTICOSTEROIDS; rodent; urinary tract; Sex Hormones; Bile acids; Non-genomic; Bronchial tract}, year = {2024}, eissn = {1873-2968}, orcid-numbers = {Saif-alnasr H, Mohammed/0009-0001-6033-653X; Gáspár, Róbert/0000-0002-1571-7579} } @{MTMT:34434798, title = {Comparison of different thermometric instruments and their potential applications in stress and noncontact production by testing parameters of intensive breeding pigs}, url = {https://m2.mtmt.hu/api/publication/34434798}, author = {Köteles, Dávid and Baccouri, Wissem and Tóth, Violetta and Gáspár, Róbert and Csaba, Utasi and Mikó, Edit}, booktitle = {The International Symposium on Animal Science}, unique-id = {34434798}, year = {2023}, pages = {41}, orcid-numbers = {Tóth, Violetta/0000-0002-1394-716X; Gáspár, Róbert/0000-0002-1571-7579; Mikó, Edit/0000-0001-6389-3502} } @article{MTMT:34407637, title = {GASTROINTESTINAL ACTIVITY IN AWAKE SCHIZOPHRENIA-LIKE WISKET RATS}, url = {https://m2.mtmt.hu/api/publication/34407637}, author = {Kékesi, Gabriella and Plesz, Szonja and Adlan, Leatitia and Horváth, Gyöngyi and Szűcs, Kálmán Ferenc and Gáspár, Róbert}, doi = {10.1016/j.ibneur.2023.08.1167}, journal-iso = {IBRO NEUROSCI REP}, journal = {IBRO NEUROSCIENCE REPORTS}, volume = {15}, unique-id = {34407637}, year = {2023}, eissn = {2667-2421}, pages = {S589}, orcid-numbers = {Kékesi, Gabriella/0000-0002-0185-2155; Horváth, Gyöngyi/0000-0002-6025-4577; Gáspár, Róbert/0000-0002-1571-7579} } @article{MTMT:34396514, title = {The combined uterorelaxant effect of sildenafil and terbutalin in the rat: The potential benefit of co-administration of low doses}, url = {https://m2.mtmt.hu/api/publication/34396514}, author = {Barna, Tamara and Szűcs, Kálmán Ferenc and Mirdamadi, Seyedmohsen and Gáspár, Róbert}, doi = {10.1016/j.heliyon.2023.e22488}, journal-iso = {HELIYON}, journal = {HELIYON}, volume = {9}, unique-id = {34396514}, year = {2023}, eissn = {2405-8440}, orcid-numbers = {Gáspár, Róbert/0000-0002-1571-7579} } @{MTMT:34378798, title = {Estrus detection in pigs based on testing urine with aquaphotomics}, url = {https://m2.mtmt.hu/api/publication/34378798}, author = {Gillay, Zoltán and Kovács, Zoltán and Bázár, György and Roszkos, Róbert and Csavajda, Éva and Hingyi, Hajnalka and Henrik, Baranyay and Gáspár, Róbert and Szűcs, Kálmán Ferenc and Tóth, Tamás}, booktitle = {3rd Aquaphotomics European Conference: Book of Abstracts}, unique-id = {34378798}, year = {2023}, pages = {21}, orcid-numbers = {Bázár, György/0000-0001-9829-4366; Gáspár, Róbert/0000-0002-1571-7579; Tóth, Tamás/0000-0003-4457-1473} } @article{MTMT:34207754, title = {Elderly rats fed with a high-fat high-sucrose diet developed sex-dependent metabolic syndrome regardless of long-term metformin and liraglutide treatment}, url = {https://m2.mtmt.hu/api/publication/34207754}, author = {Ivić, Vedrana and Zjalić, Milorad and Blažetić, Senka and Fenrich, Matija and Labak, Irena and Scitovski, Rudolf and Szűcs, Kálmán Ferenc and Ducza, Eszter and Tábi, Tamás and Bagaméry, Fruzsina and Szökő, Éva and Vuković, Rosemary and Rončević, Alen and Mandić, Dario and Debeljak, Željko and Berecki, Monika and Balog, Marta and Seres, Adrienn and Sztojkov-Ivanov, Anita and Hajagos-Tóth, Judit and Gajović, Srećko and Imširović, Alen and Bakula, Marina and Mahiiovych, Solomiia and Gáspár, Róbert and G. Vari, Sandor and Heffer, Marija}, doi = {10.3389/fendo.2023.1181064}, journal-iso = {FRONT ENDOCRINOL}, journal = {FRONTIERS IN ENDOCRINOLOGY}, volume = {14}, unique-id = {34207754}, issn = {1664-2392}, year = {2023}, eissn = {1664-2392}, orcid-numbers = {Tábi, Tamás/0000-0001-5343-0205; Bagaméry, Fruzsina/0000-0001-7905-0104; Szökő, Éva/0000-0003-1464-6403; Gáspár, Róbert/0000-0002-1571-7579} } @CONFERENCE{MTMT:34170498, title = {Role of aquaporin 5 in the regulation of pregnant uterus contraction}, url = {https://m2.mtmt.hu/api/publication/34170498}, author = {Kemény, Kata Kira and Seres, Adrienn and Gáspár, Róbert and Barna, Tamara and Mirdamadi, Seyedmohsen and Surányi, Andrea and Németh, Gábor László and Altorjay, Ábel Tamás and Molnár, András and Ducza, Eszter}, booktitle = {4th European Spontaneous Preterm Birth Congress Abstract Book}, unique-id = {34170498}, year = {2023}, pages = {1}, orcid-numbers = {Kemény, Kata Kira/0000-0002-2746-5372; Gáspár, Róbert/0000-0002-1571-7579; Surányi, Andrea/0000-0002-1168-7261; Németh, Gábor László/0000-0003-1829-3457; Altorjay, Ábel Tamás/0000-0002-9052-8671} } @CONFERENCE{MTMT:34152373, title = {GUT MICROBIOME COMPOSITION AND GASTROINTESTINAL ACTIVITY IN THE WISKET RAT MODEL OF SCHIZOPHRENIA}, url = {https://m2.mtmt.hu/api/publication/34152373}, author = {Kékesi, Gabriella and Plesz, Szonja Bianka and Adlan, Leatitia Gabriella and Horváth, Gyöngyi and Szűcs, Kálmán Ferenc and Gáspár, Róbert and Ligeti, Balázs and Zádori, Zoltán Sándor}, booktitle = {FAMÉ 2023}, unique-id = {34152373}, year = {2023}, pages = {124-124}, orcid-numbers = {Kékesi, Gabriella/0000-0002-0185-2155; Horváth, Gyöngyi/0000-0002-6025-4577; Gáspár, Róbert/0000-0002-1571-7579; Zádori, Zoltán Sándor/0000-0001-7312-618X} } @article{MTMT:34105139, title = {Common mechanisms of placental dysfunction in preeclampsia, gestational diabetes, and COVID-19 in pregnant women}, url = {https://m2.mtmt.hu/api/publication/34105139}, author = {Vari, S. G. and Shevchuk, O. and Boychuk, A. and Kramar, S. and Nebesna, Z. and Yakymchuk, Y. and Kobylinska, L. and Chernyshenko, V. and Korolova, D. and Surányi, Andrea and Altorjay, Ábel Tamás and Gáspár, Róbert}, doi = {10.15407/ubj95.03.005}, journal-iso = {UKRAINIAN BIOCHEMICAL JOURNAL}, journal = {UKRAINIAN BIOCHEMICAL JOURNAL}, volume = {95}, unique-id = {34105139}, issn = {2409-4943}, abstract = {COVID-19 infection, preeclampsia and gestational diabetes mellitus in pregnancy cause similar changes in the placenta and influence development of the fetus between conception and birth in gestation. Proper uterine and placental vascularization is essential for normal fetal development. The transplacental exchange is regulated and maintained by the placental endothelium. During placental implantation, the trophoblast differentiates into two distinct layers, the inner cytotrophoblast and outer syncytiotrophoblast, which are key elements of the human placental barrier. Proinflammatory cytokines exacerbate ischemic events and create an upward spiral of an inflammatory reaction in the placenta. Placental pathology in gestational COVID-19 shows desquamation and damage of trophoblast and chronic histiocytic intervillositis. Similar lesions also occur in gestational diabetes mellitus and preeclampsia. The systemic inflammatory response of the mother, the increased inflammation in the placenta and cytokine production by placental trophoblasts should be monitored throughout pregnancy. Placental angiogenesis can be evaluated by serum vascular endothelial growth factor, Annexin A2, placental growth factor or sclerostin. Tissue damage can be assessed by measuring levels of serum lactate dehydrogenase and myeloperoxidase. Blood flow can be monitored with three-dimensional Doppler and pathological changes can be documented with paraffin-embedded tissue sections stained with hematoxylin and eosin, and electron microscope images as well as immunohistochemistry tests for vascular endothelial growth factor, placental growth factor, sclerostin and Annexin A2. The damage of maternal and fetal vascular perfusion (villitis and fibrin deposition) is a common mechanism of gestational diseases. The placenta lesions liberate anti-endothelial factors that lead to anti-angiogenic conditions and are the common mechanism of maternal placental vascular malperfusion in gestational diseases. Keywords: dysfunction, inflammation, pathology, placenta, pregnancy, vascularization}, year = {2023}, eissn = {2413-5003}, pages = {5-11}, orcid-numbers = {Surányi, Andrea/0000-0002-1168-7261; Altorjay, Ábel Tamás/0000-0002-9052-8671; Gáspár, Róbert/0000-0002-1571-7579} } @article{MTMT:34105120, title = {Prediction of gastroesophageal reflux episodes by smooth muscle electromyography: A translational study in rats and adolescents}, url = {https://m2.mtmt.hu/api/publication/34105120}, author = {Nagy, Anikó and Szűcs, Kálmán Ferenc and Grosz, György and Süle, Miklós and Fekete, Ferenc and Karoliny, Anna and Borsos, Mariann and Papp, Zsuzsanna and Vigh, Dóra and Gáspár, Róbert}, doi = {10.1016/j.heliyon.2023.e18859}, journal-iso = {HELIYON}, journal = {HELIYON}, volume = {9}, unique-id = {34105120}, year = {2023}, eissn = {2405-8440}, orcid-numbers = {Nagy, Anikó/0000-0002-9847-0566; Fekete, Ferenc/0000-0003-0969-6684; Gáspár, Róbert/0000-0002-1571-7579} }