TY - JOUR AU - Masa, Roland AU - Pelsőczi-Kovács, István AU - Aigner, Zoltán AU - Oszkó, Albert Zoltán AU - Turzó, Kinga Mónika AU - Ungvári, Krisztina TI - Surface Free Energy and Composition Changes and Ob Cellular Response to CHX-, PVPI-, and ClO2-Treated Titanium Implant Materials JF - JOURNAL OF FUNCTIONAL BIOMATERIALS J2 - J FUNCT BIOMATER VL - 13 PY - 2022 IS - 4 PG - 11 SN - 2079-4983 DO - 10.3390/jfb13040202 UR - https://m2.mtmt.hu/api/publication/33215364 ID - 33215364 N1 - Department of Oral Biology and Experimental Dental Research, Faculty of Dentistry, University of Szeged, Tisza Lajos krt. 64, Szeged, H-6720, Hungary Department of Prosthodontics, Faculty of Dentistry, University of Szeged, Tisza Lajos krt. 64, Szeged, H-6720, Hungary Institute of Pharmaceutical Technology and Regulatory Affairs, Faculty of Pharmacy, University of Szeged, Zrínyi u. 9., Szeged, H-6720, Hungary ELI-HU Non-Profit Ltd., Wolfgang Sandner u. 3., Szeged, H-6728, Hungary Dental School, Medical Faculty, University of Pécs, Tüzér u. 1, Pécs, H-7623, Hungary Export Date: 04 January 2024; Cited By: 1; Correspondence Address: K. Turzó; Dental School, Medical Faculty, University of Pécs, Pécs, Tüzér u. 1, H-7623, Hungary; email: turzo.kinga@pte.hu AB - The study evaluated the interaction of a titanium dental implant surface with three different antibacterial solutions: chlorhexidine, povidone-iodine, and chlorine dioxide. Implant surface decontamination is greatly challenging modern implant dentistry. Alongside mechanical cleaning, different antibacterial agents are widely used, though these could alter implant surface properties. Commercially pure (CP) grade 4 titanium (Ti) discs were treated with three different chemical agents (chlorhexidine 0.2% (CHX), povidone-iodine 10% (PVPI), chlorine dioxide 0.12% (ClO2)) for 5 min. Contact angle measurements, X-ray photoelectron spectroscopy (XPS) analysis, and cell culture studies were performed. Attachment and proliferation of primary human osteoblast cells were investigated via MTT (dimethylthiazol–diphenyl tetrazolium bromide), alamarBlue, LDH (lactate dehydrogenase), and fluorescent assays. Contact angle measurements showed that PVPI-treated samples (Θ = 24.9 ± 4.1) gave no difference compared with controls (Θ = 24.6 ± 5.4), while CHX (Θ = 47.2 ± 4.1) and ClO2 (Θ = 39.2 ± 9.8) treatments presented significantly higher Θ values. All samples remained in the hydrophilic region. XPS analysis revealed typical surface elements of CP grade 4 titanium (Ti, O, and C). Both MTT and alamarBlue cell viability assays showed similarity between treated and untreated control groups. The LDH test revealed no significant difference, and fluorescent staining confirmed these results. Although there was a difference in surface wettability, a high proliferation rate was observed in all treated groups. The in vitro study proved that CHX, PVPI, and ClO2 are proper candidates as dental implant decontamination agents. LA - English DB - MTMT ER - TY - JOUR AU - Kondoros, Balázs Attila AU - Berkesi, Ottó AU - Tóth, Zsolt AU - Aigner, Zoltán AU - Ambrus, Rita AU - Pannonhalminé Csóka, Ildikó TI - Cyclodextrin Complexation of Fenofibrate by Co-Grinding Method and Monitoring the Process Using Complementary Analytical Tools JF - PHARMACEUTICS J2 - PHARMACEUTICS VL - 14 PY - 2022 IS - 7 PG - 21 SN - 1999-4923 DO - 10.3390/pharmaceutics14071329 UR - https://m2.mtmt.hu/api/publication/32901984 ID - 32901984 LA - English DB - MTMT ER - TY - JOUR AU - Kondoros, Balázs Attila AU - Jójártné Laczkovich, Orsolya AU - Berkesi, Ottó AU - Révész, Piroska AU - Pannonhalminé Csóka, Ildikó AU - Ambrus, Rita AU - Aigner, Zoltán TI - Development of Solvent-Free Co-Ground Method to Produce Terbinafine Hydrochloride Cyclodextrin Binary Systems; Structural and In Vitro Characterizations JF - PHARMACEUTICS J2 - PHARMACEUTICS VL - 14 PY - 2022 IS - 4 PG - 19 SN - 1999-4923 DO - 10.3390/pharmaceutics14040744 UR - https://m2.mtmt.hu/api/publication/32774497 ID - 32774497 LA - English DB - MTMT ER - TY - JOUR AU - Kohajda, Zsófia AU - Virág, László AU - Hornyik, Tibor AU - Husti, Zoltán AU - Sztojkov-Ivanov, Anita AU - Nagy, Norbert AU - Horváth, András AU - Varga, Richárd Sándor AU - Prorok, János AU - Szlovák, Jozefina AU - Tóth, Noémi AU - Gazdag, Péter AU - Topal, Leila AU - Naveed, Muhammad AU - Árpádffy-Lovas, Tamás AU - Pászti, Bence József AU - Magyar, Tibor AU - Koncz, Istvan AU - Déri, Szilvia AU - Demeter-Haludka, Vivien AU - Aigner, Zoltán AU - Ördög, Balázs AU - Patfalusi, Márta AU - Tálosi, László AU - Tiszlavicz, László AU - Földesi, Imre AU - Jost, Norbert László AU - Baczkó, István AU - Varró, András TI - In vivo and cellular antiarrhythmic and cardiac electrophysiological effects of desethylamiodarone in dog cardiac preparations JF - BRITISH JOURNAL OF PHARMACOLOGY J2 - BR J PHARMACOL VL - 179 PY - 2022 IS - 13 SP - 3382 EP - 3402 PG - 21 SN - 0007-1188 DO - 10.1111/bph.15812 UR - https://m2.mtmt.hu/api/publication/32640430 ID - 32640430 N1 - ELKH-SZTE Research Group for Cardiovascular Pharmacology, Eötvös Loránd Research Network, Szeged, Hungary Department of Pharmacology and Pharmacotherapy, University of Szeged, Szeged, Hungary Department of Pharmacology and Pharmacotherapy, Interdisciplinary Excellence Centre, University of Szeged, Szeged, Hungary Department of Pharmacodynamics and Biopharmacy, University of Szeged, Szeged, Hungary Institute of Pharmaceutical Technology and Regulatory Affairs, University of Szeged, Szeged, Hungary Department of Toxicology, ATRC Aurigon Toxicological Research Center Ltd., Dunakeszi, Hungary Department of Pharmacognosy, Faculty of Pharmacy, University of Szeged, Szeged, Hungary Department of Pathology, Faculty of Medicine, University of Szeged, Szeged, Hungary Department of Laboratory Medicine, Faculty of Medicine, University of Szeged, Szeged, Hungary Export Date: 24 March 2022 CODEN: BJPCB Correspondence Address: Varró, A.; ELKH-SZTE Research Group for Cardiovascular Pharmacology, Hungary; email: varro.andras@med.u-szeged.hu LA - English DB - MTMT ER - TY - JOUR AU - Kristó, Katalin AU - Szilvia, Módra AU - Varga, Viktória AU - Süvegh, Károly AU - Ludasi, Krisztina AU - Aigner, Zoltán AU - Kelemen, András AU - Sovány, Tamás AU - Hódi, Klára AU - Regdon, Géza (ifj.) TI - Investigation of Surface Properties and Free Volumes of Chitosan-Based Buccal Mucoadhesive Drug Delivery Films Containing Ascorbic Acid JF - PHARMACEUTICS J2 - PHARMACEUTICS VL - 14 PY - 2022 IS - 2 PG - 18 SN - 1999-4923 DO - 10.3390/pharmaceutics14020345 UR - https://m2.mtmt.hu/api/publication/32638727 ID - 32638727 N1 - Institute of Pharmaceutical Technology and Regulatory Affairs, University of Szeged, Szeged, H-6720, Hungary Department of Physical Chemistry and Materials Science, University of Szeged, Szeged, H-6720, Hungary Department of Nuclear Chemistry, Eötvös Loránd University, Budapest, H-1518, Hungary Department of Applied Informatics, University of Szeged, Szeged, H-6725, Hungary Cited By :2 Export Date: 21 June 2022 Correspondence Address: Kristó, K.; Institute of Pharmaceutical Technology and Regulatory Affairs, Hungary; email: kristo.katalin@szte.hu LA - English DB - MTMT ER - TY - CONF AU - Kondoros, Balázs Attila AU - Aigner, Zoltán TI - Együtt-őrléssel előállított fenofibrát tartalmú ciklodextrin-komplexek vizsgálata T2 - MKE Kristályosítási és Gyógyszerformulálási Szakosztály 13. Kerekasztal Konferenciája PY - 2021 SP - 32 EP - 33 PG - 2 UR - https://m2.mtmt.hu/api/publication/32902108 ID - 32902108 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Robert-Alexandru, Vlad AU - Sovány, Tamás AU - Kristó, Katalin AU - Ibrahim, Yousif AU - Adriana, Ciurba AU - Aigner, Zoltán AU - Daniela, Lucia Muntean AU - Regdon, Géza (ifj.) TI - Structural and thermal analysis of cannabidiol orodispersible formulations JF - FARMACIA (BUCHAREST) J2 - FARMACIA VL - 69 PY - 2021 IS - 3 SP - 426 EP - 433 PG - 8 SN - 0014-8237 DO - 10.31925/farmacia.2021.3.5 UR - https://m2.mtmt.hu/api/publication/32086882 ID - 32086882 LA - English DB - MTMT ER - TY - CHAP AU - Kondoros, Balázs Attila AU - Berkesi, Ottó AU - Aigner, Zoltán ED - Szathmári, Balázs TI - Fenofibrát tartalmú ciklodextrin-komplexek előállítása oldószer mentes technológiával és a folyamat analitikai jellemzése T2 - XIV. Szent-Györgyi Konferencia kiadványa: 2021. április 16-17. PB - Budapesti Műszaki és Gazdaságtudományi Egyetem CY - Budapest SN - 9789634218494 PY - 2021 SP - 30 EP - 30 PG - 1 UR - https://m2.mtmt.hu/api/publication/32027620 ID - 32027620 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Bíró, Tivadar AU - Bocsik, Alexandra AU - Jurišić Dukovski, Bisera AU - Gróf, Ilona AU - Lovrić, Jasmina AU - Pannonhalminé Csóka, Ildikó AU - Deli, Mária Anna AU - Aigner, Zoltán TI - New Approach in Ocular Drug Delivery. In vitro and ex vivo Investigation of Cyclodextrin-Containing, Mucoadhesive Eye Drop Formulations TS - In vitro and ex vivo Investigation of Cyclodextrin-Containing, Mucoadhesive Eye Drop Formulations JF - DRUG DESIGN DEVELOPMENT AND THERAPY J2 - DRUG DES DEV THER VL - 15 PY - 2021 SP - 351 EP - 360 PG - 10 SN - 1177-8881 DO - 10.2147/DDDT.S264745 UR - https://m2.mtmt.hu/api/publication/31890902 ID - 31890902 AB - Background: Optimal transcorneal penetration is necessary for ocular therapy; meanwhile, it is limited by the complex structure and defensive mechanisms of the eye. Antimicrobial stability of topical ophthalmic formulations is especially important. According to previous studies, the mostly used preservative, benzalkonium-chloride is irritative and toxic on corneal epithelial cells; therefore, novel non-toxic, antimicrobial agents are required. In this study, prednisolone-containing ophthalmic formulations were developed with expected optimal permeation without toxic or irritative effects. Methods: The toxicity and permeability of prednisolone-containing eye drops were studied on a human corneal epithelial cell line (HCE-T) and ex vivo cornea model. The lipophilic drug is dissolved by the formation of cyclodextrin inclusion complex. Zinc-containing mucoadhesive biopolymer was applied as an alternative preservative agent, whose toxicity was compared with benzalkonium-chloride. Results: As the results show, benzalkonium-chloride-containing samples were toxic on HCE-T cells. The biopolymer caused no cell damage after the treatment. This was confirmed by immunohistochemistry assay. The in vitro permeability was significantly higher in formulations with prednisolone-cyclodextrin complex compared with suspension formulation. According to the ex vivo permeability study, the biopolymer-containing samples had significantly lower permeability. Conclusion: Considering the mucoadhesive attribute of target formulations, prolonged absorption is expected after application with less frequent administration. It can be stated that the compositions are innovative approaches as novel non-toxic ophthalmic formulations with optimal drug permeability. LA - English DB - MTMT ER - TY - CHAP AU - Kondoros, Balázs Attila AU - Aigner, Zoltán ED - Uhljar, Luca Éva TI - Evaluation of fenofibrate-cyclodextrin complexes prepared by co-grinding method T2 - III. Symposium of Young Researchers on Pharmaceutical Technology, Biotechnology and Regulatory Science PB - Szegedi Tudományegyetem (SZTE) CY - Szeged PY - 2021 SP - 33 EP - 33 PG - 1 DO - 10.14232/syrptbrs.2021.op21 UR - https://m2.mtmt.hu/api/publication/31859072 ID - 31859072 LA - English DB - MTMT ER -