@article{MTMT:33215364, title = {Surface Free Energy and Composition Changes and Ob Cellular Response to CHX-, PVPI-, and ClO2-Treated Titanium Implant Materials}, url = {https://m2.mtmt.hu/api/publication/33215364}, author = {Masa, Roland and Pelsőczi-Kovács, István and Aigner, Zoltán and Oszkó, Albert Zoltán and Turzó, Kinga Mónika and Ungvári, Krisztina}, doi = {10.3390/jfb13040202}, journal-iso = {J FUNCT BIOMATER}, journal = {JOURNAL OF FUNCTIONAL BIOMATERIALS}, volume = {13}, unique-id = {33215364}, abstract = {The study evaluated the interaction of a titanium dental implant surface with three different antibacterial solutions: chlorhexidine, povidone-iodine, and chlorine dioxide. Implant surface decontamination is greatly challenging modern implant dentistry. Alongside mechanical cleaning, different antibacterial agents are widely used, though these could alter implant surface properties. Commercially pure (CP) grade 4 titanium (Ti) discs were treated with three different chemical agents (chlorhexidine 0.2% (CHX), povidone-iodine 10% (PVPI), chlorine dioxide 0.12% (ClO2)) for 5 min. Contact angle measurements, X-ray photoelectron spectroscopy (XPS) analysis, and cell culture studies were performed. Attachment and proliferation of primary human osteoblast cells were investigated via MTT (dimethylthiazol–diphenyl tetrazolium bromide), alamarBlue, LDH (lactate dehydrogenase), and fluorescent assays. Contact angle measurements showed that PVPI-treated samples (Θ = 24.9 ± 4.1) gave no difference compared with controls (Θ = 24.6 ± 5.4), while CHX (Θ = 47.2 ± 4.1) and ClO2 (Θ = 39.2 ± 9.8) treatments presented significantly higher Θ values. All samples remained in the hydrophilic region. XPS analysis revealed typical surface elements of CP grade 4 titanium (Ti, O, and C). Both MTT and alamarBlue cell viability assays showed similarity between treated and untreated control groups. The LDH test revealed no significant difference, and fluorescent staining confirmed these results. Although there was a difference in surface wettability, a high proliferation rate was observed in all treated groups. The in vitro study proved that CHX, PVPI, and ClO2 are proper candidates as dental implant decontamination agents.}, year = {2022}, eissn = {2079-4983}, orcid-numbers = {Oszkó, Albert Zoltán/0000-0002-6215-2451} } @article{MTMT:32901984, title = {Cyclodextrin Complexation of Fenofibrate by Co-Grinding Method and Monitoring the Process Using Complementary Analytical Tools}, url = {https://m2.mtmt.hu/api/publication/32901984}, author = {Kondoros, Balázs Attila and Berkesi, Ottó and Tóth, Zsolt and Aigner, Zoltán and Ambrus, Rita and Pannonhalminé Csóka, Ildikó}, doi = {10.3390/pharmaceutics14071329}, journal-iso = {PHARMACEUTICS}, journal = {PHARMACEUTICS}, volume = {14}, unique-id = {32901984}, issn = {1999-4923}, year = {2022}, eissn = {1999-4923}, orcid-numbers = {Kondoros, Balázs Attila/0000-0001-8435-5893; Berkesi, Ottó/0000-0001-6184-1768; Tóth, Zsolt/0000-0003-1329-9470; Ambrus, Rita/0000-0001-5496-1710; Pannonhalminé Csóka, Ildikó/0000-0003-0807-2781} } @article{MTMT:32774497, title = {Development of Solvent-Free Co-Ground Method to Produce Terbinafine Hydrochloride Cyclodextrin Binary Systems; Structural and In Vitro Characterizations}, url = {https://m2.mtmt.hu/api/publication/32774497}, author = {Kondoros, Balázs Attila and Jójártné Laczkovich, Orsolya and Berkesi, Ottó and Révész, Piroska and Pannonhalminé Csóka, Ildikó and Ambrus, Rita and Aigner, Zoltán}, doi = {10.3390/pharmaceutics14040744}, journal-iso = {PHARMACEUTICS}, journal = {PHARMACEUTICS}, volume = {14}, unique-id = {32774497}, issn = {1999-4923}, year = {2022}, eissn = {1999-4923}, orcid-numbers = {Kondoros, Balázs Attila/0000-0001-8435-5893; Berkesi, Ottó/0000-0001-6184-1768; Révész, Piroska/0000-0002-5336-6052; Pannonhalminé Csóka, Ildikó/0000-0003-0807-2781; Ambrus, Rita/0000-0001-5496-1710} } @article{MTMT:32640430, title = {In vivo and cellular antiarrhythmic and cardiac electrophysiological effects of desethylamiodarone in dog cardiac preparations}, url = {https://m2.mtmt.hu/api/publication/32640430}, author = {Kohajda, Zsófia and Virág, László and Hornyik, Tibor and Husti, Zoltán and Sztojkov-Ivanov, Anita and Nagy, Norbert and Horváth, András and Varga, Richárd Sándor and Prorok, János and Szlovák, Jozefina and Tóth, Noémi and Gazdag, Péter and Topal, Leila and Naveed, Muhammad and Árpádffy-Lovas, Tamás and Pászti, Bence József and Magyar, Tibor and Koncz, Istvan and Déri, Szilvia and Demeter-Haludka, Vivien and Aigner, Zoltán and Ördög, Balázs and Patfalusi, Márta and Tálosi, László and Tiszlavicz, László and Földesi, Imre and Jost, Norbert László and Baczkó, István and Varró, András}, doi = {10.1111/bph.15812}, journal-iso = {BR J PHARMACOL}, journal = {BRITISH JOURNAL OF PHARMACOLOGY}, volume = {179}, unique-id = {32640430}, issn = {0007-1188}, year = {2022}, eissn = {1476-5381}, pages = {3382-3402}, orcid-numbers = {Prorok, János/0000-0001-8419-8859; Ördög, Balázs/0000-0002-8971-3079; Tiszlavicz, László/0000-0003-1134-6587; Földesi, Imre/0000-0002-3329-8136; Baczkó, István/0000-0002-9588-0797; Varró, András/0000-0003-0745-3603} } @article{MTMT:32638727, title = {Investigation of Surface Properties and Free Volumes of Chitosan-Based Buccal Mucoadhesive Drug Delivery Films Containing Ascorbic Acid}, url = {https://m2.mtmt.hu/api/publication/32638727}, author = {Kristó, Katalin and Szilvia, Módra and Varga, Viktória and Süvegh, Károly and Ludasi, Krisztina and Aigner, Zoltán and Kelemen, András and Sovány, Tamás and Hódi, Klára and Regdon, Géza (ifj.)}, doi = {10.3390/pharmaceutics14020345}, journal-iso = {PHARMACEUTICS}, journal = {PHARMACEUTICS}, volume = {14}, unique-id = {32638727}, issn = {1999-4923}, year = {2022}, eissn = {1999-4923}, orcid-numbers = {Varga, Viktória/0000-0001-9933-7604; Süvegh, Károly/0000-0001-8147-0546; Sovány, Tamás/0000-0003-3392-7788; Hódi, Klára/0000-0002-0794-1423; Regdon, Géza (ifj.)/0000-0002-6921-3069} } @CONFERENCE{MTMT:32902108, title = {Együtt-őrléssel előállított fenofibrát tartalmú ciklodextrin-komplexek vizsgálata}, url = {https://m2.mtmt.hu/api/publication/32902108}, author = {Kondoros, Balázs Attila and Aigner, Zoltán}, booktitle = {MKE Kristályosítási és Gyógyszerformulálási Szakosztály 13. Kerekasztal Konferenciája}, unique-id = {32902108}, year = {2021}, pages = {32-33} } @article{MTMT:32086882, title = {Structural and thermal analysis of cannabidiol orodispersible formulations}, url = {https://m2.mtmt.hu/api/publication/32086882}, author = {Robert-Alexandru, Vlad and Sovány, Tamás and Kristó, Katalin and Ibrahim, Yousif and Adriana, Ciurba and Aigner, Zoltán and Daniela, Lucia Muntean and Regdon, Géza (ifj.)}, doi = {10.31925/farmacia.2021.3.5}, journal-iso = {FARMACIA}, journal = {FARMACIA (BUCHAREST)}, volume = {69}, unique-id = {32086882}, issn = {0014-8237}, year = {2021}, eissn = {2065-0019}, pages = {426-433}, orcid-numbers = {Sovány, Tamás/0000-0003-3392-7788; Regdon, Géza (ifj.)/0000-0002-6921-3069} } @{MTMT:32027620, title = {Fenofibrát tartalmú ciklodextrin-komplexek előállítása oldószer mentes technológiával és a folyamat analitikai jellemzése}, url = {https://m2.mtmt.hu/api/publication/32027620}, author = {Kondoros, Balázs Attila and Berkesi, Ottó and Aigner, Zoltán}, booktitle = {XIV. Szent-Györgyi Konferencia kiadványa: 2021. április 16-17.}, unique-id = {32027620}, year = {2021}, pages = {30-30}, orcid-numbers = {Berkesi, Ottó/0000-0001-6184-1768} } @article{MTMT:31890902, title = {New Approach in Ocular Drug Delivery. In vitro and ex vivo Investigation of Cyclodextrin-Containing, Mucoadhesive Eye Drop Formulations}, url = {https://m2.mtmt.hu/api/publication/31890902}, author = {Bíró, Tivadar and Bocsik, Alexandra and Jurišić Dukovski, Bisera and Gróf, Ilona and Lovrić, Jasmina and Pannonhalminé Csóka, Ildikó and Deli, Mária Anna and Aigner, Zoltán}, doi = {10.2147/DDDT.S264745}, journal-iso = {DRUG DES DEV THER}, journal = {DRUG DESIGN DEVELOPMENT AND THERAPY}, volume = {15}, unique-id = {31890902}, issn = {1177-8881}, abstract = {Background: Optimal transcorneal penetration is necessary for ocular therapy; meanwhile, it is limited by the complex structure and defensive mechanisms of the eye. Antimicrobial stability of topical ophthalmic formulations is especially important. According to previous studies, the mostly used preservative, benzalkonium-chloride is irritative and toxic on corneal epithelial cells; therefore, novel non-toxic, antimicrobial agents are required. In this study, prednisolone-containing ophthalmic formulations were developed with expected optimal permeation without toxic or irritative effects. Methods: The toxicity and permeability of prednisolone-containing eye drops were studied on a human corneal epithelial cell line (HCE-T) and ex vivo cornea model. The lipophilic drug is dissolved by the formation of cyclodextrin inclusion complex. Zinc-containing mucoadhesive biopolymer was applied as an alternative preservative agent, whose toxicity was compared with benzalkonium-chloride. Results: As the results show, benzalkonium-chloride-containing samples were toxic on HCE-T cells. The biopolymer caused no cell damage after the treatment. This was confirmed by immunohistochemistry assay. The in vitro permeability was significantly higher in formulations with prednisolone-cyclodextrin complex compared with suspension formulation. According to the ex vivo permeability study, the biopolymer-containing samples had significantly lower permeability. Conclusion: Considering the mucoadhesive attribute of target formulations, prolonged absorption is expected after application with less frequent administration. It can be stated that the compositions are innovative approaches as novel non-toxic ophthalmic formulations with optimal drug permeability.}, year = {2021}, pages = {351-360}, orcid-numbers = {Pannonhalminé Csóka, Ildikó/0000-0003-0807-2781; Deli, Mária Anna/0000-0001-6084-6524} } @{MTMT:31859072, title = {Evaluation of fenofibrate-cyclodextrin complexes prepared by co-grinding method}, url = {https://m2.mtmt.hu/api/publication/31859072}, author = {Kondoros, Balázs Attila and Aigner, Zoltán}, booktitle = {III. Symposium of Young Researchers on Pharmaceutical Technology, Biotechnology and Regulatory Science}, doi = {10.14232/syrptbrs.2021.op21}, unique-id = {31859072}, year = {2021}, pages = {33-33} }