TY - JOUR AU - Kovács-Öller, Tamás AU - Szarka, Gergely AU - Hoffmann, Gyula AU - Péntek, Loretta AU - Valentin, Gréta AU - Ross, Liliana AU - Völgyi, Béla TI - Extrinsic and Intrinsic Factors Determine Expression Levels of Gap Junction-Forming Connexins in the Mammalian Retina JF - BIOMOLECULES J2 - BIOMOLECULES VL - 13 PY - 2023 IS - 7 PG - 15 SN - 2218-273X DO - 10.3390/biom13071119 UR - https://m2.mtmt.hu/api/publication/34063775 ID - 34063775 AB - Gap junctions (GJs) are not static bridges; instead, GJs as well as the molecular building block connexin (Cx) proteins undergo major expression changes in the degenerating retinal tissue. Various progressive diseases, including retinitis pigmentosa, glaucoma, age-related retinal degeneration, etc., affect neurons of the retina and thus their neuronal connections endure irreversible changes as well. Although Cx expression changes might be the hallmarks of tissue deterioration, GJs are not static bridges and as such they undergo adaptive changes even in healthy tissue to respond to the ever-changing environment. It is, therefore, imperative to determine these latter adaptive changes in GJ functionality as well as in their morphology and Cx makeup to identify and distinguish them from alterations following tissue deterioration. In this review, we summarize GJ alterations that take place in healthy retinal tissue and occur on three different time scales: throughout the entire lifespan, during daily changes and as a result of quick changes of light adaptation. LA - English DB - MTMT ER - TY - JOUR AU - Szarka, Gergely AU - Hoffmann, Gyula AU - Kovács-Öller, Tamás AU - Völgyi, Béla TI - Serotonin is a gap junction-permeable neuronal tracer in the mouse retina JF - FRONTIERS IN OPHTHALMOLOGY J2 - FRONT OPHTHALMOL VL - 3 PY - 2023 SN - 2674-0826 DO - 10.3389/fopht.2023.1151024 UR - https://m2.mtmt.hu/api/publication/33750145 ID - 33750145 N1 - Export Date: 12 February 2024 Correspondence Address: Völgyi, B.; Szentágothai Research Centre, Hungary; email: volgyibela@gmail.com LA - English DB - MTMT ER - TY - JOUR AU - Hoffmann, Gyula AU - Mátrai, Norbert AU - Bakonyi, Gábor AU - Vili, Nóra AU - Gyurácz, József AU - Lenczl, Mihály AU - Kisfali, Péter AU - Stranczinger, Szilvia AU - Magonyi, Nóra Mária AU - Mátics, Erika AU - Mátics, Róbert TI - Contrasting mtDNA and microsatellite data of great reed warbler Acrocephalus arundinaceus breeding populations on a small geographic scale. JF - BIOLOGIA FUTURA J2 - BIOL FUTURA VL - 73 PY - 2022 IS - 4 SP - 445 EP - 453 PG - 9 SN - 2676-8615 DO - 10.1007/s42977-022-00127-2 UR - https://m2.mtmt.hu/api/publication/33034854 ID - 33034854 AB - The great reed warbler has two genetically distinguishable haplogroups: "Clade A" occurs in higher proportions in Western Europe and Kazakhstan, and colonised Europe and Asia from a refugium in South-West Europe; and "Clade B", which is more common in Eastern Europe, and colonised parts of Europe from a refugium in the Middle East. Our aims were (i) to analyse the rate of differentiation in Hungarian breeding populations in order to see whether European-scale pattern is visible or not on as a small scale as the territory of Hungary and (ii) to compare the results obtained with mtDNA sequencing and microsatellite markers. To analyse the genetic differentiation, the mtDNA control region II was sequenced in 68 adult breeding birds, and 51 were fingerprinted at 11 microsatellite loci, while both analyses were performed on 36 birds (a total of 83 birds). The microsatellite data gave a better resolution and represented the fine-scale pattern of the suspected recolonisation. The lack of genetic differentiation among the breeding populations based on mitochondrial data seems to support this finding, because the admixture of the clades in this particular geographic region obliterates differentiation. Accordingly, the Fst values from different branches are significantly based on microsatellite data only. The mtDNA methods only give reliable results when a geographic and ecological factor plays a role in the population subdivision, but in the case of an intermixing population larger-scale studies are needed. LA - English DB - MTMT ER - TY - JOUR AU - Ganczer, Alma AU - Szarka, Gergely AU - Balogh, Márton AU - Hoffmann, Gyula AU - Tengölics, Ádám Jonatán AU - Kenyon, Garrett AU - Kovács-Öller, Tamás AU - Völgyi, Béla TI - Transience of the Retinal Output Is Determined by a Great Variety of Circuit Elements JF - CELLS J2 - CELLS-BASEL VL - 11 PY - 2022 IS - 5 PG - 21 SN - 2073-4409 DO - 10.3390/cells11050810 UR - https://m2.mtmt.hu/api/publication/32714658 ID - 32714658 LA - English DB - MTMT ER - TY - JOUR AU - Kocsis, Marianna AU - Bodó, Alexandra AU - Kőszegi, Tamás AU - Jakabfi-Csepregi, Rita AU - Filep, Rita AU - Hoffmann, Gyula AU - Farkas, Ágnes TI - Quality Assessment of Goldenrod, Milkweed and Multifloral Honeys Based on Botanical Origin, Antioxidant Capacity and Mineral Content JF - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES J2 - INT J MOL SCI VL - 23 PY - 2022 IS - 2 PG - 13 SN - 1661-6596 DO - 10.3390/ijms23020769 UR - https://m2.mtmt.hu/api/publication/32593179 ID - 32593179 N1 - * Megosztott szerzőség LA - English DB - MTMT ER - TY - JOUR AU - Balogh, Boglárka AU - Szarka, Gergely AU - Tengölics, Ádám Jonatán AU - Hoffmann, Gyula AU - Völgyi, Béla AU - Kovács-Öller, Tamás TI - LED-Induced Microglial Activation and Rise in Caspase3 Suggest a Reorganization in the Retina JF - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES J2 - INT J MOL SCI VL - 22 PY - 2021 IS - 19 PG - 11 SN - 1661-6596 DO - 10.3390/ijms221910418 UR - https://m2.mtmt.hu/api/publication/32266647 ID - 32266647 AB - Vision is our primary sense as the human eye is the gateway for more than 65% of information reaching the human brain. Today’s increased exposure to different wavelengths and intensities of light from light emitting diode (LED) sources could induce retinal degeneration and accompanying neuronal cell death. Damage induced by chronic phototoxic reactions occurring in the retina accumulates over years and it has been suggested as being responsible for the etiology of many debilitating ocular conditions. In this work, we examined how LED stimulation affects vision by monitoring changes in the expression of death and survival factors as well as microglial activation in LED-induced damage (LID) of the retinal tissue. We found an LED-exposure-induced increase in the mRNA levels of major apoptosis-related markers BAX, Bcl-2, and Caspase-3 and accompanying widespread microglial and Caspase-3 activation. Everyday LED light exposure was accounted for in all the described changes in the retinal tissue of mice in this study, indicating that overuse of non-filtered direct LED light can have detrimental effects on the human retina as well. LA - English DB - MTMT ER - TY - CHAP AU - Mátics, Erika AU - Hoffmann, Gyula AU - Farkas, Sándor AU - Mátics, Róbert ED - Purger, Jenő TI - A fényszennyezés (templomkivilágítás) hatása a gyöngybagolyra (Tyto alba) és a macskabagolyra (Strix aluco) T2 - 2. Magyar Bagolykutató Konferencia PB - PTE TTK Biológiai Intézet Ökológiai Tanszék CY - Pécs SN - 9789634295716 PY - 2020 SP - 15 PG - 1 UR - https://m2.mtmt.hu/api/publication/34392719 ID - 34392719 LA - Hungarian DB - MTMT ER - TY - CHAP AU - Mátics, Erika AU - Hoffmann, Gyula AU - Mátics, Róbert ED - Purger, Jenő TI - A gyöngybagoly (Tyto alba) útihalál (roadkill) vizsgálata Magyarországon és Európában T2 - 2. Magyar Bagolykutató Konferencia PB - PTE TTK Biológiai Intézet Ökológiai Tanszék CY - Pécs SN - 9789634295716 PY - 2020 SP - 14 PG - 1 UR - https://m2.mtmt.hu/api/publication/34392715 ID - 34392715 LA - Hungarian DB - MTMT ER - TY - GEN AU - Muhammad, Yaqoob Dayo AU - Szatmári, Dávid Zoltán AU - Hoffmann, Gyula TI - EFFECT OF INTRACELLULAR CALCIUM LEVEL ON ACTIN RELATED APOPTOTIC PROCESSES PY - 2020 UR - https://m2.mtmt.hu/api/publication/33643056 ID - 33643056 LA - English DB - MTMT ER - TY - JOUR AU - Vellainé, Takács Krisztina AU - Sztankovics, Dániel AU - Hoffmann, Gyula AU - Kopper, László AU - Gálosi, Rita TI - A biológiai óra és a daganatok JF - KLINIKAI ONKOLÓGIA J2 - KLINIKAI ONKOLÓGIA VL - 7 PY - 2020 IS - 2 SP - 167 EP - 175 PG - 9 SN - 2064-5058 UR - https://m2.mtmt.hu/api/publication/31655118 ID - 31655118 LA - Hungarian DB - MTMT ER -