@article{MTMT:34063775, title = {Extrinsic and Intrinsic Factors Determine Expression Levels of Gap Junction-Forming Connexins in the Mammalian Retina}, url = {https://m2.mtmt.hu/api/publication/34063775}, author = {Kovács-Öller, Tamás and Szarka, Gergely and Hoffmann, Gyula and Péntek, Loretta and Valentin, Gréta and Ross, Liliana and Völgyi, Béla}, doi = {10.3390/biom13071119}, journal-iso = {BIOMOLECULES}, journal = {BIOMOLECULES}, volume = {13}, unique-id = {34063775}, issn = {2218-273X}, abstract = {Gap junctions (GJs) are not static bridges; instead, GJs as well as the molecular building block connexin (Cx) proteins undergo major expression changes in the degenerating retinal tissue. Various progressive diseases, including retinitis pigmentosa, glaucoma, age-related retinal degeneration, etc., affect neurons of the retina and thus their neuronal connections endure irreversible changes as well. Although Cx expression changes might be the hallmarks of tissue deterioration, GJs are not static bridges and as such they undergo adaptive changes even in healthy tissue to respond to the ever-changing environment. It is, therefore, imperative to determine these latter adaptive changes in GJ functionality as well as in their morphology and Cx makeup to identify and distinguish them from alterations following tissue deterioration. In this review, we summarize GJ alterations that take place in healthy retinal tissue and occur on three different time scales: throughout the entire lifespan, during daily changes and as a result of quick changes of light adaptation.}, year = {2023}, eissn = {2218-273X}, orcid-numbers = {Kovács-Öller, Tamás/0000-0002-3353-4485; Hoffmann, Gyula/0000-0002-2206-6997; Völgyi, Béla/0000-0001-7481-390X} } @article{MTMT:33750145, title = {Serotonin is a gap junction-permeable neuronal tracer in the mouse retina}, url = {https://m2.mtmt.hu/api/publication/33750145}, author = {Szarka, Gergely and Hoffmann, Gyula and Kovács-Öller, Tamás and Völgyi, Béla}, doi = {10.3389/fopht.2023.1151024}, journal-iso = {FRONT OPHTHALMOL}, journal = {FRONTIERS IN OPHTHALMOLOGY}, volume = {3}, unique-id = {33750145}, year = {2023}, eissn = {2674-0826}, orcid-numbers = {Hoffmann, Gyula/0000-0002-2206-6997; Kovács-Öller, Tamás/0000-0002-3353-4485; Völgyi, Béla/0000-0001-7481-390X} } @article{MTMT:33034854, title = {Contrasting mtDNA and microsatellite data of great reed warbler Acrocephalus arundinaceus breeding populations on a small geographic scale.}, url = {https://m2.mtmt.hu/api/publication/33034854}, author = {Hoffmann, Gyula and Mátrai, Norbert and Bakonyi, Gábor and Vili, Nóra and Gyurácz, József and Lenczl, Mihály and Kisfali, Péter and Stranczinger, Szilvia and Magonyi, Nóra Mária and Mátics, Erika and Mátics, Róbert}, doi = {10.1007/s42977-022-00127-2}, journal-iso = {BIOL FUTURA}, journal = {BIOLOGIA FUTURA}, volume = {73}, unique-id = {33034854}, issn = {2676-8615}, abstract = {The great reed warbler has two genetically distinguishable haplogroups: "Clade A" occurs in higher proportions in Western Europe and Kazakhstan, and colonised Europe and Asia from a refugium in South-West Europe; and "Clade B", which is more common in Eastern Europe, and colonised parts of Europe from a refugium in the Middle East. Our aims were (i) to analyse the rate of differentiation in Hungarian breeding populations in order to see whether European-scale pattern is visible or not on as a small scale as the territory of Hungary and (ii) to compare the results obtained with mtDNA sequencing and microsatellite markers. To analyse the genetic differentiation, the mtDNA control region II was sequenced in 68 adult breeding birds, and 51 were fingerprinted at 11 microsatellite loci, while both analyses were performed on 36 birds (a total of 83 birds). The microsatellite data gave a better resolution and represented the fine-scale pattern of the suspected recolonisation. The lack of genetic differentiation among the breeding populations based on mitochondrial data seems to support this finding, because the admixture of the clades in this particular geographic region obliterates differentiation. Accordingly, the Fst values from different branches are significantly based on microsatellite data only. The mtDNA methods only give reliable results when a geographic and ecological factor plays a role in the population subdivision, but in the case of an intermixing population larger-scale studies are needed.}, keywords = {DIFFERENTIATION; Hungary; MICROSATELLITE; mtDNA; Great reed warbler}, year = {2022}, eissn = {2676-8607}, pages = {445-453}, orcid-numbers = {Hoffmann, Gyula/0000-0002-2206-6997; Bakonyi, Gábor/0000-0002-7132-7970; Gyurácz, József/0000-0001-7407-1715; Magonyi, Nóra Mária/0009-0007-9521-4368} } @article{MTMT:32714658, title = {Transience of the Retinal Output Is Determined by a Great Variety of Circuit Elements}, url = {https://m2.mtmt.hu/api/publication/32714658}, author = {Ganczer, Alma and Szarka, Gergely and Balogh, Márton and Hoffmann, Gyula and Tengölics, Ádám Jonatán and Kenyon, Garrett and Kovács-Öller, Tamás and Völgyi, Béla}, doi = {10.3390/cells11050810}, journal-iso = {CELLS-BASEL}, journal = {CELLS}, volume = {11}, unique-id = {32714658}, year = {2022}, eissn = {2073-4409}, orcid-numbers = {Hoffmann, Gyula/0000-0002-2206-6997; Kovács-Öller, Tamás/0000-0002-3353-4485; Völgyi, Béla/0000-0001-7481-390X} } @article{MTMT:32593179, title = {Quality Assessment of Goldenrod, Milkweed and Multifloral Honeys Based on Botanical Origin, Antioxidant Capacity and Mineral Content}, url = {https://m2.mtmt.hu/api/publication/32593179}, author = {Kocsis, Marianna and Bodó, Alexandra and Kőszegi, Tamás and Jakabfi-Csepregi, Rita and Filep, Rita and Hoffmann, Gyula and Farkas, Ágnes}, doi = {10.3390/ijms23020769}, journal-iso = {INT J MOL SCI}, journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES}, volume = {23}, unique-id = {32593179}, issn = {1661-6596}, year = {2022}, eissn = {1422-0067}, orcid-numbers = {Hoffmann, Gyula/0000-0002-2206-6997; Farkas, Ágnes/0000-0002-8590-3203} } @article{MTMT:32266647, title = {LED-Induced Microglial Activation and Rise in Caspase3 Suggest a Reorganization in the Retina}, url = {https://m2.mtmt.hu/api/publication/32266647}, author = {Balogh, Boglárka and Szarka, Gergely and Tengölics, Ádám Jonatán and Hoffmann, Gyula and Völgyi, Béla and Kovács-Öller, Tamás}, doi = {10.3390/ijms221910418}, journal-iso = {INT J MOL SCI}, journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES}, volume = {22}, unique-id = {32266647}, issn = {1661-6596}, abstract = {Vision is our primary sense as the human eye is the gateway for more than 65% of information reaching the human brain. Today’s increased exposure to different wavelengths and intensities of light from light emitting diode (LED) sources could induce retinal degeneration and accompanying neuronal cell death. Damage induced by chronic phototoxic reactions occurring in the retina accumulates over years and it has been suggested as being responsible for the etiology of many debilitating ocular conditions. In this work, we examined how LED stimulation affects vision by monitoring changes in the expression of death and survival factors as well as microglial activation in LED-induced damage (LID) of the retinal tissue. We found an LED-exposure-induced increase in the mRNA levels of major apoptosis-related markers BAX, Bcl-2, and Caspase-3 and accompanying widespread microglial and Caspase-3 activation. Everyday LED light exposure was accounted for in all the described changes in the retinal tissue of mice in this study, indicating that overuse of non-filtered direct LED light can have detrimental effects on the human retina as well.}, keywords = {APOPTOSIS; DEGENERATION; light; microglia; Retina; bcl-2; caspase; bax; LED}, year = {2021}, eissn = {1422-0067}, orcid-numbers = {Balogh, Boglárka/0000-0002-4022-8953; Hoffmann, Gyula/0000-0002-2206-6997; Völgyi, Béla/0000-0001-7481-390X; Kovács-Öller, Tamás/0000-0002-3353-4485} } @{MTMT:34392719, title = {A fényszennyezés (templomkivilágítás) hatása a gyöngybagolyra (Tyto alba) és a macskabagolyra (Strix aluco)}, url = {https://m2.mtmt.hu/api/publication/34392719}, author = {Mátics, Erika and Hoffmann, Gyula and Farkas, Sándor and Mátics, Róbert}, booktitle = {2. Magyar Bagolykutató Konferencia}, unique-id = {34392719}, year = {2020}, pages = {15-16}, orcid-numbers = {Hoffmann, Gyula/0000-0002-2206-6997} } @{MTMT:34392715, title = {A gyöngybagoly (Tyto alba) útihalál (roadkill) vizsgálata Magyarországon és Európában}, url = {https://m2.mtmt.hu/api/publication/34392715}, author = {Mátics, Erika and Hoffmann, Gyula and Mátics, Róbert}, booktitle = {2. Magyar Bagolykutató Konferencia}, unique-id = {34392715}, year = {2020}, pages = {14-15}, orcid-numbers = {Hoffmann, Gyula/0000-0002-2206-6997} } @misc{MTMT:33643056, title = {EFFECT OF INTRACELLULAR CALCIUM LEVEL ON ACTIN RELATED APOPTOTIC PROCESSES}, url = {https://m2.mtmt.hu/api/publication/33643056}, author = {Muhammad, Yaqoob Dayo and Szatmári, Dávid Zoltán and Hoffmann, Gyula}, unique-id = {33643056}, year = {2020}, orcid-numbers = {Hoffmann, Gyula/0000-0002-2206-6997} } @article{MTMT:31655118, title = {A biológiai óra és a daganatok}, url = {https://m2.mtmt.hu/api/publication/31655118}, author = {Vellainé, Takács Krisztina and Sztankovics, Dániel and Hoffmann, Gyula and Kopper, László and Gálosi, Rita}, journal-iso = {KLINIKAI ONKOLÓGIA}, journal = {KLINIKAI ONKOLÓGIA}, volume = {7}, unique-id = {31655118}, issn = {2064-5058}, year = {2020}, pages = {167-175}, orcid-numbers = {Hoffmann, Gyula/0000-0002-2206-6997; Kopper, László/0000-0002-4921-3678} }