TY - JOUR AU - Mavrogeni, Panayiota AU - Molnár, András AU - Molnár, Viktória AU - Tamás, László AU - Maihoub, Stefani TI - Correlation Between the Pitch and Loudness of Tinnitus, Hearing Levels, and Tinnitus Handicap Inventory Scores in Patients with Chronic Subjective Tinnitus JF - JOURNAL OF CLINICAL MEDICINE J2 - J CLIN MED VL - 13 PY - 2024 IS - 23 PG - 11 SN - 2077-0383 DO - 10.3390/jcm13237261 UR - https://m2.mtmt.hu/api/publication/35613051 ID - 35613051 N1 - Mavrogeni, P.; Molnár, A. contributed equally to this work and are co-first authors. AB - Objectives: The aim of this study was to investigate the relationships between tinnitus pitch and loudness, the frequency of hearing loss, hearing level, and the Tinnitus Handicap Inventory (THI) scores reported by patients. Methods: In total, 139 patients (50 men and 89 women; mean age ± SD, 60.19 ± 11.47 years) who suffered from chronic primary tinnitus associated with sensorineural hearing loss were included in the study. Participants underwent pure-tone audiometry and tinnitus pitch matching assessments. Additionally, all participants completed the Hungarian version of the THI questionnaire. Correlations were assessed using simple linear, Spearman’s, and Pearson’s correlation tests, and a linear regression model was applied. The Mann–Whitney U test was also used. Results: This study identified a significant correlation between the pitch of tinnitus and the frequency of hearing loss (p = 0.000 *; rho = 0.549). There was also a significant correlation between tinnitus noise and hearing levels (p = 0.000 *; rho = 0.375). Age was shown to significantly affect tinnitus loudness (p = 0.016 *) and hearing levels (p = 0.000 *) as determined by a linear regression model. Tinnitus duration only significantly influenced tinnitus loudness (p = 0.022). There was no significant effect of sex on tinnitus or audiometry parameters. Total THI scores were influenced solely by tinnitus loudness (p = 0.021 *). Furthermore, sex did have an effect on total THI scores, with women reporting higher scores (p = 0.000 *). Conclusions: This study concluded that there is a significant correlation between the pitch and loudness of tinnitus and hearing levels, suggesting a connection in their underlying mechanisms. The intensity of tinnitus and hearing level are primarily affected by ageing processes. Furthermore, the severity of self-perceived tinnitus is mainly related to the loudness of tinnitus. LA - English DB - MTMT ER - TY - JOUR AU - Uri, Imre AU - Horváth, Angéla AU - Tamás, László AU - Polony, Gábor AU - Dános, Kornél TI - A PNI (Prognostic Nutritional Index) a többi tápláltsági státusz markernél jobban korrelál a túléléssel fej-nyaki daganatok esetén JF - FÜL-ORR-GÉGEGYÓGYÁSZAT J2 - FÜL-ORR-GÉGEGYÓGYÁSZAT VL - 70 PY - 2024 IS - 3 SP - 151 SN - 0016-237X UR - https://m2.mtmt.hu/api/publication/35477568 ID - 35477568 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Gurbi, Bianka AU - Dános, Kornél AU - Birtalan, Ede AU - Krenács, Tibor AU - Kovács, Borbála AU - Tamás, László AU - Csala, Miklós AU - Varga, Attila TI - Potential Prognostic Role of Protein Kinase D Isoforms in Head and Neck Cancers JF - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES J2 - INT J MOL SCI VL - 25 PY - 2024 IS - 19 PG - 15 SN - 1661-6596 DO - 10.3390/ijms251910274 UR - https://m2.mtmt.hu/api/publication/35417664 ID - 35417664 N1 - Export Date: 24 November 2024 AB - Head and neck squamous cell carcinomas (HNSCC) are among the most common malignancies in men worldwide. Nevertheless, their clinical management is hampered by the limited availability of reliable predictive and prognostic biomarkers. Protein kinase D (PKD) isoforms contribute to major cellular processes. However, their potential role in HNSCC has not been studied systematically, which is the focus of this study. A total of 63 therapy-naive patients with squamous cell carcinoma were consecutively enrolled. Tissue microarray duplicate cores from each case were tested in situ for PKD1, PKD2, and PKD3 expression using immunohistochemistry, and the results were correlated with clinicopathological parameters. We found a high frequency of PKD1/PKD2 positive cases in oropharyngeal and PKD2 positive cases in laryngeal localizations. Only high PKD2 levels were statistically linked to elevated tumor grades, more advanced TNM (3–4) tumor stages, and p16INK4a expression, while elevated PKD3 levels were associated with favorable disease-specific survival. Both PKD2 and PKD3 have been proposed to promote tumor cell proliferation, migration/invasion, and angiogenesis. However, the role of PKD3 was elusive in some cancers. Our findings suggest that testing for PKD isotypes with immunohistochemistry may support the diagnostic estimation of tumor progression and prognosis in HNSCC with a potential therapeutic relevance. LA - English DB - MTMT ER - TY - GEN AU - Gáborján, Anita AU - Koscsó, Gábor AU - Garai, Réka AU - Tamás, László AU - Vicsi, Klára AU - Hacki, Tamás TI - Prevention of noise-induced hearing loss in children – recommendations for safe listening at events PY - 2024 PG - 16 DO - 10.21203/rs.3.rs-4467179/v1 UR - https://m2.mtmt.hu/api/publication/35202120 ID - 35202120 LA - English DB - MTMT ER - TY - JOUR AU - Uri, Imre AU - Horváth, Angéla AU - Tamás, László AU - Polony, Gábor AU - Dános, Kornél TI - Prognostic nutritional index (PNI) correlates with survival in head and neck cancer patients more precisely than other nutritional markers – real world data JF - EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY J2 - EUR ARCH OTO-RHINO-L VL - online first PY - 2024 PG - 13 SN - 0937-4477 DO - 10.1007/s00405-024-08865-w UR - https://m2.mtmt.hu/api/publication/35162164 ID - 35162164 N1 - Export Date: 24 November 2024 CODEN: EAOTE AB - The survival benefit with higher body mass index (BMI) of patients suffering from head and neck squamous cell carcinoma (HNSCC) is documented as BMI paradox. As the early re-nourishment of high-risk patients determine survival, we searched for a nutritional status marker suitable for everyday screening. Grouping patients based on the 8th Edition of TNM Classification, we investigated for the first time the candidate nutritional status markers among TNM8 subgroups, including the newly introduced p16 positive oropharyngeal squamous cell cancer (OPSCC) patients. LA - English DB - MTMT ER - TY - JOUR AU - Répássy, Gábor Dénes (Ifj.) AU - Hargas, Dóra AU - Molnár, András AU - Maihoub, Stefani AU - Tamás, László TI - Influencing Factors of Survival in Hypopharyngeal Squamous Cell Cancer JF - JOURNAL OF CLINICAL MEDICINE J2 - J CLIN MED VL - 13 PY - 2024 IS - 13 PG - 13 SN - 2077-0383 DO - 10.3390/jcm13133853 UR - https://m2.mtmt.hu/api/publication/35078458 ID - 35078458 LA - English DB - MTMT ER - TY - JOUR AU - Székely, László Attila AU - Uri, Imre AU - Luka, Ágnes AU - Gáborján, Anita AU - Tamás, László AU - Polony, Gábor TI - Audiological outcomes after revision stapes surgeries: a systematic review JF - EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY J2 - EUR ARCH OTO-RHINO-L VL - 281 PY - 2024 SP - 5051 EP - 5059 PG - 9 SN - 0937-4477 DO - 10.1007/s00405-024-08741-7 UR - https://m2.mtmt.hu/api/publication/34919091 ID - 34919091 N1 - Department of Oto-Rhino-Laryngology, Head and Neck Surgery, Semmelweis Egyetem (Semmelweis University), Szigony Utca 36, Budapest, 1083, Hungary Department of Voice, Speech and Swallowing Therapy, Faculty of Health Sciences, Semmelweis University, Budapest, Hungary Export Date: 26 November 2024 CODEN: EAOTE Correspondence Address: Székely, L.; Department of Oto-Rhino-Laryngology, Szigony Utca 36, Hungary; email: szekely.laszlo1@semmelweis.hu LA - English DB - MTMT ER - TY - JOUR AU - Kecskeméti, Nóra AU - Kondé, Márton AU - Szigeti F., Judit AU - Baranyi, Ildikó AU - Paksi, Ádám AU - Küstel, Marianna AU - Polony, Gábor AU - Tamás, László AU - Barkóczi, Beáta AU - Lakatos, Lili AU - Horváth, Zsuzsanna AU - Gáborján, Anita TI - A társszakmák szoros együttműködésének szerepe a postmeningitises, súlyos fokú halláscsökkenés optimális és sikeres rehabilitációjában. Esettanulmány JF - FÜL-ORR-GÉGEGYÓGYÁSZAT J2 - FÜL-ORR-GÉGEGYÓGYÁSZAT VL - 70 PY - 2024 IS - 1 SP - 18 EP - 21 PG - 4 SN - 0016-237X UR - https://m2.mtmt.hu/api/publication/34777714 ID - 34777714 N1 - Ellenőrizve teljes szöveg alapján GT LA - Hungarian DB - MTMT ER - TY - JOUR AU - Fekete, Szilvia AU - Juhász, János AU - Makra, Nóra AU - Dunai, Zsuzsanna AU - Kristóf, Katalin AU - Ostorházi, Eszter AU - Tamás, László AU - Szabó, Dóra AU - Kecskeméti, Nóra AU - Polony, Gábor TI - Characterization of middle ear microbiome in otitis media with effusion in Hungarian children: Alloiococcus otitidis may potentially hamper the microbial diversity JF - HELIYON J2 - HELIYON VL - 10 PY - 2024 IS - 21 PG - 11 SN - 2405-8440 DO - 10.1016/j.heliyon.2024.e39380 UR - https://m2.mtmt.hu/api/publication/34656287 ID - 34656287 LA - English DB - MTMT ER - TY - CHAP AU - Tamás, László ED - Sándor, József TI - A légutak akut elzáródása T2 - Sebészet tankönyv és tudománytörténet: traumatológiai, szülészeti és urológiai alapismeretekkel kiegészítve PB - Semmelweis Kiadó és Multimédia Stúdió CY - Budapest SN - 9789633315910 PY - 2023 SP - 92 EP - 95 PG - 4 UR - https://m2.mtmt.hu/api/publication/34498331 ID - 34498331 LA - Hungarian DB - MTMT ER -