TY - JOUR AU - Sándor, Luca Fatime AU - Huh, Joon B. AU - Benkő, Péter AU - Hiraga, Toru AU - Poliska, Szilard AU - Dobó-Nagy, Csaba AU - Simpson, Joanna P. AU - Homer, Natalie Z.M. AU - Mahata, Bidesh AU - Győri, Dávid Sándor TI - De novo steroidogenesis in tumor cells drives bone metastasis and osteoclastogenesis JF - CELL REPORTS J2 - CELL REP VL - 43 PY - 2024 IS - 3 PG - 21 SN - 2211-1247 DO - 10.1016/j.celrep.2024.113936 UR - https://m2.mtmt.hu/api/publication/34746956 ID - 34746956 N1 - Department of Physiology, Semmelweis University School of Medicine, Budapest, 1094, Hungary Department of Histology and Cell Biology, Matsumoto Dental University, Nagano, Shiojiri, 399-0781, Japan Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Debrecen, Debrecen, 4032, Hungary Department of Oral Diagnostics, Semmelweis University School of Dentistry, Budapest, 1088, Hungary Mass Spectrometry Core, Edinburgh Clinical Research Facility, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, EH16 4TJ, United Kingdom University of Edinburgh/BHF Centre for Cardiovascular Sciences, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, EH16 4TJ, United Kingdom Department of Pathology, University of Cambridge, Cambridgeshire, Cambridge, CB21QP, United Kingdom Export Date: 5 April 2024 Correspondence Address: Gyori, D.S.; Department of Physiology, Hungary; email: gyori.david@semmelweis.hu LA - English DB - MTMT ER - TY - JOUR AU - Báskay, János AU - Pénzes, Dorottya AU - Kontsek, Endre AU - Pesti, Adrián István AU - Kiss, András AU - Carvalho, Bruna Katherine Guimarães AU - Szócska, Miklós AU - Szabó, Bence Tamás AU - Dobó-Nagy, Csaba AU - Csete, Dániel AU - Mócsai, Attila AU - Németh, Orsolya AU - Pollner, Péter AU - Mijiritsky, Eitan AU - Kivovics, Márton TI - Are Artificial Intelligence-Assisted Three-Dimensional Histological Reconstructions Reliable for the Assessment of Trabecular Microarchitecture? JF - JOURNAL OF CLINICAL MEDICINE J2 - J CLIN MED VL - 13 PY - 2024 IS - 4 PG - 15 SN - 2077-0383 DO - 10.3390/jcm13041106 UR - https://m2.mtmt.hu/api/publication/34596805 ID - 34596805 N1 - Data-Driven Health Division of National Laboratory for Health Security, Health Services Management Training Centre, Semmelweis University, Kútvölgyi út 2, Budapest, 1125, Hungary Department of Biological Physics, Eötvös Loránd University, Pázmány Péter Sétány 1/a, Budapest, 1117, Hungary Department of Community Dentistry, Semmelweis University, Szentkirályi Utca 40, Budapest, 1088, Hungary Department of Pathology, Forensic and Insurance Medicine, Semmelweis University, Üllői út 93, Budapest, 1091, Hungary Department of Oral Diagnostics, Semmelweis University, Szentkirályi Utca 47, Budapest, 1088, Hungary Department of Physiology, Semmelweis University, Tűzoltó u. 34-37, Budapest, 1094, Hungary Department of Head and Neck Surgery and Maxillofacial Surgery, Tel-Aviv Sourasky Medical Center, School of Medicine, Tel Aviv University, Tel Aviv64239, Israel Goldschleger School of Dental Medicine, Faculty of Medicine, Tel Aviv University, Tel Aviv, 39040, Israel Export Date: 7 April 2024 Correspondence Address: Kivovics, M.; Department of Community Dentistry, Szentkirályi Utca 40, Hungary; email: kivovics.marton@semmelweis.hu AB - This study aimed to create a three-dimensional histological reconstruction through the AI-assisted classification of tissues and the alignment of serial sections. The secondary aim was to evaluate if the novel technique for histological reconstruction accurately replicated the trabecular microarchitecture of bone. This was performed by conducting micromorphometric measurements on the reconstruction and comparing the results obtained with those of microCT reconstructions. A bone biopsy sample was harvested upon re-entry following sinus floor augmentation. Following microCT scanning and histological processing, a modified version of the U-Net architecture was trained to categorize tissues on the sections. Detector-free local feature matching with transformers was used to create the histological reconstruction. The micromorphometric parameters were calculated using Bruker’s CTAn software (version 1.18.8.0, Bruker, Kontich, Belgium) for both histological and microCT datasets. Correlation coefficients calculated between the micromorphometric parameters measured on the microCT and histological reconstruction suggest a strong linear relationship between the two with ⍴-values of 0.777, 0.717, 0.705, 0.666, and 0.687 for BV/TV, BS/TV, Tb.Pf Tb.Th, and Tb.Sp, respectively. Bland–Altman and mountain plots suggest good agreement between BV/TV measurements on the two reconstruction methods. This novel method for three-dimensional histological reconstruction provides researchers with a tool that enables the assessment of accurate trabecular microarchitecture and histological information simultaneously. LA - English DB - MTMT ER - TY - JOUR AU - Rangics, Anna AU - Répássy, Gábor Dénes (Ifj.) AU - Gyulai-Gaál, Szabolcs AU - Dobó-Nagy, Csaba AU - Tamás, László AU - Simonffy, László TI - Management of Odontogenic Sinusitis: Results with Single-Step FESS and Dentoalveolar Surgery JF - JOURNAL OF PERSONALIZED MEDICINE J2 - J PERS MED VL - 13 PY - 2023 IS - 9 PG - 13 SN - 2075-4426 DO - 10.3390/jpm13091291 UR - https://m2.mtmt.hu/api/publication/34136132 ID - 34136132 AB - Objective: Odontogenic sinusitis (OS) is a well-known and important border of specialties in otorhinolaryngology and dentoalveolar surgery. Odontogenic sinusitis can develop due to iatrogenic harm or odontogenic infection. The gold standard diagnostic method is clinical and radiological—CBCT (cone beam computed tomography)—examination. The treatment of this condition requires collaboration between ENT and dentoalveolar surgery specialists and can be non-surgical or surgical based on staging. This paper aims to share the results of our clinical study whereby complex therapy was administered by a dentoalveolar surgeon and an otorhinolaryngologist in cooperation. Patients and methods: We conducted a retrospective study comprising 111 OS patients who underwent complex therapy between 2016 and 2023 at Semmelweis University, Budapest, Hungary. All patients were treated with concurrent FESS (functional endoscopic sinus surgery) and dentoalveolar surgery. Follow-up was based on symptoms, clinical examination and CBCT imaging. Results: Of the 111 patients, 107 were successfully treated with concurrent FESS and dentoalveolar surgery, and only 4 had further symptoms following the complex therapy and needed retreatment. Conclusions: The complex, single-session therapy involving FESS and oral surgery is an effective treatment method, which is less invasive and associated with fewer complications compared to previous interventions, such as the Luc–Caldwell procedure. LA - English DB - MTMT ER - TY - JOUR AU - Végh, Dániel AU - Bencze, Bulcsú AU - Bányai, Dorottya AU - Végh, Ádám János AU - Rózsa, Noémi Katinka AU - Dobó-Nagy, Csaba AU - Biczo, Zita AU - Kammerhofer, Gábor AU - Ujpál, Márta AU - Díaz Agurto, Leonardo AU - Pedrinaci, Ignacio AU - Peña Cardelles, Juan Francisco AU - Magrin, Gabriel Leonardo AU - Padhye, Ninad Milind AU - Mente, Laura AU - Payer, Michael AU - Hermann, Péter TI - Preoperative HbA1c and Blood Glucose Measurements in Diabetes Mellitus before Oral Surgery and Implantology Treatments JF - INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH J2 - INT J ENV RES PUB HE VL - 20 PY - 2023 IS - 6 PG - 12 SN - 1661-7827 DO - 10.3390/ijerph20064745 UR - https://m2.mtmt.hu/api/publication/33689458 ID - 33689458 AB - Diabetes mellitus has become a worldwide epidemic and is frequently accompanied by a number of complications proportional to the duration of hyperglycemia. The aim of this narrative review is to assess the most up-to-date guidelines on DM provided by both diabetes and dental associations. Furthermore, to gather evidence on the uni/bidirectional relationships of elevated HbA1c levels on dental surgery, implantology, bone augmentation, and periodontology and to demonstrate the importance of measuring HbA1c levels before invasive dental treatments. HbA1c and blood glucose measurements are a minimally invasive method for preventing complications in diabetes mellitus. The authors conducted a literature review to determine which oral conditions are affected by diabetes mellitus. MEDLINE served as a source with the use of a specific search key. Regarding oral complications of diabetes, prevention is the most vital factor. With this publication, we hope to assist physicians and dentists to make prompt diagnoses and to help in recognizing various oral manifestations of diabetes and follow the existing guidelines. LA - English DB - MTMT ER - TY - JOUR AU - Dobai, Adrienn AU - Dembrovszky, Fanni AU - Vizkelety, Tamas AU - Barsi, Péter AU - Juhász, Fanni AU - Dobó-Nagy, Csaba TI - MRI compatibility of orthodontic brackets and wires: systematic review article JF - BMC ORAL HEALTH J2 - BMC ORAL HEALTH VL - 22 PY - 2022 IS - 1 PG - 11 SN - 1472-6831 DO - 10.1186/s12903-022-02317-9 UR - https://m2.mtmt.hu/api/publication/33030718 ID - 33030718 AB - Background Before the magnetic resonance imaging (MRI) examination fixed orthodontic devices, such as brackets and wires, cause challenges not only for the orthodontist but also for the radiologist. Essentially, the MRI-safe scan of the fixed orthodontic tools requires a proper guideline in clinical practice. Therefore, this systematic review aimed to examine all aspects of MRI-safe scan, including artifact, thermal, and debonding effects, to identify any existing gaps in knowledge in this regard and develop an evidence-based protocol. Methods The Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) statement was used in this study. The clinical question in "PIO" format was: "Does MRI examination influence the temperature of the orthodontic devices, the size of artifacts, and the debonding force in patients who have fixed orthodontic bracket and/or wire?" The search process was carried out in PubMed, PubMed Central, Scopus, and Google Scholar databases. The search resulted in 1310 articles. After selection according to the eligibility criteria, 18 studies were analyzed by two reviewers. The risk of bias was determined using the Quality In Prognosis Studies tool. Results Out of the eligible 18 studies, 10 articles examined the heating effect, 6 were about the debonding effect, and 11 measured the size of artifact regarding brackets and wires. Considering the quality assessment, the overall levels of evidence were high and medium. The published studies showed that heating and debonding effects during MRI exposure were not hazardous for patients. As some wires revealed higher temperature changes, it is suggested to remove the wire or insert a spacer between the appliances and the oral mucosa. Based on the material, ceramic and plastic brackets caused no relevant artifact and were MRI-safe. Stainless steel brackets and wires resulted in susceptibility artifacts in the orofacial region and could cause distortion in the frontal lobe, orbits, and pituitary gland. The retainer wires showed no relevant artifact. Conclusions In conclusion, the thermal and debonding effects of the fixed orthodontic brackets and wires were irrelevant or resoluble; however, the size of the artifacts was clinically relevant and determined most significantly the feasibility of fixed brackets and wires in MRI examination. LA - English DB - MTMT ER - TY - CHAP AU - Dobó-Nagy, Csaba ED - Hermann, Péter ED - Kispélyi, Ida Barbara TI - A fogorvosi anamnézis fogpótlástani vonatkozásai T2 - Fogpótlástan 1-2 PB - Semmelweis Kiadó és Multimédia Stúdió CY - Budapest SN - 9789633315392 PY - 2022 SP - 62 EP - 66 PG - 5 UR - https://m2.mtmt.hu/api/publication/32842934 ID - 32842934 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Bródy, Andrea AU - Scheich, Bálint AU - Dobó-Nagy, Csaba TI - Targeted histological evaluation shows high incidence of actinomyces infection in medication-related osteonecrosis of the jaws JF - SCIENTIFIC REPORTS J2 - SCI REP VL - 12 PY - 2022 IS - 1 PG - 8 SN - 2045-2322 DO - 10.1038/s41598-022-07375-1 UR - https://m2.mtmt.hu/api/publication/32713484 ID - 32713484 N1 - Department of Oral Diagnostics, Faculty of Dentistry, Semmelweis University, Szentkirályi u. 47, Budapest, 1088, Hungary Department of Pathology and Experimental Cancer Research, Faculty of Medicine, Semmelweis University, Üllői út 26, Budapest, 1085, Hungary Cited By :3 Export Date: 7 September 2023 Correspondence Address: Brody, A.; Department of Oral Diagnostics, Szentkirályi u. 47, Hungary; email: brody.andrea@gmail.com LA - English DB - MTMT ER - TY - JOUR AU - Körmendi, Szandra Katalin AU - Vecsei, Bálint AU - Ambrus, Szilvia AU - Orhan, Kaan AU - Dobó-Nagy, Csaba TI - Evaluation of the effect of vitamin D3 on mandibular condyles in an ovariectomized mouse model: a micro-CT study JF - BMC ORAL HEALTH J2 - BMC ORAL HEALTH VL - 21 PY - 2021 IS - 1 PG - 7 SN - 1472-6831 DO - 10.1186/s12903-021-01980-8 UR - https://m2.mtmt.hu/api/publication/32551860 ID - 32551860 AB - Background This study aimed to investigate the effect of ovariectomy and vitamin D3 on bone microstructure; this effect was examined in three regions of interest at one femoral and two mandibular sampling sites bone in an ovariectomized mouse model. Methods Thirty-six week-old female mice were randomly divided into three groups: 10 subjects were given oral cholecalciferol (vitamin D3) daily for 6 weeks after undergoing bilateral ovariectomy (D3 group), while 10 ovariectomized subjects (OVX) and 10 subjects who underwent a sham operation (SHAM) received peanut oil daily during the investigation. After extermination, the left hemimandible and femur were removed and scanned by micro-CT. The bone micromorphology parameters were analyzed and the BMD was calculated. Results The bone volume fraction (BV/TV) was significantly lower in the trabecular bone of the mandibular condyle in the OVX group than in the SHAM and D3 groups. Also there was a significant difference between the SHAM and D3 groups. The specific bone surface (BS/BV) was significantly higher in the OVX and D3 groups than in the SHAM group. Trabecular thickness (Tb.Th) was significantly higher in the SHAM group, and the trabecular bone pattern factor (Tb.Pf) was significantly higher in the OVX group than in the other two groups. Bone mineral density (BMD) of the femur and the mandible was significantly lower in the OVX group than in the SHAM and D3 groups. Conclusions Our results show that ovariectomy causes a significantly weaker bone microstructure in the mandibular condyle, where the protective effect of vitamin D3 resulted in a partial resorption. LA - English DB - MTMT ER - TY - JOUR AU - Bródy, Andrea AU - Dobó-Nagy, Csaba AU - Mensch, Károly AU - Hompoth, Zsuzsanna AU - Csomor, Judit AU - Pacurar, Mariana AU - Dobai, Adrienn TI - High-Grade B-Cell Lymphoma Not Otherwise Specified (HGBL, NOS) in the Maxillary Sinus Mimicking Periapical Inflammation: Case Report and Review of the Literature JF - APPLIED SCIENCES-BASEL J2 - APPL SCI-BASEL VL - 11 PY - 2021 IS - 19 PG - 8 SN - 2076-3417 DO - 10.3390/app11198803 UR - https://m2.mtmt.hu/api/publication/32233734 ID - 32233734 N1 - Department of Oral Diagnostics, Faculty of Dentistry, Semmelweis University, Szentkirályi u. 47, Budapest, 1088, Hungary Department of Pathology and Cancer Research, Semmelweis University, Üllői út 26, Budapest, 1085, Hungary Faculty of Dental Medicine, Universitatea Mediciná, Farmacie, Stinte si Technologie, Targu Mures, 540088, Romania Cited By :2 Export Date: 24 April 2023 Correspondence Address: Brody, A.; Department of Oral Diagnostics, Szentkirályi u. 47, Hungary; email: brody.andrea@gmail.com AB - High-grade B-cell lymphoma not otherwise specified is listed as a new group in the WHO 2017 statement as a subtype of aggressive, mature B-cell lymphomas with a poor prognosis. To our knowledge, no description of this genetic type of maxillary lymphoma has appeared in the literature until now; thus, our case provides valuable data on its symptoms, clinical behavior, response to treatment and survival rate. The present report describes the early diagnosis and treatment of an extremely rare histological subtype of B-cell lymphoma, a case of high-grade B-cell lymphoma not otherwise specified, localized in the maxillary sinus and mimicking signs and symptoms of periapical inflammation. After chemotherapy, the presented patient showed complete remission without relapse and systemic spread. As far as we know, this is the first reported case of this rare type of lymphoma associated with the maxillary sinus. Considering that high-grade B-cell lymphomas are aggressive tumors with rapid growth and poor prognosis, which are often misdiagnosed in the early stages as inflammatory disease, it is relevant to highlight the importance of a detailed evaluation of clinical signs and radiological findings during diagnosis, especially if they contradict each other. LA - English DB - MTMT ER - TY - JOUR AU - Minya, Fanni AU - Trimmel, Bálint AU - Simonffy, László AU - Dobó-Nagy, Csaba AU - Gyulai-Gaál, Szabolcs TI - Odontoma Removal and Oral Rehabilitation via Insertions of Albumin and Gentamycin Coated Bone Allograft and Dental Implants - A Case Report JF - BIOMEDICAL JOURNAL OF SCIENTIFIC AND TECHNICAL RESEARCH J2 - BIOMED J SCI TECH RES VL - 33 PY - 2021 IS - 5 SP - 26116 EP - 26120 PG - 5 SN - 2574-1241 DO - 10.26717/BJSTR.2021.33.005450 UR - https://m2.mtmt.hu/api/publication/31971197 ID - 31971197 LA - English DB - MTMT ER -