@article{MTMT:34746956, title = {De novo steroidogenesis in tumor cells drives bone metastasis and osteoclastogenesis}, url = {https://m2.mtmt.hu/api/publication/34746956}, author = {Sándor, Luca Fatime and Huh, Joon B. and Benkő, Péter and Hiraga, Toru and Poliska, Szilard and Dobó-Nagy, Csaba and Simpson, Joanna P. and Homer, Natalie Z.M. and Mahata, Bidesh and Győri, Dávid Sándor}, doi = {10.1016/j.celrep.2024.113936}, journal-iso = {CELL REP}, journal = {CELL REPORTS}, volume = {43}, unique-id = {34746956}, issn = {2211-1247}, year = {2024}, eissn = {2211-1247}, orcid-numbers = {Dobó-Nagy, Csaba/0000-0001-9530-7926; Győri, Dávid Sándor/0000-0002-2048-6752} } @article{MTMT:34596805, title = {Are Artificial Intelligence-Assisted Three-Dimensional Histological Reconstructions Reliable for the Assessment of Trabecular Microarchitecture?}, url = {https://m2.mtmt.hu/api/publication/34596805}, author = {Báskay, János and Pénzes, Dorottya and Kontsek, Endre and Pesti, Adrián István and Kiss, András and Carvalho, Bruna Katherine Guimarães and Szócska, Miklós and Szabó, Bence Tamás and Dobó-Nagy, Csaba and Csete, Dániel and Mócsai, Attila and Németh, Orsolya and Pollner, Péter and Mijiritsky, Eitan and Kivovics, Márton}, doi = {10.3390/jcm13041106}, journal-iso = {J CLIN MED}, journal = {JOURNAL OF CLINICAL MEDICINE}, volume = {13}, unique-id = {34596805}, abstract = {This study aimed to create a three-dimensional histological reconstruction through the AI-assisted classification of tissues and the alignment of serial sections. The secondary aim was to evaluate if the novel technique for histological reconstruction accurately replicated the trabecular microarchitecture of bone. This was performed by conducting micromorphometric measurements on the reconstruction and comparing the results obtained with those of microCT reconstructions. A bone biopsy sample was harvested upon re-entry following sinus floor augmentation. Following microCT scanning and histological processing, a modified version of the U-Net architecture was trained to categorize tissues on the sections. Detector-free local feature matching with transformers was used to create the histological reconstruction. The micromorphometric parameters were calculated using Bruker’s CTAn software (version 1.18.8.0, Bruker, Kontich, Belgium) for both histological and microCT datasets. Correlation coefficients calculated between the micromorphometric parameters measured on the microCT and histological reconstruction suggest a strong linear relationship between the two with ⍴-values of 0.777, 0.717, 0.705, 0.666, and 0.687 for BV/TV, BS/TV, Tb.Pf Tb.Th, and Tb.Sp, respectively. Bland–Altman and mountain plots suggest good agreement between BV/TV measurements on the two reconstruction methods. This novel method for three-dimensional histological reconstruction provides researchers with a tool that enables the assessment of accurate trabecular microarchitecture and histological information simultaneously.}, year = {2024}, eissn = {2077-0383}, orcid-numbers = {Báskay, János/0000-0002-2841-3021; Kontsek, Endre/0000-0002-8098-1392; Pesti, Adrián István/0000-0001-6706-6221; Kiss, András/0000-0002-7453-3163; Szócska, Miklós/0000-0003-0648-9778; Szabó, Bence Tamás/0000-0002-5933-3956; Dobó-Nagy, Csaba/0000-0001-9530-7926; Csete, Dániel/0000-0001-8057-225X; Mócsai, Attila/0000-0002-0512-1157; Németh, Orsolya/0000-0002-4714-1463; Pollner, Péter/0000-0003-0464-4893; Mijiritsky, Eitan/0000-0002-1661-7529; Kivovics, Márton/0000-0003-0728-7027} } @article{MTMT:34136132, title = {Management of Odontogenic Sinusitis: Results with Single-Step FESS and Dentoalveolar Surgery}, url = {https://m2.mtmt.hu/api/publication/34136132}, author = {Rangics, Anna and Répássy, Gábor Dénes (Ifj.) and Gyulai-Gaál, Szabolcs and Dobó-Nagy, Csaba and Tamás, László and Simonffy, László}, doi = {10.3390/jpm13091291}, journal-iso = {J PERS MED}, journal = {JOURNAL OF PERSONALIZED MEDICINE}, volume = {13}, unique-id = {34136132}, abstract = {Objective: Odontogenic sinusitis (OS) is a well-known and important border of specialties in otorhinolaryngology and dentoalveolar surgery. Odontogenic sinusitis can develop due to iatrogenic harm or odontogenic infection. The gold standard diagnostic method is clinical and radiological—CBCT (cone beam computed tomography)—examination. The treatment of this condition requires collaboration between ENT and dentoalveolar surgery specialists and can be non-surgical or surgical based on staging. This paper aims to share the results of our clinical study whereby complex therapy was administered by a dentoalveolar surgeon and an otorhinolaryngologist in cooperation. Patients and methods: We conducted a retrospective study comprising 111 OS patients who underwent complex therapy between 2016 and 2023 at Semmelweis University, Budapest, Hungary. All patients were treated with concurrent FESS (functional endoscopic sinus surgery) and dentoalveolar surgery. Follow-up was based on symptoms, clinical examination and CBCT imaging. Results: Of the 111 patients, 107 were successfully treated with concurrent FESS and dentoalveolar surgery, and only 4 had further symptoms following the complex therapy and needed retreatment. Conclusions: The complex, single-session therapy involving FESS and oral surgery is an effective treatment method, which is less invasive and associated with fewer complications compared to previous interventions, such as the Luc–Caldwell procedure.}, year = {2023}, eissn = {2075-4426}, orcid-numbers = {Rangics, Anna/0009-0000-4469-3345; Répássy, Gábor Dénes (Ifj.)/0000-0002-9381-2272; Gyulai-Gaál, Szabolcs/0000-0003-2419-4236; Dobó-Nagy, Csaba/0000-0001-9530-7926; Tamás, László/0000-0003-3723-9149; Simonffy, László/0000-0001-6800-7936} } @article{MTMT:33689458, title = {Preoperative HbA1c and Blood Glucose Measurements in Diabetes Mellitus before Oral Surgery and Implantology Treatments}, url = {https://m2.mtmt.hu/api/publication/33689458}, author = {Végh, Dániel and Bencze, Bulcsú and Bányai, Dorottya and Végh, Ádám János and Rózsa, Noémi Katinka and Dobó-Nagy, Csaba and Biczo, Zita and Kammerhofer, Gábor and Ujpál, Márta and Díaz Agurto, Leonardo and Pedrinaci, Ignacio and Peña Cardelles, Juan Francisco and Magrin, Gabriel Leonardo and Padhye, Ninad Milind and Mente, Laura and Payer, Michael and Hermann, Péter}, doi = {10.3390/ijerph20064745}, journal-iso = {INT J ENV RES PUB HE}, journal = {INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH}, volume = {20}, unique-id = {33689458}, issn = {1661-7827}, abstract = {Diabetes mellitus has become a worldwide epidemic and is frequently accompanied by a number of complications proportional to the duration of hyperglycemia. The aim of this narrative review is to assess the most up-to-date guidelines on DM provided by both diabetes and dental associations. Furthermore, to gather evidence on the uni/bidirectional relationships of elevated HbA1c levels on dental surgery, implantology, bone augmentation, and periodontology and to demonstrate the importance of measuring HbA1c levels before invasive dental treatments. HbA1c and blood glucose measurements are a minimally invasive method for preventing complications in diabetes mellitus. The authors conducted a literature review to determine which oral conditions are affected by diabetes mellitus. MEDLINE served as a source with the use of a specific search key. Regarding oral complications of diabetes, prevention is the most vital factor. With this publication, we hope to assist physicians and dentists to make prompt diagnoses and to help in recognizing various oral manifestations of diabetes and follow the existing guidelines.}, year = {2023}, eissn = {1660-4601}, orcid-numbers = {Végh, Dániel/0000-0002-2836-6747; Rózsa, Noémi Katinka/0000-0002-8510-7047; Dobó-Nagy, Csaba/0000-0001-9530-7926; Ujpál, Márta/0000-0003-2253-1059; Pedrinaci, Ignacio/0000-0001-7438-5044; Magrin, Gabriel Leonardo/0000-0003-0724-0560; Hermann, Péter/0000-0002-9148-0139} } @article{MTMT:33030718, title = {MRI compatibility of orthodontic brackets and wires: systematic review article}, url = {https://m2.mtmt.hu/api/publication/33030718}, author = {Dobai, Adrienn and Dembrovszky, Fanni and Vizkelety, Tamas and Barsi, Péter and Juhász, Fanni and Dobó-Nagy, Csaba}, doi = {10.1186/s12903-022-02317-9}, journal-iso = {BMC ORAL HEALTH}, journal = {BMC ORAL HEALTH}, volume = {22}, unique-id = {33030718}, issn = {1472-6831}, abstract = {Background Before the magnetic resonance imaging (MRI) examination fixed orthodontic devices, such as brackets and wires, cause challenges not only for the orthodontist but also for the radiologist. Essentially, the MRI-safe scan of the fixed orthodontic tools requires a proper guideline in clinical practice. Therefore, this systematic review aimed to examine all aspects of MRI-safe scan, including artifact, thermal, and debonding effects, to identify any existing gaps in knowledge in this regard and develop an evidence-based protocol. Methods The Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) statement was used in this study. The clinical question in "PIO" format was: "Does MRI examination influence the temperature of the orthodontic devices, the size of artifacts, and the debonding force in patients who have fixed orthodontic bracket and/or wire?" The search process was carried out in PubMed, PubMed Central, Scopus, and Google Scholar databases. The search resulted in 1310 articles. After selection according to the eligibility criteria, 18 studies were analyzed by two reviewers. The risk of bias was determined using the Quality In Prognosis Studies tool. Results Out of the eligible 18 studies, 10 articles examined the heating effect, 6 were about the debonding effect, and 11 measured the size of artifact regarding brackets and wires. Considering the quality assessment, the overall levels of evidence were high and medium. The published studies showed that heating and debonding effects during MRI exposure were not hazardous for patients. As some wires revealed higher temperature changes, it is suggested to remove the wire or insert a spacer between the appliances and the oral mucosa. Based on the material, ceramic and plastic brackets caused no relevant artifact and were MRI-safe. Stainless steel brackets and wires resulted in susceptibility artifacts in the orofacial region and could cause distortion in the frontal lobe, orbits, and pituitary gland. The retainer wires showed no relevant artifact. Conclusions In conclusion, the thermal and debonding effects of the fixed orthodontic brackets and wires were irrelevant or resoluble; however, the size of the artifacts was clinically relevant and determined most significantly the feasibility of fixed brackets and wires in MRI examination.}, keywords = {IN-VITRO; orthodontics; orthodontic wire; orthodontic bracket; Orthodontic retainers; Imaging artifacts; diagnostic quality; APPLIANCES; Fixed orthodontics appliances}, year = {2022}, eissn = {1472-6831}, orcid-numbers = {Dobai, Adrienn/0000-0003-1643-0649; Dembrovszky, Fanni/0000-0001-6953-3591; Barsi, Péter/0000-0002-3574-9973; Dobó-Nagy, Csaba/0000-0001-9530-7926} } @{MTMT:32842934, title = {A fogorvosi anamnézis fogpótlástani vonatkozásai}, url = {https://m2.mtmt.hu/api/publication/32842934}, author = {Dobó-Nagy, Csaba}, booktitle = {Fogpótlástan 1-2}, unique-id = {32842934}, year = {2022}, pages = {62-66}, orcid-numbers = {Dobó-Nagy, Csaba/0000-0001-9530-7926} } @article{MTMT:32713484, title = {Targeted histological evaluation shows high incidence of actinomyces infection in medication-related osteonecrosis of the jaws}, url = {https://m2.mtmt.hu/api/publication/32713484}, author = {Bródy, Andrea and Scheich, Bálint and Dobó-Nagy, Csaba}, doi = {10.1038/s41598-022-07375-1}, journal-iso = {SCI REP}, journal = {SCIENTIFIC REPORTS}, volume = {12}, unique-id = {32713484}, issn = {2045-2322}, year = {2022}, eissn = {2045-2322}, orcid-numbers = {Bródy, Andrea/0000-0001-8085-8418; Dobó-Nagy, Csaba/0000-0001-9530-7926} } @article{MTMT:32551860, title = {Evaluation of the effect of vitamin D3 on mandibular condyles in an ovariectomized mouse model: a micro-CT study}, url = {https://m2.mtmt.hu/api/publication/32551860}, author = {Körmendi, Szandra Katalin and Vecsei, Bálint and Ambrus, Szilvia and Orhan, Kaan and Dobó-Nagy, Csaba}, doi = {10.1186/s12903-021-01980-8}, journal-iso = {BMC ORAL HEALTH}, journal = {BMC ORAL HEALTH}, volume = {21}, unique-id = {32551860}, issn = {1472-6831}, abstract = {Background This study aimed to investigate the effect of ovariectomy and vitamin D3 on bone microstructure; this effect was examined in three regions of interest at one femoral and two mandibular sampling sites bone in an ovariectomized mouse model. Methods Thirty-six week-old female mice were randomly divided into three groups: 10 subjects were given oral cholecalciferol (vitamin D3) daily for 6 weeks after undergoing bilateral ovariectomy (D3 group), while 10 ovariectomized subjects (OVX) and 10 subjects who underwent a sham operation (SHAM) received peanut oil daily during the investigation. After extermination, the left hemimandible and femur were removed and scanned by micro-CT. The bone micromorphology parameters were analyzed and the BMD was calculated. Results The bone volume fraction (BV/TV) was significantly lower in the trabecular bone of the mandibular condyle in the OVX group than in the SHAM and D3 groups. Also there was a significant difference between the SHAM and D3 groups. The specific bone surface (BS/BV) was significantly higher in the OVX and D3 groups than in the SHAM group. Trabecular thickness (Tb.Th) was significantly higher in the SHAM group, and the trabecular bone pattern factor (Tb.Pf) was significantly higher in the OVX group than in the other two groups. Bone mineral density (BMD) of the femur and the mandible was significantly lower in the OVX group than in the SHAM and D3 groups. Conclusions Our results show that ovariectomy causes a significantly weaker bone microstructure in the mandibular condyle, where the protective effect of vitamin D3 resulted in a partial resorption.}, keywords = {microstructure; osteoporosis; osteoporosis; micro-CT; Condyle; BONE-DENSITY; Estrogen-deficiency}, year = {2021}, eissn = {1472-6831}, orcid-numbers = {Vecsei, Bálint/0000-0001-5748-7276; Dobó-Nagy, Csaba/0000-0001-9530-7926} } @article{MTMT:32233734, title = {High-Grade B-Cell Lymphoma Not Otherwise Specified (HGBL, NOS) in the Maxillary Sinus Mimicking Periapical Inflammation: Case Report and Review of the Literature}, url = {https://m2.mtmt.hu/api/publication/32233734}, author = {Bródy, Andrea and Dobó-Nagy, Csaba and Mensch, Károly and Hompoth, Zsuzsanna and Csomor, Judit and Pacurar, Mariana and Dobai, Adrienn}, doi = {10.3390/app11198803}, journal-iso = {APPL SCI-BASEL}, journal = {APPLIED SCIENCES-BASEL}, volume = {11}, unique-id = {32233734}, abstract = {High-grade B-cell lymphoma not otherwise specified is listed as a new group in the WHO 2017 statement as a subtype of aggressive, mature B-cell lymphomas with a poor prognosis. To our knowledge, no description of this genetic type of maxillary lymphoma has appeared in the literature until now; thus, our case provides valuable data on its symptoms, clinical behavior, response to treatment and survival rate. The present report describes the early diagnosis and treatment of an extremely rare histological subtype of B-cell lymphoma, a case of high-grade B-cell lymphoma not otherwise specified, localized in the maxillary sinus and mimicking signs and symptoms of periapical inflammation. After chemotherapy, the presented patient showed complete remission without relapse and systemic spread. As far as we know, this is the first reported case of this rare type of lymphoma associated with the maxillary sinus. Considering that high-grade B-cell lymphomas are aggressive tumors with rapid growth and poor prognosis, which are often misdiagnosed in the early stages as inflammatory disease, it is relevant to highlight the importance of a detailed evaluation of clinical signs and radiological findings during diagnosis, especially if they contradict each other.}, year = {2021}, eissn = {2076-3417}, orcid-numbers = {Bródy, Andrea/0000-0001-8085-8418; Dobó-Nagy, Csaba/0000-0001-9530-7926; Mensch, Károly/0000-0002-7764-1944; Dobai, Adrienn/0000-0003-1643-0649} } @article{MTMT:31971197, title = {Odontoma Removal and Oral Rehabilitation via Insertions of Albumin and Gentamycin Coated Bone Allograft and Dental Implants - A Case Report}, url = {https://m2.mtmt.hu/api/publication/31971197}, author = {Minya, Fanni and Trimmel, Bálint and Simonffy, László and Dobó-Nagy, Csaba and Gyulai-Gaál, Szabolcs}, doi = {10.26717/BJSTR.2021.33.005450}, journal-iso = {BIOMED J SCI TECH RES}, journal = {BIOMEDICAL JOURNAL OF SCIENTIFIC AND TECHNICAL RESEARCH}, volume = {33}, unique-id = {31971197}, issn = {2574-1241}, year = {2021}, pages = {26116-26120}, orcid-numbers = {Minya, Fanni/0000-0002-0590-4813; Trimmel, Bálint/0000-0003-2308-2312; Simonffy, László/0000-0001-6800-7936; Dobó-Nagy, Csaba/0000-0001-9530-7926; Gyulai-Gaál, Szabolcs/0000-0003-2419-4236} }