TY - GEN AU - Szabó, Viktória AU - Csákány-Papp, Noémi AU - Görög, Marietta AU - Madácsy, Tamara AU - Varga, Árpád AU - Kiss, Aletta Kata AU - Tél, Bálint AU - Jójárt, Boldizsár AU - Crul, Tim AU - Dudás, Krisztina Márta AU - Bagyánszki, Mária AU - Bódi, Nikolett AU - Ayaydin, Ferhan AU - Shyam, Jee AU - Tiszlavicz, László AU - Stauderman, Kenneth AU - Hebbar, Sudarshan AU - Pallagi, Petra AU - Maléth, József TI - The inhibition of Orai1 calcium channel reduces the progression of chronic pancreatitis PY - 2023 SP - 1 UR - https://m2.mtmt.hu/api/publication/34672053 ID - 34672053 LA - English DB - MTMT ER - TY - JOUR AU - Almási, Szintia AU - Pancsa, Tamás AU - Tiszlavicz, László AU - Sejben, Anita TI - Cerebral manifestation and diagnostic dilemma of Rosai-Dorfman disease. [case report] TS - [case report] JF - CNS Oncology J2 - CNS Oncol VL - 12 PY - 2023 IS - 4 PG - 4 SN - 2045-0907 DO - 10.2217/cns-2023-0006 UR - https://m2.mtmt.hu/api/publication/34565527 ID - 34565527 N1 - Szövegében 3 oldalnál rövidebb esetismertetés, ezért besorolása rövid közlemény az MTA V. Osztályának ajánlása alapján. (SzF, SZTE admin5, 2024-02-22) AB - Rosai-Dorfman disease (RDD) is a rare, S100-positive histiocytic proliferation, that can cause both nodal and extranodal illness. We present a case of a 53-year-old male patient. Magnetic resonance imaging described a plaque-like meningeal lesion, and the preoperative diagnosis was meningioma. Histologically, dense infiltration of lymphocytes, plasma cells, and histiocytes was seen, furthermore, the presence of emperipolesis in the sample was pronounced. In the histiocytes nuclear and cytoplasmic positivity with S100 protein, and nuclear positivity with Cyclin D1 was observed. The case was concluded as RDD. Morphological appearance of intracranial RDD with imaging procedures can present a differential diagnostic challenge. The correct diagnosis is based on the presence of histiocytes with emperipolesis, and properly defined immunohistochemical characteristics. LA - English DB - MTMT ER - TY - JOUR AU - Mencser, Zoltán AU - Tóth, Tamás AU - Kis, Dávid AU - Varga, Ádám AU - Tiszlavicz, László AU - Barzó, Pál TI - Oligometasztatikus vesesejtes karcinóma idegsebészi ellátásának technikái és indikációi agyi áttétek esetén [Neurosurgical management for metastatic brain tumors in renal cell carcinoma]. [esetismertetés] TS - [esetismertetés] JF - MAGYAR ONKOLÓGIA J2 - MAGYAR ONKOLÓGIA VL - 67 PY - 2023 IS - 1 SP - 32 EP - 37 PG - 6 SN - 0025-0244 UR - https://m2.mtmt.hu/api/publication/34553621 ID - 34553621 N1 - Szövegében 3 oldalnál rövidebb esetismertetés, ezért besorolása rövid közlemény az MTA V. Osztályának ajánlása alapján. (BA, SZTE admin5, 2024-03-12) AB - The therapeutic approach to brain metastases has changed significantly in the last 30 years. The development of surgical technique, the use of new MRI techniques, preoperative surgical planning and the administration of intraoperative navigation reduced the risks of surgery and improved the results. In the case of aggressive renal cell carcinomas, we detect brain metastases relatively often, which are difficult to treat, but the improved surgical and radiosurgery techniques can also be used with success. In our report, we present the neurosurgical management of metastatic spreading of renal cell carcinoma to the brain. Modern surgical planning and more precise, tailored approach with modern radiosurgery techniques are able to improve the outcome and prolong survival even in aggressive types of renal cell carcinomas that give rise to brain metastases. In more severe cases and even in the case of multiple brain metastases, cranial surgery can be recommended. LA - Hungarian DB - MTMT ER - TY - JOUR AU - Varga, Ákos AU - Németh, István Balázs AU - Kemény, Lajos AU - Varga, János AU - Tiszlavicz, László AU - Kumar, D. AU - Dodd, S. AU - Simpson, A.W.M. AU - Buknicz, Tünde AU - Beynon, R. AU - Simpson, D. AU - Krenács, Tibor AU - Dockray, G.J. AU - Varro, A. TI - Elevated serum gastrin is associated with melanoma progression: putative role in increased migration and invasion of melanoma cells JF - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES J2 - INT J MOL SCI VL - 24 PY - 2023 IS - 23 PG - 16 SN - 1661-6596 DO - 10.3390/ijms242316851 UR - https://m2.mtmt.hu/api/publication/34443653 ID - 34443653 LA - English DB - MTMT ER - TY - CHAP AU - Paszt, Attila AU - Simonka, Zsolt AU - Budai, Krisztina AU - Horváth, Zoltán AU - Erdos, Marton AU - Vas, Márton Árpád AU - Ottlakán, Aurél AU - Nyári, Tibor András AU - Szepes, Zoltán AU - Uhercsák, Gabriella AU - Maráz, Anikó AU - Torday, László AU - Tiszlavicz, László AU - Oláh, Judit Magdolna AU - Lázár, György ifj ED - Ottlakán, Aurél ED - Papp, Andras ED - Toth, Dezso ED - Wu, Aiwen TI - Impact of neoadjuvant FLOT treatment of advanced gastric and gastroesophageal junction cancer following surgical therapy T2 - Surgical and Oncological Updates in the Management of Gastric Cancer: the Role of Neoadjuvant Therapy and Minimally Invasive Surgery PB - Frontiers Media S.A. CY - Lausanne SN - 9782832539521 T3 - Frontiers Research Topics, ISSN 1664-8714 PY - 2023 SP - 56 EP - 68 PG - 13 UR - https://m2.mtmt.hu/api/publication/34426094 ID - 34426094 N1 - Másodközlés, eredeti közlés rekordja: 33729458 LA - English DB - MTMT ER - TY - JOUR AU - Neuperger, Patricia AU - Szalontai, Klára Margit AU - Gémes, Nikolett AU - Balog, József Ágoston AU - Tiszlavicz, László AU - Furák, József AU - Lázár, György ifj AU - Puskás, László AU - Szebeni, Gábor TI - Single-cell mass cytometric analysis of peripheral immunity and multiplex plasma marker profiling of non-small cell lung cancer patients receiving PD-1 targeting immune checkpoint inhibitors in comparison with platinum-based chemotherapy JF - FRONTIERS IN IMMUNOLOGY J2 - FRONT IMMUNOL VL - 14 PY - 2023 PG - 14 SN - 1664-3224 DO - 10.3389/fimmu.2023.1243233 UR - https://m2.mtmt.hu/api/publication/34199166 ID - 34199166 N1 - Laboratory of Functional Genomics, HUN-REN Biological Research Centre, Szeged, Hungary PhD School in Biology, University of Szeged, Szeged, Hungary Csongrád County Hospital of Chest Diseases, Deszk, Hungary Department of Pathology, University of Szeged, Szeged, Hungary Department of Surgery, University of Szeged, Szeged, Hungary Avicor Ltd, Szeged, Hungary Department of Physiology, Anatomy and Neuroscience, Faculty of Science and Informatics, University of Szeged, Szeged, Hungary CS-Smartlab Devices Ltd, Kozármisleny, Hungary Export Date: 7 November 2023 Correspondence Address: Puskás, L.G.; Laboratory of Functional Genomics, Hungary; email: laszlo@avidinbiotech.com Correspondence Address: Szebeni, G.J.; Laboratory of Functional Genomics, Hungary; email: szebeni.gabor@brc.hu Funding details: Magyar Tudományos Akadémia, MTA, BO/00582/22/8, ÚNKP-23-5 -SZTE-694 Funding details: Nemzeti Kutatási Fejlesztési és Innovációs Hivatal, NKFI Funding details: Nemzeti Kutatási, Fejlesztési és Innovaciós Alap, NKFIA, C1764415 Funding details: Innovációs és Technológiai Minisztérium Funding details: National Research, Development and Innovation Office Funding text 1: This research was funded by the 2020‐1.1.6‐JÖVŐ−2021‐00003 and 142877 FK22, KFI_16-1-2017-0105 grant from the National Research, Development, and Innovation Office (NKFI), Hungary. This work was supported by the János Bolyai Research Scholarship of the Hungarian Academy of Sciences BO/00582/22/8 (GS) and by the by the ÚNKP-23-5 -SZTE-694 New National Excellence Program of the Ministry for Innovation and Technology (GS). This manuscript was supported by the KDP-2021 Program of the Ministry for Innovation and Technology from the source of the National Research, Development and Innovation Fund for NG (C1764415). LA - English DB - MTMT ER - TY - JOUR AU - Mészáros, Ádám AU - Molnár, Kinga AU - Fazakas, Csilla AU - Nógrádi, Bernát AU - Lüvi, Adél AU - Dudás, Tamás AU - Tiszlavicz, László AU - Farkas, Elek Attila AU - Krizbai, István Adorján AU - Wilhelm, Imola Mária TI - Inflammasome activation in peritumoral astrocytes is a key player in breast cancer brain metastasis development JF - ACTA NEUROPATHOLOGICA COMMUNICATIONS J2 - ACTA NEUROPATH COMM VL - 11 PY - 2023 IS - 1 PG - 17 SN - 2051-5960 DO - 10.1186/s40478-023-01646-2 UR - https://m2.mtmt.hu/api/publication/34158861 ID - 34158861 N1 - Funding Agency and Grant Number: Not applicable. Funding text: Not applicable. AB - Inflammasomes, primarily responsible for the activation of IL-1β, have emerged as critical regulators of the tumor microenvironment. By using in vivo and in vitro brain metastasis models, as well as human samples to study the role of the NLRP3 inflammasome in triple-negative breast cancer (TNBC) brain metastases, we found NLRP3 inflammasome components and IL-1β to be highly and specifically expressed in peritumoral astrocytes. Soluble factors from TNBC cells induced upregulation and activation of NLRP3 and IL-1β in astrocytes, while astrocyte-derived mediators augmented the proliferation of metastatic cells. In addition, inhibition of NLRP3 inflammasome activity using MCC950 or dampening the downstream effect of IL-1β prevented the proliferation increase in cancer cells. In vivo, MCC950 reduced IL-1β expression in peritumoral astrocytes, as well as the levels of inflammasome components and active IL-1β. Most importantly, significantly retarded growth of brain metastatic tumors was observed in mice treated with MCC950. Overall, astrocytes contribute to TNBC progression in the brain through activation of the NLRP3 inflammasome and consequent IL-1β release. We conclude that pharmacological targeting of inflammasomes may become a novel strategy in controlling brain metastatic diseases. LA - English DB - MTMT ER - TY - CONF AU - Igaz, Nóra AU - Szőke, Krisztina AU - Bocz, Csenge AU - Kovács, Dávid AU - Rónavári, Andrea AU - Szabó, Emilia Rita AU - Polanek, Róbert AU - Buhala, Andrea AU - Vizler, Csaba AU - Tiszlavicz, László AU - Rázga, Zsolt AU - Hideghéty, Katalin AU - Kónya, Zoltán AU - Csontné Kiricsi, Mónika TI - Radiosensitizing effect of metal nanoparticles in combination with histone deacetylase inhibitors T2 - FAMÉ 2023 PY - 2023 SP - 75 EP - 76 PG - 2 UR - https://m2.mtmt.hu/api/publication/34154565 ID - 34154565 LA - English DB - MTMT ER - TY - JOUR AU - Zombori-Tóth, Noémi AU - Hegedűs, Fanni AU - Almási, Szintia AU - Sejben, Anita AU - Tiszlavicz, László AU - Furák, József AU - Cserni, Gábor AU - Zombori, Tamás TI - Proposal of a grading system for squamous cell carcinoma of the lung — the prognostic importance of tumour budding, single cell invasion, and nuclear diameter JF - VIRCHOWS ARCHIV J2 - VIRCHOWS ARCH VL - 483 PY - 2023 IS - 3 SP - 393 EP - 404 PG - 12 SN - 0945-6317 DO - 10.1007/s00428-023-03612-8 UR - https://m2.mtmt.hu/api/publication/34106758 ID - 34106758 N1 - Csongrád-Csanád County Hospital of Chest Diseases, Deszk, Hungary Department of Pathology, Albert Szent-Györgyi Medical Centre, University of Szeged, Szeged, Hungary Department of Surgery, Albert Szent-Györgyi Medical Centre, University of Szeged, Szeged, Hungary Department of Pathology, Bács-Kiskun County Teaching Hospital, Kecskemét, Hungary Export Date: 22 August 2023 CODEN: VARCE Correspondence Address: Zombori, T.; Department of Pathology, Hungary; email: zombori.tamas@med.u-szeged.hu Funding details: Szegedi Tudományegyetem, SZTE, 6212 Funding text 1: Open access funding provided by University of Szeged. This work was funded by the University of Szeged (Grant number: 6212). AB - The prognostic markers of lung squamous cell carcinoma (LSCC) are less investigated. The aim of our study was to evaluate tumour budding (TB), minimal cell nest size, nuclear diameter (ND), and spread through air spaces (STAS) among patients with resected LSCC, semi-quantitatively. Furthermore, we aimed to identify a grading system for the best prognostic stratification of LSCC. Patients who underwent surgical resection at the Department of Surgery, University of Szeged between 2010 and 2016 were included. Follow-up data were collected from medical charts. Morphological characteristics were recorded from histologic revision of slides. Kaplan-Meier analysis, log rank test and Cox proportional-hazards model, ROC curve analysis, and intraclass correlation were utilised. Altogether 220 patients were included. In univariate analysis, higher degree of TB, infiltrative tumour border, larger ND, the presence of single cell invasion (SCI) and STAS were associated with adverse prognosis. Based on our results, we proposed an easily applicable grading scheme focusing on TB, ND, and SCI. In multivariate analysis, the proposed grading system (p OS< 0.001, p RFS< 0.001) and STAS (p OS= 0.008, p RFS< 0.001) were independent prognosticators. Compared to the previously introduced grading systems, ROC curve analysis revealed that the proposed grade had the highest AUC values (AUCOS: 0.83, AUCRFS: 0.78). Each category of the proposed grading system has good (ICC: 0.79–0.88) reproducibility. We validated the prognostic impact of TB, SCI, ND, and STAS in LSCC. We recommend a reproducible grading system combining TB, SCI, and ND for proper prognostic stratification of LSCC patients. Further research is required for validation of this grading scheme. © 2023, The Author(s). LA - English DB - MTMT ER - TY - JOUR AU - Szebeni, Gábor AU - Alföldi, Róbert AU - Nagy, Lajos I. AU - Neuperger, Patricia AU - Gémes, Nikolett AU - Balog, József Ágoston AU - Tiszlavicz, László AU - Puskás, László TI - Introduction of an Ultraviolet C-Irradiated 4T1 Murine Breast Cancer Whole-Cell Vaccine Model JF - VACCINES (BASEL) J2 - VACCINES-BASEL VL - 11 PY - 2023 IS - 7 PG - 18 SN - 2076-393X DO - 10.3390/vaccines11071254 UR - https://m2.mtmt.hu/api/publication/34076543 ID - 34076543 N1 - Laboratory of Functional Genomics, Biological Research Centre, Temesvári krt. 62, Szeged, H6726, Hungary Department of Physiology, Anatomy and Neuroscience, Faculty of Science and Informatics, University of Szeged, Közép fasor 52, Szeged, H6726, Hungary CS-Smartlab Devices Ltd., Ady E. u. 14, Kozármisleny, H7761, Hungary AstridBio Technologies Ltd., Wimmer Fülöp utca 1, Szeged, H6728, Hungary Avidin Ltd, Alsó Kikötő sor 11/D, Szeged, H6726, Hungary Department of Pathology, University of Szeged, Állomás u. 2, Szeged, H6725, Hungary Export Date: 20 October 2023 Correspondence Address: Szebeni, G.J.; Laboratory of Functional Genomics, Temesvári krt. 62, Hungary; email: szebeni.gabor@brc.hu Correspondence Address: Puskás, L.G.; Laboratory of Functional Genomics, Temesvári krt. 62, Hungary; email: laszlo@avidinbiotech.com Chemicals/CAS: cyclophosphamide, 50-18-0, 6055-19-2; immunoglobulin G, 97794-27-9, 308067-58-5; interleukin 2, 85898-30-2; propidium iodide, 25535-16-4; resazurin, 550-82-3; streptomycin, 57-92-1 Manufacturers: Thermo, United States Funding details: Magyar Tudományos Akadémia, MTA, BO/00582/22/8 Funding details: Nemzeti Kutatási Fejlesztési és Innovációs Hivatal, NKFIH Funding details: National Research, Development and Innovation Office Funding text 1: This research was funded by the 2020-1.1.6-JÖVŐ−2021-00003 and 142877 FK22 grants from the National Research, Development, and Innovation Office (NKFI), Hungary. This work was supported by the János Bolyai Research Scholarship of the Hungarian Academy of Sciences BO/00582/22/8 (GJS). AB - The advent of immunotherapy has revolutionized cancer treatments. However, the application of immune checkpoint inhibitors may entail severe side effects, with the risk of therapeutic resistance. The generation of chimeric antigen receptor (CAR) T-cells or CAR-NK cells requires specialized molecular laboratories, is costly, and is difficult to adapt to the rapidly growing number of cancer patients. To provide a simpler but effective immune therapy, a whole-cell tumor vaccine protocol was established based on ultraviolet C (UCV)-irradiated 4T1 triple-negative breast cancer cells. The apoptosis of tumor cells after UVC irradiation was verified using resazurin and Annexin V/propidium iodide flow cytometric assays. Protective immunity was achieved in immunized BALB/c mice, showing partial remission. Adoptive transfer of splenocytes or plasma from the mice in remission showed a protective effect in the naive BALB/c mice that received a living 4T1 tumor cell injection. 4T1-specific IgG antibodies were recorded in the plasma of the mice following immunization with the whole-cell vaccine. Interleukin-2 (IL-2) and oligonucleotide 2006 (ODN2006) adjuvants were used for the transfer of splenocytes from C57BL/6 mice into cyclophosphamide-treated BALB/c mice, resulting in prolonged survival, reduced tumor growth, and remission in 33% of the cases, without the development of the graft-versus-host disease. Our approach offers a simple, cost-effective whole-cell vaccine protocol that can be administered to immunocompetent healthy organisms. The plasma or the adoptive transfer of HLA-matching immunized donor-derived leukocytes could be used as an immune cell therapy for cancer patients. LA - English DB - MTMT ER -