@misc{MTMT:34672053,
	title = {The inhibition of Orai1 calcium channel reduces the progression of chronic pancreatitis},
	url = {https://m2.mtmt.hu/api/publication/34672053},
	author = {Szabó, Viktória and Csákány-Papp, Noémi and Görög, Marietta and Madácsy, Tamara and Varga, Árpád and Kiss, Aletta Kata and Tél, Bálint and Jójárt, Boldizsár and Crul, Tim and Dudás, Krisztina Márta and Bagyánszki, Mária and Bódi, Nikolett and Ayaydin, Ferhan and Shyam, Jee and Tiszlavicz, László and Stauderman, Kenneth and Hebbar, Sudarshan and Pallagi, Petra and Maléth, József},
	unique-id = {34672053},
	year = {2023},
	pages = {1},
	orcid-numbers = {Szabó, Viktória/0000-0001-6547-9102; Csákány-Papp, Noémi/0000-0002-3614-2698; Görög, Marietta/0000-0003-3615-3140; Madácsy, Tamara/0000-0001-5598-9723; Varga, Árpád/0000-0002-2379-139X; Kiss, Aletta Kata/0000-0001-6404-1555; Tél, Bálint/0000-0003-2066-6494; Jójárt, Boldizsár/0000-0002-2764-3925; Crul, Tim/0000-0002-6053-7016; Dudás, Krisztina Márta/0000-0003-2383-7412; Bagyánszki, Mária/0000-0003-3533-9461; Bódi, Nikolett/0000-0002-9774-1387; Tiszlavicz, László/0000-0003-1134-6587; Pallagi, Petra/0000-0001-8906-0840; Maléth, József/0000-0001-5768-3090}
}

@article{MTMT:34565527,
	title = {Cerebral manifestation and diagnostic dilemma of Rosai-Dorfman disease. [case report]},
	url = {https://m2.mtmt.hu/api/publication/34565527},
	author = {Almási, Szintia and Pancsa, Tamás and Tiszlavicz, László and Sejben, Anita},
	doi = {10.2217/cns-2023-0006},
	journal-iso = {CNS Oncol},
	journal = {CNS Oncology},
	volume = {12},
	unique-id = {34565527},
	issn = {2045-0907},
	abstract = {Rosai-Dorfman disease (RDD) is a rare, S100-positive histiocytic proliferation, that can cause both nodal and extranodal illness. We present a case of a 53-year-old male patient. Magnetic resonance imaging described a plaque-like meningeal lesion, and the preoperative diagnosis was meningioma. Histologically, dense infiltration of lymphocytes, plasma cells, and histiocytes was seen, furthermore, the presence of emperipolesis in the sample was pronounced. In the histiocytes nuclear and cytoplasmic positivity with S100 protein, and nuclear positivity with Cyclin D1 was observed. The case was concluded as RDD. Morphological appearance of intracranial RDD with imaging procedures can present a differential diagnostic challenge. The correct diagnosis is based on the presence of histiocytes with emperipolesis, and properly defined immunohistochemical characteristics.},
	year = {2023},
	eissn = {2045-0915},
	orcid-numbers = {Tiszlavicz, László/0000-0003-1134-6587; Sejben, Anita/0000-0002-9434-2989}
}

@article{MTMT:34553621,
	title = {Oligometasztatikus vesesejtes karcinóma idegsebészi ellátásának technikái és indikációi agyi áttétek esetén [Neurosurgical management for metastatic brain tumors in renal cell carcinoma]. [esetismertetés]},
	url = {https://m2.mtmt.hu/api/publication/34553621},
	author = {Mencser, Zoltán and Tóth, Tamás and Kis, Dávid and Varga, Ádám and Tiszlavicz, László and Barzó, Pál},
	journal-iso = {MAGYAR ONKOLÓGIA},
	journal = {MAGYAR ONKOLÓGIA},
	volume = {67},
	unique-id = {34553621},
	issn = {0025-0244},
	abstract = {The therapeutic approach to brain metastases has changed significantly in the last 30 years. The development of surgical technique, the use of new MRI techniques, preoperative surgical planning and the administration of intraoperative navigation reduced the risks of surgery and improved the results. In the case of aggressive renal cell carcinomas, we detect brain metastases relatively often, which are difficult to treat, but the improved surgical and radiosurgery techniques can also be used with success. In our report, we present the neurosurgical management of metastatic spreading of renal cell carcinoma to the brain. Modern surgical planning and more precise, tailored approach with modern radiosurgery techniques are able to improve the outcome and prolong survival even in aggressive types of renal cell carcinomas that give rise to brain metastases. In more severe cases and even in the case of multiple brain metastases, cranial surgery can be recommended.},
	year = {2023},
	eissn = {2060-0399},
	pages = {32-37},
	orcid-numbers = {Tóth, Tamás/0000-0003-3101-6227; Tiszlavicz, László/0000-0003-1134-6587; Barzó, Pál/0000-0001-8717-748X}
}

@article{MTMT:34443653,
	title = {Elevated serum gastrin is associated with melanoma progression: putative role in increased migration and invasion of melanoma cells},
	url = {https://m2.mtmt.hu/api/publication/34443653},
	author = {Varga, Ákos and Németh, István Balázs and Kemény, Lajos and Varga, János and Tiszlavicz, László and Kumar, D. and Dodd, S. and Simpson, A.W.M. and Buknicz, Tünde and Beynon, R. and Simpson, D. and Krenács, Tibor and Dockray, G.J. and Varro, A.},
	doi = {10.3390/ijms242316851},
	journal-iso = {INT J MOL SCI},
	journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES},
	volume = {24},
	unique-id = {34443653},
	issn = {1661-6596},
	year = {2023},
	eissn = {1422-0067},
	orcid-numbers = {Kemény, Lajos/0000-0002-2119-9501; Tiszlavicz, László/0000-0003-1134-6587; Krenács, Tibor/0000-0001-9164-065X}
}

@{MTMT:34426094,
	title = {Impact of neoadjuvant FLOT treatment of advanced gastric and gastroesophageal junction cancer following surgical therapy},
	url = {https://m2.mtmt.hu/api/publication/34426094},
	author = {Paszt, Attila and Simonka, Zsolt and Budai, Krisztina and Horváth, Zoltán and Erdos, Marton and Vas, Márton Árpád and Ottlakán, Aurél and Nyári, Tibor András and Szepes, Zoltán and Uhercsák, Gabriella and Maráz, Anikó and Torday, László and Tiszlavicz, László and Oláh, Judit Magdolna and Lázár, György ifj},
	booktitle = {Surgical and Oncological Updates in the Management of Gastric Cancer: the Role of Neoadjuvant Therapy and Minimally Invasive Surgery},
	unique-id = {34426094},
	year = {2023},
	pages = {56-68},
	orcid-numbers = {Paszt, Attila/0000-0002-1637-8652; Simonka, Zsolt/0000-0002-3490-226X; Horváth, Zoltán/0000-0002-9790-4975; Ottlakán, Aurél/0000-0002-7743-7775; Nyári, Tibor András/0000-0001-8900-6641; Szepes, Zoltán/0000-0002-9466-8719; Maráz, Anikó/0000-0002-2018-8413; Torday, László/0000-0002-2911-5499; Tiszlavicz, László/0000-0003-1134-6587; Lázár, György ifj/0000-0001-7155-2978}
}

@article{MTMT:34199166,
	title = {Single-cell mass cytometric analysis of peripheral immunity and multiplex plasma marker profiling of non-small cell lung cancer patients receiving PD-1 targeting immune checkpoint inhibitors in comparison with platinum-based chemotherapy},
	url = {https://m2.mtmt.hu/api/publication/34199166},
	author = {Neuperger, Patricia and Szalontai, Klára Margit and Gémes, Nikolett and Balog, József Ágoston and Tiszlavicz, László and Furák, József and Lázár, György ifj and Puskás, László and Szebeni, Gábor},
	doi = {10.3389/fimmu.2023.1243233},
	journal-iso = {FRONT IMMUNOL},
	journal = {FRONTIERS IN IMMUNOLOGY},
	volume = {14},
	unique-id = {34199166},
	issn = {1664-3224},
	year = {2023},
	eissn = {1664-3224},
	orcid-numbers = {Tiszlavicz, László/0000-0003-1134-6587; Furák, József/0000-0002-7224-1642; Lázár, György ifj/0000-0001-7155-2978; Szebeni, Gábor/0000-0002-6998-5632}
}

@article{MTMT:34158861,
	title = {Inflammasome activation in peritumoral astrocytes is a key player in breast cancer brain metastasis development},
	url = {https://m2.mtmt.hu/api/publication/34158861},
	author = {Mészáros, Ádám and Molnár, Kinga and Fazakas, Csilla and Nógrádi, Bernát and Lüvi, Adél and Dudás, Tamás and Tiszlavicz, László and Farkas, Elek Attila and Krizbai, István Adorján and Wilhelm, Imola Mária},
	doi = {10.1186/s40478-023-01646-2},
	journal-iso = {ACTA NEUROPATH COMM},
	journal = {ACTA NEUROPATHOLOGICA COMMUNICATIONS},
	volume = {11},
	unique-id = {34158861},
	issn = {2051-5960},
	abstract = {Inflammasomes, primarily responsible for the activation of IL-1β, have emerged as critical regulators of the tumor microenvironment. By using in vivo and in vitro brain metastasis models, as well as human samples to study the role of the NLRP3 inflammasome in triple-negative breast cancer (TNBC) brain metastases, we found NLRP3 inflammasome components and IL-1β to be highly and specifically expressed in peritumoral astrocytes. Soluble factors from TNBC cells induced upregulation and activation of NLRP3 and IL-1β in astrocytes, while astrocyte-derived mediators augmented the proliferation of metastatic cells. In addition, inhibition of NLRP3 inflammasome activity using MCC950 or dampening the downstream effect of IL-1β prevented the proliferation increase in cancer cells. In vivo, MCC950 reduced IL-1β expression in peritumoral astrocytes, as well as the levels of inflammasome components and active IL-1β. Most importantly, significantly retarded growth of brain metastatic tumors was observed in mice treated with MCC950. Overall, astrocytes contribute to TNBC progression in the brain through activation of the NLRP3 inflammasome and consequent IL-1β release. We conclude that pharmacological targeting of inflammasomes may become a novel strategy in controlling brain metastatic diseases.},
	year = {2023},
	eissn = {2051-5960},
	orcid-numbers = {Fazakas, Csilla/0000-0001-7822-5881; Tiszlavicz, László/0000-0003-1134-6587; Wilhelm, Imola Mária/0000-0003-2366-7337}
}

@CONFERENCE{MTMT:34154565,
	title = {Radiosensitizing effect of metal nanoparticles in combination with histone deacetylase inhibitors},
	url = {https://m2.mtmt.hu/api/publication/34154565},
	author = {Igaz, Nóra and Szőke, Krisztina and Bocz, Csenge and Kovács, Dávid and Rónavári, Andrea and Szabó, Emilia Rita and Polanek, Róbert and Buhala, Andrea and Vizler, Csaba and Tiszlavicz, László and Rázga, Zsolt and Hideghéty, Katalin and Kónya, Zoltán and Csontné Kiricsi, Mónika},
	booktitle = {FAMÉ 2023},
	unique-id = {34154565},
	year = {2023},
	pages = {75-76},
	orcid-numbers = {Igaz, Nóra/0000-0003-1580-4397; Rónavári, Andrea/0000-0001-7054-0975; Szabó, Emilia Rita/0000-0003-3611-2066; Polanek, Róbert/0000-0003-3645-8331; Tiszlavicz, László/0000-0003-1134-6587; Rázga, Zsolt/0000-0003-4717-8482; Hideghéty, Katalin/0000-0001-7080-2365; Kónya, Zoltán/0000-0002-9406-8596; Csontné Kiricsi, Mónika/0000-0002-8416-2052}
}

@article{MTMT:34106758,
	title = {Proposal of a grading system for squamous cell carcinoma of the lung — the prognostic importance of tumour budding, single cell invasion, and nuclear diameter},
	url = {https://m2.mtmt.hu/api/publication/34106758},
	author = {Zombori-Tóth, Noémi and Hegedűs, Fanni and Almási, Szintia and Sejben, Anita and Tiszlavicz, László and Furák, József and Cserni, Gábor and Zombori, Tamás},
	doi = {10.1007/s00428-023-03612-8},
	journal-iso = {VIRCHOWS ARCH},
	journal = {VIRCHOWS ARCHIV},
	volume = {483},
	unique-id = {34106758},
	issn = {0945-6317},
	abstract = {The prognostic markers of lung squamous cell carcinoma (LSCC) are less investigated. The aim of our study was to evaluate tumour budding (TB), minimal cell nest size, nuclear diameter (ND), and spread through air spaces (STAS) among patients with resected LSCC, semi-quantitatively. Furthermore, we aimed to identify a grading system for the best prognostic stratification of LSCC. Patients who underwent surgical resection at the Department of Surgery, University of Szeged between 2010 and 2016 were included. Follow-up data were collected from medical charts. Morphological characteristics were recorded from histologic revision of slides. Kaplan-Meier analysis, log rank test and Cox proportional-hazards model, ROC curve analysis, and intraclass correlation were utilised. Altogether 220 patients were included. In univariate analysis, higher degree of TB, infiltrative tumour border, larger ND, the presence of single cell invasion (SCI) and STAS were associated with adverse prognosis. Based on our results, we proposed an easily applicable grading scheme focusing on TB, ND, and SCI. In multivariate analysis, the proposed grading system (p OS< 0.001, p RFS< 0.001) and STAS (p OS= 0.008, p RFS< 0.001) were independent prognosticators. Compared to the previously introduced grading systems, ROC curve analysis revealed that the proposed grade had the highest AUC values (AUCOS: 0.83, AUCRFS: 0.78). Each category of the proposed grading system has good (ICC: 0.79–0.88) reproducibility. We validated the prognostic impact of TB, SCI, ND, and STAS in LSCC. We recommend a reproducible grading system combining TB, SCI, and ND for proper prognostic stratification of LSCC patients. Further research is required for validation of this grading scheme. © 2023, The Author(s).},
	keywords = {GRADE; lung squamous cell carcinoma; tumour budding; Spread through air spaces; Nuclear diameter; Single-cell invasion},
	year = {2023},
	eissn = {1432-2307},
	pages = {393-404},
	orcid-numbers = {Sejben, Anita/0000-0002-9434-2989; Tiszlavicz, László/0000-0003-1134-6587; Furák, József/0000-0002-7224-1642; Cserni, Gábor/0000-0003-1344-7744; Zombori, Tamás/0000-0002-0654-563X}
}

@article{MTMT:34076543,
	title = {Introduction of an Ultraviolet C-Irradiated 4T1 Murine Breast Cancer Whole-Cell Vaccine Model},
	url = {https://m2.mtmt.hu/api/publication/34076543},
	author = {Szebeni, Gábor and Alföldi, Róbert and Nagy, Lajos I. and Neuperger, Patricia and Gémes, Nikolett and Balog, József Ágoston and Tiszlavicz, László and Puskás, László},
	doi = {10.3390/vaccines11071254},
	journal-iso = {VACCINES-BASEL},
	journal = {VACCINES (BASEL)},
	volume = {11},
	unique-id = {34076543},
	abstract = {The advent of immunotherapy has revolutionized cancer treatments. However, the application of immune checkpoint inhibitors may entail severe side effects, with the risk of therapeutic resistance. The generation of chimeric antigen receptor (CAR) T-cells or CAR-NK cells requires specialized molecular laboratories, is costly, and is difficult to adapt to the rapidly growing number of cancer patients. To provide a simpler but effective immune therapy, a whole-cell tumor vaccine protocol was established based on ultraviolet C (UCV)-irradiated 4T1 triple-negative breast cancer cells. The apoptosis of tumor cells after UVC irradiation was verified using resazurin and Annexin V/propidium iodide flow cytometric assays. Protective immunity was achieved in immunized BALB/c mice, showing partial remission. Adoptive transfer of splenocytes or plasma from the mice in remission showed a protective effect in the naive BALB/c mice that received a living 4T1 tumor cell injection. 4T1-specific IgG antibodies were recorded in the plasma of the mice following immunization with the whole-cell vaccine. Interleukin-2 (IL-2) and oligonucleotide 2006 (ODN2006) adjuvants were used for the transfer of splenocytes from C57BL/6 mice into cyclophosphamide-treated BALB/c mice, resulting in prolonged survival, reduced tumor growth, and remission in 33% of the cases, without the development of the graft-versus-host disease. Our approach offers a simple, cost-effective whole-cell vaccine protocol that can be administered to immunocompetent healthy organisms. The plasma or the adoptive transfer of HLA-matching immunized donor-derived leukocytes could be used as an immune cell therapy for cancer patients.},
	year = {2023},
	eissn = {2076-393X},
	orcid-numbers = {Szebeni, Gábor/0000-0002-6998-5632; Tiszlavicz, László/0000-0003-1134-6587}
}