TY - JOUR AU - Acsády, László AU - Mátyás, Ferenc TI - Several ways to wake you up by the thalamus JF - NEURON J2 - NEURON VL - 111 PY - 2023 IS - 20 SP - 3140 EP - 3142 PG - 3 SN - 0896-6273 DO - 10.1016/j.neuron.2023.09.020 UR - https://m2.mtmt.hu/api/publication/34207759 ID - 34207759 LA - English DB - MTMT ER - TY - JOUR AU - Hádinger, Nóra AU - Bősz, Emília AU - Tóth, Boglárka AU - Vantomme, Gil AU - Lüthi, Anita AU - Acsády, László TI - Region-selective control of the thalamic reticular nucleus via cortical layer 5 pyramidal cells JF - NATURE NEUROSCIENCE J2 - NAT NEUROSCI VL - 26 PY - 2023 IS - 1 SP - 116 EP - 130 PG - 15 SN - 1097-6256 DO - 10.1038/s41593-022-01217-z UR - https://m2.mtmt.hu/api/publication/33540834 ID - 33540834 AB - Corticothalamic pathways, responsible for the top-down control of the thalamus, have a canonical organization such that every cortical region sends output from both layer 6 (L6) and layer 5 (L5) to the thalamus. Here we demonstrate a qualitative, region-specific difference in the organization of mouse corticothalamic pathways. Specifically, L5 pyramidal cells of the frontal cortex, but not other cortical regions, establish monosynaptic connections with the inhibitory thalamic reticular nucleus (TRN). The frontal L5–TRN pathway parallels the L6–TRN projection but has distinct morphological and physiological features. The exact spike output of the L5-contacted TRN cells correlated with the level of cortical synchrony. Optogenetic perturbation of the L5–TRN connection disrupted the tight link between cortical and TRN activity. L5-driven TRN cells innervated thalamic nuclei involved in the control of frontal cortex activity. Our data show that frontal cortex functions require a highly specialized cortical control over intrathalamic inhibitory processes. LA - English DB - MTMT ER - TY - CHAP AU - Acsády, László ED - Michael, M. Halassa TI - Organization of Thalamic Inputs T2 - The Thalamus PB - Cambridge University Press CY - Cambridge SN - 1108481566 PY - 2022 SP - 27 EP - 44 PG - 64 DO - 10.1017/9781108674287.003 UR - https://m2.mtmt.hu/api/publication/33592480 ID - 33592480 LA - English DB - MTMT ER - TY - JOUR AU - Otsu, Y AU - Darcq, E AU - Pietrajtis, K AU - Mátyás, Ferenc AU - Schwartz, E AU - Bessaih, T AU - Abi, Gerges S AU - Rousseau, C V AU - Grand, T AU - Dieudonne, S AU - Paoletti, P AU - Acsády, László AU - Agulhon, C AU - Kieffer, B L AU - Diana, M A TI - Control of aversion by glycine-gated GluN1/GluN3A NMDA receptors in the adult medial habenula. JF - SCIENCE J2 - SCIENCE VL - 366 PY - 2019 IS - 6462 SP - 250 EP - 254 PG - 5 SN - 0036-8075 DO - 10.1126/science.aax1522 UR - https://m2.mtmt.hu/api/publication/30850756 ID - 30850756 N1 - Institut de Biologie de l’École Normale Supérieure (IBENS), INSERM U1024, CNRS UMR8197, École Normale Supérieure, Université PSL, Paris, 75005, France Department of Psychiatry, School of Medicine, Douglas Hospital Research Center, McGill University, Montreal, QC H4H 1R3, Canada Sorbonne Université, CNRS, INSERM, Neurosciences Paris Seine – Institut de Biologie Paris Seine (NPS-IBPS), Paris, 75005, France Laboratory of Thalamus Research, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, 1083, Hungary Research Centre for Natural Sciences Institute of Cognitive Neuroscience and Psychology, Budapest, 1117, Hungary Department of Anatomy and Histology, University of Veterinary Medicine, Budapest, 1078, Hungary Integrative Neuroscience and Cognition Center, CNRS UMR8002, Glia-Glia and Glia-Neuron Interactions Group, Paris Descartes University, Paris, 75006, France Pain Management Research Institute, Kolling Institute of Medical Research, Northern Clinical School, University of Sydney, Royal North Shore Hospital, St. Leonards, NSW 2065, Australia Neural Circuit Dynamics and Decision Making, Pasteur Institute, Paris, 75015, France Cited By :36 Export Date: 24 January 2023 CODEN: SCIEA Correspondence Address: Diana, M.A.; Sorbonne Université, France; email: marco.diana@upmc.fr Chemicals/CAS: glycine, 56-40-6, 6000-43-7, 6000-44-8 Funding details: 2017-1.2.1-NKP-2017-00002, FK124434 Funding details: National Institute on Drug Abuse, NIDA, 05010 Funding details: National Institute on Alcohol Abuse and Alcoholism, NIAAA, 16658 Funding details: Horizon 2020 Framework Programme, H2020, 693021, 742595 Funding details: European Research Council, ERC Funding details: Fondation pour la Recherche Médicale, FRM, FDT20100919977 Funding details: Nemzeti Kutatási és Technológiai Hivatal, NKTH, ANR-09-BLAN-0401, ANR-17-CE16-0014, S17JRSU003 Funding details: University of Tokyo Funding details: Centre National de la Recherche Scientifique, CNRS, PICS 7415 Funding details: Université de Genève, UNIGE Funding text 1: We thank M. Galante, R. Lambert, and N. Leresche for criticall reading the manuscript; M. McNicholas and S. Kirchherr for assistance during behavioral experiments; and B. Mathieu at the IBENS Imaging Facility. N. Nakanishi and S. Lipton (Scintillon Institute) provided the GluN3AKO mice and M. Mishina (Tokyo University) provided the GluN2AKO line. The anti-GluN3A antibody was a gift from M. Watanabe (Hokkaido University). We thank C. Bellone (Geneva University) for the scr/shRNA-expressing viruses. Funding: This study was supported by fellowships (NKTH-)ANR-09-BLAN-0401 to S.D., M.A.D., and L.A., and ANR-17-CE16-0014 to P.P., S.D., B.L.K., and M.A.D.; by Emergence Sorbonne (S17JRSU003) and CNRS (PICS 7415) to M.A.D.; by the European Research Council (693021) to P.P.; by ERC-FRONTHAL (742595) to L.A.; by grants FK124434 and 2017-1.2.1-NKP-2017-00002 to F.M.; and by the National Institute of Drug Abuse (05010) and the National Institute on Alcohol Abuse and Alcoholism (16658) to B.L.K. C.V.R. was supported by FRM grant FDT20100919977. C.A. AB - The unconventional N-methyl-d-aspartate (NMDA) receptor subunits GluN3A and GluN3B can, when associated with the other glycine-binding subunit GluN1, generate excitatory conductances purely activated by glycine. However, functional GluN1/GluN3 receptors have not been identified in native adult tissues. We discovered that GluN1/GluN3A receptors are operational in neurons of the mouse adult medial habenula (MHb), an epithalamic area controlling aversive physiological states. In the absence of glycinergic neuronal specializations in the MHb, glial cells tuned neuronal activity via GluN1/GluN3A receptors. Reducing GluN1/GluN3A receptor levels in the MHb prevented place-aversion conditioning. Our study extends the physiological and behavioral implications of glycine by demonstrating its control of negatively valued emotional associations via excitatory glycinergic NMDA receptors. LA - English DB - MTMT ER - TY - JOUR AU - Mátyás, Ferenc AU - Komlósi, Gergely AU - Babiczky, Ákos AU - Kocsis, Kinga AU - Barthó, Péter AU - Barsy, Boglárka AU - Dávid, Csaba AU - Kanti, Vivien Ildikó AU - Porrero, C. AU - Magyar, Aletta AU - Szűcs, I. AU - Clasca, F. AU - Acsády, László TI - A highly collateralized thalamic cell type with arousal-predicting activity serves as a key hub for graded state transitions in the forebrain JF - NATURE NEUROSCIENCE J2 - NAT NEUROSCI VL - 21 ET - 0 PY - 2018 IS - 11 SP - 1551 EP - 1562 PG - 12 SN - 1097-6256 DO - 10.1038/s41593-018-0251-9 UR - https://m2.mtmt.hu/api/publication/30309774 ID - 30309774 N1 - Institute of Cognitive Neuroscience and Psychology, Research Center for Natural Sciences, Hungarian Academy of Sciences, Budapest, Hungary Department of Cellular and Network Neurobiology, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary Roska Tamás Doctoral School of Sciences and Technology, Faculty of Information Technology and Bionics, Pázmány Péter Catholic University, Budapest, Hungary Department of Anatomy, Histology, and Embryology, Semmelweis University, Budapest, Hungary János Szentágothai Doctoral School of Neurosciences, Semmelweis University, Budapest, Hungary Brain Connectomics Lab, Department of Anatomy and Neuroscience, School of Medicine, Autónoma University, Madrid, Spain Department of Pathology, Szent Borbála Hospital, Tatabánya, Hungary Cited By :41 Export Date: 16 May 2023 CODEN: NANEF Correspondence Address: Mátyás, F.; Institute of Cognitive Neuroscience and Psychology, Hungary; email: matyas.ferenc@ttk.mta.hu Funding details: 118886 Funding details: KTIA_ NAP_13-2-2015-0010, KTIA_13_NAPA-I/1, KTIA_NAP_13-2-2014-0016 Funding details: Horizon 2020 Framework Programme, H2020, 742595 Funding details: European Research Council, ERC Funding details: Magyar Tudományos Akadémia, MTA, LP2012-23 Funding details: Nemzeti Kutatási és Technológiai Hivatal, NKTH, FK124434, K119650, NKTH-ANR-09-BLAN-0401, PD124034 Funding text 1: We thank Z.J. Huang (CSHL, NY, USA) for providing us with the Calb2-Cre mice and C. Smerdou and C. Ballesteros (CIMA, University of Navarre, Spain) for synthesizing the Sindbis-Pal-eGFP RNA construct. The technical help of K. Faddi, K. Varga, A. Jász and E. Szabo-Egyud is acknowledged. The authors thank the Nikon Microscopy Center at IEM, Nikon Austria GmbH, and Auro-Science Consulting Ltd for kindly providing microscopy support and thank the Human Brain Research Laboratory (IEM/HAS) for the preparation of human material. The authors thank J. Poulet, B. Hangya, and H. Bokor for comments and discussions on the manuscript. This work was supported by the National Office for Research and Technology (NKTH-ANR-09-BLAN-0401, Neurogen to L.A; K119650 to P.B.; FK124434 to F.M.; PD124034 to B.B.), “Lendület” Program of the Hungarian Academy of Sciences (LP2012-23; B.B.), Hungarian Korean Joint Laboratory Program, Hungarian Brain Research Program (grants no. KTIA_ NAP_13-2-2015-0010 to F.M., KTIA_NAP_13-2-2014-0016 to P.B. and KTIA_13_NAPA-I/1 to L.A.), ERC (FRONTHAL, 742595 to L.A.), and HBP-FLAG-ERA (118886 to L.A.). AB - Sleep cycles consist of rapid alterations between arousal states, including transient perturbation of sleep rhythms, microarousals, and full-blown awake states. Here we demonstrate that the calretinin (CR)-containing neurons in the dorsal medial thalamus (DMT) constitute a key diencephalic node that mediates distinct levels of forebrain arousal. Cell-type-specific activation of DMT/CR+ cells elicited active locomotion lasting for minutes, stereotyped microarousals, or transient disruption of sleep rhythms, depending on the parameters of the stimulation. State transitions could be induced in both slow-wave and rapid eye-movement sleep. The DMT/CR+ cells displayed elevated activity before arousal, received selective subcortical inputs, and innervated several forebrain sites via highly branched axons. Together, these features enable DMT/CR+ cells to summate subcortical arousal information and effectively transfer it as a rapid, synchronous signal to several forebrain regions to modulate the level of arousal. © 2018, The Author(s), under exclusive licence to Springer Nature America, Inc. LA - English DB - MTMT ER - TY - JOUR AU - Acsády, László TI - Heartless beat or beatless heart? JF - NATURE NEUROSCIENCE J2 - NAT NEUROSCI VL - 21 PY - 2018 IS - 5 SP - 649 EP - 651 PG - 3 SN - 1097-6256 DO - 10.1038/s41593-018-0140-2 UR - https://m2.mtmt.hu/api/publication/3398238 ID - 3398238 N1 - Cited By :1 Export Date: 1 February 2024 CODEN: NANEF Correspondence Address: Acsády, L.; Laboratory of Thalamus Research, Hungary; email: acsady@koki.hu LA - English DB - MTMT ER - TY - JOUR AU - Acsády, László AU - Harris, KD TI - Synaptic scaling in sleep JF - SCIENCE J2 - SCIENCE VL - 355 PY - 2017 IS - 6324 SP - 457 EP - 457 PG - 1 SN - 0036-8075 DO - 10.1126/science.aam7917 UR - https://m2.mtmt.hu/api/publication/3356704 ID - 3356704 LA - English DB - MTMT ER - TY - JOUR AU - Acsády, László TI - The thalamic paradox. JF - NATURE NEUROSCIENCE J2 - NAT NEUROSCI VL - 20 PY - 2017 IS - 7 SP - 901 EP - 902 PG - 2 SN - 1097-6256 DO - 10.1038/nn.4583 UR - https://m2.mtmt.hu/api/publication/3356700 ID - 3356700 LA - English DB - MTMT ER - TY - JOUR AU - Clemente-Perez, A AU - Makinson, SR AU - Higashikubo, B AU - Brovarney, S AU - Cho, FS AU - Urry, A AU - Holden, SS AU - Wimer, M AU - Dávid, Csaba AU - Fenno, LE AU - Acsády, László AU - Deisseroth, K AU - Paz, JT TI - Distinct Thalamic Reticular Cell Types Differentially Modulate Normal and Pathological Cortical Rhythms JF - CELL REPORTS J2 - CELL REP VL - 19 PY - 2017 IS - 10 SP - 2130 EP - 2142 PG - 13 SN - 2211-1247 DO - 10.1016/j.celrep.2017.05.044 UR - https://m2.mtmt.hu/api/publication/3341635 ID - 3341635 N1 - Neurosciences Graduate Program, University of California San Francisco, San Francisco, CA 94158, United States Department of Neurology, University of California, San Francisco, San Francisco, CA 94158, United States Gladstone Institute of Neurological Disease, San Francisco, CA 94158, United States Laboratory of Thalamus Research, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, 1083, Hungary Department of Anatomy, Histology, and Embryology, Semmelweis University, Budapest, 1094, Hungary Bioengineering Department, Stanford University, Stanford, CA 94305, United States Cited By :102 Export Date: 17 May 2023 Correspondence Address: Paz, J.T.; Neurosciences Graduate Program, United States; email: jeanne.paz@gladstone.ucsf.edu Chemicals/CAS: parvalbumin, 56094-12-3, 83667-75-8; somatostatin, 38916-34-6, 51110-01-1; Parvalbumins; Somatostatin Funding details: KTIA_13_NAP-A-I/1 Funding details: National Science Foundation, NSF, 1144247, 1608236, 1650113, T32-GM007449 Funding details: National Institutes of Health, NIH Funding details: U.S. Department of Defense, DOD, EP150038 Funding details: National Institute of Mental Health, NIMH Funding details: National Institute on Drug Abuse, NIDA Funding details: National Institute of General Medical Sciences, NIGMS, T32GM007449 Funding details: National Institute of Neurological Disorders and Stroke, NINDS, R00NS078118, R01NS096369 Funding details: Defense Advanced Research Projects Agency, DARPA Funding details: American Epilepsy Society, AES Funding details: Gladstone Institutes Funding details: Dravet Syndrome Foundation, DSF Funding details: Gatsby Charitable Foundation Funding details: Magyar Tudományos Akadémia, MTA Funding details: Nemzeti Kutatási Fejlesztési és Innovációs Hivatal, NKFIH, NKFI109754 Funding text 1: J.T.P. is supported by NIH/NINDS grants R00NS078118 and R01NS096369, Gladstone Institutes, the Kavli Institute for Fundamental Neuroscience, Michael Prize, DoD (EP150038), and NSF award #1608236. A.C.P. and F.S.C. are supported by National Science Foundation Graduate Research Fellowship awards #1650113 and #1144247, respectively. S.S.H. is funded by the Achievement Rewards for College Scientists Scholarship. A.C.P., F.S.C., and S.S.H. are supported by NIH grant T32-GM007449 and the Weill Foundation. S.R.M. is supported by the American Epilepsy Society and the Dravet Syndrome Foundation Postdoctoral Research Fellowship. K.D. and L.E.F. are supported by NIMH, NIDA, DARPA, and the Gatsby Foundation. C.D. and L.A. are supported by National Research Development and Innovation Office (NKFI109754) and the Hungarian Brain Research Program (KTIA_13_NAP-A-I/1). We thank the Department of Pathology, Saint Borbála Hospital, Tatabánya at the Human Brain Research lab, and Institute of Experimental Medicine, Hungarian Academy of Sciences (IEM HAS) for providing human brain tissue. We thank John Huguenard and Jordan Sorokin for the custom MATLAB software for thalamic oscillation analysis in vitro and Meredith Calvert of the Gladstone Histology & Light Microscopy Core for help with confocal microscopy and cell counting. Thanks to Gary Howard and Crystal Herron for their insightful feedback on the manuscript. AB - Integrative brain functions depend on widely distributed, rhythmically coordinated computations. Through its long-ranging connections with cortex and most senses, the thalamus orchestrates the flow of cognitive and sensory information. Essential in this process, the nucleus reticularis thalami (nRT) gates different information streams through its extensive inhibition onto other thalamic nuclei, however, we lack an understanding of how different inhibitory neuron subpopulations in nRT function as gatekeepers. We dissociated the connectivity, physiology, and circuit functions of neurons within rodent nRT, based on parvalbumin (PV) and somatostatin (SOM) expression, and validated the existence of such populations in human nRT. We found that PV, but not SOM, cells are rhythmogenic, and that PV and SOM neurons are connected to and modulate distinct thalamocortical circuits. Notably, PV, but not SOM, neurons modulate somatosensory behavior and disrupt seizures. These results provide a conceptual framework for how nRT may gate incoming information to modulate brain-wide rhythms. LA - English DB - MTMT ER - TY - JOUR AU - Halassa, MM AU - Acsády, László TI - Thalamic Inhibition: Diverse Sources, Diverse Scales. JF - TRENDS IN NEUROSCIENCES J2 - TRENDS NEUROSCI VL - 39 PY - 2016 IS - 10 SP - 680 EP - 693 PG - 14 SN - 0166-2236 DO - 10.1016/j.tins.2016.08.001 UR - https://m2.mtmt.hu/api/publication/3206618 ID - 3206618 N1 - Funding details: Klingenstein Third Generation Foundation Funding details: Wellcome Trust, WT094513 Funding details: Nemzeti Kutatási Fejlesztési és Innovációs Hivatal, NKFI 109754 Funding details: National Institute of Mental Health Funding details: National Institute of Neurological Disorders and Stroke Funding details: Alfred P. Sloan Foundation Funding details: KTIA_13_NAP-A-I/1 Funding text 1: This work was supported by the National Research Development and Innovation Office (NKFI 109754) the Hungarian Brain Research Program (grant no. KTIA_13_NAP-A-I/1) and the Wellcome Trust (WT094513) to L.A., and grants from the US National Institute of Health (NIMH, NINDS), New York University Neuroscience Institute and the Departments of Psychiatry, Neuroscience and Physiology, New York University Langone Medical Center, New York, 10016, United States Center for Neural Science, New York University, New York, 10016, United States Laboratory of Thalamus Research, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, 1083, Hungary Cited By :73 Export Date: 22 March 2021 CODEN: TNSCD Correspondence Address: Halassa, M.M.United States; email: michael.halassa@nyumc.org Funding details: KTIA_13_NAP-A-I/1 Funding details: National Institute of Mental Health, NIMH, R01MH107680 Funding details: National Institute of Neurological Disorders and Stroke, NINDS, R00NS078115 Funding details: Brain and Behavior Research Foundation, BBRF Funding details: Alfred P. Sloan Foundation Funding details: Klingenstein Third Generation Foundation, KTGF Funding details: Wellcome Trust, WT, WT094513 Funding details: Nemzeti Kutatási Fejlesztési és Innovációs Hivatal, NKFIH, NKFI 109754 Funding text 1: This work was supported by the National Research Development and Innovation Office (NKFI 109754) the Hungarian Brain Research Program (grant no. KTIA_13_NAP-A-I/1) and the Wellcome Trust (WT094513) to L.A., and grants from the US National Institute of Health (NIMH, NINDS), Brain and Behavior Foundation, Feldstein Foundation, Human Frontiers Science Program, Klingenstein Foundation, Sloan Foundation, and Simons Foundations to M.M.H. New York University Neuroscience Institute and the Departments of Psychiatry, Neuroscience and Physiology, New York University Langone Medical Center, New York, 10016, United States Center for Neural Science, New York University, New York, 10016, United States Laboratory of Thalamus Research, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, 1083, Hungary Cited By :74 Export Date: 1 April 2021 CODEN: TNSCD Correspondence Address: Halassa, M.M.United States; email: michael.halassa@nyumc.org Funding details: KTIA_13_NAP-A-I/1 Funding details: National Institutes of Health, NIH Funding details: National Institute of Mental Health, NIMH, R01MH107680 Funding details: National Institute of Neurological Disorders and Stroke, NINDS, R00NS078115 Funding details: Brain and Behavior Research Foundation, BBRF Funding details: Alfred P. Sloan Foundation Funding details: Simons Foundation, SF Funding details: Esther A. and Joseph Klingenstein Fund Funding details: Wellcome Trust, WT, WT094513 Funding details: Human Frontier Science Program, HFSP Funding details: Nemzeti Kutatási Fejlesztési és Innovációs Hivatal, NKFIH, NKFI 109754 Funding text 1: This work was supported by the National Research Development and Innovation Office (NKFI 109754) the Hungarian Brain Research Program (grant no. KTIA_13_NAP-A-I/1) and the Wellcome Trust (WT094513) to L.A., and grants from the US National Institute of Health (NIMH, NINDS), Brain and Behavior Foundation, Feldstein Foundation, Human Frontiers Science Program, Klingenstein Foundation, Sloan Foundation, and Simons Foundations to M.M.H. New York University Neuroscience Institute and the Departments of Psychiatry, Neuroscience and Physiology, New York University Langone Medical Center, New York, 10016, United States Center for Neural Science, New York University, New York, 10016, United States Laboratory of Thalamus Research, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, 1083, Hungary Cited By :74 Export Date: 7 April 2021 CODEN: TNSCD Correspondence Address: Halassa, M.M.United States; email: michael.halassa@nyumc.org Funding details: KTIA_13_NAP-A-I/1 Funding details: National Institutes of Health, NIH Funding details: National Institute of Mental Health, NIMH, R01MH107680 Funding details: National Institute of Neurological Disorders and Stroke, NINDS, R00NS078115 Funding details: Brain and Behavior Research Foundation, BBRF Funding details: Alfred P. Sloan Foundation Funding details: Simons Foundation, SF Funding details: Esther A. and Joseph Klingenstein Fund Funding details: Wellcome Trust, WT, WT094513 Funding details: Human Frontier Science Program, HFSP Funding details: Nemzeti Kutatási Fejlesztési és Innovációs Hivatal, NKFIH, NKFI 109754 Funding text 1: This work was supported by the National Research Development and Innovation Office (NKFI 109754) the Hungarian Brain Research Program (grant no. KTIA_13_NAP-A-I/1) and the Wellcome Trust (WT094513) to L.A., and grants from the US National Institute of Health (NIMH, NINDS), Brain and Behavior Foundation, Feldstein Foundation, Human Frontiers Science Program, Klingenstein Foundation, Sloan Foundation, and Simons Foundations to M.M.H. New York University Neuroscience Institute and the Departments of Psychiatry, Neuroscience and Physiology, New York University Langone Medical Center, New York, 10016, United States Center for Neural Science, New York University, New York, 10016, United States Laboratory of Thalamus Research, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, 1083, Hungary Cited By :75 Export Date: 8 April 2021 CODEN: TNSCD Correspondence Address: Halassa, M.M.United States; email: michael.halassa@nyumc.org Funding details: KTIA_13_NAP-A-I/1 Funding details: National Institutes of Health, NIH Funding details: National Institute of Mental Health, NIMH, R01MH107680 Funding details: National Institute of Neurological Disorders and Stroke, NINDS, R00NS078115 Funding details: Brain and Behavior Research Foundation, BBRF Funding details: Alfred P. Sloan Foundation Funding details: Simons Foundation, SF Funding details: Esther A. and Joseph Klingenstein Fund Funding details: Wellcome Trust, WT, WT094513 Funding details: Human Frontier Science Program, HFSP Funding details: Nemzeti Kutatási Fejlesztési és Innovációs Hivatal, NKFIH, NKFI 109754 Funding text 1: This work was supported by the National Research Development and Innovation Office (NKFI 109754) the Hungarian Brain Research Program (grant no. KTIA_13_NAP-A-I/1) and the Wellcome Trust (WT094513) to L.A., and grants from the US National Institute of Health (NIMH, NINDS), Brain and Behavior Foundation, Feldstein Foundation, Human Frontiers Science Program, Klingenstein Foundation, Sloan Foundation, and Simons Foundations to M.M.H. New York University Neuroscience Institute and the Departments of Psychiatry, Neuroscience and Physiology, New York University Langone Medical Center, New York, 10016, United States Center for Neural Science, New York University, New York, 10016, United States Laboratory of Thalamus Research, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, 1083, Hungary Cited By :75 Export Date: 12 April 2021 CODEN: TNSCD Correspondence Address: Halassa, M.M.United States; email: michael.halassa@nyumc.org Funding details: KTIA_13_NAP-A-I/1 Funding details: National Institutes of Health, NIH Funding details: National Institute of Mental Health, NIMH, R01MH107680 Funding details: National Institute of Neurological Disorders and Stroke, NINDS, R00NS078115 Funding details: Brain and Behavior Research Foundation, BBRF Funding details: Alfred P. Sloan Foundation Funding details: Simons Foundation, SF Funding details: Esther A. and Joseph Klingenstein Fund Funding details: Wellcome Trust, WT, WT094513 Funding details: Human Frontier Science Program, HFSP Funding details: Nemzeti Kutatási Fejlesztési és Innovációs Hivatal, NKFIH, NKFI 109754 Funding text 1: This work was supported by the National Research Development and Innovation Office (NKFI 109754) the Hungarian Brain Research Program (grant no. KTIA_13_NAP-A-I/1) and the Wellcome Trust (WT094513) to L.A., and grants from the US National Institute of Health (NIMH, NINDS), Brain and Behavior Foundation, Feldstein Foundation, Human Frontiers Science Program, Klingenstein Foundation, Sloan Foundation, and Simons Foundations to M.M.H. New York University Neuroscience Institute and the Departments of Psychiatry, Neuroscience and Physiology, New York University Langone Medical Center, New York, 10016, United States Center for Neural Science, New York University, New York, 10016, United States Laboratory of Thalamus Research, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, 1083, Hungary Cited By :75 Export Date: 20 April 2021 CODEN: TNSCD Correspondence Address: Halassa, M.M.United States; email: michael.halassa@nyumc.org Funding details: KTIA_13_NAP-A-I/1 Funding details: National Institutes of Health, NIH Funding details: National Institute of Mental Health, NIMH, R01MH107680 Funding details: National Institute of Neurological Disorders and Stroke, NINDS, R00NS078115 Funding details: Brain and Behavior Research Foundation, BBRF Funding details: Alfred P. Sloan Foundation Funding details: Simons Foundation, SF Funding details: Esther A. and Joseph Klingenstein Fund Funding details: Wellcome Trust, WT, WT094513 Funding details: Human Frontier Science Program, HFSP Funding details: Nemzeti Kutatási Fejlesztési és Innovációs Hivatal, NKFIH, NKFI 109754 Funding text 1: This work was supported by the National Research Development and Innovation Office (NKFI 109754) the Hungarian Brain Research Program (grant no. KTIA_13_NAP-A-I/1) and the Wellcome Trust (WT094513) to L.A., and grants from the US National Institute of Health (NIMH, NINDS), Brain and Behavior Foundation, Feldstein Foundation, Human Frontiers Science Program, Klingenstein Foundation, Sloan Foundation, and Simons Foundations to M.M.H. New York University Neuroscience Institute and the Departments of Psychiatry, Neuroscience and Physiology, New York University Langone Medical Center, New York, 10016, United States Center for Neural Science, New York University, New York, 10016, United States Laboratory of Thalamus Research, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, 1083, Hungary Cited By :75 Export Date: 26 April 2021 CODEN: TNSCD Correspondence Address: Halassa, M.M.United States; email: michael.halassa@nyumc.org Funding details: KTIA_13_NAP-A-I/1 Funding details: National Institutes of Health, NIH Funding details: National Institute of Mental Health, NIMH, R01MH107680 Funding details: National Institute of Neurological Disorders and Stroke, NINDS, R00NS078115 Funding details: Brain and Behavior Research Foundation, BBRF Funding details: Alfred P. Sloan Foundation Funding details: Simons Foundation, SF Funding details: Esther A. and Joseph Klingenstein Fund Funding details: Wellcome Trust, WT, WT094513 Funding details: Human Frontier Science Program, HFSP Funding details: Nemzeti Kutatási Fejlesztési és Innovációs Hivatal, NKFIH, NKFI 109754 Funding text 1: This work was supported by the National Research Development and Innovation Office (NKFI 109754) the Hungarian Brain Research Program (grant no. KTIA_13_NAP-A-I/1) and the Wellcome Trust (WT094513) to L.A., and grants from the US National Institute of Health (NIMH, NINDS), Brain and Behavior Foundation, Feldstein Foundation, Human Frontiers Science Program, Klingenstein Foundation, Sloan Foundation, and Simons Foundations to M.M.H. AB - The thalamus is the major source of cortical inputs shaping sensation, action, and cognition. Thalamic circuits are targeted by two major inhibitory systems: the thalamic reticular nucleus (TRN) and extrathalamic inhibitory (ETI) inputs. A unifying framework of how these systems operate is currently lacking. Here, we propose that TRN circuits are specialized to exert thalamic control at different spatiotemporal scales. Local inhibition of thalamic spike rates prevails during attentional selection, whereas global inhibition more likely prevails during sleep. In contrast, the ETI (arising from basal ganglia, zona incerta (ZI), anterior pretectum, and pontine reticular formation) provides temporally precise and focal inhibition, impacting spike timing. Together, these inhibitory systems allow graded control of thalamic output, enabling thalamocortical operations to dynamically match ongoing behavioral demands. LA - English DB - MTMT ER -