@article{MTMT:34207759,
	title = {Several ways to wake you up by the thalamus},
	url = {https://m2.mtmt.hu/api/publication/34207759},
	author = {Acsády, László and Mátyás, Ferenc},
	doi = {10.1016/j.neuron.2023.09.020},
	journal-iso = {NEURON},
	journal = {NEURON},
	volume = {111},
	unique-id = {34207759},
	issn = {0896-6273},
	year = {2023},
	eissn = {1097-4199},
	pages = {3140-3142},
	orcid-numbers = {Mátyás, Ferenc/0000-0002-3903-8896}
}

@article{MTMT:33540834,
	title = {Region-selective control of the thalamic reticular nucleus via cortical layer 5 pyramidal cells},
	url = {https://m2.mtmt.hu/api/publication/33540834},
	author = {Hádinger, Nóra and Bősz, Emília and Tóth, Boglárka and Vantomme, Gil and Lüthi, Anita and Acsády, László},
	doi = {10.1038/s41593-022-01217-z},
	journal-iso = {NAT NEUROSCI},
	journal = {NATURE NEUROSCIENCE},
	volume = {26},
	unique-id = {33540834},
	issn = {1097-6256},
	abstract = {Corticothalamic pathways, responsible for the top-down control of the thalamus, have a canonical organization such that every cortical region sends output from both layer 6 (L6) and layer 5 (L5) to the thalamus. Here we demonstrate a qualitative, region-specific difference in the organization of mouse corticothalamic pathways. Specifically, L5 pyramidal cells of the frontal cortex, but not other cortical regions, establish monosynaptic connections with the inhibitory thalamic reticular nucleus (TRN). The frontal L5–TRN pathway parallels the L6–TRN projection but has distinct morphological and physiological features. The exact spike output of the L5-contacted TRN cells correlated with the level of cortical synchrony. Optogenetic perturbation of the L5–TRN connection disrupted the tight link between cortical and TRN activity. L5-driven TRN cells innervated thalamic nuclei involved in the control of frontal cortex activity. Our data show that frontal cortex functions require a highly specialized cortical control over intrathalamic inhibitory processes.},
	year = {2023},
	eissn = {1546-1726},
	pages = {116-130},
	orcid-numbers = {Lüthi, Anita/0000-0002-4954-4143}
}

@{MTMT:33592480,
	title = {Organization of Thalamic Inputs},
	url = {https://m2.mtmt.hu/api/publication/33592480},
	author = {Acsády, László},
	booktitle = {The Thalamus},
	doi = {10.1017/9781108674287.003},
	unique-id = {33592480},
	keywords = {glutamate; terminals; GABA; electron microscopy; convergence; integration; Thalamocortical; corticothalamic; canonical; modular},
	year = {2022},
	pages = {27-44}
}

@article{MTMT:30850756,
	title = {Control of aversion by glycine-gated GluN1/GluN3A NMDA receptors in the adult medial habenula.},
	url = {https://m2.mtmt.hu/api/publication/30850756},
	author = {Otsu, Y and Darcq, E and Pietrajtis, K and Mátyás, Ferenc and Schwartz, E and Bessaih, T and Abi, Gerges S and Rousseau, C V and Grand, T and Dieudonne, S and Paoletti, P and Acsády, László and Agulhon, C and Kieffer, B L and Diana, M A},
	doi = {10.1126/science.aax1522},
	journal-iso = {SCIENCE},
	journal = {SCIENCE},
	volume = {366},
	unique-id = {30850756},
	issn = {0036-8075},
	abstract = {The unconventional N-methyl-d-aspartate (NMDA) receptor subunits GluN3A and GluN3B can, when associated with the other glycine-binding subunit GluN1, generate excitatory conductances purely activated by glycine. However, functional GluN1/GluN3 receptors have not been identified in native adult tissues. We discovered that GluN1/GluN3A receptors are operational in neurons of the mouse adult medial habenula (MHb), an epithalamic area controlling aversive physiological states. In the absence of glycinergic neuronal specializations in the MHb, glial cells tuned neuronal activity via GluN1/GluN3A receptors. Reducing GluN1/GluN3A receptor levels in the MHb prevented place-aversion conditioning. Our study extends the physiological and behavioral implications of glycine by demonstrating its control of negatively valued emotional associations via excitatory glycinergic NMDA receptors.},
	year = {2019},
	eissn = {1095-9203},
	pages = {250-254},
	orcid-numbers = {Mátyás, Ferenc/0000-0002-3903-8896}
}

@article{MTMT:30309774,
	title = {A highly collateralized thalamic cell type with arousal-predicting activity serves as a key hub for graded state transitions in the forebrain},
	url = {https://m2.mtmt.hu/api/publication/30309774},
	author = {Mátyás, Ferenc and Komlósi, Gergely and Babiczky, Ákos and Kocsis, Kinga and Barthó, Péter and Barsy, Boglárka and Dávid, Csaba and Kanti, Vivien Ildikó and Porrero, C. and Magyar, Aletta and Szűcs, I. and Clasca, F. and Acsády, László},
	doi = {10.1038/s41593-018-0251-9},
	journal-iso = {NAT NEUROSCI},
	journal = {NATURE NEUROSCIENCE},
	volume = {21},
	unique-id = {30309774},
	issn = {1097-6256},
	abstract = {Sleep cycles consist of rapid alterations between arousal states, including transient perturbation of sleep rhythms, microarousals, and full-blown awake states. Here we demonstrate that the calretinin (CR)-containing neurons in the dorsal medial thalamus (DMT) constitute a key diencephalic node that mediates distinct levels of forebrain arousal. Cell-type-specific activation of DMT/CR+ cells elicited active locomotion lasting for minutes, stereotyped microarousals, or transient disruption of sleep rhythms, depending on the parameters of the stimulation. State transitions could be induced in both slow-wave and rapid eye-movement sleep. The DMT/CR+ cells displayed elevated activity before arousal, received selective subcortical inputs, and innervated several forebrain sites via highly branched axons. Together, these features enable DMT/CR+ cells to summate subcortical arousal information and effectively transfer it as a rapid, synchronous signal to several forebrain regions to modulate the level of arousal. © 2018, The Author(s), under exclusive licence to Springer Nature America, Inc.},
	year = {2018},
	eissn = {1546-1726},
	pages = {1551-1562},
	orcid-numbers = {Mátyás, Ferenc/0000-0002-3903-8896; Babiczky, Ákos/0000-0001-5848-7374; Kanti, Vivien Ildikó/0000-0003-4715-3883; Magyar, Aletta/0000-0002-2644-4182}
}

@article{MTMT:3398238,
	title = {Heartless beat or beatless heart?},
	url = {https://m2.mtmt.hu/api/publication/3398238},
	author = {Acsády, László},
	doi = {10.1038/s41593-018-0140-2},
	journal-iso = {NAT NEUROSCI},
	journal = {NATURE NEUROSCIENCE},
	volume = {21},
	unique-id = {3398238},
	issn = {1097-6256},
	year = {2018},
	eissn = {1546-1726},
	pages = {649-651}
}

@article{MTMT:3356704,
	title = {Synaptic scaling in sleep},
	url = {https://m2.mtmt.hu/api/publication/3356704},
	author = {Acsády, László and Harris, KD},
	doi = {10.1126/science.aam7917},
	journal-iso = {SCIENCE},
	journal = {SCIENCE},
	volume = {355},
	unique-id = {3356704},
	issn = {0036-8075},
	year = {2017},
	eissn = {1095-9203},
	pages = {457-457}
}

@article{MTMT:3356700,
	title = {The thalamic paradox.},
	url = {https://m2.mtmt.hu/api/publication/3356700},
	author = {Acsády, László},
	doi = {10.1038/nn.4583},
	journal-iso = {NAT NEUROSCI},
	journal = {NATURE NEUROSCIENCE},
	volume = {20},
	unique-id = {3356700},
	issn = {1097-6256},
	year = {2017},
	eissn = {1546-1726},
	pages = {901-902}
}

@article{MTMT:3341635,
	title = {Distinct Thalamic Reticular Cell Types Differentially Modulate Normal and Pathological Cortical Rhythms},
	url = {https://m2.mtmt.hu/api/publication/3341635},
	author = {Clemente-Perez, A and Makinson, SR and Higashikubo, B and Brovarney, S and Cho, FS and Urry, A and Holden, SS and Wimer, M and Dávid, Csaba and Fenno, LE and Acsády, László and Deisseroth, K and Paz, JT},
	doi = {10.1016/j.celrep.2017.05.044},
	journal-iso = {CELL REP},
	journal = {CELL REPORTS},
	volume = {19},
	unique-id = {3341635},
	issn = {2211-1247},
	abstract = {Integrative brain functions depend on widely distributed, rhythmically coordinated computations. Through its long-ranging connections with cortex and most senses, the thalamus orchestrates the flow of cognitive and sensory information. Essential in this process, the nucleus reticularis thalami (nRT) gates different information streams through its extensive inhibition onto other thalamic nuclei, however, we lack an understanding of how different inhibitory neuron subpopulations in nRT function as gatekeepers. We dissociated the connectivity, physiology, and circuit functions of neurons within rodent nRT, based on parvalbumin (PV) and somatostatin (SOM) expression, and validated the existence of such populations in human nRT. We found that PV, but not SOM, cells are rhythmogenic, and that PV and SOM neurons are connected to and modulate distinct thalamocortical circuits. Notably, PV, but not SOM, neurons modulate somatosensory behavior and disrupt seizures. These results provide a conceptual framework for how nRT may gate incoming information to modulate brain-wide rhythms.},
	keywords = {IN-VIVO; NEURONS; EPILEPSY; OSCILLATIONS; DISCHARGES; GLOBUS-PALLIDUS; NETWORK SYNCHRONY; NUCLEUS-RETICULARIS; RECIPROCAL INHIBITORY CONNECTIONS; rat},
	year = {2017},
	eissn = {2211-1247},
	pages = {2130-2142}
}

@article{MTMT:3206618,
	title = {Thalamic Inhibition: Diverse Sources, Diverse Scales.},
	url = {https://m2.mtmt.hu/api/publication/3206618},
	author = {Halassa, MM and Acsády, László},
	doi = {10.1016/j.tins.2016.08.001},
	journal-iso = {TRENDS NEUROSCI},
	journal = {TRENDS IN NEUROSCIENCES},
	volume = {39},
	unique-id = {3206618},
	issn = {0166-2236},
	abstract = {The thalamus is the major source of cortical inputs shaping sensation, action, and cognition. Thalamic circuits are targeted by two major inhibitory systems: the thalamic reticular nucleus (TRN) and extrathalamic inhibitory (ETI) inputs. A unifying framework of how these systems operate is currently lacking. Here, we propose that TRN circuits are specialized to exert thalamic control at different spatiotemporal scales. Local inhibition of thalamic spike rates prevails during attentional selection, whereas global inhibition more likely prevails during sleep. In contrast, the ETI (arising from basal ganglia, zona incerta (ZI), anterior pretectum, and pontine reticular formation) provides temporally precise and focal inhibition, impacting spike timing. Together, these inhibitory systems allow graded control of thalamic output, enabling thalamocortical operations to dynamically match ongoing behavioral demands.},
	year = {2016},
	eissn = {1878-108X},
	pages = {680-693}
}