TY - JOUR AU - Verster, Kirsten I. AU - Cinege, Gyöngyi Ilona AU - Lipinszki, Zoltán AU - Magyar, Lilla Brigitta AU - Kurucz, Judit Éva AU - Tarnopol, Rebecca L. AU - Ábrahám, Edit AU - Darula, Zsuzsanna AU - Karageorgi, Marianthi AU - Tamsil, Josephine A. AU - Akalu, Saron M. AU - Andó, István AU - Whiteman, Noah K. TI - Evolution of insect innate immunity through domestication of bacterial toxins JF - PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA J2 - P NATL ACAD SCI USA VL - 120 PY - 2023 IS - 16 PG - 9 SN - 0027-8424 DO - 10.1073/pnas.2218334120 UR - https://m2.mtmt.hu/api/publication/33744872 ID - 33744872 N1 - Department of Integrative Biology, University of California, Berkeley, CA 94720, United States Innate Immunity Group, Institute of Genetics, Biological Research Centre, Eötvös Loránd Research Network, Szeged, 6726, Hungary MTA SZBK Lendület Laboratory of Cell Cycle Regulation, Institute of Biochemistry, Biological Research Centre, Eötvös Loránd Research Network, Szeged, 6726, Hungary Doctoral School of Biology, University of Szeged, Szeged, 6720, Hungary Department of Plant and Microbial Biology, University of California, Berkeley, CA 94720, United States Single Cell Omics Advanced Core Facility, Hungarian Centre of Excellence for Molecular Medicine, Szeged, 6728, Hungary Laboratory of Proteomics Research, Biological Research Centre, Eötvös Loránd Research Network, Szeged, 6726, Hungary Department of Biology, Stanford University, Palo Alto, CA 94305, United States Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, United States Helen Wills Neuroscience Institute, University of California, Berkeley, CA 94720, United States Cited By :2 Export Date: 10 July 2023 CODEN: PNASA Correspondence Address: Andó, I.; Innate Immunity Group, Hungary; email: ando@brc.hu Correspondence Address: Whiteman, N.K.; Department of Integrative Biology, United States; email: whiteman@berkeley.edu AB - Toxin cargo genes are often horizontally transferred by phages between bacterial species and are known to play an important role in the evolution of bacterial pathogenesis. Here, we show how these same genes have been horizontally transferred from phage or bacteria to animals and have resulted in novel adaptations. We discovered that two widespread bacterial genes encoding toxins of animal cells, cytolethal distending toxin subunit B ( cdtB ) and apoptosis-inducing protein of 56 kDa ( aip56) , were captured by insect genomes through horizontal gene transfer from bacteria or phages. To study the function of these genes in insects, we focused on Drosophila ananassae as a model. In the D. ananassae subgroup species, cdtB and aip56 are present as singular ( cdtB ) or fused copies ( cdtB::aip56 ) on the second chromosome. We found that cdtB and aip56 genes and encoded proteins were expressed by immune cells, some proteins were localized to the wasp embryo’s serosa, and their expression increased following parasitoid wasp infection. Species of the ananassae subgroup are highly resistant to parasitoid wasps, and we observed that D. ananassae lines carrying null mutations in cdtB and aip56 toxin genes were more susceptible to parasitoids than the wild type. We conclude that toxin cargo genes were captured by these insects millions of years ago and integrated as novel modules into their innate immune system. These modules now represent components of a heretofore undescribed defense response and are important for resistance to parasitoid wasps. Phage or bacterially derived eukaryotic toxin genes serve as macromutations that can spur the instantaneous evolution of novelty in animals. LA - English DB - MTMT ER - TY - JOUR AU - Magyar, Lilla Brigitta AU - Cinege, Gyöngyi Ilona AU - Kovács, A AU - Lerner, Z AU - Juhász, G AU - Lukacsovich, D AU - Jochen, W AU - Lukacsovich, T AU - Hegedűs, Z AU - Kurucz, Judit Éva AU - Hultmark, D AU - Földy, C AU - Andó, István TI - A sokmagvú óriás vérsejtek által kifejtett hatékony immunválaszt komplex morfológiai és genetikai analízise JF - IMMUNOLÓGIAI SZEMLE J2 - IMMUNOLÓGIAI SZEMLE VL - 14 PY - 2022 IS - 3 SP - 35 SN - 2061-0203 UR - https://m2.mtmt.hu/api/publication/33753829 ID - 33753829 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Cinege, Gyöngyi Ilona AU - Verster, KI AU - Lipinszki, Z AU - Ábrahám, E AU - Magyar, Lilla Brigitta AU - Tarnopol, R AU - Darula, Z AU - Kurucz, Judit Éva AU - Noah, W AU - Andó, István TI - Új modulok a veleszületett immunitásban: prokarióta eredetű domesztikált gének JF - IMMUNOLÓGIAI SZEMLE J2 - IMMUNOLÓGIAI SZEMLE VL - 14 PY - 2022 IS - 3 SP - 7 SN - 2061-0203 UR - https://m2.mtmt.hu/api/publication/33753813 ID - 33753813 LA - Hungarian DB - MTMT ER - TY - CHAP AU - Jáger, Olivér AU - Nagy, Gábor AU - Varga, Mónika AU - Sinka, Rita AU - Kurucz, Judit Éva AU - Andó, István AU - Vágvölgyi, Csaba AU - Papp, Tamás ED - Allaga, Henrietta ED - Balázs, Dóra Krisztina ED - Jáger, Olivér ED - Kovács, Terézia ED - Nagy, Viktor Dávid TI - Investigation of the potential roles of survival factor genes in Mucor circinelloides T2 - Természettudományok helyzete hazánkban PB - Doktoranduszok Országos Szövetsége (DOSZ) CY - Budapest SN - 9786158205436 PY - 2022 SP - 29 EP - 31 PG - 3 UR - https://m2.mtmt.hu/api/publication/33098713 ID - 33098713 LA - English DB - MTMT ER - TY - JOUR AU - Urbanek Krajnc, Andreja AU - Bakonyi, Tamás AU - Andó, István AU - Kurucz, Judit Éva AU - Solymosi, Norbert AU - Pongrac, Paula AU - Bercic, Rebeka Lucijana TI - The Effect of Feeding with Central European Local Mulberry Genotypes on the Development and Health Status of Silkworms and Quality Parameters of Raw Silk JF - INSECTS J2 - INSECTS VL - 13 PY - 2022 IS - 9 SN - 2075-4450 DO - 10.3390/insects13090836 UR - https://m2.mtmt.hu/api/publication/33093548 ID - 33093548 N1 - Funding Agency and Grant Number: Hungarian Scientific Research Fund [OTKA SNN 116993]; Slovenian Research Agency (ARRS) [N1-0041, P-0164, P1-0212, J4-3091] Funding text: This research was funded by Hungarian Scientific Research Fund (OTKA SNN 116993) and Slovenian Research Agency (ARRS, N1-0041, P-0164, P1-0212, J4-3091). AB - Silkworm rearing activities ceased in the 1970′s in several European countries. Attempts on the re-establishment of ecological and sustainable sericulture in Slovenia and Hungary are ongoing. The aim of the study was to assess the usability of locally adapted mulberry genotypes for sericulture and to estimate connections between leaf compound and silkworm performance parameters. A controlled feeding experiment of silkworms was performed to test the influence of leaves from selected trees on the growth of larvae, the health and microbiological status of larvae (e.g., gut bacterial microbiome, Bombyx mori nucleopolyhedrovirus infection), weight of cocoons and raw silk parameters. The Slovenian and Hungarian mulberry genotypes had significantly higher total protein contents, and lower total phenolic contents and differed significantly in some individual phenolics compared to the reference sericultural and fruit varieties. Significant differences were found in the contents of the macro- and microelements, namely S, Mn, Fe, and Sr. Based on correlative statistics and multivariate analysis, a combined positive influence of proteins, specific phenolics, and microelements on larval growth and silk thread parameters was predicted. The results of the study indicate that selected local Slovenian and Hungarian mulberry varieties are suitable for high-quality silk cocoon and raw silk production. LA - English DB - MTMT ER - TY - JOUR AU - Cinege, Gyöngyi Ilona AU - Magyar, Lilla Brigitta AU - Kovács, Attila Lajos AU - Lerner, Zita AU - Juhász, Gábor AU - Lukacsovich, David AU - Winterer, Jochen AU - Lukacsovich, Tamás AU - Hegedűs, Zoltán AU - Kurucz, Judit Éva AU - Hultmark, Dan AU - Földy, Csaba AU - Andó, István TI - Broad Ultrastructural and Transcriptomic Changes Underlie the Multinucleated Giant Hemocyte Mediated Innate Immune Response against Parasitoids JF - JOURNAL OF INNATE IMMUNITY J2 - J INNATE IMMUN VL - 14 PY - 2022 IS - 4 SP - 335 EP - 354 PG - 20 SN - 1662-811X DO - 10.1159/000520110 UR - https://m2.mtmt.hu/api/publication/32524824 ID - 32524824 N1 - * Megosztott szerzőség LA - English DB - MTMT ER - TY - JOUR AU - Jáger, Olivér AU - Nagy, Gábor AU - Varga, Mónika AU - Sinka, Rita AU - Kurucz, Judit Éva AU - Andó, István AU - Vágvölgyi, Csaba AU - Papp, Tamás TI - Caracterisation of Survival factor genes in Mucor circinelloides JF - ACTA MICROBIOLOGICA ET IMMUNOLOGICA HUNGARICA J2 - ACTA MICROBIOL IMMUNOL HUNG VL - 68 PY - 2021 IS - Suppl. 1 SP - 74 EP - 75 PG - 2 SN - 1217-8950 UR - https://m2.mtmt.hu/api/publication/33098798 ID - 33098798 LA - English DB - MTMT ER - TY - JOUR AU - Magyar, Lilla Brigitta AU - Cinege, Gyöngyi Ilona AU - Kovacs, A AU - Lerner, Z AU - Juhasz, G AU - Lukacsovich, D AU - Jochen, W AU - Lukacsovich, T AU - Hegedus, Z AU - Kurucz, Judit Éva AU - Dan, H AU - Foldy, C AU - Andó, István TI - A sokmagvú óriás vérsejtek által közvetített hatékony immunválaszt megalapozó, széleskörű ultrastrukturális és génexpressziós változások JF - IMMUNOLÓGIAI SZEMLE J2 - IMMUNOLÓGIAI SZEMLE VL - 13 PY - 2021 IS - 3 SP - 15 EP - 16 PG - 2 SN - 2061-0203 UR - https://m2.mtmt.hu/api/publication/32646522 ID - 32646522 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Cinege, Gyöngyi Ilona AU - Kirsten, IV AU - Lipinszki, Z AU - Magyar, Lilla Brigitta AU - Tarnopol, R AU - Noah, W AU - Kurucz, Judit Éva AU - Andó, István TI - A horizontális géntranszfer szerepe a veleszületett immunitás evolúciójában JF - IMMUNOLÓGIAI SZEMLE J2 - IMMUNOLÓGIAI SZEMLE VL - 13 PY - 2021 IS - 3 SP - 7 EP - 8 PG - 2 SN - 2061-0203 UR - https://m2.mtmt.hu/api/publication/32646505 ID - 32646505 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Balog, József Ágoston AU - Honti, Viktor AU - Kurucz, Judit Éva AU - Kari, Beáta AU - Puskás, László AU - Andó, István AU - Szebeni, Gábor TI - Immunoprofiling of Drosophila Hemocytes by Single-cell Mass Cytometry JF - GENOMICS PROTEOMICS & BIOINFORMATICS J2 - GENOM PROTEOM BIOINF VL - 19 PY - 2021 IS - 2 SP - 243 EP - 252 PG - 10 SN - 1672-0229 DO - 10.1016/j.gpb.2020.06.022 UR - https://m2.mtmt.hu/api/publication/31940120 ID - 31940120 N1 - Funding Agency and Grant Number: National Research, Development and Innovation Office, HungaryNational Research, Development & Innovation Office (NRDIO) - Hungary [GINOP-2.3.2-15-2016-00001, GINOP-2.3.2-152016-00030, GINOP-2.3.2-15-2016-00035, NKFI NN118207, NKFI K120142, NKFI 120140, OTKA K-131484]; New National Excellence Program of the Ministry for Innovation and Technology, Hungary [UNKP-19-4-SZTE-36]; Janos Bolyai Research Scholarship of the Hungarian Academy of SciencesHungarian Academy of Sciences [BO/00139/17/8] Funding text: This work was supported by the grants from the National Research, Development and Innovation Office, Hungary (Grant Nos. GINOP-2.3.2-15-2016-00001, GINOP-2.3.2-152016-00030 to LGP, GINOP-2.3.2-15-2016-00035 to E ' K, NKFI NN118207 and NKFI K120142 to IA, NKFI 120140 to E ' K, and OTKA K-131484 to VH). Ga ' bor J. Szebeni was supported by the New National Excellence Program of the Ministry for Innovation and Technology, Hungary (Grant No. UNKP-19-4-SZTE-36) and by the Ja ' nos Bolyai Research Scholarship of the Hungarian Academy of Sciences (Grant No. BO/00139/17/8). We are grateful to Mrs. Olga Kovalcsik for the technical help. LA - English DB - MTMT ER -