@article{MTMT:34732660,
	title = {CORRELATIONS BETWEEN SERUM AFAMIN AND LIPID PARAMETERS IN OBESE TYPE 2 DIABETIC PATIENTS},
	url = {https://m2.mtmt.hu/api/publication/34732660},
	author = {Lőrincz, Hajnalka and Ratku, Balázs and Ötvös, T. and Szentpéteri, Anita and Seres, Ildikó and Paragh, György and Harangi, Mariann and Somodi, Sándor},
	journal-iso = {ATHEROSCLEROSIS},
	journal = {ATHEROSCLEROSIS},
	volume = {379},
	unique-id = {34732660},
	issn = {0021-9150},
	year = {2023},
	eissn = {1879-1484},
	pages = {S104-S104},
	orcid-numbers = {Somodi, Sándor/0000-0002-3615-2300}
}

@article{MTMT:34693667,
	title = {Association of HDL subfraction profile with the progression of insulin resistance},
	url = {https://m2.mtmt.hu/api/publication/34693667},
	author = {Pikó, Péter and Kósa, Zsigmond and Sándor, János and Kovács, Nóra and Seres, Ildikó and Paragh, György and Ádány, Róza},
	journal-iso = {EUR J PUBLIC HEALTH},
	journal = {EUROPEAN JOURNAL OF PUBLIC HEALTH},
	volume = {33},
	unique-id = {34693667},
	issn = {1101-1262},
	year = {2023},
	eissn = {1464-360X}
}

@article{MTMT:34483385,
	title = {Gender-Dependent Associations between Serum Betatrophin Levels and Lipoprotein Subfractions in Diabetic and Nondiabetic Obese Patients},
	url = {https://m2.mtmt.hu/api/publication/34483385},
	author = {Lőrincz, Hajnalka and Bak-Csiha, Sára and Ratku, Balázs and Somodi, Sándor and Sztanek, Ferenc and Seres, Ildikó and Paragh, György and Harangi, Mariann},
	doi = {10.3390/ijms242216504},
	journal-iso = {INT J MOL SCI},
	journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES},
	volume = {24},
	unique-id = {34483385},
	issn = {1661-6596},
	abstract = {Betatrophin, also known as angiopoietin-like protein 8 (ANGPTL8), mainly plays a role in lipid metabolism. To date, associations between betatrophin and lipoprotein subfractions are poorly investigated. For this study, 50 obese patients with type 2 diabetes (T2D) and 70 nondiabetic obese (NDO) subjects matched in gender, age, and body mass index (BMI) as well as 49 gender- and age-matched healthy, normal-weight controls were enrolled. Serum betatrophin levels were measured with ELISA, and lipoprotein subfractions were analyzed using Lipoprint gel electrophoresis. Betatrophin concentrations were found to be significantly higher in the T2D and NDO groups compared to the controls in all subjects and in females, but not in males. We found significant positive correlations between triglyceride, very low density lipoprotein (VLDL), large LDL (low density lipoprotein), small LDL, high density lipoprotein (HDL) -6-10 subfractions, and betatrophin, while negative correlations were detected between betatrophin and IDL, mean LDL size, and HDL-1-5. Proportion of small HDL was the best predictor of betatrophin in all subjects. Small LDL and large HDL subfractions were found to be the best predictors in females, while in males, VLDL was found to be the best predictor of betatrophin. Our results underline the significance of serum betatrophin measurement in the cardiovascular risk assessment of obese patients with and without T2D, but gender differences might be taken into consideration.},
	year = {2023},
	eissn = {1422-0067},
	orcid-numbers = {Somodi, Sándor/0000-0002-3615-2300}
}

@article{MTMT:34323884,
	title = {Association of HDL-C subfraction profile with the progression of insulin resistance},
	url = {https://m2.mtmt.hu/api/publication/34323884},
	author = {Pikó, Péter and Kósa, Zsigmond and Sándor, János and Seres, Ildikó and Paragh, György and Ádány, Róza},
	doi = {10.1016/j.atherosclerosis.2023.06.244},
	journal-iso = {ATHEROSCLEROSIS},
	journal = {ATHEROSCLEROSIS},
	volume = {379},
	unique-id = {34323884},
	issn = {0021-9150},
	year = {2023},
	eissn = {1879-1484},
	pages = {S60-S61}
}

@article{MTMT:34214638,
	title = {Assessment of amino-terminal C-type natriuretic peptide serum level and its correlation with high-density lipoprotein structure and function in patients with end stage renal disease before and after kidney transplantation},
	url = {https://m2.mtmt.hu/api/publication/34214638},
	author = {Szentimrei, R. and Lőrincz, Hajnalka and Szentpéteri, Anita and Varga, V.E. and Seres, Ildikó and Varga, Éva and Nemes, Balázs and Harangi, Mariann and Paragh, György},
	doi = {10.1016/j.cbi.2023.110749},
	journal-iso = {CHEM-BIOL INTERACT},
	journal = {CHEMICO-BIOLOGICAL INTERACTIONS},
	volume = {385},
	unique-id = {34214638},
	issn = {0009-2797},
	year = {2023},
	eissn = {1872-7786},
	orcid-numbers = {Varga, Éva/0000-0003-2716-0541}
}

@article{MTMT:34138623,
	title = {Association of HDL Subfraction Profile with the Progression of Insulin Resistance},
	url = {https://m2.mtmt.hu/api/publication/34138623},
	author = {Pikó, Péter and Jenei, Tibor and Kósa, Zsigmond and Sándor, János and Kovács, Nóra and Seres, Ildikó and Paragh, György and Ádány, Róza},
	doi = {10.3390/ijms241713563},
	journal-iso = {INT J MOL SCI},
	journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES},
	volume = {24},
	unique-id = {34138623},
	issn = {1661-6596},
	abstract = {Type 2 diabetes mellitus (T2DM) is a major global public health problem, as it is associated with increased morbidity, mortality, and healthcare costs. Insulin resistance (IR) is a condition characterized by disturbances in carbohydrate and lipid metabolism that precedes T2DM. The aim of the present study was to investigate the association between HDL and its subfraction profile and the progression of IR, as assessed by the Homeostatic Model Assessment for IR (HOMA-IR) index, and to define cut-off values to identify an increased risk of IR. Individuals with a HOMA-IR greater than 3.63 were considered to have IR. The HDL subfractions were separated using the Lipoprint system, which identifies ten subfractions (HDL-1-10) in three subclasses as large (HDL-L), intermediate (HDL-I) and small (HDL-S). Analyses were performed on samples from 240 individuals without IR and 137 with IR from the Hungarian general and Roma populations. The HDL-1 to -6 subfractions and the HDL-L and -I classes showed a significant negative association with the progression and existence of IR. Among them, HDL-2 (B = −40.37, p = 2.08 × 10−11) and HDL-L (B = −14.85, p = 9.52 × 10−10) showed the strongest correlation. The optimal threshold was found to be 0.264 mmol/L for HDL-L and 0.102 mmol/L and above for HDL-2. Individuals with HDL-L levels below the reference value had a 5.1-fold higher risk of IR (p = 2.2 × 10−7), while those with HDL-2 levels had a 4.2-fold higher risk (p = 3.0 × 10−6). This study demonstrates that the HDL subfraction profile (especially the decrease in HDL-2 and -L) may be a useful marker for the early detection and intervention of atherogenic dyslipidemia in subjects with impaired glucose and insulin metabolism.},
	year = {2023},
	eissn = {1422-0067}
}

@article{MTMT:34087371,
	title = {Az organokinek szintjének vizsgálata elhízott 2-es típusú diabéteszes és elhízott nem diabéteszes betegekben},
	url = {https://m2.mtmt.hu/api/publication/34087371},
	author = {Lőrincz, Hajnalka and Ratku, Balázs and Bak-Csiha, Sára and Seres, Ildikó and Szabó, Zoltán and Katona, Éva Melitta and Paragh, György and Harangi, Mariann and Somodi, Sándor},
	journal-iso = {DIABETOLOGIA HUNGARICA},
	journal = {DIABETOLOGIA HUNGARICA},
	volume = {31},
	unique-id = {34087371},
	issn = {1217-372X},
	year = {2023},
	eissn = {2560-0168},
	pages = {48-49},
	orcid-numbers = {Somodi, Sándor/0000-0002-3615-2300}
}

@article{MTMT:34027446,
	title = {Association of CETP Gene Polymorphisms and Haplotypes with Cardiovascular Risk},
	url = {https://m2.mtmt.hu/api/publication/34027446},
	author = {Pikó, Péter and Jenei, Tibor and Kósa, Zsigmond and Sándor, János and Kovács, Nóra and Seres, Ildikó and Paragh, György and Ádány, Róza},
	doi = {10.3390/ijms241210281},
	journal-iso = {INT J MOL SCI},
	journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES},
	volume = {24},
	unique-id = {34027446},
	issn = {1661-6596},
	abstract = {Cholesteryl ester transfer protein (CETP) is known to influence HDL-C levels, potentially altering the profile of HDL subfractions and consequently cardiovascular risk (CVR). This study aimed to investigate the effect of five single-nucleotide polymorphisms (SNPs; rs1532624, rs5882, rs708272, rs7499892, and rs9989419) and their haplotypes (H) in the CETP gene on 10-year CVR estimated by the Systematic Coronary Risk Evaluation (SCORE), the Framingham Risk Score for Coronary Heart Disease (FRSCHD) and Cardiovascular Disease (FRSCVD) algorithms. Adjusted linear and logistic regression analyses were used to investigate the association of SNPs and 10 haplotypes (H1–H10) on 368 samples from the Hungarian general and Roma populations. The T allele of rs7499892 showed a significant association with increased CVR estimated by FRS. H5, H7, and H8 showed a significant association with increased CVR based on at least one of the algorithms. The impact of H5 was due to its effect on TG and HDL-C levels, while H7 showed a significant association with FRSCHD and H8 with FRSCVD mediated by a mechanism affecting neither TG nor HDL-C levels. Our results suggest that polymorphisms in the CETP gene may have a significant effect on CVR and that this is not mediated exclusively by their effect on TG and HDL-C levels but also by presently unknown mechanisms.},
	year = {2023},
	eissn = {1422-0067},
	orcid-numbers = {Pikó, Péter/0000-0001-5539-907X}
}

@article{MTMT:33671118,
	title = {Impaired Organokine Regulation in Non-Diabetic Obese Subjects: Halfway to the Cardiometabolic Danger Zone},
	url = {https://m2.mtmt.hu/api/publication/33671118},
	author = {Lőrincz, Hajnalka and Ratku, Balázs and Bak-Csiha, Sára and Seres, Ildikó and Szabó, Zoltán and Paragh, György and Harangi, Mariann and Somodi, Sándor},
	doi = {10.3390/ijms24044115},
	journal-iso = {INT J MOL SCI},
	journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES},
	volume = {24},
	unique-id = {33671118},
	issn = {1661-6596},
	abstract = {Altered organokine expression contributes to increased cardiometabolic risk in obesity. Our aim was to evaluate the associations of serum afamin with glucose homeostasis, atherogenic dyslipidemia, and other adipokines in severe obesity to clarify the early metabolic alterations. 106 non-diabetic obese (NDO) subjects and 62 obese patients with type 2 diabetes matched for age, gender, and body mass index (BMI) were enrolled in this study. We compared their data with 49 healthy, lean controls. Serum afamin and retinol-binding protein 4 (RBP4), as well as plasma plasminogen activator inhibitor-1 (PAI-1), were measured with ELISA, and lipoprotein subfractions were analyzed using Lipoprint gel electrophoresis. Afamin and PAI-1 found to be significantly higher in the NDO and T2M group (p < 0.001 and p < 0.001, respectively) than in the controls. In contrast, RBP4 was unexpectedly lower in the NDO and T2DM group compared to controls (p < 0.001). Afamin showed negative correlations with mean LDL size and RBP4, but positive correlations with anthropometric, glucose/lipid parameters, and PAI-1 in both the overall patients and the in NDO + T2DM groups. BMI, glucose, intermediate HDL, and small HDL were predictors of afamin. Afamin may serve as a biomarker for the severity of cardiometabolic disturbances in obesity. The complexity of organokine patterns in NDO subjects draws attention to the diverse spectrum of obesity-related comorbidities.},
	year = {2023},
	eissn = {1422-0067},
	orcid-numbers = {Somodi, Sándor/0000-0002-3615-2300}
}

@article{MTMT:33204229,
	title = {Serum progranulin level in patients with newly diagnosed untreated familial hypercholesterolemia},
	url = {https://m2.mtmt.hu/api/publication/33204229},
	author = {Nádró, Bíborka and Lőrincz, Hajnalka and Juhász, L. and Szentpéteri, A. and Sztanek, Ferenc and Seres, Ildikó and Páll, Dénes and Fülöp, Péter and Paragh, György and Harangi, Mariann},
	doi = {10.1016/j.atherosclerosis.2022.06.706},
	journal-iso = {ATHEROSCLEROSIS},
	journal = {ATHEROSCLEROSIS},
	volume = {355},
	unique-id = {33204229},
	issn = {0021-9150},
	year = {2022},
	eissn = {1879-1484},
	pages = {166}
}