TY - JOUR AU - Poles, Marietta Zita AU - Bódi, Nikolett AU - Bagyánszki, Mária AU - Fekete, Éva AU - Tamás Mészáros, András AU - Varga, Gabriella AU - Szűcs, Szilárd AU - Nászai, Anna AU - Kiss, Liliána AU - Kozlov, Andrey AU - Boros, Mihály AU - Kaszaki, József TI - Reduction of gastrointestinal nitrosative stress by exogenous methane: neuroprotection through xanthine oxidoreductase inhibition JF - EUROPEAN SURGICAL RESEARCH J2 - EUR SURG RES VL - 59 PY - 2018 IS - Suppl 1. SP - 36 EP - 36 PG - 1 SN - 0014-312X UR - https://m2.mtmt.hu/api/publication/30482041 ID - 30482041 LA - English DB - MTMT ER - TY - JOUR AU - Poles, Marietta Zita AU - Bódi, Nikolett AU - Bagyánszki, Mária AU - Fekete, Éva AU - Mészáros, András AU - Varga, Gabriella AU - Szűcs, Szilárd AU - Nászai, Anna AU - Kiss, Liliána AU - Kozlov, Andrey V AU - Boros, Mihály AU - Kaszaki, József TI - Reduction of nitrosative stress by methane: Neuroprotection through xanthine oxidoreductase inhibition in a rat model of mesenteric ischemia-reperfusion JF - FREE RADICAL BIOLOGY AND MEDICINE J2 - FREE RADICAL BIO MED VL - 120 PY - 2018 SP - 160 EP - 169 PG - 10 SN - 0891-5849 DO - 10.1016/j.freeradbiomed.2018.03.024 UR - https://m2.mtmt.hu/api/publication/3351594 ID - 3351594 N1 - Megjegyzés-27360030 N1 Funding details: GINOP-2.3.2-15-2016-00015, IPM, Institute for Research in Fundamental Sciences N1 Funding details: EFOP-3.6.2-16-2017-00006, IPM, Institute for Research in Fundamental Sciences N1 Funding details: TSZ:34232-3/2016/INTFIN, Ministry of Human Resources and Social Security N1 Funding details: UNKP-17-2 N1 Funding details: NKFI K120232, HIIRO, Health Innovation, Investment and Research Office N1 Funding details: NKFI 116689, HIIRO, Health Innovation, Investment and Research Office N1 Funding text: The authors wish to thank Thomas Williams for the proof reading of the article, Csilla Mester and Nikolett Zádoriné Berettka for the skillful technical assistance. Supported by research grants from the National Research Development and Innovation Office , NKFI K120232, NKFI 116689 , the Hungarian Science Research Fund , GINOP-2.3.2-15-2016-00015, EFOP-3.6.2-16-2017-00006 , Ministry of Human Resources TSZ:34232-3/2016/INTFIN , and New National Excellence Program of the Hungarian Ministry of Human Capacities , UNKP-17-2 . Megjegyzés-27360032 N1 Funding details: GINOP-2.3.2-15-2016-00015, IPM, Institute for Research in Fundamental Sciences N1 Funding details: EFOP-3.6.2-16-2017-00006, IPM, Institute for Research in Fundamental Sciences N1 Funding details: TSZ:34232-3/2016/INTFIN, Ministry of Human Resources and Social Security N1 Funding details: UNKP-17-2 N1 Funding details: NKFI K120232, HIIRO, Health Innovation, Investment and Research Office N1 Funding details: NKFI 116689, HIIRO, Health Innovation, Investment and Research Office N1 Funding text: The authors wish to thank Thomas Williams for the proof reading of the article, Csilla Mester and Nikolett Zádoriné Berettka for the skillful technical assistance. Supported by research grants from the National Research Development and Innovation Office , NKFI K120232, NKFI 116689 , the Hungarian Science Research Fund , GINOP-2.3.2-15-2016-00015, EFOP-3.6.2-16-2017-00006 , Ministry of Human Resources TSZ:34232-3/2016/INTFIN , and New National Excellence Program of the Hungarian Ministry of Human Capacities , UNKP-17-2 . Megjegyzés-27360034 N1 Funding details: GINOP-2.3.2-15-2016-00015, IPM, Institute for Research in Fundamental Sciences N1 Funding details: EFOP-3.6.2-16-2017-00006, IPM, Institute for Research in Fundamental Sciences N1 Funding details: TSZ:34232-3/2016/INTFIN, Ministry of Human Resources and Social Security N1 Funding details: UNKP-17-2 N1 Funding details: NKFI K120232, HIIRO, Health Innovation, Investment and Research Office N1 Funding details: NKFI 116689, HIIRO, Health Innovation, Investment and Research Office N1 Funding text: The authors wish to thank Thomas Williams for the proof reading of the article, Csilla Mester and Nikolett Zádoriné Berettka for the skillful technical assistance. Supported by research grants from the National Research Development and Innovation Office , NKFI K120232, NKFI 116689 , the Hungarian Science Research Fund , GINOP-2.3.2-15-2016-00015, EFOP-3.6.2-16-2017-00006 , Ministry of Human Resources TSZ:34232-3/2016/INTFIN , and New National Excellence Program of the Hungarian Ministry of Human Capacities , UNKP-17-2 . Megjegyzés-27360043 N1 Funding details: GINOP-2.3.2-15-2016-00015, IPM, Institute for Research in Fundamental Sciences N1 Funding details: EFOP-3.6.2-16-2017-00006, IPM, Institute for Research in Fundamental Sciences N1 Funding details: TSZ:34232-3/2016/INTFIN, Ministry of Human Resources and Social Security N1 Funding details: UNKP-17-2 N1 Funding details: NKFI K120232, HIIRO, Health Innovation, Investment and Research Office N1 Funding details: NKFI 116689, HIIRO, Health Innovation, Investment and Research Office N1 Funding text: The authors wish to thank Thomas Williams for the proof reading of the article, Csilla Mester and Nikolett Zádoriné Berettka for the skillful technical assistance. Supported by research grants from the National Research Development and Innovation Office , NKFI K120232, NKFI 116689 , the Hungarian Science Research Fund , GINOP-2.3.2-15-2016-00015, EFOP-3.6.2-16-2017-00006 , Ministry of Human Resources TSZ:34232-3/2016/INTFIN , and New National Excellence Program of the Hungarian Ministry of Human Capacities , UNKP-17-2 . Megjegyzés-27360050 N1 Funding details: GINOP-2.3.2-15-2016-00015, IPM, Institute for Research in Fundamental Sciences N1 Funding details: EFOP-3.6.2-16-2017-00006, IPM, Institute for Research in Fundamental Sciences N1 Funding details: TSZ:34232-3/2016/INTFIN, Ministry of Human Resources and Social Security N1 Funding details: UNKP-17-2 N1 Funding details: NKFI K120232, HIIRO, Health Innovation, Investment and Research Office N1 Funding details: NKFI 116689, HIIRO, Health Innovation, Investment and Research Office N1 Funding text: The authors wish to thank Thomas Williams for the proof reading of the article, Csilla Mester and Nikolett Zádoriné Berettka for the skillful technical assistance. Supported by research grants from the National Research Development and Innovation Office , NKFI K120232, NKFI 116689 , the Hungarian Science Research Fund , GINOP-2.3.2-15-2016-00015, EFOP-3.6.2-16-2017-00006 , Ministry of Human Resources TSZ:34232-3/2016/INTFIN , and New National Excellence Program of the Hungarian Ministry of Human Capacities , UNKP-17-2 . LA - English DB - MTMT ER - TY - JOUR AU - Poles, Marietta Zita AU - Bódi, Nikolett AU - Bagyánszki, Mária AU - Fekete, Éva AU - Mészáros, András AU - Andrey, Kozlov AU - Boros, Mihály AU - Kaszaki, József TI - A metáninhaláció elősegíti a myentericus nitrerg neuronok régióspecifikus adaptivitását patkány ischemia/reperfúzió modellen JF - MAGYAR SEBÉSZET J2 - MAGYAR SEBÉSZET VL - 70 PY - 2017 IS - 3 SP - 268 EP - 268 PG - 1 SN - 0025-0295 UR - https://m2.mtmt.hu/api/publication/3314865 ID - 3314865 N1 - előadás LA - Hungarian DB - MTMT ER - TY - GEN AU - Poles, Marietta Zita AU - Bódi, Nikolett AU - Bagyánszki, Mária AU - Fekete, Éva AU - Mészáros, András AU - Kozlov, A AU - Boros, Mihály AU - Kaszaki, József ED - Boros, Mihály ED - Vladimir, Jakovljevic ED - Dragan, M Djuric TI - Methane Inhalation Enhances Adaptive Responses Of Nitrergic Neurons To Intestinal Ischemia-Reperfusion In A Region-Dependent Way In Rats PY - 2017 SP - 7 EP - 7 PG - 1 UR - https://m2.mtmt.hu/api/publication/3233709 ID - 3233709 LA - English DB - MTMT ER - TY - CHAP AU - Poles, Marietta Zita AU - Bódi, Nikolett AU - Talapka, Petra AU - Varga, Gabriella AU - Pál, Alexandra AU - Bagyánszki, Mária AU - Kaszaki, József AU - Fekete, Éva AU - Boros, Mihály ED - Csiszár, Imre ED - Kőmíves, Péter Miklós TI - Exogén metán hatása a myentericus nitrerg neuronok kvantitatív sajátságaira és a bélcsatorna motilitására mesenterális ischaemia-reperfúzió alatt kísérletes patkánymodellen T2 - Tavaszi Szél 2014 Konferencia = Spring Wind 2014: Konferenciakötet V. PB - Doktoranduszok Országos Szövetsége (DOSZ) CY - Debrecen SN - 9789638956095 PY - 2014 SP - 518 EP - 528 PG - 11 UR - https://m2.mtmt.hu/api/publication/3084698 ID - 3084698 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Bódi, Nikolett AU - Wirth, Roland AU - G, Maróti AU - Talapka, Petra AU - Fekete, Éva AU - K L, Kovács TI - Gut region-specific alterations in the composition of the intestinal microbiota in streptozotocin-induced diabetic rats JF - UNITED EUROPEAN GASTROENTEROLOGY JOURNAL J2 - UEG JOURNAL VL - 2 PY - 2014 IS - Suppl 1 SN - 2050-6406 UR - https://m2.mtmt.hu/api/publication/2870340 ID - 2870340 LA - English DB - MTMT ER - TY - JOUR AU - Talapka, Petra AU - Nagy, Lajos István AU - Pál, Alexandra AU - Poles, Marietta Zita AU - Magyariné, Berkó Anikó AU - Bagyánszki, Mária AU - Puskás, László AU - Fekete, Éva AU - Bódi, Nikolett TI - Alleviated mucosal and neuronal damage in a rat model of Crohn's disease JF - WORLD JOURNAL OF GASTROENTEROLOGY J2 - WORLD J LGASTROENTEROL VL - 20 PY - 2014 IS - 44 SP - 16690 EP - 16697 PG - 8 SN - 1007-9327 DO - 10.3748/wjg.v20.i44.16690 UR - https://m2.mtmt.hu/api/publication/2796003 ID - 2796003 N1 - Department of Physiology, Anatomy and Neuroscience, Faculty of Sciences and Informatics, University of Szeged, Közép fasor 52, Szeged, H-6726, Hungary Avidin Ltd., Also Kikötösor 11, Szeged, H-672, Hungary Cited By :6 Export Date: 21 February 2023 CODEN: WJGAF Correspondence Address: Bódi, N.; Department of Physiology, Közép fasor 52, Hungary Molecular Sequence Numbers: GENBANK: NM012580, NM012583; Chemicals/CAS: trinitrobenzenesulfonic acid, 16655-63-3, 2508-19-2; heme oxygenase, 9059-22-7; Heme Oxygenase (Decyclizing); Hmox1 protein, rat; RNA, Messenger; Trinitrobenzenesulfonic Acid Funding details: 108309 AB - AIM: To establish a rat model suitable to investigate the repetitive relapsing inflammations (RRI) characteristic to Crohn's disease. METHODS: Colitis was induced by 2,4,6-trinitrobenzenesulfonic acid (TNBS). RRI were mimicked by repeating administrations of TNBS. Tissue samples were taken from control, once, twice and three times treated rats from the inflamed and adjacent non-inflamed colonic segments at different timepoints during the acute intestinal inflammation. The means of the ulcerated area were measured to evaluate the macroscopic mu-cosal damage. The density of myenteric neurons was determined on whole mounts by HuC/HuD immunohistochemistry. Heme oxygenase-1 (HO-1) expression was evaluated by molecular biological techniques. RESULTS: TNBS-treated rats displayed severe colitis, but the mortality was negligible, and an increase of body weight was characteristic throughout the experimental period. The widespread loss of myenteric neurons, and marked but transient HO-1 up-regulation were demonstrated after the first TNBS administration. After repeated doses the length of the recovery time and extent of the ulcerous colonic segments were markedly decreased, and the neuronal loss was on a smaller scale and was limited to the inflamed area. HO-1 mRNA level was notably greater than after a single dose and overexpression was sustained throughout the timepoints examined. Nevertheless, the HO-1 protein up-regulation after the second TNBS treatment proved to be transient. Following the third treatment HO-1 protein expression could not be detected. CONCLUSION: Experimentally provoked RRI may exert a protective preconditioning effect against the mucosal and neuronal damage. The persistent up-regulation of HO-1 mRNA expression may correlate with this. (C) 2014 Baishideng Publishing Group Inc. All rights reserved. LA - English DB - MTMT ER - TY - JOUR AU - Wirth, Roland AU - Bódi, Nikolett AU - Maróti, Gergely AU - Bagyánszki, Mária AU - Talapka, Petra AU - Fekete, Éva AU - Bagi, Zoltán AU - Kovács, Kornél Lajos TI - Regionally Distinct Alterations in the Composition of the Gut Microbiota in Rats with Streptozotocin-Induced Diabetes JF - PLOS ONE J2 - PLOS ONE VL - 9 PY - 2014 IS - 12 PG - 15 SN - 1932-6203 DO - 10.1371/journal.pone.0110440 UR - https://m2.mtmt.hu/api/publication/2789092 ID - 2789092 AB - The aim of this study was to map the microbiota distribution along the gut and establish whether colon/faecal samples from diabetic rats adequately reflect the diabetic alterations in the microbiome. Streptozotocin-treated rats were used to model type 1 diabetes mellitus (T1D). Segments of the duodenum, ileum and colon were dissected, and the microbiome of the lumen material was analysed by using next-generation DNA sequencing, from phylum to genus level. The intestinal luminal contents were compared between diabetic, insulin-treated diabetic and healthy control rats. No significant differences in bacterial composition were found in the luminal contents from the duodenum of the experimental animal groups, whereas distinct patterns were seen in the ileum and colon, depending on the history of the luminal samples. Ileal samples from diabetic rats exhibited particularly striking alterations, while the richness and diversity obscured some of the modifications in the colon. Characteristic rearrangements in microbiome composition and diversity were detected after insulin treatment, though the normal gut flora was not restored. The Proteobacteria displayed more pronounced shifts than those of the predominant phyla (Firmicutes and Bacteroidetes) in the rat model of T1D. Diabetes and insulin replacement affect the composition of the gut microbiota in different, gut region-specific manners. The luminal samples from the ileum appear more suitable for diagnostic purposes than the colon/faeces. The Proteobacteria should be at the focus of diagnosis and potential therapy. Klebsiella are recommended as biomarkers of T1D. LA - English DB - MTMT ER - TY - JOUR AU - Poles, Marietta Zita AU - Mészáros, András AU - Bódi, Nikolett AU - Bagyánszki, Mária AU - Varga, Gabriella AU - Fekete, Éva AU - Kaszaki, József AU - Boros, Mihály TI - Effect of methane on gastrointestinal motility in ischemia-reperfusion JF - MAGYAR SEBÉSZET J2 - MAGYAR SEBÉSZET VL - 67 PY - 2014 IS - 3 SP - 235 EP - 236 PG - 2 SN - 0025-0295 UR - https://m2.mtmt.hu/api/publication/2727086 ID - 2727086 LA - English DB - MTMT ER - TY - JOUR AU - Bódi, Nikolett AU - Jancsó, Zsanett AU - Talapka, Petra AU - Pál, Alexandra AU - Poles, Marietta Zita AU - Bagyánszki, Mária AU - Hermesz, Edit AU - Fekete, Éva TI - Gut region-specific rearrangement of the cellular and subcellular compartments of nitric oxide synthase isoforms after chronic ethanol consumption in rats JF - HISTOLOGY AND HISTOPATHOLOGY J2 - HISTOL HISTOPATHOL VL - 29 PY - 2014 IS - 12 SP - 1547 EP - 1555 PG - 9 SN - 0213-3911 UR - https://m2.mtmt.hu/api/publication/2726239 ID - 2726239 LA - English DB - MTMT ER -