TY  - JOUR
AU  - Ecker, András
AU  - Bagi, Bence
AU  - Vértes, Eszter
AU  - Steinbach-Németh, Orsolya
AU  - Karlócai, Rita
AU  - Papp, Orsolya I
AU  - Miklós, István
AU  - Hájos, Norbert
AU  - Freund, Tamás
AU  - Gulyás, Attila
AU  - Káli, Szabolcs
TI  - Hippocampal sharp wave-ripples and the associated sequence replay emerge from structured synaptic interactions in a network model of area CA3
JF  - ELIFE
J2  - ELIFE
VL  - 11
PY  - 2022
PG  - 29
SN  - 2050-084X
DO  - 10.7554/eLife.71850
UR  - https://m2.mtmt.hu/api/publication/32660835
ID  - 32660835
AB  - Hippocampal place cells are activated sequentially as an animal explores its environment. These activity sequences are internally recreated ('replayed'), either in the same or reversed order, during bursts of activity (sharp wave-ripples [SWRs]) that occur in sleep and awake rest. SWR-associated replay is thought to be critical for the creation and maintenance of long-term memory. In order to identify the cellular and network mechanisms of SWRs and replay, we constructed and simulated a data-driven model of area CA3 of the hippocampus. Our results show that the chain-like structure of recurrent excitatory interactions established during learning not only determines the content of replay, but is essential for the generation of the SWRs as well. We find that bidirectional replay requires the interplay of the experimentally confirmed, temporally symmetric plasticity rule, and cellular adaptation. Our model provides a unifying framework for diverse phenomena involving hippocampal plasticity, representations, and dynamics, and suggests that the structured neural codes induced by learning may have greater influence over cortical network states than previously appreciated.
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Tóth, Krisztina
AU  - Lénárt, Nikolett
AU  - Berki, Péter
AU  - Fekete, Rebeka
AU  - Cserépné Szabadits, Eszter
AU  - Pósfai, Balázs
AU  - Cserép, Csaba
AU  - Alatshan, Ahmad
AU  - Benkő, Szilvia
AU  - Kiss, Dániel
AU  - Hübner, Christian A.
AU  - Gulyás, Attila
AU  - Kaila, Kai
AU  - Környei, Zsuzsanna
AU  - Dénes, Ádám
TI  - The NKCC1 ion transporter modulates microglial phenotype and inflammatory response to brain injury in a cell-autonomous manner
JF  - PLOS BIOLOGY
J2  - PLOS BIOL
VL  - 20
PY  - 2022
IS  - 1
PG  - 31
SN  - 1544-9173
DO  - 10.1371/journal.pbio.3001526
UR  - https://m2.mtmt.hu/api/publication/32636201
ID  - 32636201
N1  - Momentum Laboratory of Neuroimmunology, Institute of Experimental Medicine, Budapest, Hungary            
            János Szentágothai Doctoral School of Neurosciences, Semmelweis University, Budapest, Hungary            
            Laboratory of Cerebral Cortex Research, Institute of Experimental Medicine, Budapest, Hungary            
            Department of Physiology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary            
            Doctoral School of Molecular Cellular and Immune Biology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary            
            Software Engineering Institute, John von Neumann Faculty of Informatics, Óbuda University, Budapest, Hungary            
            University Hospital Jena, Friedrich Schiller University, Jena, Germany            
            Molecular and Integrative Biosciences and Neuroscience Center (HiLIFE), University of Helsinki, Helsinki, Finland            
            Export Date: 24 February 2022            
            CODEN: PBLIB            
            Correspondence Address: Dénes, Á.; Momentum Laboratory of Neuroimmunology, Hungary; email: denes.adam@koki.hu            
            Chemicals/CAS: bumetanide, 28395-03-1            
            Funding details: BO/00558/19/5, K131844, NKP-20 3-II, NKP-21-5, bolyai-janos-kutatasi-osztondij-105319            
            Funding details: Deutsche Forschungsgemeinschaft, DFG, SPP 1665            
            Funding details: Academy of Finland, AKA            
            Funding details: Bundesministerium für Bildung und Forschung, BMBF            
            Funding details: Magyar Tudományos Akadémia, MTA, 2019-2.1.7-ERA-NET-2020-00004, ERC-CoG 724994, LP2016-4/2016            
            Funding details: Sigrid Juséliuksen Säätiö            
            Funding details: Nemzeti Kutatási, Fejlesztési és Innovaciós Alap, NKFIA            
            Funding details: Neuron Nadační Fond Na Podporu Vědy, Neuron, ACRoBAT 01EW1706            
            Funding details: Magyarország Kormánya            
            Funding text 1: This work was supported by ?Momentum? research grant from the Hungarian Academy of Sciences (LP2016-4/2016 to A.D.; https://mta.hu/lendulet) and ERC-CoG 724994 (to A.D.; https://erc.europa.eu/), with contribution from 2019-2.1.7-ERA-NET-2020-00004 (https://nkfih. gov.hu). Additionally, this work was funded by Hungarian National Scientific Research Fund (NKFIH-OTKA Grant No. K131844 to S.B.), the J?nos Bolyai Research Scholarship of the Hungarian Academy of Sciences (to C.C. and N.L., BO/00558/19/5; https://mta.hu/bolyai-osztondij/ bolyai-janos-kutatasi-osztondij-105319), ?NKP-20 3-II (to B.P.) and ?NKP-21-5 (to C.C. and N.L.; http://www.unkp.gov.hu/unkp-rol) of the New National Excellence Program of the Ministry for Innovation and Technology, Hungary; German Research Foundation (SPP 1665; https://www.dfg. de/en/) and the Federal Ministry of Education and Research (NEURON ACRoBAT 01EW1706) to C.A. H.; and the Academy of Finland and Sigrid Jus?lius Foundation to K.K.. Prepared with the professional support of the Doctoral Scholarship Program of th Cooperative Doctoral Program of the Ministry of Innovation and Technology Financed from The National Research, Development and Innovation Fund (to B.P.). A.A. holds a Stipendium Hungaricum Scholarship from the Government of Hungary (https://stipendiumhungaricum.hu/). K. K.?s work was supported by the Academy of Finland and by the Sigrid Jus?lius Foundation. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. We thank J?nos Szabadics for his valuable remarks on the electrophysiology part of the manuscript; L?szl? Barna and the Nikon Imaging Center at the Institute of Experimental Medicine for kindly providing microscopy support; D?ra Gali-Gy?rkei for her excellent technical assistance; and the Cell Biology Center at the Institute of Experimental Medicine.
AB  - The NKCC1 ion transporter contributes to the pathophysiology of common neurological disorders, but its function in microglia, the main inflammatory cells of the brain, has remained unclear to date. Therefore, we generated a novel transgenic mouse line in which microglial NKCC1 was deleted. We show that microglial NKCC1 shapes both baseline and reactive microglia morphology, process recruitment to the site of injury, and adaptation to changes in cellular volume in a cell-autonomous manner via regulating membrane conductance. In addition, microglial NKCC1 deficiency results in NLRP3 inflammasome priming and increased production of interleukin-1β (IL-1β), rendering microglia prone to exaggerated inflammatory responses. In line with this, central (intracortical) administration of the NKCC1 blocker, bumetanide, potentiated intracortical lipopolysaccharide (LPS)-induced cytokine levels. In contrast, systemic bumetanide application decreased inflammation in the brain. Microglial NKCC1 KO animals exposed to experimental stroke showed significantly increased brain injury, inflammation, cerebral edema, and, worse, neurological outcome. Thus, NKCC1 emerges as an important player in controlling microglial ion homeostasis and inflammatory responses through which microglia modulate brain injury. The contribution of microglia to central NKCC1 actions is likely to be relevant for common neurological disorders.
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Laszlovszky, Tamás Kristóf
AU  - Schlingloff, Dániel
AU  - Hegedüs, Panna
AU  - Freund, Tamás
AU  - Gulyás, Attila
AU  - Kepecs, Adam
AU  - Hangya, Balázs
TI  - Distinct synchronization, cortical coupling and behavioral function of two basal forebrain cholinergic neuron types (vol 93, pg 513, 2020)
JF  - NATURE NEUROSCIENCE
J2  - NAT NEUROSCI
VL  - 23
PY  - 2020
IS  - 10
SP  - 1310
EP  - 1310
PG  - 1
SN  - 1097-6256
DO  - 10.1038/s41593-020-0702-y
UR  - https://m2.mtmt.hu/api/publication/31627527
ID  - 31627527
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Laszlovszky, Tamás Kristóf
AU  - Schlingloff, Dániel
AU  - Hegedüs, Panna
AU  - Freund, Tamás
AU  - Gulyás, Attila
AU  - Kepecs, Adam
AU  - Hangya, Balázs
TI  - Distinct synchronization, cortical coupling and behavioral function of two basal forebrain cholinergic neuron types
JF  - NATURE NEUROSCIENCE
J2  - NAT NEUROSCI
VL  - 23
PY  - 2020
IS  - 8
SP  - 992
EP  - 1003
PG  - 12
SN  - 1097-6256
DO  - 10.1038/s41593-020-0648-0
UR  - https://m2.mtmt.hu/api/publication/31357306
ID  - 31357306
N1  - Lendület Laboratory of Systems Neuroscience, Institute of Experimental Medicine, Budapest, Hungary            
            János Szentágothai Doctoral School of Neurosciences, Semmelweis University, Budapest, Hungary            
            Laboratory of Cerebral Cortex Research, Institute of Experimental Medicine, Budapest, Hungary            
            Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, United States            
            Departments of Neuroscience and Psychiatry, Washington University in St Louis, St Louis, MO, United States            
            Cited By :30            
            Export Date: 20 April 2023            
            CODEN: NANEF            
            Correspondence Address: Hangya, B.; Lendület Laboratory of Systems Neuroscience, Hungary; email: hangya.balazs@koki.mta.hu            
            Funding details: National Institute of Neurological Disorders and Stroke, NINDS, R01NS075531, R01NS088661            
            Funding details: European Commission, EC;EU            
            Funding details: European Research Council, ERC, 715043, K115441, KH124345            
            Funding details: Magyar Tudományos Akadémia, MTA, LP2015-2/2015            
            Funding details: Nemzeti Kutatási és Technológiai Hivatal, NKTH            
            Funding details: Hungarian Science Foundation            
            Funding details: Nemzeti Kutatási Fejlesztési és Innovációs Hivatal, NKFIH, KH125294            
            Funding details: Ministry for Innovation and Technology, EFOP-3.6.3-VEKOP-16-2017-00009            
            Funding text 1: We thank J. Szabadics, V. Varga, L. Acsády, N. Hádinger and G. Buzsáki for insightful discussions and comments on the manuscript and K. Sviatkó for help with graphics in Fig. 8. This work was supported by the ‘Lendület’ Program of the Hungarian Academy of Sciences (LP2015-2/2015), NKFIH KH125294 and the European Research Council Starting (grant no. 715043) to B.H., NKFIH K115441 and KH124345 to A.G., NINDS R01NS088661, R01NS075531 and McKnight Cognitive Disorders Award to A.K., ÚNKP-19-3 New National Excellence Program of the Ministry for Innovation and Technology to P.H., and EFOP-3.6.3-VEKOP-16-2017-00009 to D.S. and T.L. B.H. is a member of the FENS-Kavli Network of Excellence.
AB  - Basal forebrain cholinergic neurons (BFCNs) modulate synaptic plasticity, cortical processing, brain states and oscillations. However, whether distinct types of BFCNs support different functions remains unclear. Therefore, we recorded BFCNs in vivo, to examine their behavioral functions, and in vitro, to study their intrinsic properties. We identified two distinct types of BFCNs that differ in their firing modes, synchronization properties and behavioral correlates. Bursting cholinergic neurons (Burst-BFCNs) fired synchronously, phase-locked to cortical theta activity and fired precisely timed bursts after reward and punishment. Regular-firing cholinergic neurons (Reg-BFCNs) were found predominantly in the posterior basal forebrain, displayed strong theta rhythmicity and responded with precise single spikes after behavioral outcomes. In an auditory detection task, synchronization of Burst-BFCNs to the auditory cortex predicted the timing of behavioral responses, whereas tone-evoked cortical coupling of Reg-BFCNs predicted correct detections. We propose that differential recruitment of two basal forebrain cholinergic neuron types generates behavior-specific cortical activation.
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Szőnyi, András
AU  - Zichó, Krisztián
AU  - Barth, Albert
AU  - Gönczi, Roland T.
AU  - Schlingloff, Dániel
AU  - Török, Bibiána
AU  - Bodóné Sipos, Eszter
AU  - Major, Ábel
AU  - Bardóczi, Zsuzsanna
AU  - Sós, Katalin Eszter
AU  - Gulyás, Attila
AU  - Varga, Viktor
AU  - Zelena, Dóra
AU  - Freund, Tamás
AU  - Nyíri, Gábor
TI  - Median raphe controls acquisition of negative experience in the mouse
JF  - SCIENCE
J2  - SCIENCE
VL  - 366
PY  - 2019
IS  - 6469
PG  - 12
SN  - 0036-8075
DO  - 10.1126/science.aay8746
UR  - https://m2.mtmt.hu/api/publication/30881269
ID  - 30881269
N1  - * Megosztott szerzőség
AB  - Adverse events need to be quickly evaluated and memorized, yet how these processes are coordinated is poorly understood. We discovered a large population of excitatory neurons in mouse median raphe region (MRR) expressing vesicular glutamate transporter 2 (vGluT2) that received inputs from several negative experience–related brain centers, projected to the main aversion centers, and activated the septohippocampal system pivotal for learning of adverse events. These neurons were selectively activated by aversive but not rewarding stimuli. Their stimulation induced place aversion, aggression, depression-related anhedonia, and suppression of reward-seeking behavior and memory acquisition–promoting hippocampal theta oscillations. By contrast, their suppression impaired both contextual and cued fear memory formation. These results suggest that MRR vGluT2 neurons are crucial for the acquisition of negative experiences and may play a central role in depression-related mood disorders. © 2019 American Association for the Advancement of Science. All rights reserved.
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Szőnyi, András
AU  - Sós, Katalin Eszter
AU  - Nyilas, Rita
AU  - Schlingloff, Dániel
AU  - Domonkos, Andor
AU  - Tresóné Takács, Virág
AU  - Pósfai, Balázs
AU  - Hegedüs, Panna
AU  - Priestley, James B.
AU  - Gundlach, Andrew L.
AU  - Gulyás, Attila
AU  - Varga, Viktor
AU  - Losonczy, Attila
AU  - Freund, Tamás
AU  - Nyíri, Gábor
TI  - Brainstem nucleus incertus controls contextual memory formation
JF  - SCIENCE
J2  - SCIENCE
VL  - 364
PY  - 2019
IS  - 6442
PG  - 13
SN  - 0036-8075
DO  - 10.1126/science.aaw0445
UR  - https://m2.mtmt.hu/api/publication/30725513
ID  - 30725513
AB  - Hippocampal pyramidal cells encode memory engrams, which guide adaptive behavior. Selection of engram-forming cells is regulated by somatostatin-positive dendrite-targeting interneurons, which inhibit pyramidal cells that are not required for memory formation. Here, we found that gamma-aminobutyric acid ( GABA)-releasing neurons of the mouse nucleus incertus (NI) selectively inhibit somatostatin-positive interneurons in the hippocampus, both monosynaptically and indirectly through the inhibition of their subcortical excitatory inputs. We demonstrated that NI GABAergic neurons receive monosynaptic inputs from brain areas processing important environmental information, and their hippocampal projections are strongly activated by salient environmental inputs in vivo. Optogenetic manipulations of NI GABAergic neurons can shift hippocampal network state and bidirectionally modify the strength of contextual fear memory formation. Our results indicate that brainstem NI GABAergic cells are essential for controlling contextual memories.
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Tresóné Takács, Virág
AU  - Cserép, Csaba
AU  - Schlingloff, Dániel
AU  - Pósfai, Balázs
AU  - Szőnyi, András
AU  - Sós, Katalin Eszter
AU  - Környei, Zsuzsanna
AU  - Dénes, Ádám
AU  - Gulyás, Attila
AU  - Freund, Tamás
AU  - Nyíri, Gábor
TI  - Co-transmission of acetylcholine and GABA regulates hippocampal states
JF  - NATURE COMMUNICATIONS
J2  - NAT COMMUN
VL  - 9
PY  - 2018
IS  - 1
PG  - 15
SN  - 2041-1723
DO  - 10.1038/s41467-018-05136-1
UR  - https://m2.mtmt.hu/api/publication/3399510
ID  - 3399510
N1  - These authors contributedequally: Virág T. Takács, Csaba Cserép, Dániel Schlingloff
AB  - The basal forebrain cholinergic system is widely assumed to control cortical functions via non-synaptic transmission of a single neurotransmitter. Yet, we find that mouse hippocampal cholinergic terminals invariably establish GABAergic synapses, and their cholinergic vesicles dock at those synapses only. We demonstrate that these synapses do not co-release but co-transmit GABA and acetylcholine via different vesicles, whose release is triggered by distinct calcium channels. This co-transmission evokes composite postsynaptic potentials, which are mutually cross-regulated by presynaptic autoreceptors. Although postsynaptic cholinergic receptor distribution cannot be investigated, their response latencies suggest a focal, intra- and/or peri-synaptic localisation, while GABAA receptors are detected intra-synaptically. The GABAergic component alone effectively suppresses hippocampal sharp wave-ripples and epileptiform activity. Therefore, the differentially regulated GABAergic and cholinergic co-transmission suggests a hitherto unrecognised level of control over cortical states. This novel model of hippocampal cholinergic neurotransmission may lead to alternative pharmacotherapies after cholinergic deinnervation seen in neurodegenerative disorders.
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Gulyás, Attila
AU  - Freund, Tamás
AU  - Káli, Szabolcs
TI  - The Effects of Realistic Synaptic Distribution and 3D Geometry on Signal Integration and Extracellular Field Generation of Hippocampal Pyramidal Cells and Inhibitory Neurons.
JF  - FRONTIERS IN NEURAL CIRCUITS
J2  - FRONT NEURAL CIRCUIT
VL  - 10
PY  - 2016
SN  - 1662-5110
DO  - 10.3389/fncir.2016.00088
UR  - https://m2.mtmt.hu/api/publication/3183697
ID  - 3183697
N1  - N1 Funding details: 604102, FP7, Seventh Framework Programme
N1 Funding details: 720270, FP7, Seventh Framework Programme
N1 Funding details: H2020, FP7, Seventh Framework Programme
N1 Funding details: 604102, FP7, Seventh Framework Programme
N1 Funding details: 720270, FP7, Seventh Framework Programme
N1 Funding details: H2020, FP7, Seventh Framework Programme
N1 Funding text: This work was supported by the Hungarian Scientific Research Fund (OTKA K115441), ERC-2011-ADG-294313 (SERRACO), and the EU FP7 Grant 604102 and H2020 grant 720270 (Human Brain Project).
Megjegyzés-26835820
N1 Funding details: 604102, FP7, Seventh Framework Programme
N1 Funding details: 720270, FP7, Seventh Framework Programme
N1 Funding details: H2020, FP7, Seventh Framework Programme
N1 Funding text: This work was supported by the Hungarian Scientific Research Fund (OTKA K115441), ERC-2011-ADG-294313 (SERRACO), and the EU FP7 Grant 604102 and H2020 grant 720270 (Human Brain Project).
Megjegyzés-27189873
N1 Funding details: ERC-2011-ADG-294313, OTKA, Országos Tudományos Kutatási Alapprogramok
N1 Funding details: 604102, FP7, Seventh Framework Programme
N1 Funding text: This work was supported by the Hungarian Scientific Research Fund (OTKA K115441), ERC-2011-ADG-294313 (SERRACO), and the EU FP7 Grant 604102 and H2020 grant 720270 (Human Brain Project).
Megjegyzés-27192309
N1 Funding details: ERC-2011-ADG-294313, OTKA, Országos Tudományos Kutatási Alapprogramok
N1 Funding details: 604102, FP7, Seventh Framework Programme
N1 Funding text: This work was supported by the Hungarian Scientific Research Fund (OTKA K115441), ERC-2011-ADG-294313 (SERRACO), and the EU FP7 Grant 604102 and H2020 grant 720270 (Human Brain Project).
Megjegyzés-27192938
N1 Funding details: ERC-2011-ADG-294313, OTKA, Országos Tudományos Kutatási Alapprogramok
N1 Funding details: 604102, FP7, Seventh Framework Programme
N1 Funding text: This work was supported by the Hungarian Scientific Research Fund (OTKA K115441), ERC-2011-ADG-294313 (SERRACO), and the EU FP7 Grant 604102 and H2020 grant 720270 (Human Brain Project).
Megjegyzés-27244875
N1 Funding details: ERC-2011-ADG-294313, OTKA, Országos Tudományos Kutatási Alapprogramok
N1 Funding details: 604102, FP7, Seventh Framework Programme
N1 Funding text: This work was supported by the Hungarian Scientific Research Fund (OTKA K115441), ERC-2011-ADG-294313 (SERRACO), and the EU FP7 Grant 604102 and H2020 grant 720270 (Human Brain Project).
Megjegyzés-27245376
N1 Funding details: ERC-2011-ADG-294313, OTKA, Országos Tudományos Kutatási Alapprogramok
N1 Funding details: 604102, FP7, Seventh Framework Programme
N1 Funding text: This work was supported by the Hungarian Scientific Research Fund (OTKA K115441), ERC-2011-ADG-294313 (SERRACO), and the EU FP7 Grant 604102 and H2020 grant 720270 (Human Brain Project).
Megjegyzés-27363234
N1 Funding details: ERC-2011-ADG-294313, OTKA, Országos Tudományos Kutatási Alapprogramok
N1 Funding details: 604102, FP7, Seventh Framework Programme
N1 Funding text: This work was supported by the Hungarian Scientific Research Fund (OTKA K115441), ERC-2011-ADG-294313 (SERRACO), and the EU FP7 Grant 604102 and H2020 grant 720270 (Human Brain Project).
Megjegyzés-27363255
N1 Funding details: ERC-2011-ADG-294313, OTKA, Országos Tudományos Kutatási Alapprogramok
N1 Funding details: 604102, FP7, Seventh Framework Programme
N1 Funding text: This work was supported by the Hungarian Scientific Research Fund (OTKA K115441), ERC-2011-ADG-294313 (SERRACO), and the EU FP7 Grant 604102 and H2020 grant 720270 (Human Brain Project).
Megjegyzés-27370560
N1 Funding details: ERC-2011-ADG-294313, OTKA, Országos Tudományos Kutatási Alapprogramok
N1 Funding details: 604102, FP7, Seventh Framework Programme
N1 Funding text: This work was supported by the Hungarian Scientific Research Fund (OTKA K115441), ERC-2011-ADG-294313 (SERRACO), and the EU FP7 Grant 604102 and H2020 grant 720270 (Human Brain Project).
Megjegyzés-27370742
N1 Funding details: ERC-2011-ADG-294313, OTKA, Országos Tudományos Kutatási Alapprogramok
N1 Funding details: 604102, FP7, Seventh Framework Programme
N1 Funding text: This work was supported by the Hungarian Scientific Research Fund (OTKA K115441), ERC-2011-ADG-294313 (SERRACO), and the EU FP7 Grant 604102 and H2020 grant 720270 (Human Brain Project).
Megjegyzés-27391979
N1 Funding details: ERC-2011-ADG-294313, OTKA, Országos Tudományos Kutatási Alapprogramok
N1 Funding details: 604102, FP7, Seventh Framework Programme
N1 Funding text: This work was supported by the Hungarian Scientific Research Fund (OTKA K115441), ERC-2011-ADG-294313 (SERRACO), and the EU FP7 Grant 604102 and H2020 grant 720270 (Human Brain Project).
Megjegyzés-27400171
N1 Funding details: ERC-2011-ADG-294313, OTKA, Országos Tudományos Kutatási Alapprogramok
N1 Funding details: 604102, FP7, Seventh Framework Programme
N1 Funding text: This work was supported by the Hungarian Scientific Research Fund (OTKA K115441), ERC-2011-ADG-294313 (SERRACO), and the EU FP7 Grant 604102 and H2020 grant 720270 (Human Brain Project).
Megjegyzés-27401621
N1 Funding details: ERC-2011-ADG-294313, OTKA, Országos Tudományos Kutatási Alapprogramok
N1 Funding details: 604102, FP7, Seventh Framework Programme
N1 Funding text: This work was supported by the Hungarian Scientific Research Fund (OTKA K115441), ERC-2011-ADG-294313 (SERRACO), and the EU FP7 Grant 604102 and H2020 grant 720270 (Human Brain Project).
Megjegyzés-27433082
N1 Funding details: 720270, IDEAS-ERC, FP7 Ideas: European Research Council
N1 Funding details: H2020, IDEAS-ERC, FP7 Ideas: European Research Council
N1 Funding details: 604102, IDEAS-ERC, FP7 Ideas: European Research Council
N1 Funding details: OTKA K115441, OTKA, Országos Tudományos Kutatási Alapprogramok
N1 Funding details: ERC-2011-ADG-294313, OTKA, Országos Tudományos Kutatási Alapprogramok
N1 Funding text: This work was supported by the Hungarian Scientific Research Fund (OTKA K115441), ERC-2011-ADG-294313 (SERRACO), and the EU FP7 Grant 604102 and H2020 grant 720270 (Human Brain Project).
Megjegyzés-27444466
N1 Funding details: 720270, IDEAS-ERC, FP7 Ideas: European Research Council
N1 Funding details: H2020, IDEAS-ERC, FP7 Ideas: European Research Council
N1 Funding details: 604102, IDEAS-ERC, FP7 Ideas: European Research Council
N1 Funding details: OTKA K115441, OTKA, Országos Tudományos Kutatási Alapprogramok
N1 Funding details: ERC-2011-ADG-294313, OTKA, Országos Tudományos Kutatási Alapprogramok
N1 Funding text: This work was supported by the Hungarian Scientific Research Fund (OTKA K115441), ERC-2011-ADG-294313 (SERRACO), and the EU FP7 Grant 604102 and H2020 grant 720270 (Human Brain Project).
Megjegyzés-27444467
N1 Funding details: 720270, IDEAS-ERC, FP7 Ideas: European Research Council
N1 Funding details: H2020, IDEAS-ERC, FP7 Ideas: European Research Council
N1 Funding details: 604102, IDEAS-ERC, FP7 Ideas: European Research Council
N1 Funding details: OTKA K115441, OTKA, Országos Tudományos Kutatási Alapprogramok
N1 Funding details: ERC-2011-ADG-294313, OTKA, Országos Tudományos Kutatási Alapprogramok
N1 Funding text: This work was supported by the Hungarian Scientific Research Fund (OTKA K115441), ERC-2011-ADG-294313 (SERRACO), and the EU FP7 Grant 604102 and H2020 grant 720270 (Human Brain Project).
Megjegyzés-27444540
N1 Funding details: 720270, IDEAS-ERC, FP7 Ideas: European Research Council
N1 Funding details: H2020, IDEAS-ERC, FP7 Ideas: European Research Council
N1 Funding details: 604102, IDEAS-ERC, FP7 Ideas: European Research Council
N1 Funding details: OTKA K115441, OTKA, Országos Tudományos Kutatási Alapprogramok
N1 Funding details: ERC-2011-ADG-294313, OTKA, Országos Tudományos Kutatási Alapprogramok
N1 Funding text: This work was supported by the Hungarian Scientific Research Fund (OTKA K115441), ERC-2011-ADG-294313 (SERRACO), and the EU FP7 Grant 604102 and H2020 grant 720270 (Human Brain Project).
Megjegyzés-27468551
N1 Funding details: 720270, IDEAS-ERC, FP7 Ideas: European Research Council
N1 Funding details: H2020, IDEAS-ERC, FP7 Ideas: European Research Council
N1 Funding details: 604102, IDEAS-ERC, FP7 Ideas: European Research Council
N1 Funding details: OTKA K115441, OTKA, Országos Tudományos Kutatási Alapprogramok
N1 Funding details: ERC-2011-ADG-294313, OTKA, Országos Tudományos Kutatási Alapprogramok
N1 Funding text: This work was supported by the Hungarian Scientific Research Fund (OTKA K115441), ERC-2011-ADG-294313 (SERRACO), and the EU FP7 Grant 604102 and H2020 grant 720270 (Human Brain Project).
Megjegyzés-27479383
N1 Funding details: 720270, IDEAS-ERC, FP7 Ideas: European Research Council
N1 Funding details: H2020, IDEAS-ERC, FP7 Ideas: European Research Council
N1 Funding details: 604102, IDEAS-ERC, FP7 Ideas: European Research Council
N1 Funding details: OTKA K115441, OTKA, Országos Tudományos Kutatási Alapprogramok
N1 Funding details: ERC-2011-ADG-294313, OTKA, Országos Tudományos Kutatási Alapprogramok
N1 Funding text: This work was supported by the Hungarian Scientific Research Fund (OTKA K115441), ERC-2011-ADG-294313 (SERRACO), and the EU FP7 Grant 604102 and H2020 grant 720270 (Human Brain Project).
Megjegyzés-27612994
N1 Funding details: 720270, IDEAS-ERC, FP7 Ideas: European Research Council
N1 Funding details: H2020, IDEAS-ERC, FP7 Ideas: European Research Council
N1 Funding details: 604102, IDEAS-ERC, FP7 Ideas: European Research Council
N1 Funding details: OTKA K115441, OTKA, Országos Tudományos Kutatási Alapprogramok
N1 Funding details: ERC-2011-ADG-294313, OTKA, Országos Tudományos Kutatási Alapprogramok
N1 Funding text: This work was supported by the Hungarian Scientific Research Fund (OTKA K115441), ERC-2011-ADG-294313 (SERRACO), and the EU FP7 Grant 604102 and H2020 grant 720270 (Human Brain Project).
Megjegyzés-27617128
N1 Funding details: 720270, IDEAS-ERC, FP7 Ideas: European Research Council
N1 Funding details: H2020, IDEAS-ERC, FP7 Ideas: European Research Council
N1 Funding details: 604102, IDEAS-ERC, FP7 Ideas: European Research Council
N1 Funding details: OTKA K115441, OTKA, Országos Tudományos Kutatási Alapprogramok
N1 Funding details: ERC-2011-ADG-294313, OTKA, Országos Tudományos Kutatási Alapprogramok
N1 Funding text: This work was supported by the Hungarian Scientific Research Fund (OTKA K115441), ERC-2011-ADG-294313 (SERRACO), and the EU FP7 Grant 604102 and H2020 grant 720270 (Human Brain Project).
Megjegyzés-27624905
N1 Funding details: 720270, IDEAS-ERC, FP7 Ideas: European Research Council
N1 Funding details: H2020, IDEAS-ERC, FP7 Ideas: European Research Council
N1 Funding details: 604102, IDEAS-ERC, FP7 Ideas: European Research Council
N1 Funding details: OTKA K115441, OTKA, Országos Tudományos Kutatási Alapprogramok
N1 Funding details: ERC-2011-ADG-294313, OTKA, Országos Tudományos Kutatási Alapprogramok
N1 Funding text: This work was supported by the Hungarian Scientific Research Fund (OTKA K115441), ERC-2011-ADG-294313 (SERRACO), and the EU FP7 Grant 604102 and H2020 grant 720270 (Human Brain Project).
Megjegyzés-27632327
N1 Funding details: 720270, IDEAS-ERC, FP7 Ideas: European Research Council
N1 Funding details: H2020, IDEAS-ERC, FP7 Ideas: European Research Council
N1 Funding details: 604102, IDEAS-ERC, FP7 Ideas: European Research Council
N1 Funding details: OTKA K115441, OTKA, Országos Tudományos Kutatási Alapprogramok
N1 Funding details: ERC-2011-ADG-294313, OTKA, Országos Tudományos Kutatási Alapprogramok
N1 Funding text: This work was supported by the Hungarian Scientific Research Fund (OTKA K115441), ERC-2011-ADG-294313 (SERRACO), and the EU FP7 Grant 604102 and H2020 grant 720270 (Human Brain Project).
Megjegyzés-27638707
N1 Funding details: 720270, IDEAS-ERC, FP7 Ideas: European Research Council
N1 Funding details: H2020, IDEAS-ERC, FP7 Ideas: European Research Council
N1 Funding details: 604102, IDEAS-ERC, FP7 Ideas: European Research Council
N1 Funding details: OTKA K115441, OTKA, Országos Tudományos Kutatási Alapprogramok
N1 Funding details: ERC-2011-ADG-294313, OTKA, Országos Tudományos Kutatási Alapprogramok
N1 Funding text: This work was supported by the Hungarian Scientific Research Fund (OTKA K115441), ERC-2011-ADG-294313 (SERRACO), and the EU FP7 Grant 604102 and H2020 grant 720270 (Human Brain Project).
Megjegyzés-27660904
N1 Funding details: 720270, IDEAS-ERC, FP7 Ideas: European Research Council
N1 Funding details: H2020, IDEAS-ERC, FP7 Ideas: European Research Council
N1 Funding details: 604102, IDEAS-ERC, FP7 Ideas: European Research Council
N1 Funding details: OTKA K115441, OTKA, Országos Tudományos Kutatási Alapprogramok
N1 Funding details: ERC-2011-ADG-294313, OTKA, Országos Tudományos Kutatási Alapprogramok
N1 Funding text: This work was supported by the Hungarian Scientific Research Fund (OTKA K115441), ERC-2011-ADG-294313 (SERRACO), and the EU FP7 Grant 604102 and H2020 grant 720270 (Human Brain Project).
Cited By :1            
            Export Date: 26 July 2019            
            Correspondence Address: Gulyás, A.I.; Laboratory of Cerebral Cortex Research, Institute of Experimental Medicine, Hungarian Academy of SciencesHungary; email: gulyas@koki.hu            
            Chemicals/CAS: cholecystokinin, 9011-97-6, 93443-27-7; parvalbumin, 56094-12-3, 83667-75-8            
            Funding details: FP7 Ideas: European Research Council, 720270, H2020, 604102            
            Funding details: Hungarian Scientific Research Fund, OTKA K115441, ERC-2011-ADG-294313            
            Funding text 1: This work was supported by the Hungarian Scientific Research Fund (OTKA K115441), ERC-2011-ADG-294313 (SERRACO), and the EU FP7 Grant 604102 and H2020 grant 720270 (Human Brain Project).
Cited By :1            
            Export Date: 17 August 2019            
            Correspondence Address: Gulyás, A.I.; Laboratory of Cerebral Cortex Research, Institute of Experimental Medicine, Hungarian Academy of SciencesHungary; email: gulyas@koki.hu            
            Chemicals/CAS: cholecystokinin, 9011-97-6, 93443-27-7; parvalbumin, 56094-12-3, 83667-75-8            
            Funding details: FP7 Ideas: European Research Council, 720270, H2020, 604102            
            Funding details: Hungarian Scientific Research Fund, OTKA K115441, ERC-2011-ADG-294313            
            Funding text 1: This work was supported by the Hungarian Scientific Research Fund (OTKA K115441), ERC-2011-ADG-294313 (SERRACO), and the EU FP7 Grant 604102 and H2020 grant 720270 (Human Brain Project).
Cited By :1            
            Export Date: 18 August 2019            
            Correspondence Address: Gulyás, A.I.; Laboratory of Cerebral Cortex Research, Institute of Experimental Medicine, Hungarian Academy of SciencesHungary; email: gulyas@koki.hu            
            Chemicals/CAS: cholecystokinin, 9011-97-6, 93443-27-7; parvalbumin, 56094-12-3, 83667-75-8            
            Funding details: FP7 Ideas: European Research Council, 720270, H2020, 604102            
            Funding details: Hungarian Scientific Research Fund, OTKA K115441, ERC-2011-ADG-294313            
            Funding text 1: This work was supported by the Hungarian Scientific Research Fund (OTKA K115441), ERC-2011-ADG-294313 (SERRACO), and the EU FP7 Grant 604102 and H2020 grant 720270 (Human Brain Project).
Cited By :1            
            Export Date: 21 August 2019            
            Correspondence Address: Gulyás, A.I.; Laboratory of Cerebral Cortex Research, Institute of Experimental Medicine, Hungarian Academy of SciencesHungary; email: gulyas@koki.hu            
            Chemicals/CAS: cholecystokinin, 9011-97-6, 93443-27-7; parvalbumin, 56094-12-3, 83667-75-8            
            Funding details: FP7 Ideas: European Research Council, 720270, H2020, 604102            
            Funding details: Hungarian Scientific Research Fund, OTKA K115441, ERC-2011-ADG-294313            
            Funding text 1: This work was supported by the Hungarian Scientific Research Fund (OTKA K115441), ERC-2011-ADG-294313 (SERRACO), and the EU FP7 Grant 604102 and H2020 grant 720270 (Human Brain Project).
Cited By :1            
            Export Date: 23 August 2019            
            Correspondence Address: Gulyás, A.I.; Laboratory of Cerebral Cortex Research, Institute of Experimental Medicine, Hungarian Academy of SciencesHungary; email: gulyas@koki.hu            
            Chemicals/CAS: cholecystokinin, 9011-97-6, 93443-27-7; parvalbumin, 56094-12-3, 83667-75-8            
            Funding details: FP7 Ideas: European Research Council, 720270, H2020, 604102            
            Funding details: Hungarian Scientific Research Fund, OTKA K115441, ERC-2011-ADG-294313            
            Funding text 1: This work was supported by the Hungarian Scientific Research Fund (OTKA K115441), ERC-2011-ADG-294313 (SERRACO), and the EU FP7 Grant 604102 and H2020 grant 720270 (Human Brain Project).
Cited By :1            
            Export Date: 24 August 2019            
            Correspondence Address: Gulyás, A.I.; Laboratory of Cerebral Cortex Research, Institute of Experimental Medicine, Hungarian Academy of SciencesHungary; email: gulyas@koki.hu            
            Chemicals/CAS: cholecystokinin, 9011-97-6, 93443-27-7; parvalbumin, 56094-12-3, 83667-75-8            
            Funding details: FP7 Ideas: European Research Council, 720270, H2020, 604102            
            Funding details: Hungarian Scientific Research Fund, OTKA K115441, ERC-2011-ADG-294313            
            Funding text 1: This work was supported by the Hungarian Scientific Research Fund (OTKA K115441), ERC-2011-ADG-294313 (SERRACO), and the EU FP7 Grant 604102 and H2020 grant 720270 (Human Brain Project).
Cited By :1            
            Export Date: 28 August 2019            
            Correspondence Address: Gulyás, A.I.; Laboratory of Cerebral Cortex Research, Institute of Experimental Medicine, Hungarian Academy of SciencesHungary; email: gulyas@koki.hu            
            Chemicals/CAS: cholecystokinin, 9011-97-6, 93443-27-7; parvalbumin, 56094-12-3, 83667-75-8            
            Funding details: FP7 Ideas: European Research Council, 720270, H2020, 604102            
            Funding details: Hungarian Scientific Research Fund, OTKA K115441, ERC-2011-ADG-294313            
            Funding text 1: This work was supported by the Hungarian Scientific Research Fund (OTKA K115441), ERC-2011-ADG-294313 (SERRACO), and the EU FP7 Grant 604102 and H2020 grant 720270 (Human Brain Project).
Cited By :1            
            Export Date: 14 November 2019            
            Correspondence Address: Gulyás, A.I.; Laboratory of Cerebral Cortex Research, Institute of Experimental Medicine, Hungarian Academy of SciencesHungary; email: gulyas@koki.hu            
            Chemicals/CAS: cholecystokinin, 9011-97-6, 93443-27-7; parvalbumin, 56094-12-3, 83667-75-8            
            Funding details: FP7 Ideas: European Research Council, 720270, H2020, 604102            
            Funding details: Hungarian Scientific Research Fund, OTKA K115441, ERC-2011-ADG-294313            
            Funding text 1: This work was supported by the Hungarian Scientific Research Fund (OTKA K115441), ERC-2011-ADG-294313 (SERRACO), and the EU FP7 Grant 604102 and H2020 grant 720270 (Human Brain Project).
Cited By :1            
            Export Date: 15 February 2020            
            Correspondence Address: Gulyás, A.I.; Laboratory of Cerebral Cortex Research, Institute of Experimental Medicine, Hungarian Academy of SciencesHungary; email: gulyas@koki.hu            
            Chemicals/CAS: cholecystokinin, 9011-97-6, 93443-27-7; parvalbumin, 56094-12-3, 83667-75-8            
            Funding details: Horizon 2020 Framework Programme, H2020, 720270            
            Funding details: Hungarian Scientific Research Fund, OTKA, OTKA K115441, ERC-2011-ADG-294313            
            Funding details: Seventh Framework Programme, FP7, 604102            
            Funding text 1: This work was supported by the Hungarian Scientific Research Fund (OTKA K115441), ERC-2011-ADG-294313 (SERRACO), and the EU FP7 Grant 604102 and H2020 grant 720270 (Human Brain Project).
Cited By :1            
            Export Date: 12 March 2020            
            Correspondence Address: Gulyás, A.I.; Laboratory of Cerebral Cortex Research, Institute of Experimental Medicine, Hungarian Academy of SciencesHungary; email: gulyas@koki.hu            
            Chemicals/CAS: cholecystokinin, 9011-97-6, 93443-27-7; parvalbumin, 56094-12-3, 83667-75-8            
            Funding details: Horizon 2020 Framework Programme, H2020, 720270            
            Funding details: Hungarian Scientific Research Fund, OTKA, OTKA K115441, ERC-2011-ADG-294313            
            Funding details: Seventh Framework Programme, FP7, 604102            
            Funding text 1: This work was supported by the Hungarian Scientific Research Fund (OTKA K115441), ERC-2011-ADG-294313 (SERRACO), and the EU FP7 Grant 604102 and H2020 grant 720270 (Human Brain Project).
Cited By :1            
            Export Date: 15 April 2020            
            Correspondence Address: Gulyás, A.I.; Laboratory of Cerebral Cortex Research, Institute of Experimental Medicine, Hungarian Academy of SciencesHungary; email: gulyas@koki.hu            
            Chemicals/CAS: cholecystokinin, 9011-97-6, 93443-27-7; parvalbumin, 56094-12-3, 83667-75-8            
            Funding details: Horizon 2020 Framework Programme, H2020, 720270            
            Funding details: Hungarian Scientific Research Fund, OTKA, OTKA K115441, ERC-2011-ADG-294313            
            Funding details: Seventh Framework Programme, FP7, 604102            
            Funding text 1: This work was supported by the Hungarian Scientific Research Fund (OTKA K115441), ERC-2011-ADG-294313 (SERRACO), and the EU FP7 Grant 604102 and H2020 grant 720270 (Human Brain Project).
Cited By :1            
            Export Date: 22 April 2020            
            Correspondence Address: Gulyás, A.I.; Laboratory of Cerebral Cortex Research, Institute of Experimental Medicine, Hungarian Academy of SciencesHungary; email: gulyas@koki.hu            
            Chemicals/CAS: cholecystokinin, 9011-97-6, 93443-27-7; parvalbumin, 56094-12-3, 83667-75-8            
            Funding details: Horizon 2020 Framework Programme, H2020, 720270            
            Funding details: Hungarian Scientific Research Fund, OTKA, OTKA K115441, ERC-2011-ADG-294313            
            Funding details: Seventh Framework Programme, FP7, 604102            
            Funding text 1: This work was supported by the Hungarian Scientific Research Fund (OTKA K115441), ERC-2011-ADG-294313 (SERRACO), and the EU FP7 Grant 604102 and H2020 grant 720270 (Human Brain Project).
Cited By :1            
            Export Date: 24 April 2020            
            Correspondence Address: Gulyás, A.I.; Laboratory of Cerebral Cortex Research, Institute of Experimental Medicine, Hungarian Academy of SciencesHungary; email: gulyas@koki.hu            
            Chemicals/CAS: cholecystokinin, 9011-97-6, 93443-27-7; parvalbumin, 56094-12-3, 83667-75-8            
            Funding details: Horizon 2020 Framework Programme, H2020, 720270            
            Funding details: Hungarian Scientific Research Fund, OTKA, OTKA K115441, ERC-2011-ADG-294313            
            Funding details: Seventh Framework Programme, FP7, 604102            
            Funding text 1: This work was supported by the Hungarian Scientific Research Fund (OTKA K115441), ERC-2011-ADG-294313 (SERRACO), and the EU FP7 Grant 604102 and H2020 grant 720270 (Human Brain Project).
Cited By :1            
            Export Date: 13 May 2020            
            Correspondence Address: Gulyás, A.I.; Laboratory of Cerebral Cortex Research, Institute of Experimental Medicine, Hungarian Academy of SciencesHungary; email: gulyas@koki.hu            
            Chemicals/CAS: cholecystokinin, 9011-97-6, 93443-27-7; parvalbumin, 56094-12-3, 83667-75-8            
            Funding details: Horizon 2020 Framework Programme, H2020, 720270            
            Funding details: Hungarian Scientific Research Fund, OTKA, OTKA K115441, ERC-2011-ADG-294313            
            Funding details: Seventh Framework Programme, FP7, 604102            
            Funding text 1: This work was supported by the Hungarian Scientific Research Fund (OTKA K115441), ERC-2011-ADG-294313 (SERRACO), and the EU FP7 Grant 604102 and H2020 grant 720270 (Human Brain Project).
Cited By :1            
            Export Date: 15 May 2020            
            Correspondence Address: Gulyás, A.I.; Laboratory of Cerebral Cortex Research, Institute of Experimental Medicine, Hungarian Academy of SciencesHungary; email: gulyas@koki.hu            
            Chemicals/CAS: cholecystokinin, 9011-97-6, 93443-27-7; parvalbumin, 56094-12-3, 83667-75-8            
            Funding details: Horizon 2020 Framework Programme, H2020, 720270            
            Funding details: Hungarian Scientific Research Fund, OTKA, OTKA K115441, ERC-2011-ADG-294313            
            Funding details: Seventh Framework Programme, FP7, 604102            
            Funding text 1: This work was supported by the Hungarian Scientific Research Fund (OTKA K115441), ERC-2011-ADG-294313 (SERRACO), and the EU FP7 Grant 604102 and H2020 grant 720270 (Human Brain Project).
Cited By :1            
            Export Date: 18 May 2020            
            Correspondence Address: Gulyás, A.I.; Laboratory of Cerebral Cortex Research, Institute of Experimental Medicine, Hungarian Academy of SciencesHungary; email: gulyas@koki.hu            
            Chemicals/CAS: cholecystokinin, 9011-97-6, 93443-27-7; parvalbumin, 56094-12-3, 83667-75-8            
            Funding details: Horizon 2020 Framework Programme, H2020, 720270            
            Funding details: Hungarian Scientific Research Fund, OTKA, OTKA K115441, ERC-2011-ADG-294313            
            Funding details: Seventh Framework Programme, FP7, 604102            
            Funding text 1: This work was supported by the Hungarian Scientific Research Fund (OTKA K115441), ERC-2011-ADG-294313 (SERRACO), and the EU FP7 Grant 604102 and H2020 grant 720270 (Human Brain Project).
Cited By :1            
            Export Date: 20 May 2020            
            Correspondence Address: Gulyás, A.I.; Laboratory of Cerebral Cortex Research, Institute of Experimental Medicine, Hungarian Academy of SciencesHungary; email: gulyas@koki.hu            
            Chemicals/CAS: cholecystokinin, 9011-97-6, 93443-27-7; parvalbumin, 56094-12-3, 83667-75-8            
            Funding details: Horizon 2020 Framework Programme, H2020, 720270            
            Funding details: Hungarian Scientific Research Fund, OTKA, OTKA K115441, ERC-2011-ADG-294313            
            Funding details: Seventh Framework Programme, FP7, 604102            
            Funding text 1: This work was supported by the Hungarian Scientific Research Fund (OTKA K115441), ERC-2011-ADG-294313 (SERRACO), and the EU FP7 Grant 604102 and H2020 grant 720270 (Human Brain Project).
Cited By :1            
            Export Date: 23 May 2020            
            Correspondence Address: Gulyás, A.I.; Laboratory of Cerebral Cortex Research, Institute of Experimental Medicine, Hungarian Academy of SciencesHungary; email: gulyas@koki.hu            
            Chemicals/CAS: cholecystokinin, 9011-97-6, 93443-27-7; parvalbumin, 56094-12-3, 83667-75-8            
            Funding details: Horizon 2020 Framework Programme, H2020, 720270            
            Funding details: Hungarian Scientific Research Fund, OTKA, OTKA K115441, ERC-2011-ADG-294313            
            Funding details: Seventh Framework Programme, FP7, 604102            
            Funding text 1: This work was supported by the Hungarian Scientific Research Fund (OTKA K115441), ERC-2011-ADG-294313 (SERRACO), and the EU FP7 Grant 604102 and H2020 grant 720270 (Human Brain Project).
Cited By :1            
            Export Date: 24 May 2020            
            Correspondence Address: Gulyás, A.I.; Laboratory of Cerebral Cortex Research, Institute of Experimental Medicine, Hungarian Academy of SciencesHungary; email: gulyas@koki.hu            
            Chemicals/CAS: cholecystokinin, 9011-97-6, 93443-27-7; parvalbumin, 56094-12-3, 83667-75-8            
            Funding details: Horizon 2020 Framework Programme, H2020, 720270            
            Funding details: Hungarian Scientific Research Fund, OTKA, OTKA K115441, ERC-2011-ADG-294313            
            Funding details: Seventh Framework Programme, FP7, 604102            
            Funding text 1: This work was supported by the Hungarian Scientific Research Fund (OTKA K115441), ERC-2011-ADG-294313 (SERRACO), and the EU FP7 Grant 604102 and H2020 grant 720270 (Human Brain Project).
Cited By :1            
            Export Date: 25 May 2020            
            Correspondence Address: Gulyás, A.I.; Laboratory of Cerebral Cortex Research, Institute of Experimental Medicine, Hungarian Academy of SciencesHungary; email: gulyas@koki.hu            
            Chemicals/CAS: cholecystokinin, 9011-97-6, 93443-27-7; parvalbumin, 56094-12-3, 83667-75-8            
            Funding details: Horizon 2020 Framework Programme, H2020, 720270            
            Funding details: Hungarian Scientific Research Fund, OTKA, OTKA K115441, ERC-2011-ADG-294313            
            Funding details: Seventh Framework Programme, FP7, 604102            
            Funding text 1: This work was supported by the Hungarian Scientific Research Fund (OTKA K115441), ERC-2011-ADG-294313 (SERRACO), and the EU FP7 Grant 604102 and H2020 grant 720270 (Human Brain Project).
Cited By :1            
            Export Date: 26 May 2020            
            Correspondence Address: Gulyás, A.I.; Laboratory of Cerebral Cortex Research, Institute of Experimental Medicine, Hungarian Academy of SciencesHungary; email: gulyas@koki.hu            
            Chemicals/CAS: cholecystokinin, 9011-97-6, 93443-27-7; parvalbumin, 56094-12-3, 83667-75-8            
            Funding details: Horizon 2020 Framework Programme, H2020, 720270            
            Funding details: Hungarian Scientific Research Fund, OTKA, OTKA K115441, ERC-2011-ADG-294313            
            Funding details: Seventh Framework Programme, FP7, 604102            
            Funding text 1: This work was supported by the Hungarian Scientific Research Fund (OTKA K115441), ERC-2011-ADG-294313 (SERRACO), and the EU FP7 Grant 604102 and H2020 grant 720270 (Human Brain Project).
Cited By :1            
            Export Date: 30 May 2020            
            Correspondence Address: Gulyás, A.I.; Laboratory of Cerebral Cortex Research, Institute of Experimental Medicine, Hungarian Academy of SciencesHungary; email: gulyas@koki.hu            
            Chemicals/CAS: cholecystokinin, 9011-97-6, 93443-27-7; parvalbumin, 56094-12-3, 83667-75-8            
            Funding details: Horizon 2020 Framework Programme, H2020, 720270            
            Funding details: Hungarian Scientific Research Fund, OTKA, OTKA K115441, ERC-2011-ADG-294313            
            Funding details: Seventh Framework Programme, FP7, 604102            
            Funding text 1: This work was supported by the Hungarian Scientific Research Fund (OTKA K115441), ERC-2011-ADG-294313 (SERRACO), and the EU FP7 Grant 604102 and H2020 grant 720270 (Human Brain Project).
WoS:hiba:000411893700001 2020-12-04 19:42 DOI azonosító nem egyezik
Cited By :2            
            Export Date: 17 March 2021            
            Correspondence Address: Gulyás, A.I.; Laboratory of Cerebral Cortex Research, Hungary; email: gulyas@koki.hu            
            Chemicals/CAS: cholecystokinin, 9011-97-6, 93443-27-7; parvalbumin, 56094-12-3, 83667-75-8            
            Funding details: Horizon 2020 Framework Programme, H2020, 720270            
            Funding details: Seventh Framework Programme, FP7, 604102            
            Funding details: Hungarian Scientific Research Fund, OTKA, ERC-2011-ADG-294313, OTKA K115441            
            Funding text 1: This work was supported by the Hungarian Scientific Research Fund (OTKA K115441), ERC-2011-ADG-294313 (SERRACO), and the EU FP7 Grant 604102 and H2020 grant 720270 (Human Brain Project).
Cited By :2            
            Export Date: 18 March 2021            
            Correspondence Address: Gulyás, A.I.; Laboratory of Cerebral Cortex Research, Hungary; email: gulyas@koki.hu            
            Chemicals/CAS: cholecystokinin, 9011-97-6, 93443-27-7; parvalbumin, 56094-12-3, 83667-75-8            
            Funding details: Horizon 2020 Framework Programme, H2020, 720270            
            Funding details: Seventh Framework Programme, FP7, 604102            
            Funding details: Hungarian Scientific Research Fund, OTKA, ERC-2011-ADG-294313, OTKA K115441            
            Funding text 1: This work was supported by the Hungarian Scientific Research Fund (OTKA K115441), ERC-2011-ADG-294313 (SERRACO), and the EU FP7 Grant 604102 and H2020 grant 720270 (Human Brain Project).
Cited By :2            
            Export Date: 20 March 2021            
            Correspondence Address: Gulyás, A.I.; Laboratory of Cerebral Cortex Research, Hungary; email: gulyas@koki.hu            
            Chemicals/CAS: cholecystokinin, 9011-97-6, 93443-27-7; parvalbumin, 56094-12-3, 83667-75-8            
            Funding details: Horizon 2020 Framework Programme, H2020, 720270            
            Funding details: Seventh Framework Programme, FP7, 604102            
            Funding details: Hungarian Scientific Research Fund, OTKA, ERC-2011-ADG-294313, OTKA K115441            
            Funding text 1: This work was supported by the Hungarian Scientific Research Fund (OTKA K115441), ERC-2011-ADG-294313 (SERRACO), and the EU FP7 Grant 604102 and H2020 grant 720270 (Human Brain Project).
Cited By :2            
            Export Date: 23 March 2021            
            Correspondence Address: Gulyás, A.I.; Laboratory of Cerebral Cortex Research, Hungary; email: gulyas@koki.hu            
            Chemicals/CAS: cholecystokinin, 9011-97-6, 93443-27-7; parvalbumin, 56094-12-3, 83667-75-8            
            Funding details: Horizon 2020 Framework Programme, H2020, 720270            
            Funding details: Seventh Framework Programme, FP7, 604102            
            Funding details: Hungarian Scientific Research Fund, OTKA, ERC-2011-ADG-294313, OTKA K115441            
            Funding text 1: This work was supported by the Hungarian Scientific Research Fund (OTKA K115441), ERC-2011-ADG-294313 (SERRACO), and the EU FP7 Grant 604102 and H2020 grant 720270 (Human Brain Project).
Cited By :2            
            Export Date: 30 March 2021            
            Correspondence Address: Gulyás, A.I.; Laboratory of Cerebral Cortex Research, Hungary; email: gulyas@koki.hu            
            Chemicals/CAS: cholecystokinin, 9011-97-6, 93443-27-7; parvalbumin, 56094-12-3, 83667-75-8            
            Funding details: Horizon 2020 Framework Programme, H2020, 720270            
            Funding details: Seventh Framework Programme, FP7, 604102            
            Funding details: Hungarian Scientific Research Fund, OTKA, ERC-2011-ADG-294313, OTKA K115441            
            Funding text 1: This work was supported by the Hungarian Scientific Research Fund (OTKA K115441), ERC-2011-ADG-294313 (SERRACO), and the EU FP7 Grant 604102 and H2020 grant 720270 (Human Brain Project).
Cited By :2            
            Export Date: 31 March 2021            
            Correspondence Address: Gulyás, A.I.; Laboratory of Cerebral Cortex Research, Hungary; email: gulyas@koki.hu            
            Chemicals/CAS: cholecystokinin, 9011-97-6, 93443-27-7; parvalbumin, 56094-12-3, 83667-75-8            
            Funding details: Horizon 2020 Framework Programme, H2020, 720270            
            Funding details: Seventh Framework Programme, FP7, 604102            
            Funding details: Hungarian Scientific Research Fund, OTKA, ERC-2011-ADG-294313, OTKA K115441            
            Funding text 1: This work was supported by the Hungarian Scientific Research Fund (OTKA K115441), ERC-2011-ADG-294313 (SERRACO), and the EU FP7 Grant 604102 and H2020 grant 720270 (Human Brain Project).
Cited By :2            
            Export Date: 1 April 2021            
            Correspondence Address: Gulyás, A.I.; Laboratory of Cerebral Cortex Research, Hungary; email: gulyas@koki.hu            
            Chemicals/CAS: cholecystokinin, 9011-97-6, 93443-27-7; parvalbumin, 56094-12-3, 83667-75-8            
            Funding details: Horizon 2020 Framework Programme, H2020, 720270            
            Funding details: Seventh Framework Programme, FP7, 604102            
            Funding details: Hungarian Scientific Research Fund, OTKA, ERC-2011-ADG-294313, OTKA K115441            
            Funding text 1: This work was supported by the Hungarian Scientific Research Fund (OTKA K115441), ERC-2011-ADG-294313 (SERRACO), and the EU FP7 Grant 604102 and H2020 grant 720270 (Human Brain Project).
Cited By :2            
            Export Date: 6 April 2021            
            Correspondence Address: Gulyás, A.I.; Laboratory of Cerebral Cortex Research, Hungary; email: gulyas@koki.hu            
            Chemicals/CAS: cholecystokinin, 9011-97-6, 93443-27-7; parvalbumin, 56094-12-3, 83667-75-8            
            Funding details: Horizon 2020 Framework Programme, H2020, 720270            
            Funding details: Seventh Framework Programme, FP7, 604102            
            Funding details: Hungarian Scientific Research Fund, OTKA, ERC-2011-ADG-294313, OTKA K115441            
            Funding text 1: This work was supported by the Hungarian Scientific Research Fund (OTKA K115441), ERC-2011-ADG-294313 (SERRACO), and the EU FP7 Grant 604102 and H2020 grant 720270 (Human Brain Project).
Cited By :2            
            Export Date: 7 April 2021            
            Correspondence Address: Gulyás, A.I.; Laboratory of Cerebral Cortex Research, Hungary; email: gulyas@koki.hu            
            Chemicals/CAS: cholecystokinin, 9011-97-6, 93443-27-7; parvalbumin, 56094-12-3, 83667-75-8            
            Funding details: Horizon 2020 Framework Programme, H2020, 720270            
            Funding details: Seventh Framework Programme, FP7, 604102            
            Funding details: Hungarian Scientific Research Fund, OTKA, ERC-2011-ADG-294313, OTKA K115441            
            Funding text 1: This work was supported by the Hungarian Scientific Research Fund (OTKA K115441), ERC-2011-ADG-294313 (SERRACO), and the EU FP7 Grant 604102 and H2020 grant 720270 (Human Brain Project).
Cited By :2            
            Export Date: 13 April 2021            
            Correspondence Address: Gulyás, A.I.; Laboratory of Cerebral Cortex Research, Hungary; email: gulyas@koki.hu            
            Chemicals/CAS: cholecystokinin, 9011-97-6, 93443-27-7; parvalbumin, 56094-12-3, 83667-75-8            
            Funding details: Horizon 2020 Framework Programme, H2020, 720270            
            Funding details: Seventh Framework Programme, FP7, 604102            
            Funding details: Hungarian Scientific Research
AB  - In vivo and in vitro multichannel field and somatic intracellular recordings are frequently used to study mechanisms of network pattern generation. When interpreting these data, neurons are often implicitly considered as electrotonically compact cylinders with a homogeneous distribution of excitatory and inhibitory inputs. However, the actual distributions of dendritic length, diameter, and the densities of excitatory and inhibitory input are non-uniform and cell type-specific. We first review quantitative data on the dendritic structure and synaptic input and output distribution of pyramidal cells (PCs) and interneurons in the hippocampal CA1 area. Second, using multicompartmental passive models of four different types of neurons, we quantitatively explore the effect of differences in dendritic structure and synaptic distribution on the errors and biases of voltage clamp measurements of inhibitory and excitatory postsynaptic currents. Finally, using the 3-dimensional distribution of dendrites and synaptic inputs we calculate how different inhibitory and excitatory inputs contribute to the generation of local field potential in the hippocampus. We analyze these effects at different realistic background activity levels as synaptic bombardment influences neuronal conductance and thus the propagation of signals in the dendritic tree. We conclude that, since dendrites are electrotonically long and entangled in 3D, somatic intracellular and field potential recordings miss the majority of dendritic events in some cell types, and thus overemphasize the importance of perisomatic inhibitory inputs and belittle the importance of complex dendritic processing. Modeling results also suggest that PCs and inhibitory neurons probably use different input integration strategies. In PCs, second- and higher-order thin dendrites are relatively well-isolated from each other, which may support branch-specific local processing as suggested by studies of active dendritic integration. In the electrotonically compact parvalbumin- and cholecystokinincontaining interneurons, synaptic events are visible in the whole dendritic arbor, and thus the entire dendritic tree may form a single integrative element. Calretinin-containing interneurons were found to be electrotonically extended, which suggests the possibility of complex dendritic processing in this cell type. Our results also highlight the need for the integration of methods that allow the measurement of dendritic processes into studies of synaptic interactions and dynamics in neural networks.
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Kohus, Zsolt
AU  - Káli, Szabolcs
AU  - Rovira Esteban, Laura
AU  - Schlingloff, Dániel
AU  - Papp, Orsolya
AU  - Freund, Tamás
AU  - Hájos, Norbert
AU  - Gulyás, Attila
TI  - Properties and dynamics of inhibitory synaptic communication within the CA3 microcircuits of pyramidal cells and interneurons expressing parvalbumin or cholecystokinin
JF  - JOURNAL OF PHYSIOLOGY-LONDON
J2  - J PHYSIOL-LONDON
VL  - 594
PY  - 2016
IS  - 13
SP  - 3745
EP  - 3774
PG  - 30
SN  - 0022-3751
DO  - 10.1113/JP272231
UR  - https://m2.mtmt.hu/api/publication/3078169
ID  - 3078169
N1  - Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary            
            János Szentágothai, PhD Program of Semmelweis University, Budapest, Hungary            
            Péter Pázmány Catholic University, Faculty of Information Technology, Budapest, Hungary            
            Cited By :31            
            Export Date: 19 May 2022            
            CODEN: JPHYA            
            Correspondence Address: Gulyás, A.I.; Institute of Experimental Medicine, Hungary; email: gulyas@koki.hu            
            Chemicals/CAS: cholecystokinin, 9011-97-6, 93443-27-7; parvalbumin, 56094-12-3, 83667-75-8            
            Funding details: Horizon 2020 Framework Programme, H2020, 720270
AB  - Different hippocampal activity patterns are determined primarily by the interaction of excitatory cells and different types of interneurons. To understand the mechanisms underlying the generation of different network dynamics the properties of synaptic transmission need to be uncovered. Perisomatic inhibition has been shown to be critical for the generation of sharp wave-ripples, gamma oscillations as well as pathological epileptic activities. Therefore, we decided to quantitatively and systematically characterize the temporal properties of the synaptic transmission between perisomatic inhibitory neurons and pyramidal cells in the CA3 area of mouse hippocampal slices, using action potential patterns recorded during physiological and pathological network states. PV+ and CCK+ interneurons had distinct intrinsic physiological features. Interneurons of the same type formed reciprocally connected subnetworks, while the connectivity between interneuron classes was sparse. The characteristics of unitary interactions depended on the identity of both synaptic partners, while the short-term plasticity of synaptic transmission depended mainly on the presynaptic cell type. PV+ interneurons showed frequency-dependent depression, while more complex dynamics characterized the output of CCK+ interneurons. We quantitatively captured the dynamics of transmission at these different types of connection with simple mathematical models, and described in detail the response to physiological and pathological discharge patterns. Our data suggest that the temporal propeties of PV+ interneuron transmission may contribute to sharp wave-ripple generation. These findings support the view that intrinsic and synaptic features of PV+ cells make them ideally suited for the generation of physiological network oscillations, while CCK+ cells implement more subtle, graded control in the hippocampus. This article is protected by copyright. All rights reserved.
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Gulyás, Attila
AU  - Freund, Tamás
TI  - Generation of physiological and pathological high frequency oscillations: the role of perisomatic inhibition in sharp-wave ripple and interictal spike generation.
JF  - CURRENT OPINION IN NEUROBIOLOGY
J2  - CURR OPIN NEUROBIOL
VL  - 31
PY  - 2015
SP  - 26
EP  - 32
PG  - 7
SN  - 0959-4388
DO  - 10.1016/j.conb.2014.07.020
UR  - https://m2.mtmt.hu/api/publication/2719984
ID  - 2719984
N1  - Funding details: 604102            
            Funding details: NNF 85659, K83251            
            Funding details: European Research Council, ERC-2011-ADG-294313            
            Funding details: Hungarian Scientific Research Fund            
            Funding text 1: The authors work was supported by the Hungarian Scientific 
            Research Fund ( OTKA K83251 , NNF 85659 ), European Research Council ( 
            ERC-2011-ADG-294313 ; SERRACO) and the EU FP grant no. 604102 (Human 
            Brain
Cited By :29            
            Export Date: 20 March 2021            
            CODEN: COPUE            
            Correspondence Address: Gulyás, A.I.; Institute of Experimental Medicine, Hungarian Academy of Sciences, Szigony u 43, H-1083 Budapest, Hungary; email: gulyas@koki.hu            
            Chemicals/CAS: parvalbumin, 56094-12-3, 83667-75-8; Parvalbumins            
            Funding details: 604102            
            Funding details: Seventh Framework Programme, FP7, 294313            
            Funding details: European Research Council, ERC            
            Funding details: Hungarian Scientific Research Fund, OTKA, K83251, NNF 85659            
            Funding text 1: The authors work was supported by the Hungarian Scientific Research Fund ( OTKA K83251 , NNF 85659 ), European Research Council ( ERC-2011-ADG-294313 ; SERRACO) and the EU FP grant no. 604102 (Human Brain Project).
Cited By :29            
            Export Date: 31 March 2021            
            CODEN: COPUE            
            Correspondence Address: Gulyás, A.I.; Institute of Experimental Medicine, Hungarian Academy of Sciences, Szigony u 43, H-1083 Budapest, Hungary; email: gulyas@koki.hu            
            Chemicals/CAS: parvalbumin, 56094-12-3, 83667-75-8; Parvalbumins            
            Funding details: 604102            
            Funding details: Seventh Framework Programme, FP7, 294313            
            Funding details: European Research Council, ERC            
            Funding details: Hungarian Scientific Research Fund, OTKA, K83251, NNF 85659            
            Funding text 1: The authors work was supported by the Hungarian Scientific Research Fund ( OTKA K83251 , NNF 85659 ), European Research Council ( ERC-2011-ADG-294313 ; SERRACO) and the EU FP grant no. 604102 (Human Brain Project).
Cited By :30            
            Export Date: 6 April 2021            
            CODEN: COPUE            
            Correspondence Address: Gulyás, A.I.; Institute of Experimental Medicine, Hungarian Academy of Sciences, Szigony u 43, H-1083 Budapest, Hungary; email: gulyas@koki.hu            
            Chemicals/CAS: parvalbumin, 56094-12-3, 83667-75-8; Parvalbumins            
            Funding details: 604102            
            Funding details: Seventh Framework Programme, FP7, 294313            
            Funding details: European Research Council, ERC            
            Funding details: Hungarian Scientific Research Fund, OTKA, K83251, NNF 85659            
            Funding text 1: The authors work was supported by the Hungarian Scientific Research Fund ( OTKA K83251 , NNF 85659 ), European Research Council ( ERC-2011-ADG-294313 ; SERRACO) and the EU FP grant no. 604102 (Human Brain Project).
Cited By :30            
            Export Date: 7 April 2021            
            CODEN: COPUE            
            Correspondence Address: Gulyás, A.I.; Institute of Experimental Medicine, Hungarian Academy of Sciences, Szigony u 43, H-1083 Budapest, Hungary; email: gulyas@koki.hu            
            Chemicals/CAS: parvalbumin, 56094-12-3, 83667-75-8; Parvalbumins            
            Funding details: 604102            
            Funding details: Seventh Framework Programme, FP7, 294313            
            Funding details: European Research Council, ERC            
            Funding details: Hungarian Scientific Research Fund, OTKA, K83251, NNF 85659            
            Funding text 1: The authors work was supported by the Hungarian Scientific Research Fund ( OTKA K83251 , NNF 85659 ), European Research Council ( ERC-2011-ADG-294313 ; SERRACO) and the EU FP grant no. 604102 (Human Brain Project).
Cited By :30            
            Export Date: 13 April 2021            
            CODEN: COPUE            
            Correspondence Address: Gulyás, A.I.; Institute of Experimental Medicine, Hungarian Academy of Sciences, Szigony u 43, H-1083 Budapest, Hungary; email: gulyas@koki.hu            
            Chemicals/CAS: parvalbumin, 56094-12-3, 83667-75-8; Parvalbumins            
            Funding details: 604102            
            Funding details: Seventh Framework Programme, FP7, 294313            
            Funding details: European Research Council, ERC            
            Funding details: Hungarian Scientific Research Fund, OTKA, K83251, NNF 85659            
            Funding text 1: The authors work was supported by the Hungarian Scientific Research Fund ( OTKA K83251 , NNF 85659 ), European Research Council ( ERC-2011-ADG-294313 ; SERRACO) and the EU FP grant no. 604102 (Human Brain Project).
AB  - Sharp-wave-ripple complexes (SWRs) and interictal-spikes are physiological and pathological forms of irregularly occurring transient high activity events in the hippocampal EEG. They share similar features and carry high-frequency oscillations with different spectral features. Recent results reveal similarities and differences in the generation of the two types of transients, and argue that parvalbumin containing basket cells (PVBCs) are crucial in synchronizing neuronal activity in both cases. SWRs are generated in the reciprocally connected network of inhibitory PVBCs, while in the pathological case, synchronous failure of perisomatic inhibition triggers massive pyramidal cell burst firing. While physiological ripple oscillation is primarily the result of phasic perisomatic inhibitory currents, pathological high-frequency ripples are population spikes of partially synchronous, massively bursting, uninhibited pyramidal cells.
LA  - English
DB  - MTMT
ER  -