TY - JOUR AU - Tuboly, Gábor AU - Horváth, Gyöngyi AU - Nagy, Kamilla AU - Nagy, Edit TI - Personalized analysis of pain–weather associations: a pilot study JF - IDEGGYOGYASZATI SZEMLE / CLINICAL NEUROSCIENCE J2 - IDEGGYOGY SZEMLE VL - 77 PY - 2024 IS - 3-4 SP - 77 EP - 87 PG - 11 SN - 0019-1442 DO - 10.18071/isz.77.0077 UR - https://m2.mtmt.hu/api/publication/34779925 ID - 34779925 AB - Background and purpose – It is a wellknown belief that weather can influence human health, including pain sensation. However, the current data are controversial, which might be due to the wide range of interindividual differences. The present study aimed to characterize the individual pain– weather associations during chronic pain by utilizing several data analytical methods. Methods – The study included 3-3 patients with (P1, P3, and P4) or without (P2, P5, P6) diabetes mellitus and signs of trigeminal neuralgia or low back pain. Subjective pain scores (0–10) and 12 weather parameters (terrestrial, geomagnetic, and solar) were recorded for one month repeated three times daily. Nonparametric Spearman’s correlation (Sp), multiple regression (Mx), and principal component (PCA) analyses were performed to evaluate associations between pain and meteorological factors obtained at the day of recorded pain value, 2 days before and 2 days after the recorded pain, and the changes in these parameters (5 × 12 parameters). Complex scores were calculated based on the results of these analyses. Results – While the temperature had the highest effects on the pain levels in most of the participants, huge interindividual dif­ferences in the degree and the direction of the associations between pain and weather parameters could be obtained. The analytic methods also revealed subjectspecific results, and the synthesis of different statistical methods as total scores provided a personalized map for each patient, which showed disparate patterns across the study participants. Thus, Participants 2 and 5 had higher scores for Mx compared to Sp; furthermore, certain factors showed opposite direction in their associations with the pain level depending on the type of analysis (Sp vs Mx). In contrast, P3 had a lower score for Mx compared to Sp, which might suggest a low level of weather sensitivity on the association between the different weather parameters in this subject. Furthermore, participants P4 and P6 had a very high level of weather sensitivity, while P1 had an opposite pattern. Regarding the time point-related effects on the pain level, most patients were sensitive to parameters obtained at the same day or two days before, except the P1 subject, who had the highest sensitivity to weather parameters detected two days after. Conclusion – The present study highlights the importance of integrating different data analysis approaches to elucidate the individual connections between pain and most of the weather parameters. In conclusion, complex personalized profiling should be considered for the characterization of pain–weather associations by applying different data analytical approaches, which may provide feedback to physicians and patients. LA - English DB - MTMT ER - TY - CONF AU - Plesz, Szonja Bianka AU - Adlan, Leatitia Gabriella AU - Büki, Alexandra AU - Horváth, Gyöngyi AU - Ligeti, Balázs AU - Zádori, Zoltán Sándor AU - Kékesi, Gabriella TI - Exploring the gut-brain connection: How does microbiome composition relate to cognitive behavior in Wisket model rats? T2 - 7th Hungarian Neuroscience Doctoral Conference for Undergraduate Students, Graduate Students and Junior Post-Docs (HUNDOC) Booklet PY - 2024 SP - 86 UR - https://m2.mtmt.hu/api/publication/34577105 ID - 34577105 LA - English DB - MTMT ER - TY - CONF AU - Adlan, Leatitia Gabriella AU - Plesz, Szonja Bianka AU - Büki, Alexandra AU - Horváth, Gyöngyi AU - Ligeti, Balázs AU - Zádori, Zoltán Sándor AU - Kékesi, Gabriella TI - The Firmicutes/Bacteroidetes ratio in the triple-hit Wisket model rats of schizophrenia T2 - International Neuroscience Conference, Pécs 2024 PY - 2024 SP - 74 UR - https://m2.mtmt.hu/api/publication/34577022 ID - 34577022 LA - English DB - MTMT ER - TY - CONF AU - Plesz, Szonja Bianka AU - Adlan, Leatitia Gabriella AU - Büki, Alexandra AU - Ligeti, Balázs AU - Zádori, Zoltán Sándor AU - Horváth, Gyöngyi AU - Kékesi, Gabriella TI - A Lactobacillaceae baktériumok előfordulása a szkizofrénia Wisket állatmodelljének mikrobiomjában T2 - A XI. Eötvözet Konferencián elhangzó előadások rövid összefoglalója PY - 2023 SP - 24 EP - 24 PG - 1 UR - https://m2.mtmt.hu/api/publication/34577063 ID - 34577063 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Plesz, Szonja Bianka AU - Adlan, Leatitia Gabriella AU - Büki, Alexandra AU - Horváth, Gyöngyi AU - Ligeti, Balázs AU - Zádori, Zoltán AU - Kékesi, Gabriella TI - DECREASED LACTOBACILLACEAE ABUNDANCE IN THE GUT MICROBIOTA OF A ‘THREE-HIT’ SCHIZOPHRENIA RAT MODEL (WISKET) JF - IBRO NEUROSCIENCE REPORTS J2 - IBRO NEUROSCI REP VL - 15 PY - 2023 SP - S630 SN - 2667-2421 DO - 10.1016/j.ibneur.2023.08.1256 UR - https://m2.mtmt.hu/api/publication/34407638 ID - 34407638 LA - English DB - MTMT ER - TY - JOUR AU - Kékesi, Gabriella AU - Plesz, Szonja AU - Adlan, Leatitia AU - Horváth, Gyöngyi AU - Szűcs, Kálmán Ferenc AU - Gáspár, Róbert TI - GASTROINTESTINAL ACTIVITY IN AWAKE SCHIZOPHRENIA-LIKE WISKET RATS JF - IBRO NEUROSCIENCE REPORTS J2 - IBRO NEUROSCI REP VL - 15 PY - 2023 SP - S589 SN - 2667-2421 DO - 10.1016/j.ibneur.2023.08.1167 UR - https://m2.mtmt.hu/api/publication/34407637 ID - 34407637 LA - English DB - MTMT ER - TY - JOUR AU - Hernadi, Zsófia AU - Adlan, Leatitia Gabriella AU - Kékesi, Gabriella AU - Büki, Alexandra AU - Tuboly, Gabor AU - Horváth, Gyöngyi TI - PERSONALIZED BEHAVIORAL ANALYSIS OF RODENTS IN HOME-CAGE CONDITION JF - IBRO NEUROSCIENCE REPORTS J2 - IBRO NEUROSCI REP VL - 15 PY - 2023 SP - S579 SN - 2667-2421 DO - 10.1016/j.ibneur.2023.08.1146 UR - https://m2.mtmt.hu/api/publication/34407636 ID - 34407636 LA - English DB - MTMT ER - TY - JOUR AU - Adlan, Leatitia Gabriella AU - Plesz, Szonja Bianka AU - Büki, Alexandra AU - Horváth, Gyöngyi AU - Ligeti, Balázs AU - Zádori, Zoltán AU - Kékesi, Gabriella TI - GUT MICROBIAL ABUNDANCE IN THE SCHIZOPHRENIA-LIKE WISKET RAT MODEL JF - IBRO NEUROSCIENCE REPORTS J2 - IBRO NEUROSCI REP VL - 15 PY - 2023 SP - S522 SN - 2667-2421 DO - 10.1016/j.ibneur.2023.08.1027 UR - https://m2.mtmt.hu/api/publication/34407635 ID - 34407635 LA - English DB - MTMT ER - TY - JOUR AU - Horváth, Gyöngyi AU - Tuboly, Gábor AU - Nagy, Kamilla AU - Nagy, Edit TI - PERSONALIZED ANALYSIS OF PAIN-WEATHER ASSOCIATIONS JF - IBRO NEUROSCIENCE REPORTS J2 - IBRO NEUROSCI REP VL - 15 PY - 2023 SP - S582 SN - 2667-2421 DO - 10.1016/j.ibneur.2023.08.1153 UR - https://m2.mtmt.hu/api/publication/34268181 ID - 34268181 LA - English DB - MTMT ER - TY - JOUR AU - Kékesi, Gabriella AU - Ducza, Eszter AU - Gálity, Hristifor AU - Büki, Alexandra AU - Tóth, Kálmán AU - Tuboly, Gábor AU - Horváth, Gyöngyi TI - Neurobehavioral impairments in ciprofloxacin-treated osteoarthritic adult rats JF - IDEGGYOGYASZATI SZEMLE / CLINICAL NEUROSCIENCE J2 - IDEGGYOGY SZEMLE VL - 76 PY - 2023 IS - 9-10 SP - 327 EP - 337 PG - 11 SN - 0019-1442 DO - 10.18071/isz.76.0327 UR - https://m2.mtmt.hu/api/publication/34178429 ID - 34178429 N1 - Department of Physiology, Albert Szent-Györgyi Medical School, University of Szeged, Szeged, Hungary Department of Pharmacodynamics and Biopharmacy, Faculty of Pharmacy, University of Szeged, Szeged, Hungary Department of Orthopaedics, Albert Szent-Györgyi Health Centre, University of Szeged, Szeged, Hungary Department of Neurology, Albert Szent-Györgyi Health Centre, University of Szeged, Szeged, Hungary Export Date: 19 January 2024 CODEN: IDSZA Correspondence Address: Kékesi, G.; Department of Physiology, Dóm tér 10, Hungary; email: kekesi.gabriella@med.u-szeged.hu Chemicals/CAS: brain derived neurotrophic factor, 218441-99-7; ciprofloxacin, 85721-33-1, 86393-32-0, 128074-72-6, 128074-76-0, 192934-52-4, 93107-08-5, 86483-48-9, 96186-80-0 Funding text 1: The skilled technical assistance of Ágnes Tandari is gratefully acknowledged. AB - Background and purpose – Ciprofloxacin (CIP) is a broad-spectrum antibiotic widely used in clinical practice to treat musculoskeletal infections. Fluoroquinoloneinduced neurotoxic adverse events have been reported in a few case reports, all the preclinical studies on its neuropsychiatric side effects involved only healthy animals. This study firstly investigated the behavioral effects of CIP in an osteoarthritis rat model with joint destruction and pain, which can simulate inflammation-associated musculoskeletal pain. Furthermore, effects of CIP on regional brain-derived neurotrophic factor (BDNF) expression were examined given its major contributions to the neuromodulation and plasticity underlying behavior and cognition. Methods – Fourteen days after induction of chronic osteoarthritis, animals were administered vehicle, 33 mg/kg or 100 mg/kg CIP for five days intraperitoneally. Motor activity, behavioral motivation, and psychomotor learning were examined in a reward-based behavioral test (Ambitus) on Day 4 and sensorimotor gating by the prepulse inhibition test on Day 5. Thereafter, the prolonged BDNF mRNA and protein expression levels were measured in the hippocampus and the prefrontal cortex. Results – CIP dose-dependently reduced both locomotion and reward-motivated exploratory activity, accompanied with impaired learning ability. In contrast, there were no significant differences in startle reflex and sensory gating among treatment groups; however, CIP treatment reduced motor activity of the animals in this test, too. These alterations were associated with reduced BDNF mRNA and protein expression levels in the hippocampus but not the prefrontal cortex. Conclusion – This study revealed the detrimental effects of CIP treatment on locomotor activity and motivation/learning ability during osteoarthritic condition, which might be due to, at least partially, deficient hippocampal BDNF expression and ensuing impairments in neural and synaptic plasticity. LA - English DB - MTMT ER -