@article{MTMT:34779925,
	title = {Personalized analysis of pain–weather associations: a pilot study},
	url = {https://m2.mtmt.hu/api/publication/34779925},
	author = {Tuboly, Gábor and Horváth, Gyöngyi and Nagy, Kamilla and Nagy, Edit},
	doi = {10.18071/isz.77.0077},
	journal-iso = {IDEGGYOGY SZEMLE},
	journal = {IDEGGYOGYASZATI SZEMLE / CLINICAL NEUROSCIENCE},
	volume = {77},
	unique-id = {34779925},
	issn = {0019-1442},
	abstract = {Background and purpose – It is a wellknown belief that weather can influence human health, including pain sensation. However, the current data are controversial, which might be due to the wide range of interindividual differences. The present study aimed to characterize the individual pain– weather associations during chronic pain by utilizing several data analytical methods. Methods – The study included 3-3 patients with (P1, P3, and P4) or without (P2, P5, P6) diabetes mellitus and signs of trigeminal neuralgia or low back pain. Subjective pain scores (0–10) and 12 weather parameters (terrestrial, geomagnetic, and solar) were recorded for one month repeated three times daily. Nonparametric Spearman’s correlation (Sp), multiple regression (Mx), and principal component (PCA) analyses were performed to evaluate associations between pain and meteorological factors obtained at the day of recorded pain value, 2 days before and 2 days after the recorded pain, and the changes in these parameters (5 × 12 parameters). Complex scores were calculated based on the results of these analyses. Results – While the temperature had the highest effects on the pain levels in most of the participants, huge interindividual dif­ferences in the degree and the direction of the associations between pain and weather parameters could be obtained. The analytic methods also revealed subjectspecific results, and the synthesis of different statistical methods as total scores provided a personalized map for each patient, which showed disparate patterns across the study participants. Thus, Participants 2 and 5 had higher scores for Mx compared to Sp; furthermore, certain factors showed opposite direction in their associations with the pain level depending on the type of analysis (Sp vs Mx). In contrast, P3 had a lower score for Mx compared to Sp, which might suggest a low level of weather sensitivity on the association between the different weather parameters in this subject. Furthermore, participants P4 and P6 had a very high level of weather sensitivity, while P1 had an opposite pattern. Regarding the time point-related effects on the pain level, most patients were sensitive to parameters obtained at the same day or two days before, except the P1 subject, who had the highest sensitivity to weather parameters detected two days after. Conclusion – The present study highlights the importance of integrating different data analysis approaches to elucidate the individual connections between pain and most of the weather parameters. In conclusion, complex personalized profiling should be considered for the characterization of pain–weather associations by applying different data analytical approaches, which may provide feedback to physicians and patients.},
	year = {2024},
	eissn = {2498-6208},
	pages = {77-87},
	orcid-numbers = {Tuboly, Gábor/0000-0002-9715-2267; Horváth, Gyöngyi/0000-0002-6025-4577; Nagy, Kamilla/0009-0008-8442-3858; Nagy, Edit/0000-0002-2485-6618}
}

@CONFERENCE{MTMT:34577105,
	title = {Exploring the gut-brain connection: How does microbiome composition relate to cognitive behavior in Wisket model rats?},
	url = {https://m2.mtmt.hu/api/publication/34577105},
	author = {Plesz, Szonja Bianka and Adlan, Leatitia Gabriella and Büki, Alexandra and Horváth, Gyöngyi and Ligeti, Balázs and Zádori, Zoltán Sándor and Kékesi, Gabriella},
	booktitle = {7th Hungarian Neuroscience Doctoral Conference for Undergraduate Students, Graduate Students and Junior Post-Docs (HUNDOC) Booklet},
	unique-id = {34577105},
	year = {2024},
	pages = {86},
	orcid-numbers = {Büki, Alexandra/0000-0003-2078-5231; Horváth, Gyöngyi/0000-0002-6025-4577; Zádori, Zoltán Sándor/0000-0001-7312-618X; Kékesi, Gabriella/0000-0002-0185-2155}
}

@CONFERENCE{MTMT:34577022,
	title = {The Firmicutes/Bacteroidetes ratio in the triple-hit Wisket model rats of schizophrenia},
	url = {https://m2.mtmt.hu/api/publication/34577022},
	author = {Adlan, Leatitia Gabriella and Plesz, Szonja Bianka and Büki, Alexandra and Horváth, Gyöngyi and Ligeti, Balázs and Zádori, Zoltán Sándor and Kékesi, Gabriella},
	booktitle = {International Neuroscience Conference, Pécs 2024},
	unique-id = {34577022},
	year = {2024},
	pages = {74},
	orcid-numbers = {Büki, Alexandra/0000-0003-2078-5231; Horváth, Gyöngyi/0000-0002-6025-4577; Zádori, Zoltán Sándor/0000-0001-7312-618X; Kékesi, Gabriella/0000-0002-0185-2155}
}

@CONFERENCE{MTMT:34577063,
	title = {A Lactobacillaceae baktériumok előfordulása a szkizofrénia Wisket állatmodelljének mikrobiomjában},
	url = {https://m2.mtmt.hu/api/publication/34577063},
	author = {Plesz, Szonja Bianka and Adlan, Leatitia Gabriella and Büki, Alexandra and Ligeti, Balázs and Zádori, Zoltán Sándor and Horváth, Gyöngyi and Kékesi, Gabriella},
	booktitle = {A XI. Eötvözet Konferencián elhangzó előadások rövid összefoglalója},
	unique-id = {34577063},
	year = {2023},
	pages = {24-24},
	orcid-numbers = {Büki, Alexandra/0000-0003-2078-5231; Zádori, Zoltán Sándor/0000-0001-7312-618X; Horváth, Gyöngyi/0000-0002-6025-4577; Kékesi, Gabriella/0000-0002-0185-2155}
}

@article{MTMT:34407638,
	title = {DECREASED LACTOBACILLACEAE ABUNDANCE IN THE GUT MICROBIOTA OF A ‘THREE-HIT’ SCHIZOPHRENIA RAT MODEL (WISKET)},
	url = {https://m2.mtmt.hu/api/publication/34407638},
	author = {Plesz, Szonja Bianka and Adlan, Leatitia Gabriella and Büki, Alexandra and Horváth, Gyöngyi and Ligeti, Balázs and Zádori, Zoltán and Kékesi, Gabriella},
	doi = {10.1016/j.ibneur.2023.08.1256},
	journal-iso = {IBRO NEUROSCI REP},
	journal = {IBRO NEUROSCIENCE REPORTS},
	volume = {15},
	unique-id = {34407638},
	year = {2023},
	eissn = {2667-2421},
	pages = {S630},
	orcid-numbers = {Büki, Alexandra/0000-0003-2078-5231; Horváth, Gyöngyi/0000-0002-6025-4577; Kékesi, Gabriella/0000-0002-0185-2155}
}

@article{MTMT:34407637,
	title = {GASTROINTESTINAL ACTIVITY IN AWAKE SCHIZOPHRENIA-LIKE WISKET RATS},
	url = {https://m2.mtmt.hu/api/publication/34407637},
	author = {Kékesi, Gabriella and Plesz, Szonja and Adlan, Leatitia and Horváth, Gyöngyi and Szűcs, Kálmán Ferenc and Gáspár, Róbert},
	doi = {10.1016/j.ibneur.2023.08.1167},
	journal-iso = {IBRO NEUROSCI REP},
	journal = {IBRO NEUROSCIENCE REPORTS},
	volume = {15},
	unique-id = {34407637},
	year = {2023},
	eissn = {2667-2421},
	pages = {S589},
	orcid-numbers = {Kékesi, Gabriella/0000-0002-0185-2155; Horváth, Gyöngyi/0000-0002-6025-4577; Gáspár, Róbert/0000-0002-1571-7579}
}

@article{MTMT:34407636,
	title = {PERSONALIZED BEHAVIORAL ANALYSIS OF RODENTS IN HOME-CAGE CONDITION},
	url = {https://m2.mtmt.hu/api/publication/34407636},
	author = {Hernadi, Zsófia and Adlan, Leatitia Gabriella and Kékesi, Gabriella and Büki, Alexandra and Tuboly, Gabor and Horváth, Gyöngyi},
	doi = {10.1016/j.ibneur.2023.08.1146},
	journal-iso = {IBRO NEUROSCI REP},
	journal = {IBRO NEUROSCIENCE REPORTS},
	volume = {15},
	unique-id = {34407636},
	year = {2023},
	eissn = {2667-2421},
	pages = {S579},
	orcid-numbers = {Kékesi, Gabriella/0000-0002-0185-2155; Büki, Alexandra/0000-0003-2078-5231; Horváth, Gyöngyi/0000-0002-6025-4577}
}

@article{MTMT:34407635,
	title = {GUT MICROBIAL ABUNDANCE IN THE SCHIZOPHRENIA-LIKE WISKET RAT MODEL},
	url = {https://m2.mtmt.hu/api/publication/34407635},
	author = {Adlan, Leatitia Gabriella and Plesz, Szonja Bianka and Büki, Alexandra and Horváth, Gyöngyi and Ligeti, Balázs and Zádori, Zoltán and Kékesi, Gabriella},
	doi = {10.1016/j.ibneur.2023.08.1027},
	journal-iso = {IBRO NEUROSCI REP},
	journal = {IBRO NEUROSCIENCE REPORTS},
	volume = {15},
	unique-id = {34407635},
	year = {2023},
	eissn = {2667-2421},
	pages = {S522},
	orcid-numbers = {Büki, Alexandra/0000-0003-2078-5231; Horváth, Gyöngyi/0000-0002-6025-4577; Kékesi, Gabriella/0000-0002-0185-2155}
}

@article{MTMT:34268181,
	title = {PERSONALIZED ANALYSIS OF PAIN-WEATHER ASSOCIATIONS},
	url = {https://m2.mtmt.hu/api/publication/34268181},
	author = {Horváth, Gyöngyi and Tuboly, Gábor and Nagy, Kamilla and Nagy, Edit},
	doi = {10.1016/j.ibneur.2023.08.1153},
	journal-iso = {IBRO NEUROSCI REP},
	journal = {IBRO NEUROSCIENCE REPORTS},
	volume = {15},
	unique-id = {34268181},
	year = {2023},
	eissn = {2667-2421},
	pages = {S582},
	orcid-numbers = {Horváth, Gyöngyi/0000-0002-6025-4577; Nagy, Edit/0000-0002-2485-6618}
}

@article{MTMT:34178429,
	title = {Neurobehavioral impairments in ciprofloxacin-treated osteoarthritic adult rats},
	url = {https://m2.mtmt.hu/api/publication/34178429},
	author = {Kékesi, Gabriella and Ducza, Eszter and Gálity, Hristifor and Büki, Alexandra and Tóth, Kálmán and Tuboly, Gábor and Horváth, Gyöngyi},
	doi = {10.18071/isz.76.0327},
	journal-iso = {IDEGGYOGY SZEMLE},
	journal = {IDEGGYOGYASZATI SZEMLE / CLINICAL NEUROSCIENCE},
	volume = {76},
	unique-id = {34178429},
	issn = {0019-1442},
	abstract = {Background and purpose – Ciprofloxacin (CIP) is a broad-spectrum antibiotic widely used in clinical practice to treat musculoskeletal infections. Fluoroquinoloneinduced neurotoxic adverse events have been reported in a few case reports, all the preclinical studies on its neuropsychiatric side effects involved only healthy animals. This study firstly investigated the behavioral effects of CIP in an osteoarthritis rat model with joint destruction and pain, which can simulate inflammation-associated musculoskeletal pain. Furthermore, effects of CIP on regional brain-derived neurotrophic factor (BDNF) expression were examined given its major contributions to the neuromodulation and plasticity underlying behavior and cognition. Methods – Fourteen days after induction of chronic osteoarthritis, animals were administered vehicle, 33 mg/kg or 100 mg/kg CIP for five days intraperitoneally. Motor activity, behavioral motivation, and psychomotor learning were examined in a reward-based behavioral test (Ambitus) on Day 4 and sensorimotor gating by the prepulse inhibition test on Day 5. Thereafter, the prolonged BDNF mRNA and protein expression levels were measured in the hippocampus and the prefrontal cortex. Results – CIP dose-dependently reduced both locomotion and reward-motivated exploratory activity, accompanied with impaired learning ability. In contrast, there were no significant differences in startle reflex and sensory gating among treatment groups; however, CIP treatment reduced motor activity of the animals in this test, too. These alterations were associated with reduced BDNF mRNA and protein expression levels in the hippocampus but not the prefrontal cortex. Conclusion – This study revealed the detrimental effects of CIP treatment on locomotor activity and motivation/learning ability during osteoarthritic condition, which might be due to, at least partially, deficient hippocampal BDNF expression and ensuing impairments in neural and synaptic plasticity.},
	year = {2023},
	eissn = {2498-6208},
	pages = {327-337},
	orcid-numbers = {Kékesi, Gabriella/0000-0002-0185-2155; Büki, Alexandra/0000-0003-2078-5231; Horváth, Gyöngyi/0000-0002-6025-4577}
}