@article{MTMT:34737118,
	title = {Hierarchical organization of human physical activity},
	url = {https://m2.mtmt.hu/api/publication/34737118},
	author = {Búzás, András and Makai, András and Groma, Géza and Dancsházy, Zsolt and Szendi, István and Kish, Laszlo B. and Santa Maria, Anaraquel and Dér, András},
	doi = {10.1038/s41598-024-56185-0},
	journal-iso = {SCI REP},
	journal = {SCIENTIFIC REPORTS},
	volume = {14},
	unique-id = {34737118},
	issn = {2045-2322},
	abstract = {Human physical activity (HPA), a fundamental physiological signal characteristic of bodily motion is of rapidly growing interest in multidisciplinary research. Here we report the existence of hitherto unidentified hierarchical levels in the temporal organization of HPA on the ultradian scale: on the minute's scale, passive periods are followed by activity bursts of similar intensity (‘quanta’) that are organized into superstructures on the hours- and on the daily scale. The time course of HPA can be considered a stochastic, quasi-binary process, where quanta, assigned to task-oriented actions are organized into work packages on higher levels of hierarchy. In order to grasp the essence of this complex dynamic behaviour, we established a stochastic mathematical model which could reproduce the main statistical features of real activity time series. The results are expected to provide important data for developing novel behavioural models and advancing the diagnostics of neurological or psychiatric diseases.},
	year = {2024},
	eissn = {2045-2322},
	orcid-numbers = {Santa Maria, Anaraquel/0000-0003-3505-5477}
}

@article{MTMT:34724664,
	title = {PtdIns4p is required for the autophagosomal recruitment of STX17 (syntaxin 17) to promote lysosomal fusion},
	url = {https://m2.mtmt.hu/api/publication/34724664},
	author = {Laczkó-Dobos, Hajnalka and Bhattacharjee, Arindam and Maddali, Asha Kiran and Kincses, András and Abuammar, Hussein and Sebőkné Nagy, Krisztina and Páli, Tibor and Dér, András and Hegedűs, Tamás and Csordás, Gábor and Juhász, Gábor},
	doi = {10.1080/15548627.2024.2322493},
	journal-iso = {AUTOPHAGY},
	journal = {AUTOPHAGY},
	volume = {AiP},
	unique-id = {34724664},
	issn = {1554-8627},
	year = {2024},
	eissn = {1554-8635},
	orcid-numbers = {Páli, Tibor/0000-0003-1649-1097; Hegedűs, Tamás/0000-0002-0331-9629; Csordás, Gábor/0000-0001-6871-6839; Juhász, Gábor/0000-0001-8548-8874}
}

@article{MTMT:34673907,
	title = {Lab-on-a-chip models of the blood-brain barrier: evolution, problems, perspectives},
	url = {https://m2.mtmt.hu/api/publication/34673907},
	author = {Deli, Mária Anna and Porkoláb, Gergő and Kincses, András and Mészáros, Mária and Szecskó, Anikó and Kocsis, Anna and Vigh, Judit Piroska and Valkai, Sándor and Veszelka, Szilvia and Walter, Fruzsina and Dér, András},
	doi = {10.1039/d3lc00996c},
	journal-iso = {LAB CHIP},
	journal = {LAB ON A CHIP},
	volume = {24},
	unique-id = {34673907},
	issn = {1473-0197},
	year = {2024},
	eissn = {1473-0189},
	pages = {1030-1063},
	orcid-numbers = {Deli, Mária Anna/0000-0001-6084-6524; Valkai, Sándor/0000-0001-8479-8141; Walter, Fruzsina/0000-0001-8145-2823}
}

@article{MTMT:34153921,
	title = {Spin-Label Electron Paramagnetic Resonance Spectroscopy Reveals Effects of Wastewater Filter Membrane Coated with Titanium Dioxide Nanoparticles on Bovine Serum Albumin},
	url = {https://m2.mtmt.hu/api/publication/34153921},
	author = {Sebőkné Nagy, Krisztina and Kóta, Zoltán and Kincses, András and Fazekas, Ákos Ferenc and Dér, András and László, Zsuzsanna and Páli, Tibor},
	doi = {10.3390/molecules28196750},
	journal-iso = {MOLECULES},
	journal = {MOLECULES},
	volume = {28},
	unique-id = {34153921},
	issn = {1420-3049},
	abstract = {The accumulation of proteins in filter membranes limits the efficiency of filtering technologies for cleaning wastewater. Efforts are ongoing to coat commercial filters with different materials (such as titanium dioxide, TiO2) to reduce the fouling of the membrane. Beyond monitoring the desired effect of the retention of biomolecules, it is necessary to understand what the biophysical changes are in water-soluble proteins caused by their interaction with the new coated filter membranes, an aspect that has received little attention so far. Using spin-label electron paramagnetic resonance (EPR), aided with native fluorescence spectroscopy and dynamic light scattering (DLS), here, we report the changes in the structure and dynamics of bovine serum albumin (BSA) exposed to TiO2 (P25) nanoparticles or passing through commercial polyvinylidene fluoride (PVDF) membranes coated with the same nanoparticles. We have found that the filtering process and prolonged exposure to TiO2 nanoparticles had significant effects on different regions of BSA, and denaturation of the protein was not observed, neither with the TiO2 nanoparticles nor when passing through the TiO2-coated filter membranes.},
	year = {2023},
	eissn = {1420-3049},
	pages = {0-17},
	orcid-numbers = {Kóta, Zoltán/0000-0003-2420-8773; László, Zsuzsanna/0000-0001-8130-7482; Páli, Tibor/0000-0003-1649-1097}
}

@article{MTMT:34129738,
	title = {Impact of protein–chromophore interaction on the retinal excited state and photocycle of Gloeobacter rhodopsin: role of conserved tryptophan residues},
	url = {https://m2.mtmt.hu/api/publication/34129738},
	author = {Misra, Ramprasad and Das, Ishita and Dér, András and Steinbach, Gábor and Shim, Jin-gon and Busse, Wayne and Jung, Kwang-Hwan and Zimányi, László and Sheves, Mordechai},
	doi = {10.1039/D3SC02961A},
	journal-iso = {CHEM SCI},
	journal = {CHEMICAL SCIENCE},
	volume = {14},
	unique-id = {34129738},
	issn = {2041-6520},
	abstract = {The conserved tryptophan residues in the vicinity of the retinal in microbial rhodopsins affect the retinal excited state charge distribution, increase the isomerization quantum yield, and affect the retinal double bond reisomerization rate during photocycle.},
	year = {2023},
	eissn = {2041-6539},
	pages = {9951-9958},
	orcid-numbers = {Misra, Ramprasad/0000-0002-1599-404X; Steinbach, Gábor/0000-0001-7137-7030; Zimányi, László/0000-0002-5101-2023; Sheves, Mordechai/0000-0002-5048-8169}
}

@article{MTMT:34064958,
	title = {Microsecond All-Optical Modulation by Biofunctionalized Porous Silicon Microcavity},
	url = {https://m2.mtmt.hu/api/publication/34064958},
	author = {Petrovszki, Dániel and Valkai, Sándor and Kelemen, Lóránd and Nagy, László and Agarwal, Vivechana and Krekic, Szilvia and Zimányi, László and Dér, András},
	doi = {10.3390/nano13142070},
	journal-iso = {NANOMATERIALS-BASEL},
	journal = {NANOMATERIALS},
	volume = {13},
	unique-id = {34064958},
	abstract = {We successfully created a composite photonic structure out of porous silicon (PSi) microcavities doped by the photochromic protein, photoactive yellow protein (PYP). Massive incorporation of the protein molecules into the pores was substantiated by a 30 nm shift of the resonance dip upon functionalization, and light-induced reflectance changes of the device due to the protein photocycle were recorded. Model calculations for the photonic properties of the device were consistent with earlier results on the nonlinear optical properties of the protein, whose degree of incorporation into the PSi structure was also estimated. The successful proof-of-concept results are discussed in light of possible practical applications in the future.},
	year = {2023},
	eissn = {2079-4991},
	orcid-numbers = {Valkai, Sándor/0000-0001-8479-8141; Kelemen, Lóránd/0000-0001-7772-2165; Agarwal, Vivechana/0000-0003-2168-853X; Zimányi, László/0000-0002-5101-2023}
}

@article{MTMT:34025208,
	title = {Keszthelyi Lajos, a karizmatikus vezető és tanítómester},
	url = {https://m2.mtmt.hu/api/publication/34025208},
	author = {Dér, András},
	journal-iso = {FIZIKAI SZEMLE},
	journal = {FIZIKAI SZEMLE},
	volume = {73},
	unique-id = {34025208},
	issn = {0015-3257},
	year = {2023},
	pages = {101-106}
}

@article{MTMT:34012278,
	title = {Photoactive Yellow Protein Adsorption at Hydrated Polyethyleneimine and Poly-l-Glutamic Acid Interfaces},
	url = {https://m2.mtmt.hu/api/publication/34012278},
	author = {Krekic, Szilvia and Mero, Mark and Kuhl, Michel and Balasubramanian, Kannan and Dér, András and Heiner, Zsuzsanna},
	doi = {10.3390/molecules28104077},
	journal-iso = {MOLECULES},
	journal = {MOLECULES},
	volume = {28},
	unique-id = {34012278},
	issn = {1420-3049},
	abstract = {Chiral and achiral vibrational sum-frequency generation (VSFG) spectroscopy was performed in the 1400–1700 and 2800–3800 cm−1 range to study the interfacial structure of photoactive yellow protein (PYP) adsorbed on polyethyleneimine (PEI) and poly-l-glutamic acid (PGA) surfaces. Nanometer-thick polyelectrolyte layers served as the substrate for PYP adsorption, with 6.5-pair layers providing the most homogeneous surfaces. When the topmost material was PGA, it acquired a random coil structure with a small number of β2-fibrils. Upon adsorption on oppositely charged surfaces, PYP yielded similar achiral spectra. However, the VSFG signal intensity increased for PGA surfaces with a concomitant redshift of the chiral Cα-H and N–H stretching bands, suggesting increased adsorption for PGA compared to PEI. At low wavenumbers, both the backbone and the side chains of PYP induced drastic changes to all measured chiral and achiral VSFG spectra. Decreasing ambient humidity led to the loss of tertiary structure with a re-orientation of α-helixes, evidenced by a strongly blue-shifted chiral amide I band of the β-sheet structure with a shoulder at 1654 cm−1. Our observations indicate that chiral VSFG spectroscopy is not only capable of determining the main type of secondary structure of PYP, i.e., β-scaffold, but is also sensitive to tertiary protein structure.},
	year = {2023},
	eissn = {1420-3049},
	orcid-numbers = {Mero, Mark/0000-0001-5454-583X; Heiner, Zsuzsanna/0000-0002-9458-9164}
}

@article{MTMT:33846356,
	title = {Reconsidering Dogmas about the Growth of Bacterial Populations},
	url = {https://m2.mtmt.hu/api/publication/33846356},
	author = {Ughy, Bettina and Nagyapáti, Sarolta and Lajkó, Dézi Bianka and Letoha, Tamas and Prohaszka, Adam and Deeb, Dima and Dér, András and Pettkó-Szandtner, Aladár and Szilák, László},
	doi = {10.3390/cells12101430},
	journal-iso = {CELLS-BASEL},
	journal = {CELLS},
	volume = {12},
	unique-id = {33846356},
	abstract = {The growth of bacterial populations has been described as a dynamic process of continuous reproduction and cell death. However, this is far from the reality. In a well fed, growing bacterial population, the stationary phase inevitably occurs, and it is not due to accumulated toxins or cell death. A population spends the most time in the stationary phase, where the phenotype of the cells alters from the proliferating ones, and only the colony forming unit (CFU) decreases after a while, not the total cell concentration. A bacterial population can be considered as a virtual tissue as a result of a specific differentiation process, in which the exponential-phase cells develop to stationary-phase cells and eventually reach the unculturable form. The richness of the nutrient had no effect on growth rate or on stationary cell density. The generation time seems not to be a constant value, but it depended on the concentration of the starter cultures. Inoculations with serial dilutions of stationary populations reveal a so-called minimal stationary cell concentration (MSCC) point, up to which the cell concentrations remain constant upon dilutions; that seems to be universal among unicellular organisms.},
	year = {2023},
	eissn = {2073-4409},
	orcid-numbers = {Letoha, Tamas/0000-0002-6035-4009; Prohaszka, Adam/0000-0002-2390-2387}
}

@article{MTMT:33688148,
	title = {The Use of Sensors in Blood-Brain Barrier-on-a-Chip Devices: Current Practice and Future Directions},
	url = {https://m2.mtmt.hu/api/publication/33688148},
	author = {Kincses, András and Vigh, Judit Piroska and Petrovszki, Dániel and Valkai, Sándor and Kocsis, Anna and Walter, Fruzsina and Lin, Hung-Yin and Jan, Jeng-Shiung and Deli, Mária Anna and Dér, András},
	doi = {10.3390/bios13030357},
	journal-iso = {BIOSENSORS-BASEL},
	journal = {BIOSENSORS},
	volume = {13},
	unique-id = {33688148},
	abstract = {The application of lab-on-a-chip technologies in in vitro cell culturing swiftly resulted in improved models of human organs compared to static culture insert-based ones. These chip devices provide controlled cell culture environments to mimic physiological functions and properties. Models of the blood-brain barrier (BBB) especially profited from this advanced technological approach. The BBB represents the tightest endothelial barrier within the vasculature with high electric resistance and low passive permeability, providing a controlled interface between the circulation and the brain. The multi-cell type dynamic BBB-on-chip models are in demand in several fields as alternatives to expensive animal studies or static culture inserts methods. Their combination with integrated biosensors provides real-time and noninvasive monitoring of the integrity of the BBB and of the presence and concentration of agents contributing to the physiological and metabolic functions and pathologies. In this review, we describe built-in sensors to characterize BBB models via quasi-direct current and electrical impedance measurements, as well as the different types of biosensors for the detection of metabolites, drugs, or toxic agents. We also give an outlook on the future of the field, with potential combinations of existing methods and possible improvements of current techniques.},
	year = {2023},
	eissn = {2079-6374},
	orcid-numbers = {Valkai, Sándor/0000-0001-8479-8141; Walter, Fruzsina/0000-0001-8145-2823; Jan, Jeng-Shiung/0000-0002-8379-404X; Deli, Mária Anna/0000-0001-6084-6524}
}