@article{MTMT:34093747,
	title = {Galectin-1 as a marker for microglia activation in the aging brain},
	url = {https://m2.mtmt.hu/api/publication/34093747},
	author = {Kiss, Tamás and Mir, Mohd Yaqub and Stefancsik, Gergely and Ganbat, Gantulga and Askarova, Aruzhan and Monostori, Éva and Dulka, Karolina and Szebeni, Gábor and Nyúl-Tóth, Ádám and Csiszar, Anna and Légrádi, Ádám},
	doi = {10.1016/j.brainres.2023.148517},
	journal-iso = {BRAIN RES},
	journal = {BRAIN RESEARCH},
	volume = {1818},
	unique-id = {34093747},
	issn = {0006-8993},
	abstract = {Microglia cells, the immune cells residing in the brain, express immune regulatory molecules that have a central role in the manifestation of age-related brain characteristics. Our hypothesis suggests that galectin-1, an anti-inflammatory member of the beta-galactoside-binding lectin family, regulates microglia and neuroinflammation in the aging brain. Through our in-silico analysis, we discovered a subcluster of microglia in the aged mouse brain that exhibited increased expression of galectin-1 mRNA. In our Western blotting experiments, we observed a decrease in galectin-1 protein content in our rat primary cortical cultures over time. Additionally, we found that the presence of lipopolysaccharide, an immune activator, significantly increased the expression of galectin-1 protein in microglial cells. Utilizing flow cytometry, we determined that a portion of the galectin-1 protein was localized on the surface of the microglial cells. As cultivation time increased, we observed a decrease in the expression of activation-coupled molecules in microglial cells, indicating cellular exhaustion. In our mixed rat primary cortical cell cultures, we noted a transition of amoeboid microglial cells labeled with OX42(CD11b/c) to a ramified, branched phenotype during extended cultivation, accompanied by a complete disappearance of galectin-1 expression. By analyzing the transcriptome of a distinct microglial subpopulation in an animal model of aging, we established a correlation between chronological aging and galectin-1 expression. Furthermore, our in vitro study demonstrated that galectin-1 expression is associated with the functional activation state of microglial cells exhibiting specific amoeboid morphological characteristics. Based on our findings, we identify galectin-1 as a marker for microglia activation in the context of aging.},
	keywords = {Aging; Galectin-1; neuroinflammation; microglia},
	year = {2023},
	eissn = {1872-6240},
	orcid-numbers = {Kiss, Tamás/0000-0001-5339-5227; Stefancsik, Gergely/0000-0002-2098-652X; Monostori, Éva/0000-0002-7442-3562; Dulka, Karolina/0000-0002-7368-8198; Szebeni, Gábor/0000-0002-6998-5632; Légrádi, Ádám/0000-0001-7994-1935}
}

@CONFERENCE{MTMT:33719598,
	title = {Galectin-1 as a marker for microglia activation in the aging brain},
	url = {https://m2.mtmt.hu/api/publication/33719598},
	author = {Kiss, Tamás and Mir, Mohd Yaqub and Stefancsik, Gergely and Gantulga, Ganbat and Aruzhan, Askarova and Monostori, Éva and István, Pesti and Karolina, Dulka and Gábor, Szebeni J. and Nyúl-Tóth, Ádám and Csiszar, Anna and Eszter, Farkas and Légrádi, Ádám},
	booktitle = {Joint Neuroscience Meeting of the Hungarian Neuroscience Society (MITT) & the Austrian Neuroscience Association (ANA)},
	unique-id = {33719598},
	year = {2023},
	pages = {74-74},
	orcid-numbers = {Kiss, Tamás/0000-0001-5339-5227; Monostori, Éva/0000-0002-7442-3562}
}

@article{MTMT:32733913,
	title = {α/β-Peptides as Nanomolar Triggers of Lipid Raft-Mediated Endocytosis through GM1 Ganglioside Recognition},
	url = {https://m2.mtmt.hu/api/publication/32733913},
	author = {Hetényi, Anasztázia and Szabó, Enikő and Imre, Norbert and Nath Bhaumik, Kaushik and Tököli, Attila and Füzesi, Tamás and Hollandi, Réka and Horváth, Péter and Czibula, Ágnes and Monostori, Éva and Deli, Mária Anna and Martinek, Tamás},
	doi = {10.3390/pharmaceutics14030580},
	journal-iso = {PHARMACEUTICS},
	journal = {PHARMACEUTICS},
	volume = {14},
	unique-id = {32733913},
	issn = {1999-4923},
	abstract = {Cell delivery of therapeutic macromolecules and nanoparticles is a critical drug development challenge. Translocation through lipid raft-mediated endocytic mechanisms is being sought, as it can avoid rapid lysosomal degradation. Here, we present a set of short alpha/beta-peptide tags with high affinity to the lipid raft-associated ganglioside GM1. These sequences induce effective internalization of the attached immunoglobulin cargo. The structural requirements of the GM1-peptide interaction are presented, and the importance of the membrane components are shown. The results contribute to the development of a receptor-based cell delivery platform.},
	year = {2022},
	eissn = {1999-4923},
	orcid-numbers = {Hetényi, Anasztázia/0000-0001-8080-6992; Tököli, Attila/0000-0001-8413-3182; Czibula, Ágnes/0000-0003-4461-2773; Monostori, Éva/0000-0002-7442-3562; Deli, Mária Anna/0000-0001-6084-6524; Martinek, Tamás/0000-0003-3168-8066}
}

@article{MTMT:32570862,
	title = {Fehérje méretű molekulák humán sejtekbe juttatása lipid-raft mediált endocitózissal},
	url = {https://m2.mtmt.hu/api/publication/32570862},
	author = {Hetényi, Anasztázia and Imre, Norbert and Szabó, Enikő and Bodnár, Brigitta and Szkalisity, Ábel and Gróf, Ilona and Bocsik, Alexandra and Deli, Mária Anna and Horváth, Péter and Czibula, Ágnes and Monostori, Éva and Martinek, Tamás},
	journal-iso = {BIOKÉMIA},
	journal = {BIOKÉMIA: A MAGYAR BIOKÉMIAI EGYESÜLET FOLYÓIRATA},
	volume = {45},
	unique-id = {32570862},
	issn = {0133-8455},
	year = {2021},
	eissn = {2060-8152},
	pages = {67-83},
	orcid-numbers = {Hetényi, Anasztázia/0000-0001-8080-6992; Deli, Mária Anna/0000-0001-6084-6524; Czibula, Ágnes/0000-0003-4461-2773; Monostori, Éva/0000-0002-7442-3562; Martinek, Tamás/0000-0003-3168-8066}
}

@article{MTMT:32107638,
	title = {Stromal Cells Serve Drug Resistance for Multiple Myeloma via Mitochondrial Transfer: A Study on Primary Myeloma and Stromal Cells},
	url = {https://m2.mtmt.hu/api/publication/32107638},
	author = {Matula, Zsolt and Mikala, Gábor and Lukácsi, Szilvia Zsófia and Matkó, János and Kovács, Tamás and Monostori, Éva and Uher, Ferenc and Vályi-Nagy, István},
	doi = {10.3390/cancers13143461},
	journal-iso = {CANCERS},
	journal = {CANCERS},
	volume = {13},
	unique-id = {32107638},
	year = {2021},
	eissn = {2072-6694},
	orcid-numbers = {Lukácsi, Szilvia Zsófia/0000-0003-3499-8422; Kovács, Tamás/0000-0003-4127-4545; Monostori, Éva/0000-0002-7442-3562}
}

@article{MTMT:31598466,
	title = {Proteomimetic surface fragments distinguish targets by function},
	url = {https://m2.mtmt.hu/api/publication/31598466},
	author = {Tököli, Attila and Mag, Beáta Zsófia and Bartus, Éva and Wéber, Edit and Szakonyi, Gerda and Simon, Márton and Czibula, Ágnes and Monostori, Éva and Nyitray, László and Martinek, Tamás},
	doi = {10.1039/d0sc03525d},
	journal-iso = {CHEM SCI},
	journal = {CHEMICAL SCIENCE},
	volume = {11},
	unique-id = {31598466},
	issn = {2041-6520},
	year = {2020},
	eissn = {2041-6539},
	pages = {10390-10398},
	orcid-numbers = {Tököli, Attila/0000-0001-8413-3182; Bartus, Éva/0000-0001-9976-6978; Wéber, Edit/0000-0002-5904-0619; Szakonyi, Gerda/0000-0002-4366-4283; Czibula, Ágnes/0000-0003-4461-2773; Monostori, Éva/0000-0002-7442-3562; Nyitray, László/0000-0003-4717-5994; Martinek, Tamás/0000-0003-3168-8066}
}

@article{MTMT:31598021,
	title = {A Regenerative Approach to Canine Osteoarthritis Using Allogeneic, Adipose-Derived Mesenchymal Stem Cells. Safety Results of a Long-Term Follow-Up},
	url = {https://m2.mtmt.hu/api/publication/31598021},
	author = {Kriston-Pál, Éva and Haracska, Lajos and Cooper, P. and Kiss-Tóth, E. and Szukacsov, Valéria and Monostori, Éva},
	doi = {10.3389/fvets.2020.00510},
	journal-iso = {FRONT VET SCI},
	journal = {FRONTIERS IN VETERINARY SCIENCE},
	volume = {7},
	unique-id = {31598021},
	abstract = {Mesenchymal stem cells (MSC) are emerging as an effective therapeutic tool in treating canine osteoarthritis (OA). In this report, we focused on the questions of whether MSC transplantation has long-term beneficial effects for the improvement in motion and also evaluated the safety of MSC injection. Visceral adipose tissue, a surgical waste obtained during routine ovariectomy served as a source of allogeneic MSCs and used to treat OA. Altogether, fifty-eight dogs were transplanted in the study suffering from OA in the elbow (42 animals), hip (5), knee (8), ankle (2), and hock (1). The effect of MSC transplantation was evaluated by the degree of lameness at a 4-5-years follow-up period based on the owners' subjective observations. The results showed that 83% of the OA patients improved or retained improvement in lameness. Clinical safety of the treatment was assessed by evaluating the coincidence of tumors or other diseases and other adverse reactions (such as local inflammation) after MSC cell therapy. Two incidences of local inflammation for <1 week at the site of injection were reported. No other adverse reactions were detected post-treatment. Sixteen dogs died during the study, 4 due to cancer and 12 due to other diseases, diagnosed by veterinarians. Overall, our survey suggests that MSC transplantation has long-term beneficial effects in reducing lameness. Moreover, no enrichment in a specific cause of death was observed in the transplanted animals, compared to reported literature. Our data suggest that MSC treatment could be an effective and safe long-term therapy for canine OA. © Copyright © 2020 Kriston-Pál, Haracska, Cooper, Kiss-Tóth, Szukacsov and Monostori.},
	keywords = {Dogs; Therapy; Long-term follow-up; mesenchymal stem cell; osteoarthritis; safety of therapy},
	year = {2020},
	eissn = {2297-1769},
	orcid-numbers = {Monostori, Éva/0000-0002-7442-3562}
}

@article{MTMT:31126947,
	title = {Routing Nanomolar Protein Cargoes to Lipid Raft‐Mediated/Caveolar Endocytosis through a Ganglioside GM1‐Specific Recognition Tag},
	url = {https://m2.mtmt.hu/api/publication/31126947},
	author = {Imre, Norbert and Hetényi, Anasztázia and Szabó, Enikő and Bodnár, Brigitta and Szkalisity, Ábel and Gróf, Ilona and Bocsik, Alexandra and Deli, Mária Anna and Horváth, Péter and Czibula, Ágnes and Monostori, Éva and Martinek, Tamás},
	doi = {10.1002/advs.201902621},
	journal-iso = {ADV SCI},
	journal = {ADVANCED SCIENCE},
	volume = {7},
	unique-id = {31126947},
	year = {2020},
	eissn = {2198-3844},
	orcid-numbers = {Hetényi, Anasztázia/0000-0001-8080-6992; Deli, Mária Anna/0000-0001-6084-6524; Czibula, Ágnes/0000-0003-4461-2773; Monostori, Éva/0000-0002-7442-3562; Martinek, Tamás/0000-0003-3168-8066}
}

@article{MTMT:30802849,
	title = {Altered Cell Surface N-Glycosylation of Resting and Activated T Cells in Systemic Lupus Erythematosus},
	url = {https://m2.mtmt.hu/api/publication/30802849},
	author = {Szabó, Enikő and Hornung, Ákos and Monostori, Éva and Bocskai, Márta and Czibula, Ágnes and Kovács, László},
	doi = {10.3390/ijms20184455},
	journal-iso = {INT J MOL SCI},
	journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES},
	volume = {20},
	unique-id = {30802849},
	issn = {1661-6596},
	year = {2019},
	eissn = {1422-0067},
	orcid-numbers = {Monostori, Éva/0000-0002-7442-3562; Czibula, Ágnes/0000-0003-4461-2773; Kovács, László/0000-0003-4457-1430}
}

@article{MTMT:3190069,
	title = {Systemic lupus erythematosus in the light of the regulatory effects of galectin-1 on T-cell function},
	url = {https://m2.mtmt.hu/api/publication/3190069},
	author = {Hornung, Ákos and Monostori, Éva and Kovács, László},
	doi = {10.1177/0961203316686846},
	journal-iso = {LUPUS},
	journal = {LUPUS},
	volume = {26},
	unique-id = {3190069},
	issn = {0961-2033},
	abstract = {Galectin-1 is an endogenous immunoregulatory lectin-type protein. Its most important effects are the inhibition of the differentiation and cytokine production of Th1 and Th17 cells, and the induction of apoptosis of activated T-cells. Galectin-1 has been identified as a key molecule in antitumor immune surveillance, and data are accumulating about the pathogenic role of its deficiency, and the beneficial effects of its administration in various autoimmune disease models. Initial animal and human studies strongly suggest deficiencies in both galectin-1 production and responsiveness in systemic lupus erythematosus (SLE) T-cells. Since lupus features widespread abnormalities in T-cell activation, differentiation and viability, in this review the authors wished to highlight potential points in T-cell signalling processes that may be influenced by galectin-1. These points include GM-1 ganglioside-mediated lipid raft aggregation, early activation signalling steps involving p56Lck, the exchange of the CD3 zeta-ZAP-70 to the FcRgamma-Syk pathway, defective mitogen-activated protein kinase pathway activation, impaired regulatory T-cell function, the failure to suppress the activity of interleukin 17 (IL-17) producing T-cells, and decreased suppression of the PI3K-mTOR pathway by phosphatase and tensin homolog (PTEN). These findings place galectin-1 into the group of potential pathogenic molecules in SLE.},
	year = {2017},
	eissn = {1477-0962},
	pages = {339-347},
	orcid-numbers = {Monostori, Éva/0000-0002-7442-3562; Kovács, László/0000-0003-4457-1430}
}