@article{MTMT:37050637,
	title = {Cannabidiol in Epilepsy : Restoring Locomotion and Seizure Control},
	url = {https://m2.mtmt.hu/api/publication/37050637},
	author = {Ogbu, John Ihayi and Mendes Rosa, Thysia and Nakao de Aguiar, Antônio Sérgio and Borges, Leonardo Luiz and Perjési, Pál and Napolitano, Hamilton Barbosa and Filho, Alberto Souza Sá and Fajemiroye, James Oluwagbamigbe},
	doi = {10.2174/0118715273398370251129105507},
	journal-iso = {CNS NEUROL DISORD-DR},
	journal = {CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS},
	unique-id = {37050637},
	issn = {1871-5273},
	abstract = {Epilepsy remains a global challenge, with about one-third of affected patients being resistant to treatment. Seizures and motor abnormalities characterized by movement difficulties are common in epilepsy, highlighting the need for treatments that can both improve motor outcomes and control seizures. The therapeutic potential of Cannabidiol (CBD) in this regard necessitates a review that explores its effects and underlying mechanisms of action. This study reviewed studies from major scientific databases on the use of CBD in animal and human models of epilepsy. We also integrated tools of network pharmacology and molecular modeling to investigate how CBD may interact with various biological targets. The cannabinoid broadly demonstrates minimal or no changes in motor outcomes, reinforcing its low toxicity and tolerability. Evidence suggests that CBD has potential for seizure control by prolonging the time to seizure onset and decreasing seizure severity. The antiepileptic effects of CBD involve the modulation of multiple targets or genes. This multitarget interaction network may underlie its neuroprotective effects by regulating endocannabinoid signaling, neurotransmission, inflammation, and metabolic pathways. Chemical bonding between CBD and key protein residues reinforces evidence supporting its interaction with these targets. Despite the limited clinical data and algorithmic constraints of network pharmacology, the present findings reveal the potential of CBD to improve epileptic outcomes. The multitarget mechanisms of this phytocannabinoid offer valuable insights that may guide and advance epilepsy research.},
	keywords = {EPILEPSY; Locomotion; cannabidiol; antiseizure medications.},
	year = {2026},
	eissn = {1996-3181},
	orcid-numbers = {Perjési, Pál/0000-0002-1057-9664}
}

@article{MTMT:35641339,
	title = {Centrally Acting Chalcones: From Anticancer and Antinociceptive Properties to Molecular Considerations},
	url = {https://m2.mtmt.hu/api/publication/35641339},
	author = {Turones, Larissa C. and Moreira, Caroline V. L. and Ogbu, John I. and Perjési, Pál and Borges, Igor D. and Napolitano, Hamilton B. and Ibrahim, Mohamed A. and Costa, Elson A. and Fajemiroye, James O.},
	doi = {10.1007/s40495-024-00385-9},
	journal-iso = {CURRENT PHARMACOLOGY REPORTS},
	journal = {CURRENT PHARMACOLOGY REPORTS},
	volume = {11},
	unique-id = {35641339},
	year = {2025},
	eissn = {2198-641X},
	orcid-numbers = {Perjési, Pál/0000-0002-1057-9664}
}

@article{MTMT:36438388,
	title = {(E)-2-Benzylidenecyclanones : Part XXI-Reaction of Cyclic Chalcone Analogs with Cellular Thiols: Comparison of Reactivity of (E)-2-Arylidene-1-Indanone with -1-Tetralone and -1-Benzosuberone Analogs in Thia-Michael Reactions.},
	url = {https://m2.mtmt.hu/api/publication/36438388},
	author = {Kadlecsik, Csaba András and Bognár, Gábor and Kenari, Fatemeh and Pintér, Zoltán and Ribeiro, Júlio César de Oliveira and Envall, Mário G and Carvalho-Silva, Valter H and Napolitano, Hamilton B and Perjési, Pál},
	doi = {10.3390/ijms262110573},
	journal-iso = {INT J MOL SCI},
	journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES},
	volume = {26},
	unique-id = {36438388},
	issn = {1661-6596},
	abstract = {In vitro cytotoxicity of three (E)-3-(4'-X-benzylidene)-1-indanones (2a-c) displayed lower cytotoxicity towards murine P388 and L1210 leukemic cells as well as human Molt 4/C8 and CEM T-lymphocytes than the respective six- (3a-c) and seven-membered (4a-c) analogs. To study whether thiol reactivity-as a possible basis of their mechanism of action-correlates with the observed cytotoxicities, kinetics of the non-enzyme catalyzed reactions with reduced glutathione (GSH) and N-acetylcysteine (NAC) of 2a-c were investigated. Furthermore, it was also the aim of the work to compare the thiol reactivity of the open-chain chalcones (1) and their carbocyclic analogs (2-4) with different ring sizes (n = 5-7). The reactivity of the compounds and the stereochemical outcome of the reactions were evaluated using high-pressure liquid chromatography-mass spectrometry (HPLC-MS). Molecular modeling calculations were performed to rationalize the high initial rate and low conversion of the 2a indanone in comparison with those of the carbocyclic analog tetralone (3a) and benzosuberone (4a). Thiol reactivity and cancer cell cytotoxicity showed a dependence on both the ring size and the nature of aromatic substituents.},
	keywords = {GLUTATHIONE; DFT calculations; N-acetylcysteine; CHALCONE; Anticancer activity; Thia-Michael addition; Molecular electrostatic; benzylidenebenzosuberones; benzylideneindanones; benzylidenetetralones},
	year = {2025},
	eissn = {1422-0067},
	orcid-numbers = {Kadlecsik, Csaba András/0009-0005-8238-6430; Perjési, Pál/0000-0002-1057-9664}
}

@CONFERENCE{MTMT:34814603,
	title = {Study on thiol reactivity of some six-membered cyclic chalcone analogs. Search for relationships between thiol reactivity and in vitro cancer cell cytotoxic effects},
	url = {https://m2.mtmt.hu/api/publication/34814603},
	author = {Bognár, Gábor and Rahin, Kenari and Zoltán, Pintér and Perjési, Pál},
	booktitle = {Absztraktkötet: XII. Interdiszciplináris Doktorandusz Konferencia = Book of Abstract: XII. Interdisciplinary Doctoral Conference},
	unique-id = {34814603},
	year = {2024},
	pages = {143-143},
	orcid-numbers = {Perjési, Pál/0000-0002-1057-9664}
}

@CONFERENCE{MTMT:34915245,
	title = {Study on Stereochemistry of GSH-Conjugation of Some Cyclic Chalcone Analogs, 3-(4’-X-Benzylidene)-2,3-Dihydro-1-Benzopyran-4-Ones},
	url = {https://m2.mtmt.hu/api/publication/34915245},
	author = {Zoltán, Pintér and Bognár, Gábor and Perjési, Pál},
	booktitle = {Congressus Pharmaceuticus Hungaricus XVII. and EUFEPS Annual Meeting 2024},
	unique-id = {34915245},
	year = {2024},
	pages = {382-383},
	orcid-numbers = {Perjési, Pál/0000-0002-1057-9664}
}

@CONFERENCE{MTMT:34915704,
	title = {Study on Thiol Reactivity of Some Six-Membered Cyclic Chalcone Analogs. Search for Relationships Between Thiol Reactivity and In Vitro Cancer Cell Cytotoxic Effects},
	url = {https://m2.mtmt.hu/api/publication/34915704},
	author = {Bognár, Gábor and Kenari, Fatemeh and Zoltán, Pintér and Perjési, Pál},
	booktitle = {Congressus Pharmaceuticus Hungaricus XVII. and EUFEPS Annual Meeting 2024},
	unique-id = {34915704},
	year = {2024},
	pages = {217-217},
	orcid-numbers = {Perjési, Pál/0000-0002-1057-9664}
}

@CONFERENCE{MTMT:34915719,
	title = {Study of Michael Addition Reaction Between Hydroxychalcone Derivatives and Reduced Glutathione},
	url = {https://m2.mtmt.hu/api/publication/34915719},
	author = {Aline, Bernardes and Caridad, Noda Perez and Bognár, Gábor and Zoltán, Pintér and Perjési, Pál},
	booktitle = {Congressus Pharmaceuticus Hungaricus XVII. and EUFEPS Annual Meeting 2024},
	unique-id = {34915719},
	year = {2024},
	pages = {216-216},
	orcid-numbers = {Perjési, Pál/0000-0002-1057-9664}
}

@CONFERENCE{MTMT:34915819,
	title = {Chalcones – Prosperous Candidates for Drug Development},
	url = {https://m2.mtmt.hu/api/publication/34915819},
	author = {Perjési, Pál},
	booktitle = {Congressus Pharmaceuticus Hungaricus XVII. and EUFEPS Annual Meeting 2024},
	unique-id = {34915819},
	year = {2024},
	pages = {127-127},
	orcid-numbers = {Perjési, Pál/0000-0002-1057-9664}
}

@article{MTMT:35167458,
	title = {(E)-2-Benzylidenecyclanones: Part XIX. Reaction of (E)-2-(4′-X-Benzylidene)-1-tetralones with Cellular Thiols: Comparison of Thiol Reactivities of Open-Chain Chalcones and Their Six- and Seven-Membered Cyclic Analogs},
	url = {https://m2.mtmt.hu/api/publication/35167458},
	author = {Kenari, Fatemeh and Pintér, Z. and Molnár, Szilárd and Borges, I.D. and Camargo, A.J. and Napolitano, H.B. and Perjési, Pál},
	doi = {10.3390/ijms25147773},
	journal-iso = {INT J MOL SCI},
	journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES},
	volume = {25},
	unique-id = {35167458},
	issn = {1661-6596},
	year = {2024},
	eissn = {1422-0067},
	orcid-numbers = {Molnár, Szilárd/0000-0002-4244-0069; Perjési, Pál/0000-0002-1057-9664}
}

@article{MTMT:35591986,
	title = {A comprehensive molecular description of sertraline hydrochloride: From solid state to electronic structure},
	url = {https://m2.mtmt.hu/api/publication/35591986},
	author = {Morais, A.C.B. and Aguiar, A.S.N. and Perjési, Pál and Napolitano, H.B. and Borges, L.L.},
	doi = {10.1016/j.comptc.2024.114957},
	journal-iso = {COMPUT THEOR CHEM},
	journal = {COMPUTATIONAL AND THEORETICAL CHEMISTRY},
	volume = {1242},
	unique-id = {35591986},
	issn = {2210-271X},
	year = {2024},
	eissn = {2210-2728},
	orcid-numbers = {Perjési, Pál/0000-0002-1057-9664}
}