TY - JOUR AU - Nguyen Thanh, Thuy Tien AU - Yusifov, Ziya AU - Tóth, Bence AU - Bordácsné Bocz, Katalin AU - Márton, Péter AU - Hórvölgyi, Zoltán AU - Marosi, György AU - Szolnoki, Beáta TI - Preparation and Characterization of Microencapsulated Ammonium Polyphosphate with Polyurethane Shell and Its Flame Retardance in Polypropylene JF - FIRE J2 - FIRE VL - 7 PY - 2024 IS - 3 PG - 15 SN - 2571-6255 DO - 10.3390/fire7030097 UR - https://m2.mtmt.hu/api/publication/34761885 ID - 34761885 N1 - Department of Organic Chemistry and Technology, Faculty of Chemical Technology and Biotechnology, Budapest University of Technology and Economics, Műegyetem rkp. 3., Budapest, H-1111, Hungary Department of Physical Chemistry and Materials Science, Faculty of Chemical Technology and Biotechnology, Budapest University of Technology and Economics, Műegyetem rkp. 3., Budapest, H-1111, Hungary Export Date: 5 April 2024 Correspondence Address: Szolnoki, B.; Department of Organic Chemistry and Technology, Műegyetem rkp. 3., Hungary; email: szolnoki.beata@vbk.bme.hu AB - Polypropylene (PP) shows no charring ability in burning due to the lack of hydroxyl functional groups; thus, the flame retardant system needs an additional amount of carbonizing agent. An ammonium polyphosphate (APP)-based all-in-one intumescent flame-retardant system was prepared by the in situ polymerization of polymeric methylene diphenyl diisocyanate (pMDI) with a glycerol-based and a glycerol–sorbitol-based polyol of high OH value. The microencapsulated APP with a polyurethane shell (MCAPP) of different polyols was characterized. The MCAPP with speculated improved flame retardant performance was selected for further evaluation in the PP matrix at different loadings by means of standard flammability tests. LA - English DB - MTMT ER - TY - JOUR AU - Galata, Dorián László AU - Sinka Lázárné, Melinda AU - Kiss-Kovács, Dorottya AU - Fülöp, Gergő AU - Dávid, Barnabás AU - Bogáti, Botond AU - Ficzere, Máté AU - Péterfi, Orsolya AU - Nagy, Brigitta AU - Marosi, György AU - Nagy, Zsombor Kristóf TI - Effects of omitting titanium dioxide from the film coating of a pharmaceutical tablet – An industrial case study of attempting to comply with EU regulation 2022/63 JF - EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES J2 - EUR J PHARM SCI VL - 196 PY - 2024 PG - 8 SN - 0928-0987 DO - 10.1016/j.ejps.2024.106750 UR - https://m2.mtmt.hu/api/publication/34759143 ID - 34759143 N1 - Department of Organic Chemistry and Technology, Faculty of Chemical Technology and Biotechnology, Budapest University of Technology and Economics, Műegyetem rkp. 3, Budapest, H-1111, Hungary Gedeon Richter Plc., Formulation R&D, Gyömrői u. 19-21, Budapest, H-1103, Hungary Export Date: 2 April 2024 CODEN: EPSCE Correspondence Address: Nagy, Z.K.; Department of Organic Chemistry and Technology, Műegyetem rkp. 3, Hungary; email: zsknagy@oct.bme.hu LA - English DB - MTMT ER - TY - JOUR AU - Aljamal, Amer AU - Marosi, György AU - Szolnoki, Beáta TI - The utilization of phytic acid as a reactive flame retardant in the preparation of a fully waterborne biobased epoxy system JF - FIRE AND MATERIALS J2 - FIRE MATER PY - 2024 PG - 14 SN - 0308-0501 DO - 10.1002/fam.3199 UR - https://m2.mtmt.hu/api/publication/34609152 ID - 34609152 N1 - Export Date: 19 February 2024 CODEN: FMATD Correspondence Address: Aljamal, A.; Department of Organic Chemistry and Technology, Műegyetem rkp. 3, Hungary; email: amer.aljamal@edu.bme.hu Funding details: 2019–1.3.1‐KK‐2019–00004, TKP2021‐NVA‐02 Funding details: Magyar Tudományos Akadémia, MTA, BO/00980/23/7 Funding details: Nemzeti Kutatási, Fejlesztési és Innovaciós Alap, NKFIA Funding text 1: This research was supported by The National Research, Development, and Innovation Fund of Hungary under Grant TKP2021‐NVA‐02 and 2019–1.3.1‐KK‐2019–00004 projects. Amer Aljamal would like to acknowledge the Stipendium Hungaricum scholarship program for financial support. The supports of the János Bolyai Research Scholarship of the Hungarian Academy of Sciences (No. BO/00980/23/7) and that of ÚNKP‐23‐5‐BME‐417 New National Excellence Program of the Ministry for Culture and Innovation from the source of the National Research, Development and Innovation Fund are acknowledged. AB - A fully biobased waterborne flame-retarded epoxy system was prepared using sorbitol polyglycidyl ether epoxy resin (SPE) and phytic acid (PA) as a reactive flame retardant (FR). The flame-retardant efficiency was evaluated by comparing the reference SPE-PA system with solventborne and waterborne SPE systems. Additional enhancement of intumescence and reduction of flammability was achieved by incorporating ammonium polyphosphate (APP) and melamine (MEL) into the SPE-PA system. PA, serving as a curing agent, contributed approximately 1% phosphorous content, resulting in an increased limiting oxygen index (LOI). UL-94 flammability tests demonstrated improved FR properties with PA, and the addition of 2% phosphorous from APP to SPE-PA achieved a self-extinguishing V0 UL-94 rating. Thermogravimetric analysis (TGA) revealed enhanced thermal stability and higher char yield with PA compared with other curing agents. Mass loss calorimetry (MLC) confirmed the superior charring effect of PA compared with other curing agents. The thermal insulation properties of the residual char were assessed by measuring the temperature on the back surface (Tb) of coated steel plates exposed to a 25 kW/m(2) heat flux for 1 h. The PA sample containing 3%P of APP exhibited a Tb decrease of 130 degrees C compared with the solventborne reference sample. Scanning electron microscopy analysis of the char morphology supported these findings, indicating the effectiveness of the intumescent FR system. Infrared spectra of the char residues and pyrolysis gaseous products were obtained to gain insights into the flame-retardant mechanism of the different systems. LA - English DB - MTMT ER - TY - JOUR AU - Hirsch, Edit AU - Bornemissza, Zsuzsanna AU - Nagy, Zsombor Kristóf AU - Marosi, György AU - Farkas, Attila TI - Quantitative and qualitative analysis of cell culture media powders for mammalian cells by Raman microscopy JF - SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY J2 - SPECTROCHIM ACTA A VL - 310 PY - 2024 PG - 11 SN - 1386-1425 DO - 10.1016/j.saa.2024.123906 UR - https://m2.mtmt.hu/api/publication/34544805 ID - 34544805 N1 - Export Date: 23 February 2024 CODEN: SAMCA Correspondence Address: Farkas, A.; Department of Organic Chemistry and Technology, Müegyetem rkp. 3., Hungary; email: farkas.attila@vbk.bme.hu Chemicals/CAS: Culture Media; Powders; Recombinant Proteins Funding details: 19-21, RRF-2.3.1-21-2022-00015 Funding details: European Commission, EC Funding details: Nemzeti Kutatási, Fejlesztési és Innovaciós Alap, NKFIA, K143039, ÚNKP-22-4-II-BME-128 Funding text 1: The research has been implemented with the support provided by the Ministry of Culture and Innovation of Hungary from the National Research, Development and Innovation Fund, financed under the K143039 funding scheme, and ÚNKP-22-4-II-BME-128 New National Excellence Program; Gedeon Richter Plc. Centennial Foundation (1103 Budapest, Gyömrői str. 19-21); and RRF-2.3.1-21-2022-00015 project provided by the European Union. Funding text 2: The research has been implemented with the support provided by the Ministry of Culture and Innovation of Hungary from the National Research, Development and Innovation Fund, financed under the K143039 funding scheme, and ÚNKP-22-4-II-BME-128 New National Excellence Program; Gedeon Richter Plc. Centennial Foundation (1103 Budapest, Gyömrői str. 19-21); and RRF-2.3.1-21-2022-00015 project provided by the European Union. LA - English DB - MTMT ER - TY - JOUR AU - Marosi, György AU - Bordácsné Bocz, Katalin TI - Fibers and safety in fire retarded polymer systems: Are we just at the beginning of the road? JF - EXPRESS POLYMER LETTERS J2 - EXPRESS POLYM LETT VL - 18 PY - 2024 IS - 2 SP - 116 EP - 117 PG - 2 SN - 1788-618X DO - 10.3144/expresspolymlett.2024.9 UR - https://m2.mtmt.hu/api/publication/34448262 ID - 34448262 N1 - Export Date: 22 December 2023 Correspondence Address: Marosi, G.; Department of Organic Chemistry and Technology, Műegyetem rkp. 3, Hungary; email: marosi.gyorgy@vbk.bme.hu LA - English DB - MTMT ER - TY - JOUR AU - Vadas, Dániel AU - Bordácsné Bocz, Katalin AU - Igricz, Tamás AU - Volk, János AU - Bordács, Sándor AU - Madarász, Lajos AU - Marosi, György TI - Novel manufacturing method for highly flexible poly(lactic acid) foams and ferroelectrets JF - ADVANCED INDUSTRIAL AND ENGINEERING POLYMER RESEARCH J2 - ADV INDUST ENGIN POLYMER RES VL - 7 PY - 2024 IS - 2 SP - 215 EP - 225 PG - 11 SN - 2542-5048 DO - 10.1016/j.aiepr.2023.03.005 UR - https://m2.mtmt.hu/api/publication/33836337 ID - 33836337 AB - Poly (lactic acid) (PLA) foams have demonstrated a high variety of functional characteristics, still, the rigidity of this cellular material remains a major limiting factor when it comes to implementation options. In this contribution, PLA foams with outstanding flexibility were created for the first time by a new approach of uniaxial stretching and immediate relaxation following supercritical CO2-assisted extrusion foaming. Instead of improving the resilience of the PLA raw material, structural elasticity of the foam was achieved via altering the deformation mechanism from cell wall collapse or rupture towards reversible and extensive flexural strain. In addition, PLA foams with excellent piezoelectric properties were also achieved via high-voltage corona poling, giving additional function to the lens-like anisotropic foam cells. This foaming technology creates the opportunity to produce PLA piezoelectrets in a way entirely different from the state-of-the-art methods. Correlation between the tensile as well as compression elongations and moduli, cell morphology and longitudinal piezoelectric coefficients (d33) of electretized foam samples were studied. Unprecedented reversible tensile elongations of up to 16% and total elongations of up to 35% were reached, as well as considerable d33 values in the range of 50–320 pC/N were obtained for PLA ferroelectrets. LA - English DB - MTMT ER - TY - JOUR AU - Vaskó, Dorottya AU - Domján, Júlia AU - Szűcs, Bence AU - Bakk, László AU - Hajdinák, Péter AU - Marosi, György AU - Nagy, Zsombor Kristóf AU - Hirsch, Edit AU - Fehér, Csaba TI - Development and Comparison of Alternative Methods for the Purification of Adalimumab Directly from Harvested Cell Culture Fluid JF - FOOD TECHNOLOGY AND BIOTECHNOLOGY J2 - FOOD TECHNOL BIOTECH VL - 61 PY - 2023 IS - 3 SP - 339 EP - 349 PG - 11 SN - 1330-9862 DO - 10.17113/ftb.61.03.23.8094 UR - https://m2.mtmt.hu/api/publication/34352488 ID - 34352488 N1 - Department of Organic Chemistry and Technology, Faculty of Chemical Technology and Biotechnology, Budapest University of Technology and Economics, Műegyetem rkp. 3, Budapest, 1111, Hungary Department of Applied Biotechnology and Food Science, Faculty of Chemical Technology and Biotechnology, Budapest University of Technology and Economics, Műegyetem rkp. 3, Budapest, 1111, Hungary Export Date: 2 January 2024 Correspondence Address: Hirsch, E.; Department of Organic Chemistry and Technology, Műegyetem rkp. 3, Hungary; email: hirsch.edit@vbk.bme.hu Funding details: Nemzeti Kutatási Fejlesztési és Innovációs Hivatal, NKFI, K143039, ÚNKP-21-4-II-BME-331 Funding text 1: This research was funded by the National Research, Development and Innovation Fund of Hungary under grant K143039 and ÚNKP-21-4-II-BME-331 New National Excellence Program of the Ministry of Culture and Innovation. The research was carried out in the frame of RRF-2.3.1-21-2022-00015 project provided by the European Union. AB - Research background. Protein A affinity chromatography is a well-established methodcurrently used in the pharmaceutical industry. However, the high costs usually associated with chromatographic separation of protein A and the difficulties in continuous operation make the investigation of alternative purification methods very important.Experimental approach. In this study, extraction/back-extraction and precipitation/dissolution methods were developed and optimised. They were compared with protein A and cation exchange chromatography separations in terms of yield of monoclonal antibody (mAb) and amount of residual impurities, such as DNA and host cell proteins, and amount of mAb aggregates. For a comprehensive comparison of the different methods, experiments were carried out with the same cell-free fermentation broth containing adalimumab.Results and conclusions. Protein A and cation exchange chromatographic separationsresulted in high yield and purity of adalimumab. The precipitation-based process resulted in high yield but with lower purity. The extraction-based purification resulted in low yield and purity. Thus, the precipitation-based method proved to be more promising than the extraction-based method for direct purification of adalimumab from harvested cell culture fluid.Novelty and scientific contribution. Although alternative purification methods may offerthe advantages of simplicity and low-cost operation, further significant improvementsare required to compete with the performance of chromatographic separations of adalimumab from true fermentation broth. LA - English DB - MTMT ER - TY - JOUR AU - Marosi, György TI - Funkcionális polimer rendszerek, technológiák – evolúció JF - MAGYAR KÉMIAI FOLYÓIRAT - KÉMIAI KÖZLEMÉNYEK (1997-) J2 - MAGY KÉM FOLY KÉM KÖZL VL - 129 PY - 2023 IS - 1 SP - 7 EP - 14 PG - 8 SN - 1418-9933 DO - 10.24100/MKF.2023.01.07 UR - https://m2.mtmt.hu/api/publication/34065965 ID - 34065965 N1 - "A közlemény Marosi György, az MTA levelező tagja által tartott székfoglaló előadás szerkesztett változata" "Köszönetnyilvánítás A szerző köszönetét fejezi ki a FirePharma kutatócsoport jelenlegi és korábbi tagjainak, valamint hazai és külföldi együttműködő partnereinek, azaz mindazoknak, akik a felsorolt publikációkban szerzőként szerepelnek, valamint a háttérben önzetlenül tevékenykedő, meg nem nevezett, segítőknek. A munka jelentős része az RRF-2.3.1-21-2022-00015 számú projekt keretében az Európai Unió támogatásával valósult meg, s köszönet illeti az NKFIH-t a 2019–1.3.1- KK-2019–000 04, GINOP_PLUSZ-2.1.1-21-2022-00041és OTKA K 143039 számú projektek keretében nyújtott támogatásért. Az ipari partnereket (akik felsorolására itt nincs lehetőség) illeti a köszönhet azért, hogy munkánknak gyakorlati irányt szabnak." LA - Hungarian DB - MTMT ER - TY - JOUR AU - Hirsch, Edit AU - Nacsa, Márió AU - Pantea, Eszter AU - Szabó, Edina AU - Vass, Panna AU - Domján, Júlia AU - Farkas, Attila AU - Nyiri, Zoltán AU - Eke, Zsuzsanna AU - Vigh, Tamás AU - Andersen, Sune Klint AU - Verreck, Geert AU - Marosi, György AU - Nagy, Zsombor Kristóf TI - Oligonucleotide Formulations Prepared by High-Speed Electrospinning: Maximizing Loading and Exploring Downstream Processability JF - PHARMACEUTICS J2 - PHARMACEUTICS VL - 15 PY - 2023 IS - 3 SP - 855 SN - 1999-4923 DO - 10.3390/pharmaceutics15030855 UR - https://m2.mtmt.hu/api/publication/33684897 ID - 33684897 N1 - Funding Agency and Grant Number: New National Excellence Program of the Ministry for Innovation and Technology from the source of the National Research, Development, and Innovation Fund [TKP2021-EGA-02, UNKP-21-4-II-BME-331]; Janos Bolyai Research Scholarship of the Hungarian Academy of Science Funding text: This work was supported by Grant TKP2021-EGA-02 and the UNKP-21-4-II-BME-331 New National Excellence Program of the Ministry for Innovation and Technology from the source of the National Research, Development, and Innovation Fund. This paper was supported by the Janos Bolyai Research Scholarship of the Hungarian Academy of Science. AB - The aim of this study was to develop antisense oligonucleotide tablet formulations using high-speed electrospinning. Hydroxypropyl-beta-cyclodextrin (HPβCD) was used as a stabilizer and as an electrospinning matrix. In order to optimize the morphology of the fibers, electrospinning of various formulations was carried out using water, methanol/water (1:1), and methanol as solvents. The results showed that using methanol could be advantageous due to the lower viscosity threshold for fiber formation enabling higher potential drug loadings by using less excipient. To increase the productivity of electrospinning, high-speed electrospinning technology was utilized and HPβCD fibers containing 9.1% antisense oligonucleotide were prepared at a rate of ~330 g/h. Furthermore, to increase the drug content of the fibers, a formulation with a 50% drug loading was developed. The fibers had excellent grindability but poor flowability. The ground fibrous powder was mixed with excipients to improve its flowability, which enabled the automatic tableting of the mixture by direct compression. The fibrous HPβCD–antisense oligonucleotide formulations showed no sign of physical or chemical degradation over the 1-year stability study, which also shows the suitability of the HPβCD matrix for the formulation of biopharmaceuticals. The obtained results demonstrate possible solutions for the challenges of electrospinning such as scale-up and downstream processing of the fibers. LA - English DB - MTMT ER - TY - JOUR AU - Nagy, Brigitta AU - Szabados-Nacsa, Ágnes AU - Fülöp, Gergő AU - Turák Nagyné, Anikó AU - Galata, Dorián László AU - Farkas, Attila AU - Mészáros, Lilla Alexandra AU - Nagy, Zsombor Kristóf AU - Marosi, György TI - Interpretable artificial neural networks for retrospective QbD of pharmaceutical tablet manufacturing based on a pilot-scale developmental dataset JF - INTERNATIONAL JOURNAL OF PHARMACEUTICS J2 - INT J PHARM VL - 633 PY - 2023 SN - 0378-5173 DO - 10.1016/j.ijpharm.2023.122620 UR - https://m2.mtmt.hu/api/publication/33641694 ID - 33641694 N1 - Department of Organic Chemistry and Technology, Faculty of Chemical Technology and Biotechnology, Budapest University of Technology and Economics, Műegyetem rkp. 3., Budapest, H-1111, Hungary Gedeon Richter Plc., Formulation R&D, Gyömrői u. 19-21, Budapest, H-1103, Hungary CODEN: IJPHD Correspondence Address: Nagy, B.; Department of Organic Chemistry and Technology, Műegyetem rkp. 3., Hungary; email: nagy.brigitta@edu.bme.hu LA - English DB - MTMT ER -