@article{MTMT:34761885,
	title = {Preparation and Characterization of Microencapsulated Ammonium Polyphosphate with Polyurethane Shell and Its Flame Retardance in Polypropylene},
	url = {https://m2.mtmt.hu/api/publication/34761885},
	author = {Nguyen Thanh, Thuy Tien and Yusifov, Ziya and Tóth, Bence and Bordácsné Bocz, Katalin and Márton, Péter and Hórvölgyi, Zoltán and Marosi, György and Szolnoki, Beáta},
	doi = {10.3390/fire7030097},
	journal-iso = {FIRE},
	journal = {FIRE},
	volume = {7},
	unique-id = {34761885},
	abstract = {Polypropylene (PP) shows no charring ability in burning due to the lack of hydroxyl functional groups; thus, the flame retardant system needs an additional amount of carbonizing agent. An ammonium polyphosphate (APP)-based all-in-one intumescent flame-retardant system was prepared by the in situ polymerization of polymeric methylene diphenyl diisocyanate (pMDI) with a glycerol-based and a glycerol–sorbitol-based polyol of high OH value. The microencapsulated APP with a polyurethane shell (MCAPP) of different polyols was characterized. The MCAPP with speculated improved flame retardant performance was selected for further evaluation in the PP matrix at different loadings by means of standard flammability tests.},
	year = {2024},
	eissn = {2571-6255},
	orcid-numbers = {Marosi, György/0000-0002-4774-2023; Szolnoki, Beáta/0000-0001-7214-9734}
}

@article{MTMT:34759143,
	title = {Effects of omitting titanium dioxide from the film coating of a pharmaceutical tablet – An industrial case study of attempting to comply with EU regulation 2022/63},
	url = {https://m2.mtmt.hu/api/publication/34759143},
	author = {Galata, Dorián László and Sinka Lázárné, Melinda and Kiss-Kovács, Dorottya and Fülöp, Gergő and Dávid, Barnabás and Bogáti, Botond and Ficzere, Máté and Péterfi, Orsolya and Nagy, Brigitta and Marosi, György and Nagy, Zsombor Kristóf},
	doi = {10.1016/j.ejps.2024.106750},
	journal-iso = {EUR J PHARM SCI},
	journal = {EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES},
	volume = {196},
	unique-id = {34759143},
	issn = {0928-0987},
	year = {2024},
	eissn = {1879-0720},
	orcid-numbers = {Marosi, György/0000-0002-4774-2023}
}

@article{MTMT:34609152,
	title = {The utilization of phytic acid as a reactive flame retardant in the preparation of a fully waterborne biobased epoxy system},
	url = {https://m2.mtmt.hu/api/publication/34609152},
	author = {Aljamal, Amer and Marosi, György and Szolnoki, Beáta},
	doi = {10.1002/fam.3199},
	journal-iso = {FIRE MATER},
	journal = {FIRE AND MATERIALS},
	unique-id = {34609152},
	issn = {0308-0501},
	abstract = {A fully biobased waterborne flame-retarded epoxy system was prepared using sorbitol polyglycidyl ether epoxy resin (SPE) and phytic acid (PA) as a reactive flame retardant (FR). The flame-retardant efficiency was evaluated by comparing the reference SPE-PA system with solventborne and waterborne SPE systems. Additional enhancement of intumescence and reduction of flammability was achieved by incorporating ammonium polyphosphate (APP) and melamine (MEL) into the SPE-PA system. PA, serving as a curing agent, contributed approximately 1% phosphorous content, resulting in an increased limiting oxygen index (LOI). UL-94 flammability tests demonstrated improved FR properties with PA, and the addition of 2% phosphorous from APP to SPE-PA achieved a self-extinguishing V0 UL-94 rating. Thermogravimetric analysis (TGA) revealed enhanced thermal stability and higher char yield with PA compared with other curing agents. Mass loss calorimetry (MLC) confirmed the superior charring effect of PA compared with other curing agents. The thermal insulation properties of the residual char were assessed by measuring the temperature on the back surface (Tb) of coated steel plates exposed to a 25 kW/m(2) heat flux for 1 h. The PA sample containing 3%P of APP exhibited a Tb decrease of 130 degrees C compared with the solventborne reference sample. Scanning electron microscopy analysis of the char morphology supported these findings, indicating the effectiveness of the intumescent FR system. Infrared spectra of the char residues and pyrolysis gaseous products were obtained to gain insights into the flame-retardant mechanism of the different systems.},
	keywords = {PHYTIC ACID; Waterborne epoxy; reactive flame retardant; fully biobased epoxy; intumescent flame-retardant system; self-extinguishing system},
	year = {2024},
	eissn = {1099-1018},
	orcid-numbers = {Marosi, György/0000-0002-4774-2023; Szolnoki, Beáta/0000-0001-7214-9734}
}

@article{MTMT:34544805,
	title = {Quantitative and qualitative analysis of cell culture media powders for mammalian cells by Raman microscopy},
	url = {https://m2.mtmt.hu/api/publication/34544805},
	author = {Hirsch, Edit and Bornemissza, Zsuzsanna and Nagy, Zsombor Kristóf and Marosi, György and Farkas, Attila},
	doi = {10.1016/j.saa.2024.123906},
	journal-iso = {SPECTROCHIM ACTA A},
	journal = {SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY},
	volume = {310},
	unique-id = {34544805},
	issn = {1386-1425},
	year = {2024},
	eissn = {1873-3557},
	orcid-numbers = {Marosi, György/0000-0002-4774-2023; Farkas, Attila/0000-0002-8877-2587}
}

@article{MTMT:34448262,
	title = {Fibers and safety in fire retarded polymer systems: Are we just at the beginning of the road?},
	url = {https://m2.mtmt.hu/api/publication/34448262},
	author = {Marosi, György and Bordácsné Bocz, Katalin},
	doi = {10.3144/expresspolymlett.2024.9},
	journal-iso = {EXPRESS POLYM LETT},
	journal = {EXPRESS POLYMER LETTERS},
	volume = {18},
	unique-id = {34448262},
	issn = {1788-618X},
	year = {2024},
	eissn = {1788-618X},
	pages = {116-117},
	orcid-numbers = {Marosi, György/0000-0002-4774-2023}
}

@article{MTMT:33836337,
	title = {Novel manufacturing method for highly flexible poly(lactic acid) foams and ferroelectrets},
	url = {https://m2.mtmt.hu/api/publication/33836337},
	author = {Vadas, Dániel and Bordácsné Bocz, Katalin and Igricz, Tamás and Volk, János and Bordács, Sándor and Madarász, Lajos and Marosi, György},
	doi = {10.1016/j.aiepr.2023.03.005},
	journal-iso = {ADV INDUST ENGIN POLYMER RES},
	journal = {ADVANCED INDUSTRIAL AND ENGINEERING POLYMER RESEARCH},
	volume = {7},
	unique-id = {33836337},
	issn = {2542-5048},
	abstract = {Poly (lactic acid) (PLA) foams have demonstrated a high variety of functional characteristics, still, the rigidity of this cellular material remains a major limiting factor when it comes to implementation options. In this contribution, PLA foams with outstanding flexibility were created for the first time by a new approach of uniaxial stretching and immediate relaxation following supercritical CO2-assisted extrusion foaming. Instead of improving the resilience of the PLA raw material, structural elasticity of the foam was achieved via altering the deformation mechanism from cell wall collapse or rupture towards reversible and extensive flexural strain. In addition, PLA foams with excellent piezoelectric properties were also achieved via high-voltage corona poling, giving additional function to the lens-like anisotropic foam cells. This foaming technology creates the opportunity to produce PLA piezoelectrets in a way entirely different from the state-of-the-art methods. Correlation between the tensile as well as compression elongations and moduli, cell morphology and longitudinal piezoelectric coefficients (d33) of electretized foam samples were studied. Unprecedented reversible tensile elongations of up to 16% and total elongations of up to 35% were reached, as well as considerable d33 values in the range of 50–320 pC/N were obtained for PLA ferroelectrets.},
	year = {2024},
	pages = {215-225},
	orcid-numbers = {Volk, János/0000-0003-3633-6190; Bordács, Sándor/0000-0003-0420-5997; Marosi, György/0000-0002-4774-2023}
}

@article{MTMT:34352488,
	title = {Development and Comparison of Alternative Methods for the Purification of Adalimumab Directly from Harvested Cell Culture Fluid},
	url = {https://m2.mtmt.hu/api/publication/34352488},
	author = {Vaskó, Dorottya and Domján, Júlia and Szűcs, Bence and Bakk, László and Hajdinák, Péter and Marosi, György and Nagy, Zsombor Kristóf and Hirsch, Edit and Fehér, Csaba},
	doi = {10.17113/ftb.61.03.23.8094},
	journal-iso = {FOOD TECHNOL BIOTECH},
	journal = {FOOD TECHNOLOGY AND BIOTECHNOLOGY},
	volume = {61},
	unique-id = {34352488},
	issn = {1330-9862},
	abstract = {Research background. Protein A affinity chromatography is a well-established methodcurrently used in the pharmaceutical industry. However, the high costs usually associated with chromatographic separation of protein A and the difficulties in continuous operation make the investigation of alternative purification methods very important.Experimental approach. In this study, extraction/back-extraction and precipitation/dissolution methods were developed and optimised. They were compared with protein A and cation exchange chromatography separations in terms of yield of monoclonal antibody (mAb) and amount of residual impurities, such as DNA and host cell proteins, and amount of mAb aggregates. For a comprehensive comparison of the different methods, experiments were carried out with the same cell-free fermentation broth containing adalimumab.Results and conclusions. Protein A and cation exchange chromatographic separationsresulted in high yield and purity of adalimumab. The precipitation-based process resulted in high yield but with lower purity. The extraction-based purification resulted in low yield and purity. Thus, the precipitation-based method proved to be more promising than the extraction-based method for direct purification of adalimumab from harvested cell culture fluid.Novelty and scientific contribution. Although alternative purification methods may offerthe advantages of simplicity and low-cost operation, further significant improvementsare required to compete with the performance of chromatographic separations of adalimumab from true fermentation broth.},
	year = {2023},
	eissn = {1334-2606},
	pages = {339-349},
	orcid-numbers = {Vaskó, Dorottya/0000-0002-2502-0644; Hajdinák, Péter/0000-0002-7705-2074; Marosi, György/0000-0002-4774-2023}
}

@article{MTMT:34065965,
	title = {Funkcionális polimer rendszerek, technológiák – evolúció},
	url = {https://m2.mtmt.hu/api/publication/34065965},
	author = {Marosi, György},
	doi = {10.24100/MKF.2023.01.07},
	journal-iso = {MAGY KÉM FOLY KÉM KÖZL},
	journal = {MAGYAR KÉMIAI FOLYÓIRAT - KÉMIAI KÖZLEMÉNYEK (1997-)},
	volume = {129},
	unique-id = {34065965},
	issn = {1418-9933},
	year = {2023},
	eissn = {1418-8600},
	pages = {7-14},
	orcid-numbers = {Marosi, György/0000-0002-4774-2023}
}

@article{MTMT:33684897,
	title = {Oligonucleotide Formulations Prepared by High-Speed Electrospinning: Maximizing Loading and Exploring Downstream Processability},
	url = {https://m2.mtmt.hu/api/publication/33684897},
	author = {Hirsch, Edit and Nacsa, Márió and Pantea, Eszter and Szabó, Edina and Vass, Panna and Domján, Júlia and Farkas, Attila and Nyiri, Zoltán and Eke, Zsuzsanna and Vigh, Tamás and Andersen, Sune Klint and Verreck, Geert and Marosi, György and Nagy, Zsombor Kristóf},
	doi = {10.3390/pharmaceutics15030855},
	journal-iso = {PHARMACEUTICS},
	journal = {PHARMACEUTICS},
	volume = {15},
	unique-id = {33684897},
	issn = {1999-4923},
	abstract = {The aim of this study was to develop antisense oligonucleotide tablet formulations using high-speed electrospinning. Hydroxypropyl-beta-cyclodextrin (HPβCD) was used as a stabilizer and as an electrospinning matrix. In order to optimize the morphology of the fibers, electrospinning of various formulations was carried out using water, methanol/water (1:1), and methanol as solvents. The results showed that using methanol could be advantageous due to the lower viscosity threshold for fiber formation enabling higher potential drug loadings by using less excipient. To increase the productivity of electrospinning, high-speed electrospinning technology was utilized and HPβCD fibers containing 9.1% antisense oligonucleotide were prepared at a rate of ~330 g/h. Furthermore, to increase the drug content of the fibers, a formulation with a 50% drug loading was developed. The fibers had excellent grindability but poor flowability. The ground fibrous powder was mixed with excipients to improve its flowability, which enabled the automatic tableting of the mixture by direct compression. The fibrous HPβCD–antisense oligonucleotide formulations showed no sign of physical or chemical degradation over the 1-year stability study, which also shows the suitability of the HPβCD matrix for the formulation of biopharmaceuticals. The obtained results demonstrate possible solutions for the challenges of electrospinning such as scale-up and downstream processing of the fibers.},
	year = {2023},
	eissn = {1999-4923},
	pages = {855},
	orcid-numbers = {Hirsch, Edit/0000-0002-4672-9572; Szabó, Edina/0000-0001-9616-5122; Vass, Panna/0000-0003-2206-565X; Farkas, Attila/0000-0002-8877-2587; Eke, Zsuzsanna/0000-0002-5587-5029; Marosi, György/0000-0002-4774-2023}
}

@article{MTMT:33641694,
	title = {Interpretable artificial neural networks for retrospective QbD of pharmaceutical tablet manufacturing based on a pilot-scale developmental dataset},
	url = {https://m2.mtmt.hu/api/publication/33641694},
	author = {Nagy, Brigitta and Szabados-Nacsa, Ágnes and Fülöp, Gergő and Turák Nagyné, Anikó and Galata, Dorián László and Farkas, Attila and Mészáros, Lilla Alexandra and Nagy, Zsombor Kristóf and Marosi, György},
	doi = {10.1016/j.ijpharm.2023.122620},
	journal-iso = {INT J PHARM},
	journal = {INTERNATIONAL JOURNAL OF PHARMACEUTICS},
	volume = {633},
	unique-id = {33641694},
	issn = {0378-5173},
	year = {2023},
	eissn = {1873-3476},
	orcid-numbers = {Farkas, Attila/0000-0002-8877-2587; Marosi, György/0000-0002-4774-2023}
}