TY - JOUR AU - Vámos, Orsolya AU - Komora, Péter AU - Gede, Noémi AU - Hegyi, Péter AU - Kelemen, Kata AU - Varga, Gábor AU - Mikulás, Krisztina Ágnes AU - Kerémi, Beáta AU - Kispélyi, Ida Barbara TI - The effect of nicotine-containing products on peri-implant tissues : A systematic review and network meta-analysis JF - NICOTINE AND TOBACCO RESEARCH J2 - NICOTINE TOB RES PY - 2024 SN - 1462-2203 DO - 10.1093/ntr/ntae085 UR - https://m2.mtmt.hu/api/publication/34801787 ID - 34801787 AB - Smokers have a higher chance of developing peri-implant diseases and are therefore considered an at-risk population. Our aim was to compare peri-implant characteristics in users of electronic cigarettes (EC), waterpipes (WP), cigarettes (CS), smokeless tobacco (ST), and non-smokers (non-users of any nicotine and tobacco product; NS).A systematic search of four electronic databases (PubMed, EMBASE, Web of Science, CENTRAL) was performed until April 2023, restricted to English language. Thirty-nine observational studies were included in the qualitative synthesis, of which 32 studies were included in a Bayesian network meta-analysis. Using a predesigned form, two researchers independently collected data about marginal bone loss (MBL), probing pocket depth (PPD), plaque index (PI), bleeding on probing (BOP), modified plaque index (mPI), probing pocket depth > 4mm (PPD>4), gingival index (GI), peri-implant sulcular fluid (PISF) volume, and TNF-α and IL-1β levels. QUIPS and CINeMA were used to evaluate the risk of bias and certainty of evidence.NS had the smallest MBL. Most nicotine-containing product users had significantly higher MBL (CS, MD:1.34 CrI: 0.85, 1.79; WP, MD:1.58 CrI: 0.84, 2.35; ST, MD:2.53, CrI: 1.20, 3.87) than NS. EC did not show significant difference compared to NS (MD:0.52 CrI: -0.33, 1.36). In secondary outcomes NS were ranked in first place. Subset analysis based on smoking habit, implant duration, and maintenance control revealed no differences in ranking probability.Most nicotine-containing product users presented worse peri-implant parameters compared to non-smokers, while EC users did not show significant differences to NS in many outcomes.Alternative nicotine-containing products are gaining popularity and are often considered less harmful by the general public compared to traditional cigarettes. This is the first network meta-analysis comparing users of four nicotine-containing products and non-smokers. This study shows that CS, WP and ST have a detrimental effect on the overall health of peri-implant tissues. EC users also presented inferior parameters compared to NS, however, the difference was not significant in many outcomes. It is essential to educate patients who are using nicotine-containing products, and to provide proper maintenance and appropriate cessation support. Well-designed multi-armed studies are needed for direct comparison of different products, including heated tobacco products. Greater transparency of confounding factors is needed regarding smoking habit and oral hygiene. LA - English DB - MTMT ER - TY - JOUR AU - Bérczi, Bálint AU - Borbásné Farkas, Kornélia AU - Hegyi, Péter AU - Tóth, Barbara AU - Csupor, Dezső AU - Németh, Balázs AU - Lukács, Anita AU - Czumbel, László Márk AU - Kerémi, Beáta AU - Kiss, István AU - Szabó, Andrea AU - Varga, Gábor AU - Gerber, Gábor AU - Gyöngyi, Zoltán TI - Aromatase Inhibitors and Plasma Lipid Changes in Postmenopausal Women with Breast Cancer: A Systematic Review and Meta-Analysis JF - JOURNAL OF CLINICAL MEDICINE J2 - J CLIN MED VL - 13 PY - 2024 IS - 6 PG - 20 SN - 2077-0383 DO - 10.3390/jcm13061818 UR - https://m2.mtmt.hu/api/publication/34760472 ID - 34760472 N1 - Journal Article; Review AB - Background: Women are typically diagnosed with estrogen receptor-positive breast cancer around the postmenopausal period when declining estrogen levels initiate changes in lipid profiles. Aromatase inhibitors (AI) are used to prevent the progression of cancer; however, a further reduction in estrogen levels may have detrimental effects on lipid levels, which was our working hypothesis. Methods: Our meta-analysis was conducted on the lipid profiles of postmenopausal breast cancer patients at baseline and at different treatment time points. Results: We identified 15 studies, including 1708 patients. Studies using anastrozole (ANA), exemestane (EXE), letrozole (LET), and tamoxifen (TMX) were involved. Subgroup analyses revealed that 3- and 12-month administrations of LET and EXE lead to negative changes in lipid profiles that tend to alter the lipid profile undesirably, unlike ANA and TMX. Conclusions: Our results suggest that, despite statistically significant results, EXE and LET may not be sufficient to cause severe dyslipidemia in patients without cardiovascular comorbidities according to the AHA/ACC Guideline on the Management of Blood Cholesterol. However, the results may raise the question of monitoring the effects of AIs in patients, especially those with pre-existing cardiovascular risk factors such as dyslipidemia. LA - English DB - MTMT ER - TY - JOUR AU - Golzio Navarro Cavalcante, Bianca AU - Schulze Wenning, Alexander AU - Szabó, Bence AU - Czumbel, László Márk AU - Hegyi, Péter AU - Borbély, Judit AU - Németh, Orsolya AU - Bartha, Károly AU - Gerber, Gábor AU - Varga, Gábor TI - Combined Casein Phosphopeptide-Amorphous Calcium Phosphate and Fluoride Is Not Superior to Fluoride Alone in Early Carious Lesions : A Meta-Analysis JF - CARIES RESEARCH J2 - CARIES RES VL - 58 PY - 2024 IS - 1 SP - 1 EP - 16 PG - 16 SN - 0008-6568 DO - 10.1159/000533547 UR - https://m2.mtmt.hu/api/publication/34223828 ID - 34223828 N1 - * Megosztott szerzőség AB - There is a growing need for effective methods in the management of early-stage carious lesions. Therefore, the aim of this study was to evaluate the effect of combined casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) and fluoride on white spot lesions (WSLs) compared to fluoride-only interventions. This meta-analysis was performed according to PRISMA guidelines and registered in PROSPERO (CRD42021286245). The Medline, EMBASE and Cochrane Central databases were searched until October 17, 2022. Eligible studies were randomized controlled trials (RCTs). Outcome variables included Laser Fluorescence (LF), Quantitative Light-Induced Fluorescence (QLF), and lesion area scores. The random-effects model was used for analysis, and results were given as standardized mean difference (SMD) and mean difference (MD) with a 95% Confidence Interval. Risk of Bias was assessed using the RoB 2 tool, and the level of evidence with GRADE. Our systematic search yielded 973 records after duplicate removal, 21 studies were included for qualitative synthesis, and 15 studies were eligible for quantitative analysis. No significant difference was found between CPP-ACP and fluoride versus fluoride alone in LF at 1, 3 and 6 months of use: SMD -0.30 (-0.64; 0.04); SMD -0.47 (-1.02; 0.07); SMD -0.49 (-1.13; 0.15), respectively. For QLF, the analysis did not demonstrate significant differences between these two kinds of treatment at one and six months of use: MD 0.21 (-0.30;0.71); MD 0.60 (-1.70;2.90), but at three months higher QLF values were found in the fluoride-only group compared to the CPP-ACP and fluoride combination was shown regarding the WSLs: MD 0.58 (0.25;0.91). On the contrary, data showed a small but statistically significant decrease in the lesion area in favor of the CPP-ACP plus fluoride vs fluoride alone at six months MD -0.38 (-0.72; -0.04). None of these observed changes indicated substantial clinical relevance. The combination of CPP-ACP and fluoride did not overcome the effect of fluoride given alone. Our data suggest that fluoride itself is effective in improving WSLs. However, the certainty of evidence was very low. These results indicate that further studies and future development of more effective than CPP-ACP are needed in addition to fluoride to achieve robust amelioration of WSLs. LA - English DB - MTMT ER - TY - JOUR AU - Tajti, Péter AU - Sólyom, Eleonóra AU - Váncsa, Szilárd AU - Mátrai, Péter AU - Hegyi, Péter AU - Varga, Gábor AU - Hermann, Péter AU - Borbély, Judit AU - Sculean, Anton AU - Mikulás, Krisztina Ágnes TI - Less marginal bone loss around bone-level implants restored with long abutments : A systematic review and meta-analysis JF - PERIODONTOLOGY 2000 J2 - PERIODONTOL 2000 PY - 2024 SN - 0906-6713 DO - 10.1111/prd.12534 UR - https://m2.mtmt.hu/api/publication/34165693 ID - 34165693 N1 - Funding Agency and Grant Number: This study was supported by the Centre for Translational Medicine, Semmelweis University.; Centre for Translational Medicine, Semmelweis University Funding text: This study was supported by the Centre for Translational Medicine, Semmelweis University. AB - The aim of this study was to investigate the biological outcomes of bone-level implants restored with long vs. short abutments, with regard to the 'one abutment at one time' protocol. The systematic search was performed in five databases: MEDLINE (PubMed), EMBASE, Web of Science, Scopus, and CENTRAL for randomized controlled trials up to January 14, 2023. Data were collected for marginal bone loss, bleeding on probing, and probing pocket depth by two reviewers. As effect size measure, mean difference (MD), and risk ratio (RR) were used for continuous and categorical outcomes, R-statistics software was used for conducting statistical analyses. For quality and certainty assessment, Risk of Bias Tool 2, ROBINS-I, and GRADE approach were used. The search resulted in 4055 records without any duplicates. After title, abstract, and full-text analysis, eight articles were found eligible for inclusion. Bone-level and platform-switched implants presented less marginal bone loss after 6 months and 1 year as well, when long abutments were used (MD 0.63, 95% CI: [-0.16; 1.42]) and (MD 0.26, 95% CI: [-0.02; 0.53]). However, subgroup analysis revealed no difference in marginal bone loss when applying 'one abutment at one time' protocol (p = 0.973). Bleeding on probing and probing pocket depth presented similarly good results in both groups without almost any differences (RR 0.97, 95% CI: [0.76; 1.23]) and (MD -0.05, 95% CI: [-1.11; 1.01]). Longer abutments on bone-level implants seem to be a favorable choice for decreasing early marginal bone loss, irrespective of connection timing. LA - English DB - MTMT ER - TY - JOUR AU - Kőnig, János AU - Kelemen, Kata AU - Czumbel, László Márk AU - Szabó, Bence AU - Varga, Gábor AU - Borbély, Judit AU - Németh, Orsolya AU - Hegyi, Péter AU - Hermann, Péter TI - Current status of optical scanning in facial prosthetics : A systematic review and meta-analysis JF - JOURNAL OF PROSTHODONTIC RESEARCH J2 - J PROSTHODONT RES VL - 68 PY - 2024 IS - 1 SP - 1 EP - 11 PG - 11 SN - 1883-1958 DO - 10.2186/jpr.JPR_D_22_00221 UR - https://m2.mtmt.hu/api/publication/34008188 ID - 34008188 N1 - Meta-Analysis; Systematic Review; Journal Article AB - To assess the accuracy of scanning technologies for constructing facial prostheses on human faces.Our systematic search was performed on five databases. Studies reporting on human volunteers (P) whose faces were scanned with a scanning technology were eligible. The anthropometrical interlandmark distances (ILDs) were used as indicators of accuracy; the ILDs are measured on the virtual models (I) and directly on the faces (C). The virtual models deviated from their true values (O). Studies reporting the measurements on patients with or without facial deformities were included, but cadavers or inanimate objects were reasons for exclusion. We performed a mean difference (MD) / standardized MD analysis with a random effect model. The difficulties regarding the scanning procedure mentioned in the articles were also assessed.We found 3723 records after duplicate removal. Twenty five articles were eligible for the qualitative review, and ten articles were included in the quantitative synthesis. Eight different ILDs were compared in MD analyses. The differences were between -0.54-0.43 mm. We also performed a regional three-dimensional analysis to compare scanning technologies in each major region. No significant differences were found in any of the regions and axes. The most mentioned difficulties were artifacts due to motion or blinking.The results suggest no systematic skew in linear dimensions neither between direct caliper measurements nor between measurements on the scanned models, scanning technologies, or facial regions. LA - English DB - MTMT ER - TY - CHAP AU - Varga, Gábor ED - Tulassay, Zsolt TI - Az étkezés és a tápcsatorna összehangolt működése T2 - Gasztroenterológia PB - Medicina Könyvkiadó CY - Budapest SN - 9789632268538 PY - 2023 SP - 56 EP - 66 PG - 11 UR - https://m2.mtmt.hu/api/publication/34495879 ID - 34495879 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Kőnig, János AU - Kelemen, Kata AU - Váncsa, Szilárd AU - Szabó, Bence AU - Varga, Gábor AU - Mikulás, Krisztina Ágnes AU - Borbély, Judit AU - Hegyi, Péter AU - Hermann, Péter TI - Comparative analysis of surgical and prosthetic rehabilitation in maxillectomy : A systematic review and meta-analysis on quality-of-life scores and objective speech and masticatory measurements JF - JOURNAL OF PROSTHETIC DENTISTRY J2 - J PROSTHET DENT PY - 2023 SN - 0022-3913 DO - 10.1016/j.prosdent.2023.11.023 UR - https://m2.mtmt.hu/api/publication/34453576 ID - 34453576 N1 - Assistant Lecturer, Department of Prosthodontics, Semmelweis University, Budapest, Hungary; and PhD student, Centre for Translational Medicine, Semmelweis University, Budapest, Hungary, Hungary Scientific Methodological Expert, Centre for Translational Medicine, Semmelweis University, Budapest, Hungary Biostatistician, Centre for Translational Medicine, Semmelweis University, Budapest, Hungary General & Operative Vice Director, Centre for Translational Medicine, Semmelweis University, Budapest, Hungary; Full Professor, Department of Oral Biology, Semmelweis University, Budapest, Hungary; and Supervisor, Centre for Translational Medicine, Semmelweis University, Budapest, Hungary, Hungary Assistant Professor, Department of Prosthodontics, Semmelweis University, Budapest, Hungary; and Supervisor, Centre for Translational Medicine, Semmelweis University, Budapest, Hungary, Hungary Associate Professor, Department of Prosthodontics, Semmelweis University, Budapest, Hungary; and Supervisor, Centre for Translational Medicine, Semmelweis University, Budapest, Hungary, Hungary Strategic Director, Centre for Translational Medicine, Semmelweis University, Budapest, Hungary; and Strategic Director, Institute for Translational Medicine, Medical School, University of Pécs, Pécs, Hungary, Hungary Director and Full Professor, Department of Prosthodontics, Semmelweis University, Budapest, Hungary; and Supervisor, Centre for Translational Medicine, Semmelweis University, Budapest, Hungary, Hungary Export Date: 19 January 2024 CODEN: JPDEA Correspondence Address: Hermann, P.; Department of Prosthodontics, Szentkirályi utca 47, Hungary; email: hermann.peter@semmelweis.hu AB - Patients with oro-antral communication, whether from trauma, disease, or congenital anomalies, have options for surgical reconstruction or prosthetic obturation, but guiding interdisciplinary protocols are lacking.The purpose of this systematic review and meta-analysis was to compare surgical reconstruction and prosthetic obturation, identifying correlations with baseline characteristics to determine the most effective approach for specific patients.A systematic search was conducted in 4 databases. Searching, screening, data extraction, and risk of bias assessment were performed by 2 reviewers. Eligible studies focused on patients with palatomaxillary defects from cancer-related maxilla surgeries. Traumatic or congenital defects were excluded. The study compared prosthetic restoration (either with surgical or definitive obturators) to surgical reconstruction using flaps or grafts. Patients with surgical restoration after tooth extraction were excluded. Both subjective and objective outcomes were used for comparison.Thirteen articles were included in the qualitative synthesis and 9 in the meta-analysis. Patient scores on quality-of-life questionnaires, objective speech, and masticatory ability evaluations were compared. The number of patients who underwent surgical reconstruction was 206, whereas 260 patients received prosthetic obturators. Results showed no significant differences. In the "activity" domain of the University of Washington QoL questionnaire, however, the 1.92 (0.45, 3.40) score difference was not clinically relevant. However, the heterogeneity of trials, the transient nature of subjective evaluations, the low number of participants, and major confounding biases did not allow a solid conclusion to be drawn.The growing number of maxillectomy patients demands firm evidence on which rehabilitation to choose and when it should be done. The result suggests that obturator devices and surgical reconstruction have similar effects on quality of life and health outcomes. A multicentric registry in which patient strata could be analyzed separately by age, adjuvant therapies, defect sizes, and remaining dentition is advocated. LA - English DB - MTMT ER - TY - JOUR AU - Takács, Anna AU - Hardi, Eszter AU - Golzio Navarro Cavalcante, Bianca AU - Szabó, Bence AU - Kispélyi, Ida Barbara AU - Joób-Fancsaly, Árpád AU - Mikulás, Krisztina Ágnes AU - Varga, Gábor AU - Hegyi, Péter AU - Kivovics, Márton TI - Advancing Accuracy in Guided Implant Placement : A Comprehensive Meta-Analysis: Meta-Analysis evaluation of the accuracy of available implant placement Methods JF - JOURNAL OF DENTISTRY J2 - J DENTISTRY VL - 139 PY - 2023 PG - 13 SN - 0300-5712 DO - 10.1016/j.jdent.2023.104748 UR - https://m2.mtmt.hu/api/publication/34216021 ID - 34216021 N1 - Department of Community Dentistry, Semmelweis University, Szentkirályi utca 40, Budapest, 1088, Hungary Centre for Translational Medicine, Semmelweis University, Üllői út 26, Budapest, 1085, Hungary Department of Oro-Maxillofacial Surgery and Stomatology, Semmelweis University, Mária utca 52, Budapest, 1085, Hungary Department of Oral Biology, Semmelweis University, Nagyvárad tér 4, Budapest, 1089, Hungary Department of Prosthodontics, Semmelweis University, Szentkirályi utca 47, Budapest, 1088, Hungary Institute for Translational Medicine, Szentágothai Research Centre, Medical School, University of Pécs, Szigeti út 12, Pécs, 7624, Hungary Division of Pancreatic Diseases, Heart and Vascular Center, Semmelweis University, Városmajor utca 68, Budapest, 1122, Hungary Export Date: 11 January 2024 CODEN: JDENA Correspondence Address: Kivovics, M.Szentkirályi utca 40, Hungary; email: kivovics.marton@dent.semmelweis-univ.hu AB - This meta-analysis aimed to determine the accuracy of currently available computer-assisted implant surgery (CAIS) modalities under in vitro conditions and investigate whether these novel techniques can achieve clinically acceptable accuracy.In vitro studies comparing the postoperative implant position with the preoperative plan were included. Risk of bias was assessed using the Quality Assessment Tool For In Vitro Studies (QUIN Tool) and a sensitivity analysis was conducted using funnel plots.A systematic search was performed on April 18, 2023, using the following three databases: MEDLINE (via PubMed), EMBASE, and Cochrane Central Register of Controlled Trials. No filters or restrictions were applied during the search.A total of 5,894 studies were included following study selection. Robotic- and static CAIS (sCAIS) had the most accurate and clinically acceptable outcomes. sCAIS was further divided according to the guidance level. Among the sCAIS groups, fully guided implant placement had the greatest accuracy. Augmented reality-based CAIS (AR-based CAIS) had clinically acceptable results for all the outcomes except for apical global deviation. Dynamic CAIS (dCAIS) demonstrated clinically safe results, except for horizontal apical deviation. Freehand implant placement was associated with the greatest number of errors.Fully guided sCAIS demonstrated the most predictable outcomes, whereas freehand sCAIS demonstrated the lowest accuracy. AR-based and robotic CAIS may be promising alternatives.To our knowledge, this is the first meta-analysis to evaluate the accuracy of robotic CAIS and investigate the accuracy of various CAIS modalities. LA - English DB - MTMT ER - TY - JOUR AU - Barabás-Róna, Virág AU - Bencze, Bulcsú AU - Kelemen, Kata AU - Végh, Dániel AU - Tóth, Réka AU - Kói, Tamás AU - Hegyi, Péter AU - Varga, Gábor AU - Rózsa, Noémi Katinka AU - Géczi, Zoltán TI - Effect of Chitosan on the Number of Streptococcus mutans in Saliva: A Meta-Analysis and Systematic Review JF - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES J2 - INT J MOL SCI VL - 24 PY - 2023 IS - 20 PG - 14 SN - 1661-6596 DO - 10.3390/ijms242015270 UR - https://m2.mtmt.hu/api/publication/34205710 ID - 34205710 N1 - Department of Prosthodontics, Semmelweis University, Budapest, 1085, Hungary Centre for Translational Medicine, Semmelweis University, Budapest, 1085, Hungary Department of Stochastics, Institute of Mathematics, Budapest University of Technology and Economics, Budapest, 1111, Hungary Institute for Translational Medicine, Medical School, University of Pécs, Pécs, 7622, Hungary Institute of Pancreatic Diseases, Semmelweis University, Budapest, 1085, Hungary Department of Oral Biology, Semmelweis University, Budapest, 1085, Hungary Department of Pediatric Dentistry and Orthodontics, Semmelweis University, Budapest, 1085, Hungary Export Date: 29 January 2024 Correspondence Address: Géczi, Z.; Department of Prosthodontics, Hungary; email: gaeczi.zoltan@semmelweis.hu AB - We conducted a meta-analysis and systematic review to investigate the efficacy of chitosan-containing chewing gums, and to test their inhibitory effects on Streptococcus mutans. The systematic search was performed in three databases (Cochrane Library, EMBASE, and PubMed) and included English-language randomized–controlled trials to compare the efficacy of chitosan in reducing the number of S. mutans. To assess the certainty of evidence, the GRADE tool was used. Mean differences were calculated with a 95% confidence interval for one outcome: bacterial counts in CFU/mL. The protocol of the study was registered on PROSPERO, registration number CRD42022365006. Articles were downloaded (n = 6758) from EMBASE (n = 2255), PubMed (n = 1516), and Cochrane (n = 2987). After the selection process, a total of four articles were included in the qualitative synthesis and three in the quantitative synthesis. Our results show that chitosan reduced the number of bacteria. The difference in mean quantity was −4.68 × 105. The interval of the random-effects model was [−2.15 × 106; 1.21 × 106] and the prediction interval was [1.03 × 107; 9.40 × 106]. The I2 value was 98% (p = 0.35), which indicates a high degree of heterogeneity. Chitosan has some antibacterial effects when used as a component of chewing gum, but further studies are needed. It can be a promising antimicrobial agent for prevention. LA - English DB - MTMT ER - TY - JOUR AU - Németh, Anna AU - Vitai, Viktória AU - Czumbel, László Márk AU - Szabó, Bence AU - Varga, Gábor AU - Kerémi, Beáta AU - Hegyi, Péter AU - Hermann, Péter AU - Borbély, Judit TI - Clear guidance to select the most accurate technologies for 3D printing dental models - A network meta-analysis JF - JOURNAL OF DENTISTRY J2 - J DENTISTRY VL - 134 PY - 2023 PG - 12 SN - 0300-5712 DO - 10.1016/j.jdent.2023.104532 UR - https://m2.mtmt.hu/api/publication/33788836 ID - 33788836 AB - Thus far, the findings of numerous studies conducted on the accuracy of three-dimensional (3D) printed dental models are conflicting. Therefore, the aim of the network meta-analysis (NMA) is to determine the accuracy of 3D printed dental models compared with digital reference models.Studies comparing the accuracy of 3D printed full-arch dental models manufactured using different printing techniques to initial STL files were included.This study was registered in PROSPERO (CRD42021285863). An electronic search was performed across four databases in November 2021, and search was restricted to the English language.A systematic search was conducted based on a prespecified search query. 16,303 articles were pooled after the removal of the duplicates. Following study selection and data extraction, 11 eligible studies were included in the NMA in 6 subgroups. The outcomes were specified as trueness and precision and expressed as root mean square (RMS) and absolute mean deviation values. Seven printing technologies were analyzed: stereolithography (SLA), digital light processing (DLP), fused deposition modeling/fused filament fabrication (FDM/FFF), MultiJet, PolyJet, continuous liquid interface production (CLIP), and LCD technology. The QUADAS-2 and GRADE were used to evaluate the risk of bias and certainty of evidence.SLA, DLP, and PolyJet technologies were the most accurate in producing precise full-arch dental models.The findings of the NMA suggest that SLA, DLP, and PolyJet technologies are sufficiently accurate for full-arch dental model production for prosthodontic purposes. In contrast, FDM/FFF, CLIP, and LCD technologies are less suitable for manufacturing dental devices. LA - English DB - MTMT ER -