TY - JOUR AU - Jancsik, Veronika AU - Bene, R AU - Sótonyi, Péter AU - Zachar, Gergely TI - Sub-cellular organization of the melanin-concentrating hormone neurons in the hypothalamus JF - PEPTIDES J2 - PEPTIDES VL - 99 PY - 2018 SP - 56 EP - 60 PG - 5 SN - 0196-9781 DO - 10.1016/j.peptides.2017.11.002 UR - https://m2.mtmt.hu/api/publication/3317427 ID - 3317427 LA - English DB - MTMT ER - TY - JOUR AU - Gerics, Balázs AU - Szalay, Ferenc AU - Sótonyi, Péter AU - Jancsik, Veronika TI - Diurnal variation of the melanin-concentrating hormone level in the hypothalamus JF - ACTA BIOLOGICA HUNGARICA (1983-2018) J2 - ACTA BIOL HUNG VL - 68 PY - 2017 IS - 1 SP - 14 EP - 21 PG - 8 SN - 0236-5383 DO - 10.1556/018.68.2017.1.2 UR - https://m2.mtmt.hu/api/publication/3203511 ID - 3203511 AB - Melanin-concentrating hormone (MCH), the neuropeptide produced mainly in the hypothalamus, plays an operative role in regulating food intake and the sleep/wake cycle. Considering that these physiological functions pursue diurnal variations, we checked whether the total hypothalamic MCH level depends on the time of the day. The aggregated MCH peptide content of the whole MCH neuron population was significantly higher at the end of the sleeping period (lights on), than at the end of the active period (lights off). This result, together with earlier observations, indicates that in contrast to the MCH gene expression, the level of MCH peptide is object of circadian variation in the hypothalamus. LA - English DB - MTMT ER - TY - JOUR AU - Reinitz, László Zoltán AU - Szoke, B AU - Varkonyi, EE AU - Sótonyi, Péter AU - Jancsik, Veronika TI - Three-dimensional visualization of the distribution of melanin-concentrating hormone producing neurons in the mouse hypothalamus. JF - JOURNAL OF CHEMICAL NEUROANATOMY J2 - J CHEM NEUROANAT VL - 71 PY - 2016 SP - 20 EP - 25 PG - 6 SN - 0891-0618 DO - 10.1016/j.jchemneu.2015.11.009 UR - https://m2.mtmt.hu/api/publication/3016075 ID - 3016075 AB - We present here a new procedure to represent the 3D distribution of neuronal cell bodies within the brain, using exclusively softwares free for research purposes. Our technique is based on digitalized photos of brain slices processed by immunohistochemical technique, and the 3D Slicer software. The technique presented enables transposition of immunohistochemical or in situ hybridization data to the stereotaxic mouse brain atlas (e.g. Paxinos, G., Franklin, K.B.J., 2001. The Mouse Brain in Stereotaxic Coordinates. second ed. Academic Press, San Diego). By exporting the finalized models into a popular 3D design software (3DS Max) arbitrary environment and motion simulation can be created to improve the visual understanding of the area studied. Application of this technique provides the possibility to store, analyze and compare data - e.g. on the hypothalamic neuropeptides - across experimental techniques and laboratories. The method is exemplified by visualizing the distribution of immunohistochemically identified melanin-concetrating hormone (MCH) containing perikarya within the mouse hypothalamus. LA - English DB - MTMT ER - TY - CONF AU - Reinitz, László Zoltán AU - Szőke, B AU - Gerics, Balázs AU - Sótonyi, Péter AU - Jancsik, Veronika TI - 3-D reconstruction of the distribution of melanin-concentrating hormone producing neurons in the mouse hypothalamus T2 - IBRO Workshop 2014 PY - 2014 SP - 133 UR - https://m2.mtmt.hu/api/publication/2560771 ID - 2560771 LA - English DB - MTMT ER - TY - CHAP AU - Várkonyi, E É AU - Szőke, B AU - Gerics, B AU - Jancsik, Veronika ED - Csillag, A ED - Dobolyi, Á ED - Gerber, G ED - Zacher, G TI - Diurnal variation of the melanin-concentrating hormone content of the hypothalamic melanin-concentrating hormone neurons T2 - XIV. Conference of the Hungarian Neuroscience Society [elektronikus dok.] PB - Magyar Idegtudományi Társaság CY - Budapest SN - 9789638822420 PY - 2013 SP - 41 EP - 41 PG - 1 UR - https://m2.mtmt.hu/api/publication/2528368 ID - 2528368 LA - English DB - MTMT ER - TY - CONF AU - Jancsik, Veronika AU - Sótonyi, P ED - Magyar, Anatómus Társaság TI - A melanin koncentráló hormon anabolikus hatásának neuroanatómiája T2 - Magyar Anatómus Társaság 2013. évi kongresszusa. Budapest, 2013. június 13–15 PB - Szent István Egyetem, Állatorvos-tudományi Kar C1 - Budapest PY - 2013 SP - 41 EP - 41 PG - 1 UR - https://m2.mtmt.hu/api/publication/2528344 ID - 2528344 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Jancsik, Veronika AU - Varkonyi, EE AU - Sótonyi, Péter TI - Intracellular transport of melanin-concentrating hormone in neurons JF - FEBS JOURNAL J2 - FEBS J VL - 280 PY - 2013 IS - SI SP - 203 EP - 204 PG - 2 SN - 1742-464X UR - https://m2.mtmt.hu/api/publication/2478899 ID - 2478899 LA - English DB - MTMT ER - TY - JOUR AU - Denes, L AU - Entz, László AU - Jancsik, Veronika TI - Restenosis and therapy JF - INTERNATIONAL JOURNAL OF VASCULAR MEDICINE J2 - INT J VASC MED VL - 2012 PY - 2012 PG - 9 SN - 2090-2824 DO - 10.1155/2012/406236 UR - https://m2.mtmt.hu/api/publication/1996509 ID - 1996509 N1 - Megjegyzés-23801510 N1 Cited By (since 1996):2 LA - English DB - MTMT ER - TY - JOUR AU - Várkonyi, E.É. AU - Jancsik, Veronika TI - A sokszínű melanin-koncentráló hormon JF - ÁLLATTANI KÖZLEMÉNYEK J2 - ÁLLATTANI KÖZLEMÉNYEK VL - 96 PY - 2011 IS - 1-2 SP - 127 EP - 134 PG - 8 SN - 0002-5658 UR - https://m2.mtmt.hu/api/publication/2017333 ID - 2017333 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Novák-Hazai, Diana AU - Lien, CF AU - Hajós, Ferenc AU - Halasy, Katalin AU - Gorecki, DC AU - Jancsik, Veronika TI - Synaptic alpha-dystrobrevin: Localization of a short alpha-dystrobrevin isoform in melanin-concentrating hormone neurons of the hypothalamus JF - BRAIN RESEARCH J2 - BRAIN RES VL - 1201 PY - 2008 SP - 52 EP - 59 PG - 8 SN - 0006-8993 DO - 10.1016/j.brainres.2008.01.046 UR - https://m2.mtmt.hu/api/publication/1660967 ID - 1660967 AB - The expression of the two members of the dystrobrevin (DB) family in the adult brain was thought to be highly specific for the two main cell types: alpha-dystrobrevin (alpha-DB) and beta-dystrobrevin (beta-DB) has been identified as glial and neuronal proteins, respectively. In the present work we show that a subset of neurons in the hypothalamus contains a-DB. Comparative immunohistochemical studies with two a-DB antibodies of different specificity indicate that the neurons contain short alpha-DB isoform(s) alpha-DB-2 and/or alpha-DB-4. Immunoreactive multipolar or spindle-shaped neurons form clusters with bilateral symmetry,. localized predominantly in the lateral hypothalamic area, with extensions into the zona incerta and the dorso-medial and ventro-medial hypothalamic region. a-DB immunoreactivity was localized in cell processes and at postsynaptic densities, furthermore in the endoplasmic reticulum within the perikarya. alpha-DB-positive neurons are beta-dystrobrevin immunoreactive,but alpha- and beta-DB; do not co-localize with their usual molecular anchors like dystrophins or high molecular weight forms of utrophin. Colocalization with nNOS was also not observed. The pattern of a-DB immunoreactive neurons gave a perfect colocalization with melanin-concentrating hormone (MCH) neurons throughout the whole region studied. We propose that a-DB plays a role in a structure or regulation mechanism unique to MCH-expressing neurons. (C) 2008 Published by Elsevier B.V. LA - English DB - MTMT ER -