@misc{MTMT:35649155, title = {Anhidro-aldóz oximok szintézise és cikloaddíciós reakcióinak vizsgálata}, url = {https://m2.mtmt.hu/api/publication/35649155}, author = {Kaszás, Tímea and Szakács, Bence and Bertalan, Márta and Lengyel, Ákos and Hameed, Faria and Blága, Tekla and Bay, Péter and Nilsson, J. Ulf and Somsák, László and Vágvölgyiné Tóth, Marietta}, unique-id = {35649155}, year = {2024}, orcid-numbers = {Szakács, Bence/0000-0002-9157-3028; Somsák, László/0000-0002-9103-9845} } @misc{MTMT:35573807, title = {Anhidro-aldóz oximok cikloaddíciós reakcióinak vizsgálata Cycloaddition reactions of anhydro-aldose oximes}, url = {https://m2.mtmt.hu/api/publication/35573807}, author = {Kaszás, Tímea and Szakács, Bence and Bertalan, Márta and Lengyel, Ákos and Hameed, Faria and Blága, Tekla and Somsák, László and Vágvölgyiné Tóth, Marietta}, unique-id = {35573807}, year = {2024}, orcid-numbers = {Szakács, Bence/0000-0002-9157-3028; Somsák, László/0000-0002-9103-9845} } @{MTMT:35573748, title = {Glikopiranozilidén-spiro-izoxazolinok, mint potenciális Candida Albicans ellenes szerek szintézise}, url = {https://m2.mtmt.hu/api/publication/35573748}, author = {Ecsedi, Zoárd and Shafique, Hina and Szakács, Bence and Kaszás, Tímea and Somsák, László and Vágvölgyiné Tóth, Marietta}, booktitle = {Vegyészkonferencia 2024}, unique-id = {35573748}, year = {2024}, pages = {68, P-7}, orcid-numbers = {Szakács, Bence/0000-0002-9157-3028; Somsák, László/0000-0002-9103-9845} } @article{MTMT:34813914, title = {Synthesis, in silico and kinetics evaluation of N-(beta-D-glucopyranosyl)-2-arylimidazole-4(5)-carboxamides and N-(beta-D-glucopyranosyl)-4(5)-arylimidazole-2-carboxamides as glycogen phosphorylase inhibitors}, url = {https://m2.mtmt.hu/api/publication/34813914}, author = {Homolya, Levente and Mathomes, Rachel T. and Fodor-Varga, Luca Anna and Docsa, Tibor and Juhász, László and Hayes, Joseph M. and Somsák, László}, doi = {10.3390/ijms25094591}, journal-iso = {INT J MOL SCI}, journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES}, volume = {25}, unique-id = {34813914}, issn = {1661-6596}, abstract = {Recently studied N-(β-D-glucopyranosyl)-3-aryl-1,2,4-triazole-5-carboxamides have proven to be low micromolar inhibitors of glycogen phosphorylase (GP), a validated target for the treatment of type 2 diabetes mellitus. Since in other settings, the bioisosteric replacement of the 1,2,4-triazole moiety with imidazole resulted in significantly more efficient GP inhibitors, in silico calculations using Glide molecular docking along with unbound state DFT calculations were performed on N-(β-Dglucopyranosyl)-arylimidazole-carboxamides, revealing their potential for strong GP inhibition. The syntheses of the target compounds involved the formation of an amide bond between per-O-acetylated β-D-glucopyranosylamine and the corresponding arylimidazole-carboxylic acids. Kinetics experiments on rabbit muscle GPb revealed low micromolar inhibitors, with the best inhibition constants (Kis) of ~3–4 µM obtained for 1- and 2-naphthyl-substituted N-(β-D-glucopyranosyl)-imidazolecarboxamides, 2b–c. The predicted protein–ligand interactions responsible for the observed potencies are discussed and will facilitate the structure-based design of other inhibitors targeting this important therapeutic target. Meanwhile, the importance of the careful consideration of ligand tautomeric states in binding calculations is highlighted, with the usefulness of DFT calculations in this regard proposed.}, keywords = {Glycogen phosphorylase inhibitor; Tautomers; type 2 diabetes; glucose analogues}, year = {2024}, eissn = {1422-0067}, pages = {1-21}, orcid-numbers = {Juhász, László/0000-0002-7462-7944; Somsák, László/0000-0002-9103-9845} } @article{MTMT:34528813, title = {Exo-glikál származékok átalakításainak a vizsgálata: tioladdíciós és cikloaddíciós reakciók}, url = {https://m2.mtmt.hu/api/publication/34528813}, author = {József, János and Somsák, László and Juhász, László}, doi = {10.24100/MKF.2023.03-04.147}, journal-iso = {MAGY KÉM FOLY KÉM KÖZL}, journal = {MAGYAR KÉMIAI FOLYÓIRAT - KÉMIAI KÖZLEMÉNYEK (1997-)}, volume = {129}, unique-id = {34528813}, issn = {1418-9933}, year = {2023}, eissn = {1418-8600}, pages = {147-154}, orcid-numbers = {Somsák, László/0000-0002-9103-9845; Juhász, László/0000-0002-7462-7944} } @{MTMT:34449504, title = {Half-sandwich transition metal complexes and uses thereof}, url = {https://m2.mtmt.hu/api/publication/34449504}, author = {Bay, Péter and Bokor, Éva and Somsák, László and Kacsir, István and Buglyó, Péter and Sipos, Adrienn and Kardos, Gábor and Toth, Zoltan and Kis, Gyorgy Attila}, unique-id = {34449504}, abstract = {The invention relates to half-sandwich transition metal complexes with general formula (I), (wherein in Me is a transition metal ion selected from the group consisting of Ru, Os, Rh, Ir, Pd and Pt, preferably selected from Ru, Os, Rh, Ir, X is a halogen selected from the group consisting of Cl, Br and I, preferably Cl,Ar is a capping mol. having a Cs or C6 aromatic ring substituted with one or more, preferably one to five or one to six straight or branched chain C1-C6 alkyl, preferably C1-C3 alkyl, resp.); and uses thereof, in particular in neo-plastic diseas or as antifungal agent.}, keywords = {half sandwich transition metal}, year = {2023}, orcid-numbers = {Somsák, László/0000-0002-9103-9845; Buglyó, Péter/0000-0002-6714-7598} } @misc{MTMT:34414188, title = {Synthesis of potentially biologically active carbohydrates: transformation of anhydro-aldose oximes}, url = {https://m2.mtmt.hu/api/publication/34414188}, author = {Homolya, Ágnes and Kaszás, Tímea and Szakács, Bence and Blága, Tekla and Doherty, Kyle and Velasco-Torrijos, Trinidad and Shafique, Hina and Ecsedi, Zoárd and Juhászné Tóth, Éva and Juhász, László and Nilsson, Ulf J. and Somsák, László and Vágvölgyiné Tóth, Marietta}, unique-id = {34414188}, year = {2023}, orcid-numbers = {Szakács, Bence/0000-0002-9157-3028; Juhász, László/0000-0002-7462-7944; Somsák, László/0000-0002-9103-9845} } @{MTMT:34414169, title = {Anhidro-aldóz oximok átalakítási lehetőségeinek vizsgálata}, url = {https://m2.mtmt.hu/api/publication/34414169}, author = {Szakács, Bence and Kaszás, Tímea and Blága, Tekla and Shafique, Hina and Ecsedi, Zoárd and Juhászné Tóth, Éva and Doherty, Kyle and Velasco-Torrijos, Trindad and Somsák, László and Vágvölgyiné Tóth, Marietta}, booktitle = {MKE 4. Nemzeti Konferencia 2023}, unique-id = {34414169}, year = {2023}, pages = {89. oldal, P-31}, orcid-numbers = {Szakács, Bence/0000-0002-9157-3028; Somsák, László/0000-0002-9103-9845} } @misc{MTMT:34414129, title = {Anhidro-aldóz oximok átalakítása potenciálisan biológiailag aktív szénhidrátszármazékokká}, url = {https://m2.mtmt.hu/api/publication/34414129}, author = {Szakács, Bence and Kaszás, Tímea and Blága, Tekla and Shafique, Hina and Ecsedi, Zoárd and Juhászné Tóth, Éva and Doherty, Kyle and Velasco-Torrijos, Trinidad and Somsák, László and Vágvölgyiné Tóth, Marietta}, unique-id = {34414129}, year = {2023}, orcid-numbers = {Szakács, Bence/0000-0002-9157-3028; Somsák, László/0000-0002-9103-9845} } @{MTMT:34414107, title = {Transformations of anhydro-aldose oximes into potentially biologically active carbohydrate derivatives}, url = {https://m2.mtmt.hu/api/publication/34414107}, author = {Szakács, Bence and Kaszás, Tímea and Blága, Tekla and Shafique, Hina and Ecsedi, Zoárd and Juhászné Tóth, Éva and Doherty, Kyle and Velasco-Torrijos, Trinidad and Somsák, László and Vágvölgyiné Tóth, Marietta}, booktitle = {Book of Abstract- 4th Young Researchers' International Conference on Chemistry and Chemical Engineering (YRICCCE IV)}, unique-id = {34414107}, year = {2023}, pages = {72. oldal, P25}, orcid-numbers = {Szakács, Bence/0000-0002-9157-3028; Somsák, László/0000-0002-9103-9845} }