TY - JOUR AU - Wolters, Maike AU - Foraita, Ronja AU - Moreno, Luis A. AU - Molnár, Dénes AU - Russo, Paola AU - Tornaritis, Michael AU - De Henauw, Stefaan AU - Lissner, Lauren AU - Veidebaum, Toomas AU - Winter, Theresa AU - Marron, Manuela AU - Nagrani, Rajini TI - Longitudinal associations between vitamin D status and biomarkers of inflammation in a pan-European cohort of children and adolescents JF - EUROPEAN JOURNAL OF NUTRITION J2 - EUR J NUTR PY - 2024 PG - 14 SN - 1436-6207 DO - 10.1007/s00394-024-03488-7 UR - https://m2.mtmt.hu/api/publication/35286837 ID - 35286837 N1 - Leibniz Institute for Prevention Research and Epidemiology - BIPS, Achterstrasse 30, Bremen, 28359, Germany GENUD (Growth, Exercise, Nutrition and Development) Research Group, Instituto Agroalimentario de Aragón (IA2), Instituto de Investigación Sanitaria de Aragón (IIS Aragón), University of Zaragoza, Saragossa, Spain Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición (CIBERObn), Instituto de Salud Carlos III, Madrid, Spain Department of Paediatrics, Medical School, University of Pécs, Pécs, Hungary Institute of Food Sciences, National Research Council, Avellino, Italy Research and Education Institute of Child Health, Strovolos, Cyprus Department of Public Health and Primary Care, Ghent University, Ghent, Belgium School of Public Health and Community Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden National Institute for Health Development, Tallinn, Estonia Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany Export Date: 20 September 2024 CODEN: EJNUF Correspondence Address: Wolters, M.; Leibniz Institute for Prevention Research and Epidemiology - BIPS, Achterstrasse 30, Germany; email: wolters@leibniz-bips.de LA - English DB - MTMT ER - TY - JOUR AU - Flieh, Sondos M AU - Hebestreit, Antje AU - Pohlabeln, Hermann AU - Miguel-Berges, María L AU - González-Gil, Esther M AU - Russo, Paola AU - Molnár, Dénes AU - Wijnant, Kathleen AU - Lissner, Lauren AU - Do, Stefanie AU - Solea, Tonia AU - Veidebaum, Toomas AU - Moreno, Luis A TI - Longitudinal associations between psychosomatic and emotional status and selected food portion sizes in European children and adolescents : IDEFICS/I.Family study JF - NUTRITION RESEARCH J2 - NUTR RES VL - 127 PY - 2024 SP - 84 EP - 96 PG - 13 SN - 0271-5317 DO - 10.1016/j.nutres.2024.05.004 UR - https://m2.mtmt.hu/api/publication/35069867 ID - 35069867 N1 - Growth, Exercise, Nutrition and Development (GENUD) Research Group, Faculty of Health Sciences, University of Zaragoza, Zaragoza, Spain Leibniz Institute for Prevention Research and Epidemiology – BIPS, Bremen, Germany Instituto Agroalimentario de Aragón (IA2), Zaragoza, Spain Instituto de Investigación Sanitaria Aragón (IIS Aragón), Zaragoza, Spain Institute of Food Sciences, National Research Council, Avellino, Italy Department of Pediatrics, Medical School, University of Pécs, Pécs, Hungary Departments of Public Health and Primary Care, Ghent University, Ghent, Belgium Department of Public Health and Community Medicine/Epidemiology, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden Research and Education Institute of Child Health, Strovolos, Cyprus National Institute for Health Development, Tallinn, Estonia CIBER Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, Madrid, Spain Export Date: 9 July 2024 CODEN: NTRSD Correspondence Address: González-Gil, E.M.; Growth, C. de Pedro Cerbuna, 12, Spain; email: esthergg@unizar.es AB - This study aims to investigate the influence of psychosomatic and emotional status on food portion sizes (PSs) consumption from high energy-dense food groups in European children and adolescents. We hypothesized that psychosomatic and emotional status would have a significant association with the PS selection of energy-dense food. The study included 7355 children aged between 2 and 9.9 years at baseline (T0) (48.8% females); 3869 after 2 years (T1) (48.2% females), and 2971 (51.8% females) after 6 years of follow-up (T3). Psychosomatic and emotional status were measured using emotional well-being during the last week score (KINDL) and Strengths and Difficulties Questionnaire. PS was calculated from daily food intake recorded in 24-hour dietary recalls. The associations between emotional status indicators and PS from selected energy-dense food groups were assessed by multilevel linear regression models. In the cross-sectional analysis, we observed that higher KINDL scores were linked to lower PS consumption from sweet bakery products and savory snacks in both genders. Moreover, we found that adolescent females with high emotional and peer problem scores tended to consume larger PS of carbohydrate-rich and sugar-fatty food items (P < .017). Longitudinally, higher peer problem scores were associated with increased PS from bread and rolls, margarine and lipids, and dairy products in all genders and age groups (P< .017). In adolescents, psychosomatic and emotional status could be a trigger for consuming large PS from carbohydrate-rich and sugar-fatty energy-dense foods. Thus, nutritional interventions should consider emotional status to decrease unhealthy dietary habits in children and adolescents. LA - English DB - MTMT ER - TY - JOUR AU - Foraita, Ronja AU - Witte, Janine AU - Börnhorst, Claudia AU - Gwozdz, Wencke AU - Pala, Valeria AU - Lissner, Lauren AU - Lauria, Fabio AU - Reisch, Lucia A AU - Molnár, Dénes AU - De Henauw, Stefaan AU - Moreno, Luis AU - Veidebaum, Toomas AU - Tornaritis, Michael AU - Pigeot, Iris AU - Didelez, Vanessa TI - A longitudinal causal graph analysis investigating modifiable risk factors and obesity in a European cohort of children and adolescents. JF - SCIENTIFIC REPORTS J2 - SCI REP VL - 14 PY - 2024 IS - 1 PG - 14 SN - 2045-2322 DO - 10.1038/s41598-024-56721-y UR - https://m2.mtmt.hu/api/publication/34757148 ID - 34757148 N1 - Export Date: 2 April 2024 AB - Childhood obesity is a complex disorder that appears to be influenced by an interacting system of many factors. Taking this complexity into account, we aim to investigate the causal structure underlying childhood obesity. Our focus is on identifying potential early, direct or indirect, causes of obesity which may be promising targets for prevention strategies. Using a causal discovery algorithm, we estimate a cohort causal graph (CCG) over the life course from childhood to adolescence. We adapt a popular method, the so-called PC-algorithm, to deal with missing values by multiple imputation, with mixed discrete and continuous variables, and that takes background knowledge such as the time-structure of cohort data into account. The algorithm is then applied to learn the causal structure among 51 variables including obesity, early life factors, diet, lifestyle, insulin resistance, puberty stage and cultural background of 5112 children from the European IDEFICS/I.Family cohort across three waves (2007-2014). The robustness of the learned causal structure is addressed in a series of alternative and sensitivity analyses; in particular, we use bootstrap resamples to assess the stability of aspects of the learned CCG. Our results suggest some but only indirect possible causal paths from early modifiable risk factors, such as audio-visual media consumption and physical activity, to obesity (measured by age- and sex-adjusted BMI z-scores) 6 years later. LA - English DB - MTMT ER - TY - JOUR AU - Intemann, T. AU - Bogl, L.H. AU - Hunsberger, M. AU - Lauria, F. AU - De, Henauw S. AU - Molnár, Dénes AU - Moreno, L.A. AU - Tornaritis, M. AU - Veidebaum, T. AU - Ahrens, W. AU - Hebestreit, A. TI - A Late Meal Timing Pattern Is Associated with Insulin Resistance in European Children and Adolescents JF - PEDIATRIC DIABETES J2 - PEDIATR DIABETES VL - 2024 PY - 2024 PG - 12 SN - 1399-543X DO - 10.1155/2024/6623357 UR - https://m2.mtmt.hu/api/publication/34756498 ID - 34756498 N1 - Funding Agency and Grant Number: Deutsche Forschungsgemeinschaft [391977161]; Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) [266044]; European Commission; Austrian Science Fund (FWF) through a Lise-Meitner Fellowship Funding text: The study was funded by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation); 391977161. Furthermore, we gratefully acknowledge the financial support of the European Commission within the Seventh RTD Framework Program Contract No. 266044. LHB acknowledges funding from the Austrian Science Fund (FWF) through a Lise-Meitner Fellowship Grant No. M 2449. We thank the I.Family children and their parents for participating in this extensive examination. We are grateful for the support from school boards, headmasters, and communities. Open Access funding enabled and organized by Projekt DEAL. LA - English DB - MTMT ER - TY - JOUR AU - Bokor, Szilvia AU - Csölle, Ildikó AU - Heidinger-Felső, Regina AU - Vass, Réka Anna AU - Funke Kiss, Simone AU - Ertl, Tibor AU - Molnár, Dénes TI - Dietary nutrients during gestation cause obesity and related metabolic changes by altering DNA methylation in the offspring JF - FRONTIERS IN ENDOCRINOLOGY J2 - FRONT ENDOCRINOL VL - 15 PY - 2024 PG - 17 SN - 1664-2392 DO - 10.3389/fendo.2024.1287255 UR - https://m2.mtmt.hu/api/publication/34729560 ID - 34729560 N1 - Department of Paediatrics, Medical School, University of Pécs, Pécs, Hungary National Laboratory on Human Reproduction, University of Pécs, Pécs, Hungary Doctoral School of Health Sciences, Faculty of Health Sciences, University of Pécs, Pécs, Hungary Department of Obstetrics and Gynaecology, Medical School, University of Pécs, Pécs, Hungary Obstetrics and Gynecology, Magyar Imre Hospital Ajka, Ajka, Hungary Export Date: 18 March 2024 Correspondence Address: Bokor, S.; Department of Paediatrics, Hungary; email: bokor.szilvia@pte.hu AB - Growing evidence shows that maternal nutrition from preconception until lactation has an important effect on the development of non-communicable diseases in the offspring. Biological responses to environmental stress during pregnancy, including undernutrition or overnutrition of various nutrients, are transmitted in part by DNA methylation. The aim of the present narrative review is to summarize literature data on altered DNA methylation patterns caused by maternal macronutrient or vitamin intake and its association with offspring's phenotype (obesity and related metabolic changes). With our literature search, we found evidence for the association between alterations in DNA methylation pattern of different genes caused by maternal under- or overnutrition of several nutrients (protein, fructose, fat, vitamin D, methyl-group donor nutrients) during 3 critical periods of programming (preconception, pregnancy, lactation) and the development of obesity or related metabolic changes (glucose, insulin, lipid, leptin, adiponectin levels, blood pressure, non-alcoholic fatty liver disease) in offspring. The review highlights that maternal consumption of several nutrients could individually affect the development of offspring's obesity and related metabolic changes via alterations in DNA methylation. LA - English DB - MTMT ER - TY - CHAP AU - Molnár, Dénes AU - Erhardt, Éva AU - Kovács, Éva ED - Tulassay, Tivadar TI - Kezelés T2 - Klinikai gyermekgyógyászat PB - Medicina Könyvkiadó CY - Budapest SN - 9789632286673 PY - 2024 SP - 693 EP - 693 PG - 1 UR - https://m2.mtmt.hu/api/publication/34688870 ID - 34688870 LA - Hungarian DB - MTMT ER - TY - CHAP AU - Molnár, Dénes AU - Erhardt, Éva AU - Kovács, Éva ED - Tulassay, Tivadar TI - Elhízáshoz kapcsolódó betegségek T2 - Klinikai gyermekgyógyászat PB - Medicina Könyvkiadó CY - Budapest SN - 9789632286673 PY - 2024 SP - 692 EP - 692 PG - 1 UR - https://m2.mtmt.hu/api/publication/34688869 ID - 34688869 LA - Hungarian DB - MTMT ER - TY - CHAP AU - Molnár, Dénes AU - Erhardt, Éva AU - Kovács, Éva ED - Tulassay, Tivadar TI - Az elhízás jelentősége, következményei T2 - Klinikai gyermekgyógyászat PB - Medicina Könyvkiadó CY - Budapest SN - 9789632286673 PY - 2024 SP - 688 EP - 691 PG - 4 UR - https://m2.mtmt.hu/api/publication/34688868 ID - 34688868 LA - Hungarian DB - MTMT ER - TY - CHAP AU - Molnár, Dénes AU - Erhardt, Éva AU - Kovács, Éva ED - Tulassay, Tivadar TI - A gyermekkori és a felnőttkori elhízás kapcsolata T2 - Klinikai gyermekgyógyászat PB - Medicina Könyvkiadó CY - Budapest SN - 9789632286673 PY - 2024 SP - 688 EP - 688 PG - 1 UR - https://m2.mtmt.hu/api/publication/34688867 ID - 34688867 LA - Hungarian DB - MTMT ER - TY - CHAP AU - Molnár, Dénes AU - Erhardt, Éva AU - Kovács, Éva ED - Tulassay, Tivadar TI - A kivizsgálás, a tanácsadás és a gondozás lépései T2 - Klinikai gyermekgyógyászat PB - Medicina Könyvkiadó CY - Budapest SN - 9789632286673 PY - 2024 SP - 687 EP - 687 PG - 1 UR - https://m2.mtmt.hu/api/publication/34688866 ID - 34688866 LA - Hungarian DB - MTMT ER -