TY - JOUR AU - Foraita, Ronja AU - Witte, Janine AU - Börnhorst, Claudia AU - Gwozdz, Wencke AU - Pala, Valeria AU - Lissner, Lauren AU - Lauria, Fabio AU - Reisch, Lucia A AU - Molnár, Dénes AU - De Henauw, Stefaan AU - Moreno, Luis AU - Veidebaum, Toomas AU - Tornaritis, Michael AU - Pigeot, Iris AU - Didelez, Vanessa TI - A longitudinal causal graph analysis investigating modifiable risk factors and obesity in a European cohort of children and adolescents. JF - SCIENTIFIC REPORTS J2 - SCI REP VL - 14 PY - 2024 IS - 1 PG - 14 SN - 2045-2322 DO - 10.1038/s41598-024-56721-y UR - https://m2.mtmt.hu/api/publication/34757148 ID - 34757148 N1 - Export Date: 2 April 2024 AB - Childhood obesity is a complex disorder that appears to be influenced by an interacting system of many factors. Taking this complexity into account, we aim to investigate the causal structure underlying childhood obesity. Our focus is on identifying potential early, direct or indirect, causes of obesity which may be promising targets for prevention strategies. Using a causal discovery algorithm, we estimate a cohort causal graph (CCG) over the life course from childhood to adolescence. We adapt a popular method, the so-called PC-algorithm, to deal with missing values by multiple imputation, with mixed discrete and continuous variables, and that takes background knowledge such as the time-structure of cohort data into account. The algorithm is then applied to learn the causal structure among 51 variables including obesity, early life factors, diet, lifestyle, insulin resistance, puberty stage and cultural background of 5112 children from the European IDEFICS/I.Family cohort across three waves (2007-2014). The robustness of the learned causal structure is addressed in a series of alternative and sensitivity analyses; in particular, we use bootstrap resamples to assess the stability of aspects of the learned CCG. Our results suggest some but only indirect possible causal paths from early modifiable risk factors, such as audio-visual media consumption and physical activity, to obesity (measured by age- and sex-adjusted BMI z-scores) 6 years later. LA - English DB - MTMT ER - TY - JOUR AU - Intemann, T. AU - Bogl, L.H. AU - Hunsberger, M. AU - Lauria, F. AU - De, Henauw S. AU - Molnár, Dénes AU - Moreno, L.A. AU - Tornaritis, M. AU - Veidebaum, T. AU - Ahrens, W. AU - Hebestreit, A. TI - A Late Meal Timing Pattern Is Associated with Insulin Resistance in European Children and Adolescents JF - PEDIATRIC DIABETES J2 - PEDIATR DIABETES VL - 2024 PY - 2024 PG - 12 SN - 1399-543X DO - 10.1155/2024/6623357 UR - https://m2.mtmt.hu/api/publication/34756498 ID - 34756498 N1 - Funding Agency and Grant Number: Deutsche Forschungsgemeinschaft [391977161]; Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) [266044]; European Commission; Austrian Science Fund (FWF) through a Lise-Meitner Fellowship Funding text: The study was funded by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation); 391977161. Furthermore, we gratefully acknowledge the financial support of the European Commission within the Seventh RTD Framework Program Contract No. 266044. LHB acknowledges funding from the Austrian Science Fund (FWF) through a Lise-Meitner Fellowship Grant No. M 2449. We thank the I.Family children and their parents for participating in this extensive examination. We are grateful for the support from school boards, headmasters, and communities. Open Access funding enabled and organized by Projekt DEAL. LA - English DB - MTMT ER - TY - JOUR AU - Bokor, Szilvia AU - Csölle, Ildikó AU - Heidinger-Felső, Regina AU - Vass, Réka Anna AU - Funke Kiss, Simone AU - Ertl, Tibor AU - Molnár, Dénes TI - Dietary nutrients during gestation cause obesity and related metabolic changes by altering DNA methylation in the offspring JF - FRONTIERS IN ENDOCRINOLOGY J2 - FRONT ENDOCRINOL VL - 15 PY - 2024 PG - 17 SN - 1664-2392 DO - 10.3389/fendo.2024.1287255 UR - https://m2.mtmt.hu/api/publication/34729560 ID - 34729560 N1 - Department of Paediatrics, Medical School, University of Pécs, Pécs, Hungary National Laboratory on Human Reproduction, University of Pécs, Pécs, Hungary Doctoral School of Health Sciences, Faculty of Health Sciences, University of Pécs, Pécs, Hungary Department of Obstetrics and Gynaecology, Medical School, University of Pécs, Pécs, Hungary Obstetrics and Gynecology, Magyar Imre Hospital Ajka, Ajka, Hungary Export Date: 18 March 2024 Correspondence Address: Bokor, S.; Department of Paediatrics, Hungary; email: bokor.szilvia@pte.hu AB - Growing evidence shows that maternal nutrition from preconception until lactation has an important effect on the development of non-communicable diseases in the offspring. Biological responses to environmental stress during pregnancy, including undernutrition or overnutrition of various nutrients, are transmitted in part by DNA methylation. The aim of the present narrative review is to summarize literature data on altered DNA methylation patterns caused by maternal macronutrient or vitamin intake and its association with offspring's phenotype (obesity and related metabolic changes). With our literature search, we found evidence for the association between alterations in DNA methylation pattern of different genes caused by maternal under- or overnutrition of several nutrients (protein, fructose, fat, vitamin D, methyl-group donor nutrients) during 3 critical periods of programming (preconception, pregnancy, lactation) and the development of obesity or related metabolic changes (glucose, insulin, lipid, leptin, adiponectin levels, blood pressure, non-alcoholic fatty liver disease) in offspring. The review highlights that maternal consumption of several nutrients could individually affect the development of offspring's obesity and related metabolic changes via alterations in DNA methylation. LA - English DB - MTMT ER - TY - CHAP AU - Molnár, Dénes AU - Erhardt, Éva AU - Kovács, Éva ED - Tulassay, Tivadar TI - Kezelés T2 - Klinikai gyermekgyógyászat PB - Medicina Könyvkiadó CY - Budapest SN - 9789632286673 PY - 2024 SP - 693 EP - 693 PG - 1 UR - https://m2.mtmt.hu/api/publication/34688870 ID - 34688870 LA - Hungarian DB - MTMT ER - TY - CHAP AU - Molnár, Dénes AU - Erhardt, Éva AU - Kovács, Éva ED - Tulassay, Tivadar TI - Elhízáshoz kapcsolódó betegségek T2 - Klinikai gyermekgyógyászat PB - Medicina Könyvkiadó CY - Budapest SN - 9789632286673 PY - 2024 SP - 692 EP - 692 PG - 1 UR - https://m2.mtmt.hu/api/publication/34688869 ID - 34688869 LA - Hungarian DB - MTMT ER - TY - CHAP AU - Molnár, Dénes AU - Erhardt, Éva AU - Kovács, Éva ED - Tulassay, Tivadar TI - Az elhízás jelentősége, következményei T2 - Klinikai gyermekgyógyászat PB - Medicina Könyvkiadó CY - Budapest SN - 9789632286673 PY - 2024 SP - 688 EP - 691 PG - 4 UR - https://m2.mtmt.hu/api/publication/34688868 ID - 34688868 LA - Hungarian DB - MTMT ER - TY - CHAP AU - Molnár, Dénes AU - Erhardt, Éva AU - Kovács, Éva ED - Tulassay, Tivadar TI - A gyermekkori és a felnőttkori elhízás kapcsolata T2 - Klinikai gyermekgyógyászat PB - Medicina Könyvkiadó CY - Budapest SN - 9789632286673 PY - 2024 SP - 688 EP - 688 PG - 1 UR - https://m2.mtmt.hu/api/publication/34688867 ID - 34688867 LA - Hungarian DB - MTMT ER - TY - CHAP AU - Molnár, Dénes AU - Erhardt, Éva AU - Kovács, Éva ED - Tulassay, Tivadar TI - A kivizsgálás, a tanácsadás és a gondozás lépései T2 - Klinikai gyermekgyógyászat PB - Medicina Könyvkiadó CY - Budapest SN - 9789632286673 PY - 2024 SP - 687 EP - 687 PG - 1 UR - https://m2.mtmt.hu/api/publication/34688866 ID - 34688866 LA - Hungarian DB - MTMT ER - TY - CHAP AU - Molnár, Dénes AU - Erhardt, Éva AU - Kovács, Éva ED - Tulassay, Tivadar TI - Az elhízás okai T2 - Klinikai gyermekgyógyászat PB - Medicina Könyvkiadó CY - Budapest SN - 9789632286673 PY - 2024 SP - 685 EP - 687 PG - 3 UR - https://m2.mtmt.hu/api/publication/34688864 ID - 34688864 LA - Hungarian DB - MTMT ER - TY - CHAP AU - Molnár, Dénes AU - Erhardt, Éva AU - Bokor, Szilvia ED - Tulassay, Tivadar TI - Meghatározás, mérési lehetőségeket, epidemiológia T2 - Klinikai gyermekgyógyászat PB - Medicina Könyvkiadó CY - Budapest SN - 9789632286673 PY - 2024 SP - 683 EP - 684 PG - 2 UR - https://m2.mtmt.hu/api/publication/34688863 ID - 34688863 LA - Hungarian DB - MTMT ER -