@article{MTMT:34757148,
	title = {A longitudinal causal graph analysis investigating modifiable risk factors and obesity in a European cohort of children and adolescents.},
	url = {https://m2.mtmt.hu/api/publication/34757148},
	author = {Foraita, Ronja and Witte, Janine and Börnhorst, Claudia and Gwozdz, Wencke and Pala, Valeria and Lissner, Lauren and Lauria, Fabio and Reisch, Lucia A and Molnár, Dénes and De Henauw, Stefaan and Moreno, Luis and Veidebaum, Toomas and Tornaritis, Michael and Pigeot, Iris and Didelez, Vanessa},
	doi = {10.1038/s41598-024-56721-y},
	journal-iso = {SCI REP},
	journal = {SCIENTIFIC REPORTS},
	volume = {14},
	unique-id = {34757148},
	issn = {2045-2322},
	abstract = {Childhood obesity is a complex disorder that appears to be influenced by an interacting system of many factors. Taking this complexity into account, we aim to investigate the causal structure underlying childhood obesity. Our focus is on identifying potential early, direct or indirect, causes of obesity which may be promising targets for prevention strategies. Using a causal discovery algorithm, we estimate a cohort causal graph (CCG) over the life course from childhood to adolescence. We adapt a popular method, the so-called PC-algorithm, to deal with missing values by multiple imputation, with mixed discrete and continuous variables, and that takes background knowledge such as the time-structure of cohort data into account. The algorithm is then applied to learn the causal structure among 51 variables including obesity, early life factors, diet, lifestyle, insulin resistance, puberty stage and cultural background of 5112 children from the European IDEFICS/I.Family cohort across three waves (2007-2014). The robustness of the learned causal structure is addressed in a series of alternative and sensitivity analyses; in particular, we use bootstrap resamples to assess the stability of aspects of the learned CCG. Our results suggest some but only indirect possible causal paths from early modifiable risk factors, such as audio-visual media consumption and physical activity, to obesity (measured by age- and sex-adjusted BMI z-scores) 6 years later.},
	keywords = {sleep; physical activity; Well-being; healthy diet; multiple imputation; causal structure learning; DAG; PC-algorithm; IDEFICS/I.Family cohort; Audio-visual media consumption},
	year = {2024},
	eissn = {2045-2322},
	orcid-numbers = {Molnár, Dénes/0000-0002-3675-7019}
}

@article{MTMT:34756498,
	title = {A Late Meal Timing Pattern Is Associated with Insulin Resistance in European Children and Adolescents},
	url = {https://m2.mtmt.hu/api/publication/34756498},
	author = {Intemann, T. and Bogl, L.H. and Hunsberger, M. and Lauria, F. and De, Henauw S. and Molnár, Dénes and Moreno, L.A. and Tornaritis, M. and Veidebaum, T. and Ahrens, W. and Hebestreit, A.},
	doi = {10.1155/2024/6623357},
	journal-iso = {PEDIATR DIABETES},
	journal = {PEDIATRIC DIABETES},
	volume = {2024},
	unique-id = {34756498},
	issn = {1399-543X},
	year = {2024},
	eissn = {1399-5448},
	orcid-numbers = {Molnár, Dénes/0000-0002-3675-7019}
}

@article{MTMT:34729560,
	title = {Dietary nutrients during gestation cause obesity and related metabolic changes by altering DNA methylation in the offspring},
	url = {https://m2.mtmt.hu/api/publication/34729560},
	author = {Bokor, Szilvia and Csölle, Ildikó and Heidinger-Felső, Regina and Vass, Réka Anna and Funke Kiss, Simone and Ertl, Tibor and Molnár, Dénes},
	doi = {10.3389/fendo.2024.1287255},
	journal-iso = {FRONT ENDOCRINOL},
	journal = {FRONTIERS IN ENDOCRINOLOGY},
	volume = {15},
	unique-id = {34729560},
	issn = {1664-2392},
	abstract = {Growing evidence shows that maternal nutrition from preconception until lactation has an important effect on the development of non-communicable diseases in the offspring. Biological responses to environmental stress during pregnancy, including undernutrition or overnutrition of various nutrients, are transmitted in part by DNA methylation. The aim of the present narrative review is to summarize literature data on altered DNA methylation patterns caused by maternal macronutrient or vitamin intake and its association with offspring's phenotype (obesity and related metabolic changes). With our literature search, we found evidence for the association between alterations in DNA methylation pattern of different genes caused by maternal under- or overnutrition of several nutrients (protein, fructose, fat, vitamin D, methyl-group donor nutrients) during 3 critical periods of programming (preconception, pregnancy, lactation) and the development of obesity or related metabolic changes (glucose, insulin, lipid, leptin, adiponectin levels, blood pressure, non-alcoholic fatty liver disease) in offspring. The review highlights that maternal consumption of several nutrients could individually affect the development of offspring's obesity and related metabolic changes via alterations in DNA methylation.},
	keywords = {OBESITY; NUTRITION; metabolic syndrome; DNA methylation; epigenetic; Maternal},
	year = {2024},
	eissn = {1664-2392},
	orcid-numbers = {Vass, Réka Anna/0000-0002-0436-4261; Molnár, Dénes/0000-0002-3675-7019}
}

@{MTMT:34688870,
	title = {Kezelés},
	url = {https://m2.mtmt.hu/api/publication/34688870},
	author = {Molnár, Dénes and Erhardt, Éva and Kovács, Éva},
	booktitle = {Klinikai gyermekgyógyászat},
	unique-id = {34688870},
	year = {2024},
	pages = {693-693},
	orcid-numbers = {Molnár, Dénes/0000-0002-3675-7019}
}

@{MTMT:34688869,
	title = {Elhízáshoz kapcsolódó betegségek},
	url = {https://m2.mtmt.hu/api/publication/34688869},
	author = {Molnár, Dénes and Erhardt, Éva and Kovács, Éva},
	booktitle = {Klinikai gyermekgyógyászat},
	unique-id = {34688869},
	year = {2024},
	pages = {692-692},
	orcid-numbers = {Molnár, Dénes/0000-0002-3675-7019}
}

@{MTMT:34688868,
	title = {Az elhízás jelentősége, következményei},
	url = {https://m2.mtmt.hu/api/publication/34688868},
	author = {Molnár, Dénes and Erhardt, Éva and Kovács, Éva},
	booktitle = {Klinikai gyermekgyógyászat},
	unique-id = {34688868},
	year = {2024},
	pages = {688-691},
	orcid-numbers = {Molnár, Dénes/0000-0002-3675-7019}
}

@{MTMT:34688867,
	title = {A gyermekkori és a felnőttkori elhízás kapcsolata},
	url = {https://m2.mtmt.hu/api/publication/34688867},
	author = {Molnár, Dénes and Erhardt, Éva and Kovács, Éva},
	booktitle = {Klinikai gyermekgyógyászat},
	unique-id = {34688867},
	year = {2024},
	pages = {688-688},
	orcid-numbers = {Molnár, Dénes/0000-0002-3675-7019}
}

@{MTMT:34688866,
	title = {A kivizsgálás, a tanácsadás és a gondozás lépései},
	url = {https://m2.mtmt.hu/api/publication/34688866},
	author = {Molnár, Dénes and Erhardt, Éva and Kovács, Éva},
	booktitle = {Klinikai gyermekgyógyászat},
	unique-id = {34688866},
	year = {2024},
	pages = {687-687},
	orcid-numbers = {Molnár, Dénes/0000-0002-3675-7019}
}

@{MTMT:34688864,
	title = {Az elhízás okai},
	url = {https://m2.mtmt.hu/api/publication/34688864},
	author = {Molnár, Dénes and Erhardt, Éva and Kovács, Éva},
	booktitle = {Klinikai gyermekgyógyászat},
	unique-id = {34688864},
	year = {2024},
	pages = {685-687},
	orcid-numbers = {Molnár, Dénes/0000-0002-3675-7019}
}

@{MTMT:34688863,
	title = {Meghatározás, mérési lehetőségeket, epidemiológia},
	url = {https://m2.mtmt.hu/api/publication/34688863},
	author = {Molnár, Dénes and Erhardt, Éva and Bokor, Szilvia},
	booktitle = {Klinikai gyermekgyógyászat},
	unique-id = {34688863},
	year = {2024},
	pages = {683-684},
	orcid-numbers = {Molnár, Dénes/0000-0002-3675-7019}
}