@article{MTMT:34034385, title = {A comparative study of femtosecond pulsed laser ablation of meloxicam in distilled water and in air}, url = {https://m2.mtmt.hu/api/publication/34034385}, author = {Nagy, Eszter and Heszlerné Kopniczky, Judit and Smausz Kolumbán, Tamás and Náfrádi, Máté and Alapi, Tünde and Bohus, János and Pajer, Viktor and Révész, Piroska and Ambrus, Rita and Hopp, Béla}, doi = {10.1038/s41598-023-36922-7}, journal-iso = {SCI REP}, journal = {SCIENTIFIC REPORTS}, volume = {13}, unique-id = {34034385}, issn = {2045-2322}, abstract = {The increasing prevalence of water insoluble or poorly soluble drugs calls for the development of new formulation methods. Common approaches include the reduction of particle size and degree of crystallinity. Pulsed laser ablation is a clean technique for producing sub-micrometre sized drug particles and has the potential to induce amorphization. We studied the effect of femtosecond pulsed laser ablation (ELI ALPS THz pump laser system: λ c = 781 nm, τ = 135 fs) on meloxicam in distilled water and in air. The ablated particles were characterized chemically, morphologically and in terms of crystallinity. We demonstrated that femtosecond laser ablation can induce partial amorphization of the particles in addition to a reduction in particle size. In the case of femtosecond pulsed laser ablation in air, the formation of pure meloxicam spheres showed that this technique can produce amorphous meloxicam without the use of excipients, which is a unique result. We also aimed to describe the ablation processes in both investigated media.}, year = {2023}, eissn = {2045-2322}, orcid-numbers = {Smausz Kolumbán, Tamás/0000-0002-5184-6124; Náfrádi, Máté/0000-0001-8055-0974; Alapi, Tünde/0000-0002-9869-9280; Bohus, János/0000-0003-1749-4142; Pajer, Viktor/0000-0003-2770-510X; Révész, Piroska/0000-0002-5336-6052; Hopp, Béla/0000-0002-4272-7721} } @{MTMT:34024820, title = {Nose}, url = {https://m2.mtmt.hu/api/publication/34024820}, author = {Hafner, Anita and Révész, Piroska}, booktitle = {Practical Pharmaceutics}, doi = {10.1007/978-3-031-20298-8_16}, unique-id = {34024820}, year = {2023}, pages = {345-366}, orcid-numbers = {Révész, Piroska/0000-0002-5336-6052} } @article{MTMT:33628301, title = {Preparation and Characterization of Ibuprofen Containing Nano-Embedded-Microparticles for Pulmonary Delivery}, url = {https://m2.mtmt.hu/api/publication/33628301}, author = {Party, Petra and Klement, Márk László and Révész, Piroska and Ambrus, Rita}, doi = {10.3390/pharmaceutics15020545}, journal-iso = {PHARMACEUTICS}, journal = {PHARMACEUTICS}, volume = {15}, unique-id = {33628301}, issn = {1999-4923}, abstract = {A fatal hereditary condition, cystic fibrosis (CF) causes severe lung problems. Ibuprofen (IBU), a non-steroidal anti-inflammatory drug, slows the progression of disease without causing significant side effects. Considering the poor water-solubility of the drug, IBU nanoparticles are beneficial for local pulmonary administration. We aimed to formulate a carrier-free dry powder inhaler containing nanosized IBU. We combined high-performance ultra-sonication and nano spray-drying. IBU was dissolved in ethyl acetate; after that, it was sonicated into a polyvinyl alcohol solution, where it precipitated as nanoparticles. Mannitol and leucine were added when producing dry particles using nano-spray drying. The following investigations were implemented: dynamic light scattering, laser diffraction, surface tension measurement, scanning electron microscopy, X-ray powder diffraction, differential scanning calorimetry, Fourier-transform infrared spectroscopy, in vitro dissolution test, and in vitro aerodynamic assessment (Andersen Cascade Impactor). The particle diameter of the IBU was in the nano range. The spray-dried particles showed a spherical morphology. The drug release was rapid in artificial lung media. The products represented large fine particle fractions and proper aerodynamic diameters. We successfully created an inhalable powder, containing nano-sized IBU. Along with the exceptional aerodynamic performance, the ideal particle size, shape, and drug-release profile might offer a ground-breaking local therapy for CF.}, year = {2023}, eissn = {1999-4923}, orcid-numbers = {Révész, Piroska/0000-0002-5336-6052} } @article{MTMT:33547706, title = {Soluplus® promotes efficient transport of meloxicam to the central nervous system via nasal administration}, url = {https://m2.mtmt.hu/api/publication/33547706}, author = {Sipos, Bence and Bella, Zsolt and Gróf, Ilona and Veszelka, Szilvia and Deli, Mária Anna and Szűcs, Kálmán Ferenc and Sztojkov-Ivanov, Anita and Ducza, Eszter and Gáspár, Róbert and Kecskeméti, Gábor and Janáky, Tamás and Volk, Balázs and Budai-Szűcs, Mária and Ambrus, Rita and Révész, Piroska and Pannonhalminé Csóka, Ildikó and Katona, Gábor}, doi = {10.1016/j.ijpharm.2023.122594}, journal-iso = {INT J PHARM}, journal = {INTERNATIONAL JOURNAL OF PHARMACEUTICS}, volume = {632}, unique-id = {33547706}, issn = {0378-5173}, year = {2023}, eissn = {1873-3476}, orcid-numbers = {Sipos, Bence/0000-0002-0131-4728; Deli, Mária Anna/0000-0001-6084-6524; Gáspár, Róbert/0000-0002-1571-7579; Kecskeméti, Gábor/0000-0002-5584-6869; Janáky, Tamás/0000-0002-6466-8283; Volk, Balázs/0000-0002-2019-1874; Budai-Szűcs, Mária/0000-0001-5187-5702; Révész, Piroska/0000-0002-5336-6052; Pannonhalminé Csóka, Ildikó/0000-0003-0807-2781; Katona, Gábor/0000-0003-1564-4813} } @CONFERENCE{MTMT:33231423, title = {Nifluminsav nanokristályok előállítása és vizsgálata}, url = {https://m2.mtmt.hu/api/publication/33231423}, author = {Varga, Patrícia Orsolya and Alshweiat, Areen and Pannonhalminé Csóka, Ildikó and Révész, Piroska and Bartos, Csilla and Ambrus, Rita}, booktitle = {Gyógyszertechnológiai és Ipari Gyógyszerészeti Konferencia 2022: A Magyar Gyógyszerésztudományi Társaság Gyógyszeripari Szervezetének és Gyógyszertechnológiai Szakosztályának Konferenciája}, unique-id = {33231423}, year = {2022}, orcid-numbers = {Alshweiat, Areen/0000-0001-7008-0972; Pannonhalminé Csóka, Ildikó/0000-0003-0807-2781; Révész, Piroska/0000-0002-5336-6052} } @CONFERENCE{MTMT:33199221, title = {Felületaktív anyagok hatása megesztrol-acetát tartalmú orális granulátumok szerkezetére és hatóanyagleadási profiljára}, url = {https://m2.mtmt.hu/api/publication/33199221}, author = {Sipos, Bence and Ambrus, Rita and Révész, Piroska and Pannonhalminé Csóka, Ildikó and Katona, Gábor}, booktitle = {Gyógyszertechnológiai és Ipari Gyógyszerészeti Konferencia 2022: A Magyar Gyógyszerésztudományi Társaság Gyógyszeripari Szervezetének és Gyógyszertechnológiai Szakosztályának Konferenciája}, unique-id = {33199221}, year = {2022}, pages = {44-44}, orcid-numbers = {Révész, Piroska/0000-0002-5336-6052; Pannonhalminé Csóka, Ildikó/0000-0003-0807-2781; Katona, Gábor/0000-0003-1564-4813} } @{MTMT:33098792, title = {Solubility enhancement of megestrol-acetate via micelle and polymeric micelle formulation}, url = {https://m2.mtmt.hu/api/publication/33098792}, author = {Sipos, Bence and Pannonhalminé Csóka, Ildikó and Révész, Piroska and Katona, Gábor}, booktitle = {9th BBBB International Conference on Pharmaceutical Sciences - Pharma Sciences of Tomorrow: Book of Abstracts}, unique-id = {33098792}, year = {2022}, pages = {227-228}, orcid-numbers = {Pannonhalminé Csóka, Ildikó/0000-0003-0807-2781; Révész, Piroska/0000-0002-5336-6052; Katona, Gábor/0000-0003-1564-4813} } @article{MTMT:33029379, title = {A comprehensive analysis of meloxicam particles produced by nanosecond laser ablation as a wet milling technique}, url = {https://m2.mtmt.hu/api/publication/33029379}, author = {Nagy, Eszter and Homik, Zsolt and Smausz Kolumbán, Tamás and Heszlerné Kopniczky, Judit and Náfrádi, Máté and Alapi, Tünde and Kókai, Dávid and Burián, Katalin and Révész, Piroska and Ambrus, Rita and Hopp, Béla}, doi = {10.1038/s41598-022-16728-9}, journal-iso = {SCI REP}, journal = {SCIENTIFIC REPORTS}, volume = {12}, unique-id = {33029379}, issn = {2045-2322}, year = {2022}, eissn = {2045-2322}, orcid-numbers = {Smausz Kolumbán, Tamás/0000-0002-5184-6124; Náfrádi, Máté/0000-0001-8055-0974; Alapi, Tünde/0000-0002-9869-9280; Burián, Katalin/0000-0003-1300-2374; Révész, Piroska/0000-0002-5336-6052; Hopp, Béla/0000-0002-4272-7721} } @{MTMT:32868295, title = {Preparation and investigation of meloxicam potassium containing cyclodextrin nanoparticles intended for nasal application}, url = {https://m2.mtmt.hu/api/publication/32868295}, author = {Varga, Patrícia Orsolya and Ambrus, Rita and Révész, Piroska and Kókai, Dávid and Burián, Katalin and Bella, Zsolt and Fenyvesi, Ferenc and Bartos, Csilla}, booktitle = {IV. Symposium of Young Researchers on Pharmaceutical Technology, Biotechnology and Regulatory Science : book of abstracts}, doi = {10.14232/syrptbrs.2022.32}, unique-id = {32868295}, year = {2022}, pages = {32-32}, orcid-numbers = {Révész, Piroska/0000-0002-5336-6052; Burián, Katalin/0000-0003-1300-2374; Fenyvesi, Ferenc/0000-0003-2890-0783} } @article{MTMT:32864997, title = {Mucoadhesive meloxicam-loaded nanoemulsions: development, characterization and nasal applicability studies}, url = {https://m2.mtmt.hu/api/publication/32864997}, author = {Sipos, Bence and Pannonhalminé Csóka, Ildikó and Szivacski, Nimród and Budai-Szűcs, Mária and Schelz, Zsuzsanna and Zupkó, István and Révész, Piroska and Volk, Balázs and Katona, Gábor}, doi = {10.1016/j.ejps.2022.106229}, journal-iso = {EUR J PHARM SCI}, journal = {EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES}, volume = {175}, unique-id = {32864997}, issn = {0928-0987}, year = {2022}, eissn = {1879-0720}, orcid-numbers = {Sipos, Bence/0000-0002-0131-4728; Pannonhalminé Csóka, Ildikó/0000-0003-0807-2781; Budai-Szűcs, Mária/0000-0001-5187-5702; Schelz, Zsuzsanna/0000-0002-8519-4830; Zupkó, István/0000-0003-3243-5300; Révész, Piroska/0000-0002-5336-6052; Volk, Balázs/0000-0002-2019-1874; Katona, Gábor/0000-0003-1564-4813} }