@article{MTMT:32124909, title = {Automated procedure assessing the accuracy of HRCT–PET registration applied in functional virtual bronchoscopy}, url = {https://m2.mtmt.hu/api/publication/32124909}, author = {Opposits, Gábor and Nagy, Marianna and Barta, Zoltán and Aranyi, Sándor Csaba and Szabó, Dániel and Makai, Attila and Varga, Imre and Galuska, László and Trón, Lajos and Balkay, László and Emri, Miklós}, doi = {10.1186/s13550-021-00810-w}, journal-iso = {EJNMMI RES}, journal = {EJNMMI RESEARCH}, volume = {11}, unique-id = {32124909}, issn = {2191-219X}, abstract = {Background Bronchoscopy serves as direct visualisation of the airway. Virtual bronchoscopy provides similar visual information using a non-invasive imaging procedure(s). Early and accurate image-guided diagnosis requires the possible highest performance, which might be approximated by combining anatomical and functional imaging. This communication describes an advanced functional virtual bronchoscopic (fVB) method based on the registration of PET images to high-resolution diagnostic CT images instead of low-dose CT images of lower resolution obtained from PET/CT scans. PET/CT and diagnostic CT data were collected from 22 oncological patients to develop a computer-aided high-precision fVB. Registration of segmented images was performed using elastix. Results For virtual bronchoscopy, we used an in-house developed segmentation method. The quality of low- and high-dose CT image registrations was characterised by expert's scoring the spatial distance of manually paired corresponding points and by eight voxel intensity-based (dis)similarity parameters. The distribution of (dis)similarity parameter correlating best with anatomic scoring was bootstrapped, and 95% confidence intervals were calculated separately for acceptable and insufficient registrations. We showed that mutual information (MI) of the eight investigated (dis)similarity parameters displayed the closest correlation with the anatomy-based distance metrics used to characterise the quality of image registrations. The 95% confidence intervals of the bootstrapped MI distribution were [0.15, 0.22] and [0.28, 0.37] for insufficient and acceptable registrations, respectively. In case of any new patient, a calculated MI value of registered low- and high-dose CT image pair within the [0.28, 0.37] or the [0.15, 0.22] interval would suggest acceptance or rejection, respectively, serving as an aid for the radiologist. Conclusion A computer-aided solution was proposed in order to reduce reliance on radiologist's contribution for the approval of acceptable image registrations.}, year = {2021}, eissn = {2191-219X}, orcid-numbers = {Opposits, Gábor/0000-0002-0065-224X; Aranyi, Sándor Csaba/0000-0001-9569-5404} } @article{MTMT:31547669, title = {Quantitative retrobulbar SPECT/CT measurement in Graves' ophtalmopathy}, url = {https://m2.mtmt.hu/api/publication/31547669}, author = {Barna, Sándor Kristóf and Garai, Ildikó and Galuska, László and Nagy, Endre and Varga, József}, journal-iso = {EUR J NUCL MED MOL I}, journal = {EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING}, volume = {46}, unique-id = {31547669}, issn = {1619-7070}, abstract = {Aim/Introduction: Graves' ophtalmopathy (GO) in immunologically active or incative state requires different treatments. We have examined more than 1000 patients' retrobulbar uptake with [Tc-99m]DTPA in the last 15 years, evaluated by a custom software using manual ROIs on a standardized thick slice containing the retrobulbar space. The clinicians mainly used this method for differentiating active from non-active ophtalmopathy, with 10x10-6 ID/mL as threshold. We investigated the potential of quantitative SPECT/ CT by more available software and more reproducible VOI positioning to simplify the method. Materials and Methods: SPECT projection images of twenty-six retrobulbar regions of 13 patients with suspected active GO were acquired 20 min after administering 400 MBq [Tc-99m]DTPA (128 projections x 30 sec, 128x128 matrix with ... mm pixel size); followed by a CT (120 kV, 40 mAs, 1.5 pitch, 90/min rotation with abdomen filter). OSEM iterative reconstruction included CT-based attenuation correction, Monte Carlo-based scatter correction, and resolution recovery. We drew three sets of VOIs, utilizing both SPECT and CT information. Method A: 2 cm diameter sphere to the retrobulbar area showing the highest uptake; method B: a cone covering the whole retrobulbar territory; and Method C: an 1 mL standard sphere to the highest activity in the retrobulbar area. The uptake was expressed as (a) activity concentration, (b) total VOI activity, or (c) maximal concentration; each normalized to the injected dose. The same parameters were tested when normalized to body weight as well. For each quantitative measure Pearson's r, and Kendall's tau-b correlation coefficients were calculated with the former method as reference. Results: Total and maximal VOI uptake values as well as measures corrected for body weight showed weaker correlation with the reference method than mean activity concentrations. We obtained better correlation with the larger sphere (2 cm vs. 1.2 cm diameter), and even slightly better with the conical VOI. Conclusion: We found that defining the retrobulbar area is much easier when utilizing the CT image as well. For the sake of simplicity and reproducibility, we select the sphere with 2 cm diameter as the VOI of choice, since drawing the conical region is more subjective. As the present analysis aimed at the best correlation with the reference method that did not take body size into account, we plan to consider activity concentration normalized to body weight as well during the forthcoming clinical evaluation based on a larger patient group. References: None.}, year = {2019}, eissn = {1619-7089}, pages = {S489} } @article{MTMT:30549924, title = {First comparative results about the direct effect of traditional cigarette and e-cigarette smoking on lung alveolocapillary membrane using dynamic ventilation scintigraphy}, url = {https://m2.mtmt.hu/api/publication/30549924}, author = {Barna, Sándor Kristóf and Rózsa, Dávid and Varga, József and Fodor, Andrea and Szilasi, Mária and Galuska, László and Garai, Ildikó}, doi = {10.1097/MNM.0000000000000957}, journal-iso = {NUCL MED COMMUN}, journal = {NUCLEAR MEDICINE COMMUNICATIONS}, volume = {40}, unique-id = {30549924}, issn = {0143-3636}, year = {2019}, eissn = {1473-5628}, pages = {153-158} } @article{MTMT:3362260, title = {Early stage Graves' disease is uniformly accompanied by orbital immune activity even in patients who fail to develop orbithopathy during follow-up}, url = {https://m2.mtmt.hu/api/publication/3362260}, author = {Berta, Eszter and Bodor, Miklós and Galuska, László and Paragh, György and Erdei, Annamária and Gazdag, Annamária and Ujhelyi, Bernadett and Berényi, Ervin László and Katkó, Mónika and Gazsó, Andrea and Nagy, Endre}, doi = {10.1055/s-0043-125065}, journal-iso = {EXP CLIN ENDOCR DIAB}, journal = {EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES}, volume = {126}, unique-id = {3362260}, issn = {0947-7349}, abstract = {Purpose. Graves' orbitopathy (GO) is a complication of Graves' disease (GD), the development of which cannot be predicted at the time of diagnosis of GD. Our aims were (i) to test if orbital 99mTc-labelled diethylenetriamine pentaacetic acid single-photon emission computer tomography (DTPA SPECT) can predict development of GO later during the course of the disease and (ii) to study whether orbital immune activity can be detected in GD patients who do not develop GO during follow-up.Methods. Fifty-four orbits of 27 patients with newly diagnosed GD were entered into the case-control study. Individuals showing signs of GO at enrolment were excluded. During the two-year follow up, eye signs were recorded every 3 months. Orbital DTPA uptakes on SPECT images were measured when entering the study and at the end of the follow-up period, or when clinical signs of GO developed, whichever occurred first.Results. During thefollow up, 6 patients (22%) were diagnosed with GO. There was no significant difference between the initial DTPA uptakes of the patients with or without later developing GO (10.45?1.72 MBq/cm vs. 9.18?1.18 MBq/cm3 respectively). However, the DTPA uptakes of both GD groups (ie. with and without GO) were higher than that of the control group (7.45?1.36 MBq/cm3, p<0.05).Conclusions. We have shown that GD is accompanied by moderate orbital immune activity in GD patients without GO, irrespective of later development of GO. Why this orbital autoimmunity remains subclinical in the majority of the cases, and progresses into clinically detectable GO in others, remains unclear.}, keywords = {pajzsmirigy; endokrin orbitopathia}, year = {2018}, eissn = {1439-3646}, pages = {628-631} } @article{MTMT:3323579, title = {The role of 99mTc-DTPA retrobulbar SPECT in staging and follow-up of Graves' orbitopathy}, url = {https://m2.mtmt.hu/api/publication/3323579}, author = {Galuska, László and Barna, Sándor Kristóf and Varga, József and Garai, Ildikó and Nagy, Endre}, doi = {10.5603/NMR.a2018.0005}, journal-iso = {NUCL MED REV CENT E EUR}, journal = {NUCLEAR MEDICINE REVIEW: CENTRAL AND EASTERN EUROPE}, volume = {21}, unique-id = {3323579}, issn = {1506-9680}, abstract = {The pathogenesis of Graves' orbitopathy (GO) is not completely understood. Coexistent hyperfunction of the thyroid gland is frequent; however, GO may also coexist with hypo- or euthyrodism. The course of GO is largely independent of thyroid function, although elevated serum TSH is known to negatively interfere with GO course. GO is severe in 10 % of the cases; sight threatening complications may also develop. A successful therapy of GO requires the assesment of both the severity and activity of orbital inflammation. Based on relevant studies and our own experiences, the possible management choices are reviewed here. For this purpose, we compare the clinical value of imaging techniques for detecting the activity of the disease. During the last 15 years, we used 99mTc-DTPA retrobulbar SPECT routinely in more than 1400 patients to facilitate the right therapeutic decision. This diagnostic utility simplified management decisions compared to previously applied alternative techniques. We recommended the routine use of 99mTc-DTPA retrobulbar SPECT for the evaluation and follow-up of GO.}, year = {2018}, eissn = {1644-4345}, pages = {54-58} } @article{MTMT:3323559, title = {The potential role of FDG PET-CT in the characterization of the activity of Crohn’s disease, staging follow-up and prognosis estimation: a pilot study}, url = {https://m2.mtmt.hu/api/publication/3323559}, author = {Palatka, Károly and Kacska, Sándor and Lovas, Szilvia and Garai, Ildikó and Varga, József and Galuska, László}, doi = {10.1080/00365521.2017.1390600}, journal-iso = {SCAND J GASTROENTERO}, journal = {SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY}, volume = {53}, unique-id = {3323559}, issn = {0036-5521}, abstract = {Objectives: FDG PET-CT is a global, noninvasive, sensitive method to determine the location and activity of inflammatory lesions. Segmental FDG uptake is proportional with immune cell infiltration of bowel. Our aim was to evaluate prospectively the role of PET in patients with active Crohn's disease (CD) before and after one year's biological therapy, and to compare simple endoscopic score for CD (SES-CD), CD activity index (CDAI) and global PET scores. We also analyzed the prognostic value of initial PET scores.Patients: Twelve patients were selected: six male/six female, ages between 18 and 39, average: 24 years, with CDAI values >300.Methods: We scored the FDG uptake in the small intestine and the four colon segments (on a scale 0-3 for each), and summed them thus forming a global PET score. The scoring was based on the maximal standardized uptake value of the intestinal segment, related to the SUVmax of the liver (as a reference for normal tissue activity). The SES-CD, CDAI and global PET scores before and after treatment were statistically compared.Results: There were significant changes in CDAI and SES-CD after therapy, PET scores improved only in patients' subgroup with high (>4) initial PET score, indicating good prognosis of biological treatment. In active disease, PET was more informative than endoscopy to access the extent of the inflammation, and small intestine involvement.Conclusions: FDG PET-CT score is a promising, noninvasive complementary method in the staging, treatment planning and follow-up of CD. Limitation of the study is the small number of patients.}, keywords = {Inflammation; Crohn's disease; INFLAMMATORY-BOWEL-DISEASE; vascular inflammation; psoriasis; POSITRON-EMISSION-TOMOGRAPHY; PET-CT; CLINICAL-PRACTICE; FDG; NONINVASIVE ASSESSMENT; fecal calprotectin; F-18-FDG PET/CT; SURROGATE MARKERS; STANDARDIZED UPTAKE VALUES}, year = {2018}, eissn = {1502-7708}, pages = {24-30} } @article{MTMT:30614967, title = {Comparison of cigarette and ecigarette smoking to alveolocapillary membrane by dynamic ventilation scintigraphy}, url = {https://m2.mtmt.hu/api/publication/30614967}, author = {Barna, Sándor Kristóf and Garai, Ildikó and Rozsa, D. and Varga, József and Fodor, A. and Szilasi, Mária and Galuska, László}, journal-iso = {EUR J NUCL MED MOL I}, journal = {EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING}, volume = {43}, unique-id = {30614967}, issn = {1619-7070}, year = {2016}, eissn = {1619-7089}, pages = {S603-S604} } @article{MTMT:3165639, title = {Comparison of Three Imaging Methods for the Visualization of Splenic-Autotransplants in Large Animal Model}, url = {https://m2.mtmt.hu/api/publication/3165639}, author = {Mikó, Irén and Pető, Katalin and Deák, Ádám and Németh, N. and Ványolos, Erzsébet and Furka, Andrea and Furka, István and Nagy, T. and Garai, Ildikó and Galuska, László and Varga, József}, doi = {10.1159/000446131}, journal-iso = {EUR SURG RES}, journal = {EUROPEAN SURGICAL RESEARCH}, volume = {57}, unique-id = {3165639}, issn = {0014-312X}, year = {2016}, eissn = {1421-9921}, pages = {122-122}, orcid-numbers = {Ványolos, Erzsébet/0000-0002-5483-0275} } @article{MTMT:3093736, title = {Multiparametric labeling optimization and synthesis of 68Ga-labeled compounds applying a continuous-flow microfluidic methodology}, url = {https://m2.mtmt.hu/api/publication/3093736}, author = {Máté, Gábor and Szikra, Dezső and Jakub, Šimeček and Szandra, Szilágyi and Trencsényi, György and Hans-Jürgen, Wester and Kertész, István and Galuska, László}, doi = {10.1556/1846.2016.00004}, journal-iso = {J FLOW CHEM}, journal = {JOURNAL OF FLOW CHEMISTRY}, volume = {6}, unique-id = {3093736}, issn = {2062-249X}, year = {2016}, eissn = {2063-0212}, pages = {86-93}, orcid-numbers = {Trencsényi, György/0000-0001-6456-6212} } @article{MTMT:3368110, title = {There is a detectable immune activity in the orbits of all patients diagnosed with Graves' regardless of later development of Graves' orbitopathy}, url = {https://m2.mtmt.hu/api/publication/3368110}, author = {Berta, Eszter and Ujhelyi, Bernadett and Szabados, Lajos and Galuska, László and Erdei, Annamária and Gazdag, Annamária and Halmi, Sándor and Nagy, Endre and Bodor, Miklós}, doi = {10.1530/endoabs.37.GP.27.08}, journal-iso = {ENDOCR ABSTR}, journal = {ENDOCRINE ABSTRACTS}, volume = {37}, unique-id = {3368110}, issn = {1470-3947}, year = {2015}, eissn = {1479-6848} }