TY - JOUR AU - Alasztics, Bálint AU - Kovács, Árpád Ferenc AU - Pállinger, Éva AU - Szabó-Taylor, Katalin AU - Szabó, Gábor AU - Molvarec, Attila AU - Koller, Ákos AU - Rigó, János TI - Upregulation of exofacial peroxiredoxin-thioredoxin system of lymphocytes and monocytes in preeclampsia JF - PREGNANCY HYPERTENSION J2 - PREGNANCY HYPERTENS VL - 31 PY - 2023 SP - 54 EP - 59 PG - 6 SN - 2210-7789 DO - 10.1016/j.preghy.2022.12.002 UR - https://m2.mtmt.hu/api/publication/33334444 ID - 33334444 LA - English DB - MTMT ER - TY - JOUR AU - Molvarec, Attila AU - Czegle, Ibolya TI - Menopause and its management: A review JF - DEVELOPMENTS IN HEALTH SCIENCES J2 - DEV HEALTH SCI VL - 4 PY - 2022 IS - 2 SP - 38 EP - 41 PG - 4 SN - 2630-9378 DO - 10.1556/2066.2021.00050 UR - https://m2.mtmt.hu/api/publication/32819161 ID - 32819161 LA - English DB - MTMT ER - TY - JOUR AU - Alasztics, Bálint AU - Kovács, Árpád Ferenc AU - Molvarec, Attila AU - Koller, Ákos AU - Szabó, Gábor AU - Fekete, Nóra AU - Buzás, Edit Irén AU - Pállinger, Éva AU - Rigó, János TI - Platelet-derived extracellular vesicles may contribute to the hypercoagulable state in preeclampsia JF - JOURNAL OF REPRODUCTIVE IMMUNOLOGY J2 - J REPROD IMMUNOL VL - 148 PY - 2021 PG - 6 SN - 0165-0378 DO - 10.1016/j.jri.2021.103380 UR - https://m2.mtmt.hu/api/publication/32201054 ID - 32201054 LA - English DB - MTMT ER - TY - CHAP AU - Molvarec, Attila ED - Igaz, Péter TI - Primary Ovarian Insufficiency T2 - Practical Clinical Endocrinology PB - Springer Netherlands CY - Cham SN - 9783030620110 PY - 2021 SP - 413 EP - 418 PG - 6 DO - 10.1007/978-3-030-62011-0_41 UR - https://m2.mtmt.hu/api/publication/31936190 ID - 31936190 LA - English DB - MTMT ER - TY - JOUR AU - Molvarec, Attila TI - The immunology of preeclampsia JF - DEVELOPMENTS IN HEALTH SCIENCES J2 - DEV HEALTH SCI VL - 3 PY - 2020 IS - 1 SP - 20 EP - 20 PG - 1 SN - 2630-9378 UR - https://m2.mtmt.hu/api/publication/32819173 ID - 32819173 LA - English DB - MTMT ER - TY - JOUR AU - Csibi, Noémi AU - Brubel, Réka AU - Dobó, Noémi AU - Mészáros, Katalin AU - Molvarec, Attila AU - Lukovich, Péter AU - Rigó, János AU - Bokor, Attila TI - Gamma-Synuclein Levels Are Elevated in Peritoneal Fluid of Patients with Endometriosis. JF - MEDICAL SCIENCE MONITOR J2 - MED SCI MONIT VL - 26 PY - 2020 SP - e922137 PG - 6 SN - 1234-1010 DO - 10.12659/MSM.922137 UR - https://m2.mtmt.hu/api/publication/31339784 ID - 31339784 AB - BACKGROUND The role of gamma-synuclein (SNCG) has been widely examined in malignant conditions due to its possible role in disease progression, but very little information is available on its theoretical function on endometriosis formation. MATERIAL AND METHODS Between January 2016 and December 2016, we collected peritoneal fluid and plasma samples from 45 consecutive female patients, of which 15 were without endometriosis, 15 had minimal to mild endometriosis, and 15 had moderate to severe endometriosis. The statistical power was 0.98. We evaluated SNCG levels in the peritoneal fluid and plasma of patients diagnosed with endometriosis, and we compared them with the levels obtained from disease-free control subjects by using enzyme-linked immunosorbent assay. RESULTS SNCG levels were statistically significantly (1.2-fold) higher in the peritoneal fluid of patients with endometriosis compared to controls (p=0.04). We did not find a significant difference between SNCG levels in the plasma of our endometriosis patients and the control group (p=0.086). However, despite previous data showing very limited expression of SNCG in healthy tissues, we found SNCG in the peritoneal fluid of all of the patients in our healthy control group. CONCLUSIONS Levels of SNCG were statistically significantly higher in the peritoneal fluid of patients with endometriosis compared to disease-free controls, which may indicate its possible role the formation and progression of the disease. Moreover, its biological function should be further investigated due to the conflicting results concerning its expression in healthy tissues. LA - English DB - MTMT ER - TY - JOUR AU - Molvarec, Attila TI - Újdonságok a nőgyógyászati endokrinológiában JF - MEDICAL TRIBUNE J2 - MEDICAL TRIBUNE VL - 16 PY - 2018 IS - 2 SP - 10 EP - 11 PG - 2 SN - 1589-1283 UR - https://m2.mtmt.hu/api/publication/3355834 ID - 3355834 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Biró, Orsolya AU - Alasztics, Bálint AU - Molvarec, Attila AU - Joó, József Gábor AU - Nagy, Bálint AU - Rigó, János TI - Various levels of circulating exosomal total-miRNA and miR-210 hypoxamiR in different forms of pregnancy hypertension JF - PREGNANCY HYPERTENSION J2 - PREGNANCY HYPERTENS VL - 10 PY - 2017 SP - 207 EP - 212 PG - 6 SN - 2210-7789 DO - 10.1016/j.preghy.2017.09.002 UR - https://m2.mtmt.hu/api/publication/3273020 ID - 3273020 AB - Introduction: Hypertension is a common complication during pregnancy, affecting 10% of pregnant women worldwide. Several microRNA (miRNA) were shown to be involved in hypertensive disorders of pregnancy. In preeclampsia (PE), placental dysfunction causes the enhanced release of extracellular vesicle-derived miRNAs. The hypoxia-sensitive hsa-mir-210 is the most common PE-associated miRNA, but its exosomal profile has not been investigated. Objectives: Our aims were to measure exosomal total-miRNA concentration and to perform expression analysis of circulating exosomal hsa-miR-210 in women affected by chronic hypertension (CHT) gestational hypertension (GHT) or PE. Materials and methods: We collected plasma samples from women with CHT, GHT, PE (moderate: mPE and severe: sPE) and from normotensive pregnancies. Exosomal miRNAs were extracted and miRNA concentration was measured. RT-PCR was carried out with hsa-miR-210-3p-specific primers and relative expression was calculated using the comparative Ct method. Results: The total-miRNA concentration was different in the disease subgroups, and was significantly higher in mPE and sPE compared to the other groups. We found a significant difference in the relative exosomal hsa-miR-210-3p expression between all hypertensive groups compared to the normotensive samples, but significant upregulation was only observed in case of mPE and sPE patients. Both the level of total-miRNA and hsa-miR-210 expression was higher in case of severe PE. Conclusions: The level of circulating exosomal total-miRNA and hsa-miR-210 was elevated in women with PE, and it was higher in the severe form. We showed that hsa-miR-210 is secreted via exosomes, which may have a role in the pathomechanism of the disease. © 2017 International Society for the Study of Hypertension in Pregnancy. LA - English DB - MTMT ER - TY - JOUR AU - Biró, Orsolya AU - Fóthi, Ábel AU - Alasztics, Bálint AU - Molvarec, Attila AU - Tamás, Orbán AU - Rigó, János TI - The expression profile of miR-517 family members in preeclamptic placenta and circulating exosome samples JF - PREGNANCY HYPERTENSION J2 - PREGNANCY HYPERTENS VL - 9 PY - 2017 SP - 46 PG - 1 SN - 2210-7789 DO - 10.1016/j.preghy.2017.07.098 UR - https://m2.mtmt.hu/api/publication/3269946 ID - 3269946 AB - Introduction Preeclampsia is the major cause of maternal and fetal morbidity and mortality, affecting 3–8% of pregnancies worldwide. Recent findings suggest that placenta-specific miRNAs may contribute to pregnancy-related diseases. The miR- 517 family was proposed as a major contributing factor to trophoblast dysfunction. Objectives Our aim was to analyze the expression of the miR-517 family members in placenta and circulating exosome samples comparing normal (N) and preeclamptic (PE) pregnancies. Methods PE and N placenta samples were collected from C-sections and stored in RNA-later. Blood samples were drawn from each pregnant in the third trimester. Plasma was separated, and exosomes were isolated by precipitation method. Short RNAs were extracted from the diluted exosomes on column, and total-RNA was isolated from the placenta samples with TRIzol. Expression analysis was carried out by qPCR with primers specific to miR-517a/b, miR-517c, and mir-517-5p; and relative expression was calculated using the comparative Ct method. Results We found significant differences in the expression of all assessed miRNAs between PE and N pregnancies. The level of placental hsa-miR-517a/b, hsa-miR-517c, and hsa-miR-517-5p was ∼2–3 times higher, comparing affected and control groups. The deviation was more pronounced in exosomal samples since all three miRNAs were expressed 4–6-times higher in the disease group. As expected, the level of miR-517a/b and c was ∼100 times higher than the passenger strand, miR-517-5p in both types of samples. Based on these data, it can be assumed that the sorting of these miRNAs varies between affected and normal pregnancy. Conclusion Placenta-specific miRNAs are believed to play important role in the regulation of pregnancy. We found that miR-517 family members are overexpressed both in preeclamptic placenta and circulating exosome samples. It can be assumed that the sorting of these miRNAs varies between affected and normal pregnancy. LA - English DB - MTMT ER - TY - CHAP AU - Molvarec, Attila ED - Szilágyi, András TI - Hyperprolactinaemia vérzészavarokban és meddőségben T2 - A női infertilitás endokrinológiai vonatkozásai PB - Betűvirág CY - Budapest SN - 9789631283266 PY - 2017 SP - 40 EP - 45 PG - 6 UR - https://m2.mtmt.hu/api/publication/3258493 ID - 3258493 LA - Hungarian DB - MTMT ER -