@article{MTMT:33334444, title = {Upregulation of exofacial peroxiredoxin-thioredoxin system of lymphocytes and monocytes in preeclampsia}, url = {https://m2.mtmt.hu/api/publication/33334444}, author = {Alasztics, Bálint and Kovács, Árpád Ferenc and Pállinger, Éva and Szabó-Taylor, Katalin and Szabó, Gábor and Molvarec, Attila and Koller, Ákos and Rigó, János}, doi = {10.1016/j.preghy.2022.12.002}, journal-iso = {PREGNANCY HYPERTENS}, journal = {PREGNANCY HYPERTENSION}, volume = {31}, unique-id = {33334444}, issn = {2210-7789}, year = {2023}, eissn = {2210-7797}, pages = {54-59}, orcid-numbers = {Alasztics, Bálint/0000-0002-4011-8439; Kovács, Árpád Ferenc/0000-0002-7742-160X; Pállinger, Éva/0000-0002-5789-0951; Szabó-Taylor, Katalin/0000-0002-4763-3521; Szabó, Gábor/0000-0002-8573-8260; Molvarec, Attila/0000-0002-3229-3034; Koller, Ákos/0000-0003-3256-8701; Rigó, János/0000-0003-2762-6516} } @article{MTMT:32819161, title = {Menopause and its management: A review}, url = {https://m2.mtmt.hu/api/publication/32819161}, author = {Molvarec, Attila and Czegle, Ibolya}, doi = {10.1556/2066.2021.00050}, journal-iso = {DEV HEALTH SCI}, journal = {DEVELOPMENTS IN HEALTH SCIENCES}, volume = {4}, unique-id = {32819161}, issn = {2630-9378}, year = {2022}, eissn = {2630-936X}, pages = {38-41}, orcid-numbers = {Molvarec, Attila/0000-0002-3229-3034; Czegle, Ibolya/0000-0001-7240-4678} } @article{MTMT:32201054, title = {Platelet-derived extracellular vesicles may contribute to the hypercoagulable state in preeclampsia}, url = {https://m2.mtmt.hu/api/publication/32201054}, author = {Alasztics, Bálint and Kovács, Árpád Ferenc and Molvarec, Attila and Koller, Ákos and Szabó, Gábor and Fekete, Nóra and Buzás, Edit Irén and Pállinger, Éva and Rigó, János}, doi = {10.1016/j.jri.2021.103380}, journal-iso = {J REPROD IMMUNOL}, journal = {JOURNAL OF REPRODUCTIVE IMMUNOLOGY}, volume = {148}, unique-id = {32201054}, issn = {0165-0378}, year = {2021}, eissn = {1872-7603}, orcid-numbers = {Alasztics, Bálint/0000-0002-4011-8439; Kovács, Árpád Ferenc/0000-0002-7742-160X; Molvarec, Attila/0000-0002-3229-3034; Koller, Ákos/0000-0003-3256-8701; Szabó, Gábor/0000-0002-8573-8260; Buzás, Edit Irén/0000-0002-3744-206X; Pállinger, Éva/0000-0002-5789-0951; Rigó, János/0000-0003-2762-6516} } @{MTMT:31936190, title = {Primary Ovarian Insufficiency}, url = {https://m2.mtmt.hu/api/publication/31936190}, author = {Molvarec, Attila}, booktitle = {Practical Clinical Endocrinology}, doi = {10.1007/978-3-030-62011-0_41}, unique-id = {31936190}, year = {2021}, pages = {413-418}, orcid-numbers = {Molvarec, Attila/0000-0002-3229-3034} } @article{MTMT:32819173, title = {The immunology of preeclampsia}, url = {https://m2.mtmt.hu/api/publication/32819173}, author = {Molvarec, Attila}, journal-iso = {DEV HEALTH SCI}, journal = {DEVELOPMENTS IN HEALTH SCIENCES}, volume = {3}, unique-id = {32819173}, issn = {2630-9378}, year = {2020}, eissn = {2630-936X}, pages = {20-20}, orcid-numbers = {Molvarec, Attila/0000-0002-3229-3034} } @article{MTMT:31339784, title = {Gamma-Synuclein Levels Are Elevated in Peritoneal Fluid of Patients with Endometriosis.}, url = {https://m2.mtmt.hu/api/publication/31339784}, author = {Csibi, Noémi and Brubel, Réka and Dobó, Noémi and Mészáros, Katalin and Molvarec, Attila and Lukovich, Péter and Rigó, János and Bokor, Attila}, doi = {10.12659/MSM.922137}, journal-iso = {MED SCI MONIT}, journal = {MEDICAL SCIENCE MONITOR}, volume = {26}, unique-id = {31339784}, issn = {1234-1010}, abstract = {BACKGROUND The role of gamma-synuclein (SNCG) has been widely examined in malignant conditions due to its possible role in disease progression, but very little information is available on its theoretical function on endometriosis formation. MATERIAL AND METHODS Between January 2016 and December 2016, we collected peritoneal fluid and plasma samples from 45 consecutive female patients, of which 15 were without endometriosis, 15 had minimal to mild endometriosis, and 15 had moderate to severe endometriosis. The statistical power was 0.98. We evaluated SNCG levels in the peritoneal fluid and plasma of patients diagnosed with endometriosis, and we compared them with the levels obtained from disease-free control subjects by using enzyme-linked immunosorbent assay. RESULTS SNCG levels were statistically significantly (1.2-fold) higher in the peritoneal fluid of patients with endometriosis compared to controls (p=0.04). We did not find a significant difference between SNCG levels in the plasma of our endometriosis patients and the control group (p=0.086). However, despite previous data showing very limited expression of SNCG in healthy tissues, we found SNCG in the peritoneal fluid of all of the patients in our healthy control group. CONCLUSIONS Levels of SNCG were statistically significantly higher in the peritoneal fluid of patients with endometriosis compared to disease-free controls, which may indicate its possible role the formation and progression of the disease. Moreover, its biological function should be further investigated due to the conflicting results concerning its expression in healthy tissues.}, year = {2020}, eissn = {1643-3750}, pages = {e922137}, orcid-numbers = {Molvarec, Attila/0000-0002-3229-3034; Rigó, János/0000-0003-2762-6516; Bokor, Attila/0000-0001-5353-6990} } @article{MTMT:3355834, title = {Újdonságok a nőgyógyászati endokrinológiában}, url = {https://m2.mtmt.hu/api/publication/3355834}, author = {Molvarec, Attila}, journal-iso = {MEDICAL TRIBUNE}, journal = {MEDICAL TRIBUNE}, volume = {16}, unique-id = {3355834}, issn = {1589-1283}, year = {2018}, pages = {10-11}, orcid-numbers = {Molvarec, Attila/0000-0002-3229-3034} } @article{MTMT:3273020, title = {Various levels of circulating exosomal total-miRNA and miR-210 hypoxamiR in different forms of pregnancy hypertension}, url = {https://m2.mtmt.hu/api/publication/3273020}, author = {Biró, Orsolya and Alasztics, Bálint and Molvarec, Attila and Joó, József Gábor and Nagy, Bálint and Rigó, János}, doi = {10.1016/j.preghy.2017.09.002}, journal-iso = {PREGNANCY HYPERTENS}, journal = {PREGNANCY HYPERTENSION}, volume = {10}, unique-id = {3273020}, issn = {2210-7789}, abstract = {Introduction: Hypertension is a common complication during pregnancy, affecting 10% of pregnant women worldwide. Several microRNA (miRNA) were shown to be involved in hypertensive disorders of pregnancy. In preeclampsia (PE), placental dysfunction causes the enhanced release of extracellular vesicle-derived miRNAs. The hypoxia-sensitive hsa-mir-210 is the most common PE-associated miRNA, but its exosomal profile has not been investigated. Objectives: Our aims were to measure exosomal total-miRNA concentration and to perform expression analysis of circulating exosomal hsa-miR-210 in women affected by chronic hypertension (CHT) gestational hypertension (GHT) or PE. Materials and methods: We collected plasma samples from women with CHT, GHT, PE (moderate: mPE and severe: sPE) and from normotensive pregnancies. Exosomal miRNAs were extracted and miRNA concentration was measured. RT-PCR was carried out with hsa-miR-210-3p-specific primers and relative expression was calculated using the comparative Ct method. Results: The total-miRNA concentration was different in the disease subgroups, and was significantly higher in mPE and sPE compared to the other groups. We found a significant difference in the relative exosomal hsa-miR-210-3p expression between all hypertensive groups compared to the normotensive samples, but significant upregulation was only observed in case of mPE and sPE patients. Both the level of total-miRNA and hsa-miR-210 expression was higher in case of severe PE. Conclusions: The level of circulating exosomal total-miRNA and hsa-miR-210 was elevated in women with PE, and it was higher in the severe form. We showed that hsa-miR-210 is secreted via exosomes, which may have a role in the pathomechanism of the disease. © 2017 International Society for the Study of Hypertension in Pregnancy.}, keywords = {PREECLAMPSIA; microRNA; exosome; Maternal circulation}, year = {2017}, eissn = {2210-7797}, pages = {207-212}, orcid-numbers = {Biró, Orsolya/0000-0002-4300-3602; Alasztics, Bálint/0000-0002-4011-8439; Molvarec, Attila/0000-0002-3229-3034; Joó, József Gábor/0000-0001-9820-6514; Nagy, Bálint/0000-0002-0295-185X; Rigó, János/0000-0003-2762-6516} } @article{MTMT:3269946, title = {The expression profile of miR-517 family members in preeclamptic placenta and circulating exosome samples}, url = {https://m2.mtmt.hu/api/publication/3269946}, author = {Biró, Orsolya and Fóthi, Ábel and Alasztics, Bálint and Molvarec, Attila and Tamás, Orbán and Rigó, János}, doi = {10.1016/j.preghy.2017.07.098}, journal-iso = {PREGNANCY HYPERTENS}, journal = {PREGNANCY HYPERTENSION}, volume = {9}, unique-id = {3269946}, issn = {2210-7789}, abstract = {Introduction Preeclampsia is the major cause of maternal and fetal morbidity and mortality, affecting 3–8% of pregnancies worldwide. Recent findings suggest that placenta-specific miRNAs may contribute to pregnancy-related diseases. The miR- 517 family was proposed as a major contributing factor to trophoblast dysfunction. Objectives Our aim was to analyze the expression of the miR-517 family members in placenta and circulating exosome samples comparing normal (N) and preeclamptic (PE) pregnancies. Methods PE and N placenta samples were collected from C-sections and stored in RNA-later. Blood samples were drawn from each pregnant in the third trimester. Plasma was separated, and exosomes were isolated by precipitation method. Short RNAs were extracted from the diluted exosomes on column, and total-RNA was isolated from the placenta samples with TRIzol. Expression analysis was carried out by qPCR with primers specific to miR-517a/b, miR-517c, and mir-517-5p; and relative expression was calculated using the comparative Ct method. Results We found significant differences in the expression of all assessed miRNAs between PE and N pregnancies. The level of placental hsa-miR-517a/b, hsa-miR-517c, and hsa-miR-517-5p was ∼2–3 times higher, comparing affected and control groups. The deviation was more pronounced in exosomal samples since all three miRNAs were expressed 4–6-times higher in the disease group. As expected, the level of miR-517a/b and c was ∼100 times higher than the passenger strand, miR-517-5p in both types of samples. Based on these data, it can be assumed that the sorting of these miRNAs varies between affected and normal pregnancy. Conclusion Placenta-specific miRNAs are believed to play important role in the regulation of pregnancy. We found that miR-517 family members are overexpressed both in preeclamptic placenta and circulating exosome samples. It can be assumed that the sorting of these miRNAs varies between affected and normal pregnancy.}, year = {2017}, eissn = {2210-7797}, pages = {46-47}, orcid-numbers = {Biró, Orsolya/0000-0002-4300-3602; Alasztics, Bálint/0000-0002-4011-8439; Molvarec, Attila/0000-0002-3229-3034; Rigó, János/0000-0003-2762-6516} } @{MTMT:3258493, title = {Hyperprolactinaemia vérzészavarokban és meddőségben}, url = {https://m2.mtmt.hu/api/publication/3258493}, author = {Molvarec, Attila}, booktitle = {A női infertilitás endokrinológiai vonatkozásai}, unique-id = {3258493}, year = {2017}, pages = {40-45}, orcid-numbers = {Molvarec, Attila/0000-0002-3229-3034} }