@article{MTMT:34772135,
	title = {POS1219 INCIDENCE, FEATURES AND OUTCOME OF DISEASE RELAPSE AFTER COVID-19 VACCINATION IN PATIENTS WITH IDIOPATHIC INFLAMMATORY MYOPATHIES},
	url = {https://m2.mtmt.hu/api/publication/34772135},
	author = {Béldi, T. G. and Nagy-Vincze, Melinda and Szabó, Krisztina and Vincze, Anett and Miltényi-Szabó, B. and Varga, Z. and Varga, József and Griger, Zoltán},
	doi = {10.1136/annrheumdis-2023-eular.4867},
	journal-iso = {ANN RHEUM DIS},
	journal = {ANNALS OF THE RHEUMATIC DISEASES},
	volume = {82},
	unique-id = {34772135},
	issn = {0003-4967},
	year = {2023},
	eissn = {1468-2060},
	pages = {944-944}
}

@article{MTMT:34764935,
	title = {Investigation of volumetric measurements from gated myocardial perfusion Multi-Pinhole SPECT with shortening acquisition time},
	url = {https://m2.mtmt.hu/api/publication/34764935},
	author = {Alamin, M. and Barna, Sándor Kristóf and Linczerné, V. Bencze and Kukuts, K. and Oszlanszki, A. and Varga, József and Krizsán, A. and Forgács, A. and Garai, Ildikó},
	journal-iso = {EUR J NUCL MED MOL I},
	journal = {EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING},
	volume = {50},
	unique-id = {34764935},
	issn = {1619-7070},
	year = {2023},
	eissn = {1619-7089},
	pages = {S836-S836}
}

@article{MTMT:33854100,
	title = {Pruritogenic molecules in the skin of patients with dermatomyositis},
	url = {https://m2.mtmt.hu/api/publication/33854100},
	author = {Vincze, Anett and Lisztes, Erika and Szabó, Katalin and Béldi, Tibor Gábor and Nagy-Vincze, Melinda and Pór, Ágnes and Varga, József and Dankó, Katalin and Bíró, Tamás and Tóth, Balázs István and Griger, Zoltán},
	doi = {10.3389/fmed.2023.1168359},
	journal-iso = {FRONT MED},
	journal = {FRONTIERS IN MEDICINE},
	volume = {10},
	unique-id = {33854100},
	abstract = {Introduction: Pruritus is a common excruciating symptom in systemic autoimmune diseases such as dermatomyositis (DM) but the pathogenesis is not fully understood. We intended to investigate the targeted expression analysis of candidate molecules involved in the development of pruritus in lesional vs. non-lesional skin samples of patients affected with active DM. We looked for correlations between the investigated pruriceptive signaling molecules, disease activity, and itching sensation of DM patients.
		Methods: Interleukins (IL-33 and IL-6), tumor necrosis factor α (TNF-α), peroxisome proliferator-activated receptor γ (PPAR-γ), and ion channels belonging to the transient receptor potential (TRP) family were analyzed. The expression of TNF-α, PPAR-γ, IL-33, IL-6, and TRP channels in lesional DM skin was evaluated by RT-qPCR and immunohistochemistry and was compared with non-lesional DM skin samples. Pruritus, disease activity, and damage of DM were evaluated by the 5-D itch scale and Cutaneous Dermatomyositis Disease Area and Severity Index (CDASI), respectively. Statistical analysis was performed with IBM SPSS 28 software.
		Results: A total of 17 active DM patients participated in the study. We could show that the itching score was positively correlated with the CDASI activity score (Kendall's tau-b = 0.571; p = 0.003). TNF-α gene expression was significantly higher in lesional DM skin than in non-lesional DM skin (p = 0.009) and differed in the subgroups of patients with different itch intensities (p = 0.038). The mRNA expression of lesional IL-6 correlated positively with 5-D itch and CDASI activity score (Kendall's tau-b = 0.585; p = 0.008 and 0.45; p = 0.013, respectively). TRPV4 expressions were positively correlated with CDASI damage score (Kendall's tau-b = 0.626; p < 0.001), but the mRNA expressions of the TRP family, PPAR-γ, IL-6, and IL-33 were not different in lesional and non-lesional samples. Immunohistochemistry analysis did not find significant alterations in the expressions of TNF-α, PPAR-γ, IL-6, and IL-33 in lesional and non-lesional regions.
		Discussion: Our results argue that cutaneous disease activity, TNF-α, and IL-6 might play a central role in DM-associated itch, while TRPV4 plays a central role in tissue regeneration.},
	keywords = {pruritus; dermatomyositis; IL-6; TRP CHANNELS; INFLAMMATORY MYOPATHIES; Itch; TNF-α = tumor necrosis factor α},
	year = {2023},
	eissn = {2296-858X}
}

@article{MTMT:33742807,
	title = {In Vivo evaluation of newly synthesized 213Bi-conjugated alpha-melanocyte stimulating hormone (α-MSH) peptide analogues in melanocortin-1 receptor (MC1-R) positive experimental melanoma model},
	url = {https://m2.mtmt.hu/api/publication/33742807},
	author = {Kálmán-Szabó, Ibolya and Képes, Zita and Fekete, Anikó and Vágner, Adrienn and Nagy, G. and Szücs, Dániel and Gyuricza, Barbara and Arató, Viktória Zsófia and Varga, József and Kárpáti, Levente and Garai, Ildikó and Mándity, István and Bruchertseifer, F. and Elek, János and Szikra, Dezső and Trencsényi, György},
	doi = {10.1016/j.jpba.2023.115374},
	journal-iso = {J PHARMACEUT BIOMED ANAL},
	journal = {JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS},
	volume = {229},
	unique-id = {33742807},
	issn = {0731-7085},
	abstract = {Given the rising pervasiveness of melanocortin-1 receptor (MC1-R) positive melanoma malignum (MM) and pertinent metastases, radiolabelled receptor-affine alpha-melanocyte stimulating hormone-analogue (α-MSH analogue) imaging probes would be of crucial importance in timely tumor diagnostic assessment. Herein we aimed at investigating the biodistribution and the MM targeting potential of newly synthesized 213Bi-conjugated MC1-R specific peptide-based radioligands with the establishment of MC1-R overexpressing MM preclinical model. DOTA-conjugated NAP, -HOLD, -FOLD, -and MARSamide were labelled with 213Bi. Ex vivo biodistribution studies were conducted post-administration of 3.81 ± 0.32 MBq [213Bi]Bi-DOTA conjugated deriva-tives into twenty B16-F10 tumor-bearing C57BL/6 J and healthy mice. Organ Level Internal Dose Assessment (OLINDA) and IDAC-Dose were used to calculate translational data-based absorbed radiation dose in human organs. Moderate or low %ID/g uptake of [213Bi]Bi-DOTA conjugated NAP, -HOLD, -and MARSamide and significantly increased [213Bi]Bi-DOTA-FOLDamide accumulation was observed in the thoracic and abdominal organs (p ≤ 0.01). High [213Bi]Bi-DOTA-NAP (%ID/g:3.76 ± 0.96), -and FOLDamide (%ID/g:3.28 ± 0.95) tumor tracer activity confirmed their MC1-R-affinity. The bladder wall received the highest radiation absorbed dose followed by the kidneys (bladder wall: 1.95·10-2 and 8.97·10-2 mSv/MBq; kidneys: 7.47·10-3 vs. 5.88·10-2 mSv/MBq measured by IDAC and OLINDA; respectively) indicating the suitability of the NAPamide derivative for clinical use. These novel [213Bi]Bi-DOTA-linked peptide probes displaying meaningful MC1-R affinity could be promising molecular probes in MM imaging.},
	year = {2023},
	eissn = {1873-264X},
	orcid-numbers = {Képes, Zita/0000-0003-2889-8521; Kárpáti, Levente/0000-0002-9091-3027; Mándity, István/0000-0003-2865-6143; Trencsényi, György/0000-0001-6456-6212}
}

@article{MTMT:33687590,
	title = {Incidence, features and outcome of disease relapse after COVID ‐19 vaccination in patients with idiopathic inflammatory myopathies},
	url = {https://m2.mtmt.hu/api/publication/33687590},
	author = {Nagy-Vincze, Melinda and Béldi, Tibor and Szabó, Katalin and Vincze, Anett and Miltényi‐Szabó, Balázs and Varga, Zsófia and Varga, József and Griger, Zoltán},
	doi = {10.1002/mus.27811},
	journal-iso = {MUSCLE NERVE},
	journal = {MUSCLE & NERVE},
	volume = {67},
	unique-id = {33687590},
	issn = {0148-639X},
	abstract = {Introduction/Aims: Vaccination against coronavirus disease 2019 (COVID-19) is relatively safe in patients with idiopathic inflammatory myopathies (IIM); however, myositis flares following vaccination have been poorly studied. We aimed to evaluate the frequency, features, and outcomes of disease relapses in patients with IIM following COVID-19 vaccination. Methods: A cohort of 176 IIM patients were interviewed after the third wave of the COVID-19 pandemic and followed prospectively. Relapses were determined using the disease state criteria and the outcome of the flares with myositis response criteria, calculating the total improvement score (TIS). Results: A total of 146 (82.9%) patients received a vaccination, 17/146 (11.6%) patients had a relapse within 3 mo, and 13/146 (8.9%) patients within 1 mo. The relapse rate of unvaccinated patients was 3.3%. Three months after the post-vaccination relapses, 70.6% of the patients (12/17) achieved an improvement of disease activity (average TIS score: 30 ± 15.81; seven minor, five moderate, and zero major improvements). Six months after flares improvement was detected in 15/17(88.2%) of relapsed patients (average TIS score: 43.1 ± 19.53; 3 minimal, 8 moderate, and 4 major). Forward stepwise logistic regression analysis revealed that the active state of myositis at the time of injection (p <.0001; odds ratio, 33; confidence interval, 9–120) was significantly associated with the occurrence of a relapse. Discussion: A minority of the vaccinated IIM patients had a confirmed disease flare after COVID-19 vaccination and the majority of the relapses improved after individualized treatment. An active disease state at the time of vaccination probably contributes to the increased risk of a post vaccination myositis flare.},
	year = {2023},
	eissn = {1097-4598},
	pages = {371-377},
	orcid-numbers = {Varga, József/0000-0001-5797-9625}
}

@article{MTMT:33602997,
	title = {Psoriatic arthritis and its special features predispose not only for osteoporosis but also for fractures and falls},
	url = {https://m2.mtmt.hu/api/publication/33602997},
	author = {Halasi, Andrea and Szegedi, Andrea and Törőcsik, Dániel and Varga, József and Farmasi, Nikolett and Szűcs, Gabriella and Tarr, Tünde and Gaál, János},
	doi = {10.1111/1346-8138.16710},
	journal-iso = {J DERMATOL},
	journal = {JOURNAL OF DERMATOLOGY},
	volume = {50},
	unique-id = {33602997},
	issn = {0385-2407},
	abstract = {Limited data are available on the predisposing factors to fractures and falls of patients with psoriatic arthritis (PsA). Our study intended to explore the differences between PsA patients and controls, concerning bone mineral density (BMD), the 10-year fracture risk, the number of prevalent fractures, the frequency of falls and to investigate the association of the same factors with PsA disease characteristics within the PsA group. Medical reports of 61 PsA patients and 69 consecutive, age-matched controls were analyzed, physical examination and bone mineral density (BMD, and T-score) were performed, and the 10-year fracture risk was calculated. The results were subjected to statistical analysis. Femoral neck BMD, as well as vertebral and femoral neck T-scores were lower, the odds ratio (OR) for low BMD and the 10-year risk of hip fracture was higher (p = 0.0029; 0.0002, p < 0.0001, OR = 21,9, p = 0.014) in the PsA group. The PsA patients were more predisposed to prevalent fractures, including peripheral fractures, and vertebral fractures as well as falls (OR 3.42; 2.26; 13.33; 3.95, respectively), compared to controls. Within the PsA group (beyond the age) scalp psoriasis and late-onset psoriasis, were significantly associated with a greater number of prevalent fractures (p = 0.0049; 0.029), while the number of falls per year correlated with late-onset psoriasis and the flexural psoriasis (p = 0.007; 0.023). Our results suggest that PsA is an independent risk factor for reduced bone density and falls hence to related bone fractures. Patients with late-onset psoriasis are more likely to suffer falls and related fractures, especially if their disease is characterized by the involvement of the hairy scalp and body folds.},
	year = {2023},
	eissn = {1346-8138},
	pages = {608-614},
	orcid-numbers = {Gaál, János/0000-0003-0462-1392}
}

@article{MTMT:32530741,
	title = {Imaging with [99mTc]HMPAO - a novel perspective: investigation of [99mTc] HMPAO leg muscle uptake in metabolic diseases},
	url = {https://m2.mtmt.hu/api/publication/32530741},
	author = {Képes, Zita and Mikó, Márton and Kukuts, Kornél and Esze, Regina and Barna, Sándor Kristóf and Somodi, Sándor and Káplár, Miklós and Varga, József and Garai, Ildikó},
	doi = {10.1177/02841851211063601},
	journal-iso = {ACTA RADIOL},
	journal = {ACTA RADIOLOGICA},
	volume = {64},
	unique-id = {32530741},
	issn = {0284-1851},
	abstract = {Background: Sensitive imaging modalities in the diagnosis of microcircular complications of the lower extremities induced by metabolic diseases are becoming a focus of interest. Purpose: To investigate the [99mTc]HMPAO uptake of the legs in type 2 diabetes mellitus (T2DM) and obesity, and to search for associations with clinical parameters and nerve conducting studies. Material and Methods: A total of 57 patients with controlled T2DM and 46 obese participants without DM were enrolled in the study. [99mTc]HMPAO SPECT/CT examinations were performed to evaluate the radiopharmaceutical accumulation of the legs. For the quantitative assessment of tracer uptake, standardized uptake value (SUVpeak) was measured in fixed spheric volumes of interest placed on both sural muscles on the attenuation-corrected images. Measurement of current perception threshold applying Neurometer (NM-01/CPT) was used to evaluate peripheral nerve dysfunction. Laboratory parameters assessing the glucose homeostasis of the study participants were also measured. Results: In the diabetic group, significantly lower leg SUV values were detected compared to the non-DM obese group (median: 0.517 vs. 0.607; P < 0.001). Body mass index (BMI) (P < 0.0001), age (P=0.0283), HbA1c (P =0.0068), and glucose level (P =0.0044) proved to be significant predictors of muscle tracer uptake. Neurometer studies showed positive correlation with HbA1c levels in the T2DM group (P=0.0002). Conclusion: We assume that [99mTc]HMPAO uptake of leg muscles is associated with microcirculation, so quantitative [99mTc]HMPAO SPECT/CT might be a sensitive method for evaluating lower limb microvascular alterations. BMI, age, HbA1c, and glucose level may be significant predictors of peripheral vascular abnormalities triggered by metabolic disturbances. Keywords: [99mTc]HMPAO, lower extremity, microcirculation, polyneuropathy, obesity, type 2 diabetes mellitus},
	keywords = {MICROCIRCULATION; OBESITY; Lower Extremity; polyneuropathy; type 2 diabetes mellitus; [99mTc]HMPAO},
	year = {2023},
	eissn = {1600-0455},
	pages = {187-194},
	orcid-numbers = {Képes, Zita/0000-0003-2889-8521; Somodi, Sándor/0000-0002-3615-2300}
}

@{MTMT:33131925,
	title = {Parametric imaging used in nuclear medicine},
	url = {https://m2.mtmt.hu/api/publication/33131925},
	author = {Knoll, Peter and Tsapaki, Virgina and Varga, József and Šámal, Martin},
	booktitle = {Nuclear Medicine and Molecular Imaging},
	doi = {10.1016/B978-0-12-822960-6.00129-0},
	unique-id = {33131925},
	year = {2022},
	pages = {567-578}
}

@article{MTMT:33131920,
	title = {Initial clinical experience with dedicated multi-pinhole (MPH) collimator for 99mTc-HMPAO brain perfusion SPECT.},
	url = {https://m2.mtmt.hu/api/publication/33131920},
	author = {Képes, Zita and Kukuts, Kornél and Oszlánszki, Attila and Mihovk, Iván and Krizsán, Áron Krisztián and Barna, Sándor Kristóf and Robinson, Andrew and Deidda, Daniel and Mester, János and Varga, József and Garai, Ildikó and Forgács, Attila},
	doi = {10.1967/s002449912474},
	journal-iso = {HELL J NUCL MED},
	journal = {HELLENIC JOURNAL OF NUCLEAR MEDICINE},
	volume = {25},
	unique-id = {33131920},
	issn = {1790-5427},
	abstract = {Dedicated multi-pinhole (MPH) collimators have been successfully tested in selected clinical investigations. The aim of our work was to report initial experiences with an MPH collimator set designed for brain perfusion single photon emission tomography (SPECT).Ten patients underwent sequential technetium-99m-hexamethylpropyleneamineoxime (99mTc-HMPAO) SPECT with a dual-head SPECT camera equipped with conventional low-energy parallel hole collimators (LEHR), and with a triple-head system equipped with MPH collimators. Low-energy parallel hole collimators data were reconstructed by filtered back projection (FBP), ordered subset expectation maximization (OSEM), software for tomographic image reconstruction (STIR). In addition, both the parallel hole data and MPH data were reconstructed by Tera-TomoTM 3D iterative reconstruction denoted LEHR_TT3D and MPH_TT3D, respectively. Five medical experts visually compared the reconstructed images of the five data sets and defined a ranking sequence from the lowest (1) to the highest (5) image quality. Results were compared using the Friedman test. P values below 0.05 were considered significant.Low-energy parallel hole collimators acquisition resulted in 5 million, while MPH acquisition in 13 million total counts with 30 and 34 minutes of acquisition time, respectively. Mean rank coefficients of the reconstruction methods were 1.96±0.52, 2.66±0.46, 2.86±0.60, 3.62±0.55, 3.9±0.68 for FBP, STIR, LEHR_TT3D, LEHR_OSEM, MPH_TT3D respectively. The differences between MPH_TT3D-FBP (P<0.01); MPH_TT3D-STIR (P<0.05); LEHR_OSEM-FBP (P<0.01) were significant.Image quality provided by MPH collimator is comparable to that provided by conventional LEHR imaging. Higher sensitivity has the potential to shorten acquisition time or to reduce the amount of administered activity.},
	keywords = {RECONSTRUCTION; brain perfusion; image quality; Multi-pinhole collimator},
	year = {2022},
	pages = {143-147},
	orcid-numbers = {Képes, Zita/0000-0003-2889-8521}
}

@article{MTMT:32895197,
	title = {Clinical, Serological, and Genetic Characteristics of a Hungarian Myositis-Scleroderma Overlap Cohort},
	url = {https://m2.mtmt.hu/api/publication/32895197},
	author = {Szabó, Katalin and Bodoki, Levente and Nagy-Vincze, Melinda and Beldi, Tibor and Vincze, Anett and Zilahi, Erika and Varga, József and Szűcs, Gabriella and Dankó, Katalin and Griger, Zoltán},
	doi = {10.1155/2022/6251232},
	journal-iso = {BIOMED RES INT},
	journal = {BIOMED RESEARCH INTERNATIONAL},
	volume = {2022},
	unique-id = {32895197},
	issn = {2314-6133},
	abstract = {Overlap myositis is a distinct subgroup of idiopathic inflammatory myositis (IIM) with various clinical phenotypes. The aim of this study was to determine the clinical, serological, and genetic features of systemic sclerosis (SSc)-IIM overlap patients. It was a retrospective study using clinical database of 39 patients, fulfilling both the criteria of SSc and IIM. 56.4% of the patients had limited cutaneous, 43.6% had diffuse cutaneous SSc, whereas 7.7% of the patients had dermatomyositis and 92.3% polymyositis. The two diseases occurred simultaneously in 58.97%, while 10.26% in myositis and 30.77% in scleroderma were initially diagnosed. The frequencies of organ involvement were interstitial lung disease 71.8%, dysphagia 66.7%, cardiac involvement 41%, pulmonary arterial hypertension (PAH) 30.8%, and renal involvement 12.8%, respectively. The presence of human leukocyte antigen eth HLA THORN - DRB1 * 03 and DQA1 * 051 * 01 alleles were significantly higher in the overlap patients than in healthy controls (82.35% vs. 27.54%; p < 0.0001 and 88.24% vs. 30.16; p < 0.0001). Certain clinical parameters, such as fever at diagnosis (41.67% vs. 7.41%, p = 0.0046), cardiac involvement (83.33% vs. 22.22%, p = 0.0008), subcutaneous calcinosis (41.66 vs. 11.11, p = 0.01146), and claw hand deformity (25% vs. 11.11%, p = 0.00016) were significantly associated with the presence of PAH. Upon comparison, the overlap patients and anti-Jo-1 positive antisynthetase patients showed similarities in terms of genetic results and major clinical features; however, SSc-IIM overlap patients could be distinguished with higher erythrocyte sedimentation rate (ESR) level, more frequent presence of Raynaud's phenomenon (p < 0.0001; OR: 20.00), dysphagia (p < 0.0001; OR: 15.63), and infrequent livedo reticularis (p < 0.01; OR: 0.11). SSc-IIM overlap myositis is a unique group within IIM-s possessing characteristic clinical features.},
	year = {2022},
	eissn = {2314-6141}
}