TY - JOUR AU - Kozsup, Máté AU - Zhou, XueQuan AU - Farkas, Etelka AU - Bényei, Attila Csaba AU - Bonnet, Sylvestre AU - Patonay, Tamás AU - Kónya, Krisztina AU - Buglyó, Péter TI - Synthesis, characterization and cytotoxicity studies of Co(III)-flavonolato complexes JF - JOURNAL OF INORGANIC BIOCHEMISTRY J2 - J INORG BIOCHEM VL - 217 PY - 2021 PG - 12 SN - 0162-0134 DO - 10.1016/j.jinorgbio.2021.111382 UR - https://m2.mtmt.hu/api/publication/31881424 ID - 31881424 N1 - Department of Inorganic and Analytical Chemistry, University of Debrecen, Egyetem tér 1, Debrecen, H-4032, Hungary Leiden Institute of Chemistry, Universiteit Leiden, Einsteinweg 55, Leiden, 2333 CC, Netherlands Department of Physical Chemistry, University of Debrecen, Egyetem tér 1, Debrecen, H-4032, Hungary Department of Organic Chemistry, University of Debrecen, Egyetem tér 1, Debrecen, H-4032, Hungary Export Date: 24 February 2021 CODEN: JIBID Correspondence Address: Buglyó, P.; Department of Inorganic and Analytical Chemistry, Egyetem tér 1, Hungary; email: buglyo@science.unideb.hu Funding details: European Commission, EC Funding details: European Regional Development Fund, FEDER, GINOP-2.3.2-15-2016-00008 Funding text 1: The research was supported by the EU and co-financed by the European Regional Development Fund under the project GINOP-2.3.2-15-2016-00008 . Funding Agency and Grant Number: EUEuropean Commission; European Regional Development FundEuropean Commission [GINOP2.3.215201600008] Funding text: The research was supported by the EU and cofinanced by the European Regional Development Fund under the project GINOP2.3.215201600008. AB - Hypoxia activated Co(III) complexes as prodrugs may provide with a selective delivery of cytotoxic or antibacterial compounds. Whithin this field sixteen novel Co(III) ternary complexes with the general formula [Co (4N)(flav)](ClO4)2, where 4N = tris(2-aminoethyl)amine (tren) or tris(2-pyridylmethyl)amine (tpa) and flav = deprotonated form of differently substituted flavonols have been synthesized, characterized, and their cytotoxicity assayed under both normoxic and hypoxic conditions. Molecular structures of two free flavonols and seven complexes are also reported. In all the complexes the bioligands exhibited the expected (O,O) coordination mode and the complexes showed a slightly distorted octahedral geometry. Cyclic voltammetric studies revealed that both the substituents of the flavonoles and the type of 4N donor ligands had an impact on the reduction potential of the complex. The ones containing tren demonstrated significantly higher stability than the tpa analogues, making these former compounds promising candidates for the development of hypoxia-activated prodrug complexes. Tpa complexes showed higher activity against both selected human cancer cell lines (A549, A431) than their free ligand flavonols, indicating that the anticancer activity of the bioligand can be enhanced upon complexation. However, slight hypoxia-selectivity was found only for a tren complex (11) with moderate cytotoxicity. LA - English DB - MTMT ER - TY - JOUR AU - Jordán, Sándor AU - Pajtás, Dávid AU - Patonay, Tamás AU - Langer, Peter AU - Kónya, Krisztina TI - Synthesis of 6,7-Dibromoflavone and Its Regioselective Diversification via Suzuki-Miyaura Reactions JF - SYNTHESIS-STUTTGART J2 - SYNTHESIS-STUTTGART VL - 49 PY - 2017 IS - 9 SP - 1983 EP - 1992 PG - 10 SN - 0039-7881 DO - 10.1055/s-0036-1588376 UR - https://m2.mtmt.hu/api/publication/26755248 ID - 26755248 AB - The first synthesis pathway to 6,7-dibromoflavone and its transformations to 7-aryl-6-bromo- and 6,7-diarylflavones by Suzuki-Miyaura reactions are presented. Due to the different electronic effects of bromo substituents, the first attack proceeded with good site selectivity at position 7. LA - English DB - MTMT ER - TY - JOUR AU - Pajtás, Dávid AU - Kónya, Krisztina AU - Kiss, Attila AU - Džubák, Petr AU - Pethő, Zoltán Dénes AU - Varga, Zoltán AU - Panyi, György AU - Patonay, Tamás TI - Optimization of the Synthesis of Flavone–Amino Acid and Flavone–Dipeptide Hybrids via Buchwald–Hartwig Reaction JF - JOURNAL OF ORGANIC CHEMISTRY J2 - J ORG CHEM VL - 82 PY - 2017 IS - 9 SP - 4578 EP - 4587 PG - 10 SN - 0022-3263 DO - 10.1021/acs.joc.7b00124 UR - https://m2.mtmt.hu/api/publication/3245969 ID - 3245969 AB - The article describes the development of Buchwald–Hartwig amination of different bromoflavones with amino acid and peptide derivatives as nitrogen source giving unique structures. The previously observed racemization, which occurred during the synthesis of flavone-amino acid hybrids, was successfully prevented in most cases. The biological assays of these novel structures showed cytotoxic effects on different cancer cell lines. LA - English DB - MTMT ER - TY - JOUR AU - Kondor, Zoltán AU - Herczeg, Mihály AU - Borbás, Anikó AU - Patonay, Tamás AU - Kónya, Krisztina TI - Application of Carbohydrates with Methylene or Vinyl Groups in Heck-Mizoroki Cross-Coupling Reactions with O-Heterocycles JF - SYNLETT J2 - SYNLETT VL - 27 PY - 2016 IS - 19 SP - 2709 EP - 2715 PG - 7 SN - 0936-5214 DO - 10.1055/s-0036-1588591 UR - https://m2.mtmt.hu/api/publication/3196723 ID - 3196723 AB - Structurally novel carbohydrate-O-heterocycle derivatives linked by various unsaturated carbon bridges were synthesized by palladium-catalyzed cross-coupling reactions. LA - English DB - MTMT ER - TY - BOOK ED - Patonay, Tamás ED - Kónya, Krisztina TI - Synthesis and Modification of Heterocycles by Metal-Catalyzed Cross-coupling Reactions T3 - Topics in Heterocyclic Chemsistry ; 45. ET - 0 PB - Springer Netherlands CY - Zürich PY - 2016 SP - 74 SN - 9783319326108 DO - 10.1007/978-3-319-32610-8 UR - https://m2.mtmt.hu/api/publication/3130871 ID - 3130871 LA - English DB - MTMT ER - TY - JOUR AU - Marcel, Sonneck AU - David, Kuhrt AU - Kónya, Krisztina AU - Patonay, Tamás AU - Alexander, Villinger AU - Peter, Langer TI - Regioselective Suzuki–Miyaura Cross-Coupling Reactions of the Bis(triflate) of 1,4-Dihydroxy-9H-fluoren-9-one JF - SYNLETT J2 - SYNLETT VL - 27 PY - 2016 IS - 1 SP - 75 EP - 79 PG - 5 SN - 0936-5214 DO - 10.1055/s-0035-1560211 UR - https://m2.mtmt.hu/api/publication/2988368 ID - 2988368 AB - 1,4-Diaryl-9H-fluoren-9-ones were prepared by regioselective Suzuki–Miyaura cross-coupling reaction of the bis(triflate) of 1,4-dihydroxy-9H-fluoren-9-one. The reactions proceeded with excellent site selectivity. The first attack occurs at position 1, due to electronic reasons. LA - English DB - MTMT ER - TY - JOUR AU - Kondor, Zoltán AU - Dilver, P Fuentes AU - Christian, Vogel AU - Patonay, Tamás AU - Kónya, Krisztina TI - Synthesis of Flavonoid/Chromonoid–β-d-Ribofuranose Derivatives by Palladium-Catalyzed Cross-Coupling Reactions JF - SYNLETT J2 - SYNLETT VL - 27 PY - 2016 IS - 1 SP - 888 EP - 892 PG - 5 SN - 0936-5214 DO - 10.1055/s-0035-1561273 UR - https://m2.mtmt.hu/api/publication/2988367 ID - 2988367 AB - Structurally novel carbohydrate–flavone and –chromone derivatives with an unsaturated carbon bridge were synthesized by a phosphine-free palladium-catalyzed cross-coupling reaction. LA - English DB - MTMT ER - TY - JOUR AU - Pajtás, Dávid AU - Patonay, Tamás AU - Kónya, Krisztina TI - Synthesis of 8-Bromoflavone and Its Buchwald–Hartwig Reaction with Amines JF - SYNTHESIS-STUTTGART J2 - SYNTHESIS-STUTTGART VL - 48 PY - 2016 IS - 1 SP - 97 EP - 102 PG - 6 SN - 0039-7881 DO - 10.1055/s-0035-1560325 UR - https://m2.mtmt.hu/api/publication/2988364 ID - 2988364 AB - Simple and convenient synthesis of 8-bromoflavone was achieved, starting from 2-bromophenol through 3′-bromo-2′-hydroxyacetophenone whose preparation was managed to be solved by optimized Fries rearrangement. The Buchwald–Hartwig reaction of 8-bromoflavone with different type of primary and secondary amines was carried out. LA - English DB - MTMT ER - TY - JOUR AU - Pajtás, Dávid AU - Károly, Dihen AU - Patonay, Tamás AU - Kónya, Krisztina AU - Alexander, Villinger AU - Peter, Langer TI - Site-Selective Suzuki–Miyaura Reaction of 6,8-Dibromoflavone JF - SYNLETT J2 - SYNLETT VL - 26 PY - 2015 IS - 18 SP - 2601 EP - 2605 PG - 5 SN - 0936-5214 DO - 10.1055/s-0035-1560633 UR - https://m2.mtmt.hu/api/publication/3035594 ID - 3035594 AB - 8-Aryl- and 6,8-diarylflavones were prepared by Suzuki–Miyaura reactions of 6,8-dibromoflavone. In spite of the greater steric hindrance, the first attack proceeded with good site selectivity at position 8. LA - English DB - MTMT ER - TY - PAT AU - Patonay, Tamás AU - Szilvássy, Zoltán AU - Peitl, Barna AU - Vigh, Laszlo AU - Toeroek, Zsolt AU - Berényi, Sándor Zsolt AU - Horvath, Ibolya AU - Balogh, Gabor AU - Somsák, László AU - Kiss, Attila AU - Drimba, Laszlo Peter AU - Molnarne, Hatvani Ilona TI - Heat shock proteins (HSP)-inducing compounds to enhance insulin sensitization in the treatment of type 2 diabetes. PY - 2015 UR - https://m2.mtmt.hu/api/publication/2906550 ID - 2906550 AB - The invention relates to the use of 2'-methylthioauron-1,1-dioxides of general formula I wherein R represents a C1-8 straight or branched chain alkyl groups; showing heat shock protein (HSP) co-inducing properties to enhance the insulin sensitizing effect in the treatment of type 2 diabetes. The invention furthermore relates to a pharmaceutical prepn. contg. compds. showing HSP co-inducing properties to enhance the insulin sensitizing effect in the treatment of type 2 diabetes. [on SciFinder(R)] LA - English DB - MTMT ER -