@article{MTMT:31881424,
	title = {Synthesis, characterization and cytotoxicity studies of Co(III)-flavonolato complexes},
	url = {https://m2.mtmt.hu/api/publication/31881424},
	author = {Kozsup, Máté and Zhou, XueQuan and Farkas, Etelka and Bényei, Attila Csaba and Bonnet, Sylvestre and Patonay, Tamás and Kónya, Krisztina and Buglyó, Péter},
	doi = {10.1016/j.jinorgbio.2021.111382},
	journal-iso = {J INORG BIOCHEM},
	journal = {JOURNAL OF INORGANIC BIOCHEMISTRY},
	volume = {217},
	unique-id = {31881424},
	issn = {0162-0134},
	abstract = {Hypoxia activated Co(III) complexes as prodrugs may provide with a selective delivery of cytotoxic or antibacterial
		compounds. Whithin this field sixteen novel Co(III) ternary complexes with the general formula [Co
		(4N)(flav)](ClO4)2, where 4N = tris(2-aminoethyl)amine (tren) or tris(2-pyridylmethyl)amine (tpa) and flav =
		deprotonated form of differently substituted flavonols have been synthesized, characterized, and their cytotoxicity
		assayed under both normoxic and hypoxic conditions. Molecular structures of two free flavonols and seven
		complexes are also reported. In all the complexes the bioligands exhibited the expected (O,O) coordination mode
		and the complexes showed a slightly distorted octahedral geometry. Cyclic voltammetric studies revealed that
		both the substituents of the flavonoles and the type of 4N donor ligands had an impact on the reduction potential
		of the complex. The ones containing tren demonstrated significantly higher stability than the tpa analogues,
		making these former compounds promising candidates for the development of hypoxia-activated prodrug
		complexes. Tpa complexes showed higher activity against both selected human cancer cell lines (A549, A431)
		than their free ligand flavonols, indicating that the anticancer activity of the bioligand can be enhanced upon
		complexation. However, slight hypoxia-selectivity was found only for a tren complex (11) with moderate
		cytotoxicity.},
	keywords = {X-ray structures; Anticancer; Redox behavior; Co-III complexes; Flavonoles; Hypoxia activation},
	year = {2021},
	eissn = {1873-3344},
	orcid-numbers = {Buglyó, Péter/0000-0002-6714-7598}
}

@article{MTMT:26755248,
	title = {Synthesis of 6,7-Dibromoflavone and Its Regioselective Diversification via Suzuki-Miyaura Reactions},
	url = {https://m2.mtmt.hu/api/publication/26755248},
	author = {Jordán, Sándor and Pajtás, Dávid and Patonay, Tamás and Langer, Peter and Kónya, Krisztina},
	doi = {10.1055/s-0036-1588376},
	journal-iso = {SYNTHESIS-STUTTGART},
	journal = {SYNTHESIS-STUTTGART},
	volume = {49},
	unique-id = {26755248},
	issn = {0039-7881},
	abstract = {The first synthesis pathway to 6,7-dibromoflavone and its transformations to 7-aryl-6-bromo- and 6,7-diarylflavones by Suzuki-Miyaura reactions are presented. Due to the different electronic effects of bromo substituents, the first attack proceeded with good site selectivity at position 7.},
	keywords = {PALLADIUM; CATALYSIS; regioselectivity; flavones; Suzuki-Miyaura reaction},
	year = {2017},
	eissn = {1437-210X},
	pages = {1983-1992}
}

@article{MTMT:3245969,
	title = {Optimization of the Synthesis of Flavone–Amino Acid and Flavone–Dipeptide Hybrids via Buchwald–Hartwig Reaction},
	url = {https://m2.mtmt.hu/api/publication/3245969},
	author = {Pajtás, Dávid and Kónya, Krisztina and Kiss, Attila and Džubák, Petr and Pethő, Zoltán Dénes and Varga, Zoltán and Panyi, György and Patonay, Tamás},
	doi = {10.1021/acs.joc.7b00124},
	journal-iso = {J ORG CHEM},
	journal = {JOURNAL OF ORGANIC CHEMISTRY},
	volume = {82},
	unique-id = {3245969},
	issn = {0022-3263},
	abstract = {The article describes the development of Buchwald–Hartwig amination of different bromoflavones with amino acid and peptide derivatives as nitrogen source giving unique structures. The previously observed racemization, which occurred during the synthesis of flavone-amino acid hybrids, was successfully prevented in most cases. The biological assays of these novel structures showed cytotoxic effects on different cancer cell lines.},
	year = {2017},
	eissn = {1520-6904},
	pages = {4578-4587},
	orcid-numbers = {Kiss, Attila/0000-0003-3601-5143; Panyi, György/0000-0001-6227-3301}
}

@article{MTMT:3196723,
	title = {Application of Carbohydrates with Methylene or Vinyl Groups in Heck-Mizoroki Cross-Coupling Reactions with O-Heterocycles},
	url = {https://m2.mtmt.hu/api/publication/3196723},
	author = {Kondor, Zoltán and Herczeg, Mihály and Borbás, Anikó and Patonay, Tamás and Kónya, Krisztina},
	doi = {10.1055/s-0036-1588591},
	journal-iso = {SYNLETT},
	journal = {SYNLETT},
	volume = {27},
	unique-id = {3196723},
	issn = {0936-5214},
	abstract = {Structurally novel carbohydrate-O-heterocycle derivatives linked by various unsaturated carbon bridges were synthesized by palladium-catalyzed cross-coupling reactions.},
	keywords = {Chromones; flavones; Palladium catalysis; aurones; Heck-Mizoroki reaction; carbohydrate-heterocycle conjugates},
	year = {2016},
	eissn = {1437-2096},
	pages = {2709-2715},
	orcid-numbers = {Herczeg, Mihály/0000-0002-7938-9789; Borbás, Anikó/0000-0001-8462-4547}
}

@book{MTMT:3130871,
	title = {Synthesis and Modification of Heterocycles by Metal-Catalyzed Cross-coupling Reactions},
	url = {https://m2.mtmt.hu/api/publication/3130871},
	isbn = {9783319326085},
	doi = {10.1007/978-3-319-32610-8},
	editor = {Patonay, Tamás and Kónya, Krisztina},
	publisher = {Springer Netherlands},
	unique-id = {3130871},
	year = {2016}
}

@article{MTMT:2988368,
	title = {Regioselective Suzuki–Miyaura Cross-Coupling Reactions of the Bis(triflate) of 1,4-Dihydroxy-9H-fluoren-9-one},
	url = {https://m2.mtmt.hu/api/publication/2988368},
	author = {Marcel, Sonneck and David, Kuhrt and Kónya, Krisztina and Patonay, Tamás and Alexander, Villinger and Peter, Langer},
	doi = {10.1055/s-0035-1560211},
	journal-iso = {SYNLETT},
	journal = {SYNLETT},
	volume = {27},
	unique-id = {2988368},
	issn = {0936-5214},
	abstract = {1,4-Diaryl-9H-fluoren-9-ones were prepared by regioselective Suzuki–Miyaura cross-coupling reaction of the bis(triflate) of 1,4-dihydroxy-9H-fluoren-9-one. The reactions proceeded with excellent site selectivity. The first attack occurs at position 1, due to electronic reasons.},
	keywords = {PALLADIUM; CATALYSIS; HETEROCYCLES; regioselectivity; Suzuki-Miyaura reaction},
	year = {2016},
	eissn = {1437-2096},
	pages = {75-79}
}

@article{MTMT:2988367,
	title = {Synthesis of Flavonoid/Chromonoid–β-d-Ribofuranose Derivatives by Palladium-Catalyzed Cross-Coupling Reactions},
	url = {https://m2.mtmt.hu/api/publication/2988367},
	author = {Kondor, Zoltán and Dilver, P Fuentes and Christian, Vogel and Patonay, Tamás and Kónya, Krisztina},
	doi = {10.1055/s-0035-1561273},
	journal-iso = {SYNLETT},
	journal = {SYNLETT},
	volume = {27},
	unique-id = {2988367},
	issn = {0936-5214},
	abstract = {Structurally novel carbohydrate–flavone and –chromone derivatives with an unsaturated carbon bridge were synthesized by a phosphine-free palladium-catalyzed cross-coupling reaction.},
	keywords = {PALLADIUM; CATALYSIS; cross-coupling; Isomerism; Mizoroki–Heck reaction},
	year = {2016},
	eissn = {1437-2096},
	pages = {888-892}
}

@article{MTMT:2988364,
	title = {Synthesis of 8-Bromoflavone and Its Buchwald–Hartwig Reaction with Amines},
	url = {https://m2.mtmt.hu/api/publication/2988364},
	author = {Pajtás, Dávid and Patonay, Tamás and Kónya, Krisztina},
	doi = {10.1055/s-0035-1560325},
	journal-iso = {SYNTHESIS-STUTTGART},
	journal = {SYNTHESIS-STUTTGART},
	volume = {48},
	unique-id = {2988364},
	issn = {0039-7881},
	abstract = {Simple and convenient synthesis of 8-bromoflavone was achieved, starting from 2-bromophenol through 3′-bromo-2′-hydroxyacetophenone whose preparation was managed to be solved by optimized Fries rearrangement. The Buchwald–Hartwig reaction of 8-bromoflavone with different type of primary and secondary amines was carried out.},
	keywords = {PALLADIUM; CATALYSIS; flavones; Buchwald-Hartwig; Buchwald–Hartwig reaction; Fries rearrangement},
	year = {2016},
	eissn = {1437-210X},
	pages = {97-102}
}

@article{MTMT:3035594,
	title = {Site-Selective Suzuki–Miyaura Reaction of 6,8-Dibromoflavone},
	url = {https://m2.mtmt.hu/api/publication/3035594},
	author = {Pajtás, Dávid and Károly, Dihen and Patonay, Tamás and Kónya, Krisztina and Alexander, Villinger and Peter, Langer},
	doi = {10.1055/s-0035-1560633},
	journal-iso = {SYNLETT},
	journal = {SYNLETT},
	volume = {26},
	unique-id = {3035594},
	issn = {0936-5214},
	abstract = {8-Aryl- and 6,8-diarylflavones were prepared by Suzuki–Miyaura reactions of 6,8-dibromoflavone. In spite of the greater steric hindrance, the first attack proceeded with good site selectivity at position 8.},
	keywords = {PALLADIUM; CATALYSIS; regioselectivity; flavones; Suzuki-Miyaura reaction},
	year = {2015},
	eissn = {1437-2096},
	pages = {2601-2605}
}

@{MTMT:2906550,
	title = {Heat shock proteins (HSP)-inducing compounds to enhance insulin sensitization in the treatment of type 2 diabetes.},
	url = {https://m2.mtmt.hu/api/publication/2906550},
	author = {Patonay, Tamás and Szilvássy, Zoltán and Peitl, Barna and Vigh, Laszlo and Toeroek, Zsolt and Berényi, Sándor Zsolt and Horvath, Ibolya and Balogh, Gabor and Somsák, László and Kiss, Attila and Drimba, Laszlo Peter and Molnarne, Hatvani Ilona},
	unique-id = {2906550},
	abstract = {The invention relates to the use of 2'-methylthioauron-1,1-dioxides of general formula I wherein R represents a C1-8 straight or branched chain alkyl groups; showing heat shock protein (HSP) co-inducing properties to enhance the insulin sensitizing effect in the treatment of type 2 diabetes. The invention furthermore relates to a pharmaceutical prepn. contg. compds. showing HSP co-inducing properties to enhance the insulin sensitizing effect in the treatment of type 2 diabetes. [on SciFinder(R)]},
	keywords = {antidiabetic methylthioaurondioxide deriv insulin sensitizer diabetes mellitus treatment; heat shock protein inducer antidiabetic insulin sensitization diabetes mellitus},
	year = {2015},
	orcid-numbers = {Somsák, László/0000-0002-9103-9845; Kiss, Attila/0000-0003-3601-5143}
}