TY - JOUR AU - Vasilakopoulou, A. AU - Naas, T. AU - Gonzalez, C. AU - Vila, J. AU - Szabó, Dóra AU - Riccobono, E. AU - Kamotsay, K. AU - Reissier, S. AU - Berbel, D. AU - Aszalós, Zoltán AU - Rosenmoller, M. AU - Stankov-Puges, M. AU - Georgiou, P.-C. AU - Vourli, S. AU - Volland, H. AU - Pournaras, S. TI - A multicentre evaluation of the NG-test DetecTool OXA-23 for the rapid detection of OXA-23 carbapenemase directly from blood cultures JF - JAC-ANTIMICROBIAL RESISTANCE J2 - JAC-ANTIMICROB RESIST VL - 6 PY - 2024 IS - 2 PG - 4 SN - 2632-1823 DO - 10.1093/jacamr/dlae029 UR - https://m2.mtmt.hu/api/publication/34744814 ID - 34744814 LA - English DB - MTMT ER - TY - JOUR AU - Fernandez-Pittol, Mariana AU - Bosch, Jordi AU - Balleste-Delpierre, Clara AU - Gonzalez, Camille AU - Vasilakopoulou, Alexandra AU - Berbel, Damaris AU - Riccobono, Eleonora AU - Gatermann, Soeren AU - Kamotsay, Katalin AU - Reissier, Sophie AU - Szabó, Dóra AU - Aszalós, Zoltán AU - Francius, Laura AU - Volland, Herve AU - Stankov-Puges, Milovan AU - Rosenmoller, Magda AU - Naas, Thierry AU - Vila, Jordi TI - Multicenter study to assess the use of BL-DetecTool for the detection of CTX-M-type ESBLs and carbapenemases directly from clinical specimens JF - JOURNAL OF CLINICAL MICROBIOLOGY J2 - J CLIN MICROBIOL PY - 2024 PG - 9 SN - 0095-1137 DO - 10.1128/jcm.01136-23 UR - https://m2.mtmt.hu/api/publication/34666768 ID - 34666768 LA - English DB - MTMT ER - TY - JOUR AU - Fekete, Szilvia AU - Juhász, János AU - Makra, Nóra AU - Dunai, Zsuzsanna AU - Kristóf, Katalin AU - Ostorházi, Eszter AU - Tamás, László AU - Szabó, Dóra AU - Kecskeméti, Nóra AU - Polony, Gábor TI - Middle ear microbiome in otitis media with effusion, the role of Alloiococcus otitidis JF - HELIYON J2 - HELIYON VL - in press PY - 2024 PG - 27 SN - 2405-8440 DO - 10.2139/ssrn.4693874 UR - https://m2.mtmt.hu/api/publication/34656287 ID - 34656287 LA - English DB - MTMT ER - TY - JOUR AU - Oliver, Antonio AU - Rojo-Molinero, Estrella AU - Arca-Suarez, Jorge AU - Beşli, Yeşim AU - Bogaerts, Pierre AU - Cantón, Rafael AU - Cimen, Cansu AU - Croughs, Peter D AU - Denis, Olivier AU - Giske, Christian G AU - Graells, Tíscar AU - Daniel Huang, Te-Din AU - Iorga, Bogdan I AU - Karatuna, Onur AU - Kocsis, Béla AU - Kronenberg, Andreas AU - López-Causapé, Carla AU - Malhotra-Kumar, Surbhi AU - Martínez, Luis Martínez AU - Mazzariol, Annarita AU - Meyer, Sylvain AU - Naas, Thierry AU - Notermans, Daan W AU - Oteo-Iglesias, Jesús AU - Pedersen, Torunn AU - Pirš, Mateja AU - Poeta, Patricia AU - Poirel, Laurent AU - Pournaras, Spyros AU - Sundsfjord, Arnfinn AU - Szabó, Dóra AU - Tambić-Andrašević, Arjana AU - Vatcheva-Dobrevska, Rossitza AU - Vitkauskienė, Astra AU - Jeannot, Katy TI - Pseudomonas aeruginosa antimicrobial susceptibility profiles, resistance mechanisms and international clonal lineages. update from ESGARS-ESCMID/ISARPAE Group. TS - update from ESGARS-ESCMID/ISARPAE Group. JF - CLINICAL MICROBIOLOGY AND INFECTION J2 - CLIN MICROBIOL INFEC VL - In press PY - 2024 SN - 1198-743X DO - 10.1016/j.cmi.2023.12.026 UR - https://m2.mtmt.hu/api/publication/34481244 ID - 34481244 AB - Pseudomonas aeruginosa, a ubiquitous opportunistic pathogen considered one of the paradigms of antimicrobial resistance, is among the main causes of hospital-acquired and chronic infections associated with significant morbidity and mortality. This growing threat results from the extraordinary capacity of P. aeruginosa to develop antimicrobial resistance through chromosomal mutations, the increasing prevalence of transferable resistance determinants (such as the carbapenemases and the extended spectrum β-lactamases), and the global expansion of epidemic lineages. The general objective of this initiative is to provide a comprehensive update of P. aeruginosa resistance mechanisms, especially for the extensively drug-resistant (XDR)/difficult to treat resistance (DTR) international high-risk epidemic lineages, and how the recently approved β-lactams and β-lactam/β-lactamase inhibitor combinations may affect resistance mechanisms and the definition of susceptibility profiles.To address this challenge, the European Study Group for Antimicrobial Resistance Surveillance (ESGARS) from the European Society of Clinical Microbiology and Infectious Diseases (ESCMID) launched the "Improving Surveillance of Antibiotic-Resistant Pseudomonas aeruginosa in Europe" (ISARPAE) initiative in 2022, supported by the Joint programming initiative on antimicrobial resistance (JPIAMR) network call and included a panel of over 40 researchers from 18 European Countries. Thus, an ESGARS-ISARPAE position paper was designed and the final version agreed after four rounds of revision and discussion by all panel members.To provide an update on (i) the emerging resistance mechanisms to classical and novel antipseudomonal agents, with a particular focus on β-lactams, (ii) the susceptibility profiles associated with the most relevant β-lactam resistance mechanisms, (iii) the impact of the novel agents and resistance mechanisms on the definitions of resistance profiles and (iv) the globally expanding XDR/DTR high-risk lineages and their association with transferable resistance mechanisms.The evidence presented herein can be used for coordinated epidemiological surveillance and decision-making at the European and global level. LA - English DB - MTMT ER - TY - CHAP AU - Szabó, Dóra ED - Tulassay, Zsolt TI - A bélrendszer baktériumflórája T2 - Gasztroenterológia PB - Medicina Könyvkiadó CY - Budapest SN - 9789632268538 PY - 2023 SP - 120 EP - 130 PG - 11 UR - https://m2.mtmt.hu/api/publication/34493971 ID - 34493971 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Persely, Alíz AU - Beszedics, B. AU - Pálóczi, Krisztina AU - Piroska, Márton AU - Alijanpourotaghsara, Amirreza AU - Strelnikov, David AU - Vessal, A. AU - Szabó, Helga AU - Hernyes, Anita AU - Zöldi, Luca AU - Jokkel, Zsófia AU - Fekete, A. AU - Juhász, János AU - Makra, Nóra AU - Szabó, Dóra AU - Buzás, Edit Irén AU - Tárnoki, Ádám Domonkos AU - Tárnoki, Dávid László TI - Analysis of Genetic and MRI Changes, Blood Markers, and Risk Factors in a Twin Pair Discordant of Progressive Supranuclear Palsy JF - MEDICINA-LITHUANIA J2 - MED LITH VL - 59 PY - 2023 IS - 10 PG - 18 SN - 1010-660X DO - 10.3390/medicina59101696 UR - https://m2.mtmt.hu/api/publication/34271363 ID - 34271363 N1 - Medical Imaging Centre, Semmelweis University, Budapest, 1082, Hungary Neurology Department, Medical Centre Hungarian Defence Forces, Budapest, 1134, Hungary Department of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, 1085, Hungary Central Radiological Diagnostic Department, Medical Centre Hungarian Defence Forces, Budapest, 1134, Hungary Institute of Medical Microbiology, Semmelweis University, Budapest, 1085, Hungary Faculty of Information Technology and Bionics, Pazmany Peter Catholic University, Budapest, 1085, Hungary Export Date: 23 January 2024 Correspondence Address: Tarnoki, D.L.; Medical Imaging Centre, Hungary; email: tarnoki4@gmail.com Chemicals/CAS: Biomarkers LA - English DB - MTMT ER - TY - JOUR AU - Gulyás, Dániel AU - Kamotsay, Katalin AU - Szabó, Dóra AU - Kocsis, Béla TI - Investigation of Delafloxacin Resistance in Multidrug-Resistant Escherichia coli Strains and the Detection of E. coli ST43 International High-Risk Clone JF - MICROORGANISMS J2 - MICROORGANISMS VL - 11 PY - 2023 IS - 6 PG - 11 SN - 2076-2607 DO - 10.3390/microorganisms11061602 UR - https://m2.mtmt.hu/api/publication/34043587 ID - 34043587 N1 - Institute of Medical Microbiology, Semmelweis University, Budapest, 1089, Hungary Central Microbiology Laboratory, National Institute of Hematology and Infectious Disease, Central Hospital of Southern-Pest, Budapest, 1097, Hungary Human Microbiota Study Group, Semmelweis University-Eötvös Lóránd Research Network, Budapest, 1089, Hungary Cited By :1 Export Date: 11 January 2024 Correspondence Address: Kocsis, B.; Institute of Medical Microbiology, Hungary; email: kocsis.bela@med.semmelweis-univ.hu AB - Delafloxacin is a novel fluoroquinolone agent that is approved for clinical application. In this study, we analyzed the antibacterial efficacy of delafloxacin in a collection of 47 Escherichia coli strains. Antimicrobial susceptibility testing was performed by the broth microdilution method and minimum inhibitory concentration (MIC) values were determined for delafloxacin, ciprofloxacin, levofloxacin, moxifloxacin, ceftazidime, cefotaxime, and imipenem. Two multidrug-resistant E. coli strains, which exhibited delafloxacin and ciprofloxacin resistance as well as extended-spectrum beta-lactamase (ESBL) phenotype, were selected for whole-genome sequencing (WGS). In our study, delafloxacin and ciprofloxacin resistance rates were 47% (22/47) and 51% (24/47), respectively. In the strain collection, 46 E. coli were associated with ESBL production. The MIC50 value for delafloxacin was 0.125 mg/L, while all other fluoroquinolones had an MIC50 value of 0.25 mg/L in our collection. Delafloxacin susceptibility was detected in 20 ESBL positive and ciprofloxacin resistant E. coli strains; by contrast, E. coli strains that exhibited a ciprofloxacin MIC value above 1 mg/L were delafloxacin-resistant. WGS analysis on the two selected E. coli strains (920/1 and 951/2) demonstrated that delafloxacin resistance is mediated by multiple chromosomal mutations, namely, five mutations in E. coli 920/1 (gyrA S83L, D87N, parC S80I, E84V, and parE I529L) and four mutations in E. coli 951/2 (gyrA S83L, D87N, parC S80I, and E84V). Both strains carried an ESBL gene, blaCTX-M-1 in E. coli 920/1 and blaCTX-M-15 in E. coli 951/2. Based on multilocus sequence typing, both strains belong to the E. coli sequence type 43 (ST43). In this paper, we report a remarkable high rate (47%) of delafloxacin resistance among multidrug-resistant E. coli as well as the E. coli ST43 international high-risk clone in Hungary. LA - English DB - MTMT ER - TY - CHAP AU - Szabó, Dóra AU - Dobó, Márta AU - Sándor, József ED - Sándor, József TI - A mikrobióta sebészeti jelentősége T2 - Sebészet tankönyv és tudománytörténet: traumatológiai, szülészeti és urológiai alapismeretekkel kiegészítve PB - Semmelweis Kiadó és Multimédia Stúdió CY - Budapest SN - 9789633315910 PY - 2023 SP - 62 EP - 67 PG - 6 UR - https://m2.mtmt.hu/api/publication/34027246 ID - 34027246 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Szabó, Dóra AU - Ostorházi, Eszter AU - Stercz, Balázs AU - Makra, Nóra AU - Pénzes, Kinga AU - Kristóf, Katalin AU - Antal, István AU - Réthelyi, János AU - Zsigmond, Réka Ildikó AU - Birtalan, Ede AU - Merkely, Béla Péter AU - Tamás, László TI - Specific nasopharyngeal Corynebacterium strains serve as gatekeepers against SARS-CoV-2 infection JF - GEROSCIENCE: OFFICIAL JOURNAL OF THE AMERICAN AGING ASSOCIATION (AGE) J2 - GEROSCIENCE VL - 45 PY - 2023 IS - 5 SP - 2927 EP - 2938 PG - 12 SN - 2509-2715 DO - 10.1007/s11357-023-00850-1 UR - https://m2.mtmt.hu/api/publication/34026885 ID - 34026885 AB - The SARS-CoV-2 virus is still causing a worldwide problem. The virus settles primarily on the nasal mucosa, and the infection and its course depend on individual susceptibility. Our aim was to investigate the nasopharynx composition’s role in the individual susceptibility. During the first phase of SARS-CoV-2 pandemic, nasopharyngeal microbiome samples of close contact unvaccinated patients were investigated by 16S rRNA analysis and by culturing. The whole genome of cultured Corynebacteria was sequenced. The relative expression of ACE2, TMPRSS2, and cathepsin L on Caco-2 cells and the strength of S1-ACE2 binding were determined in the presence of Corynebacteria . From 55 close contacts exposed to identical SARS-CoV-2 exposure, 26 patients became infected and 29 remained uninfected. The nasopharyngeal microbiome analysis showed significantly higher abundance of Corynebacteria in uninfected group. Corynebacterium accolens could be cultivated only from uninfected individuals and Corynebacterium propinquum from both infected and uninfected. Corynebacteria from uninfected patient significantly reduced the ACE2 and cathepsin L expression. C. accolens significantly reduced the TMPRSS2 expression compared to other Corynebacteria . Furthermore, Corynebacterium spp. weakened the binding of the S1-ACE2. Most C. accolens isolates harbored the TAG lipase LipS1 gene. Based on these results, the presence of Corynebacterium spp. in the nasopharyngeal microbiota, especially C. accolens strains, could reduce the individual susceptibility to SARS-CoV-2 infection by several mechanisms: by downregulation the ACE2, the TMPRSS2 receptors, and cathepsin L in the host; through the inhibition of S1-ACE2 binding; and lipase production. These results suggest the use of C. accolens strains as probiotics in the nasopharynx in the future. LA - English DB - MTMT ER - TY - BOOK ED - Szabó, Dóra AU - Dobay, Orsolya AU - Ghidán, Ágoston AU - Horváth, Andrea AU - Kádár, Béla AU - Kis, Zoltán AU - Kocsis, Béla AU - Nagy, Orsolya AU - Ostorházi, Eszter AU - Stercz, Balázs AU - Szabó, Dóra AU - Takács, Mária TI - Az orvosi mikrobiológia alapja – e-tankönyv ET - 2 PB - Semmelweis Kiadó CY - Budapest PY - 2022 SP - 397 SN - 9789633315705 UR - https://m2.mtmt.hu/api/publication/34494073 ID - 34494073 N1 - 2. bővített kiadás LA - Hungarian DB - MTMT ER -