TY - JOUR AU - Déli, Éva Katalin AU - Peters, James F. AU - Kisvárday, Zoltán TI - How the Brain Becomes the Mind: Can Thermodynamics Explain the Emergence and Nature of Emotions? JF - ENTROPY J2 - ENTROPY-SWITZ VL - 24 PY - 2022 IS - 10 SP - 1498 SN - 1099-4300 DO - 10.3390/e24101498 UR - https://m2.mtmt.hu/api/publication/33212776 ID - 33212776 AB - The neural systems’ electric activities are fundamental for the phenomenology of consciousness. Sensory perception triggers an information/energy exchange with the environment, but the brain’s recurrent activations maintain a resting state with constant parameters. Therefore, perception forms a closed thermodynamic cycle. In physics, the Carnot engine is an ideal thermodynamic cycle that converts heat from a hot reservoir into work, or inversely, requires work to transfer heat from a low- to a high-temperature reservoir (the reversed Carnot cycle). We analyze the high entropy brain by the endothermic reversed Carnot cycle. Its irreversible activations provide temporal directionality for future orientation. A flexible transfer between neural states inspires openness and creativity. In contrast, the low entropy resting state parallels reversible activations, which impose past focus via repetitive thinking, remorse, and regret. The exothermic Carnot cycle degrades mental energy. Therefore, the brain’s energy/information balance formulates motivation, sensed as position or negative emotions. Our work provides an analytical perspective of positive and negative emotions and spontaneous behavior from the free energy principle. Furthermore, electrical activities, thoughts, and beliefs lend themselves to a temporal organization, an orthogonal condition to physical systems. Here, we suggest that an experimental validation of the thermodynamic origin of emotions might inspire better treatment options for mental diseases. LA - English DB - MTMT ER - TY - CONF AU - Talapka, Petra AU - Nóra, Gargya AU - Kocsis, Zsolt AU - Vera, Etelka Szarvas AU - Kisvárday, Zoltán TI - Dendritic synaptome of GABAergic interneurons in the mouse visual cortex T2 - International Neuroscience Meeting, Budapest 2022 PY - 2022 SP - 109 UR - https://m2.mtmt.hu/api/publication/32863677 ID - 32863677 LA - English DB - MTMT ER - TY - JOUR AU - Talapka, Petra AU - Bába, Bence Béla AU - Mészár, Zoltán AU - Kisvárday, Réka Eszter AU - Kocsis, Zsolt AU - Srivastava, Mohit AU - Kisvárday, Zoltán TI - Application of the mirror technique for block-face scanning electron microscopy. JF - BRAIN STRUCTURE & FUNCTION J2 - BRAIN STRUCT FUNC VL - 227 PY - 2022 IS - 6 SP - 1933 EP - 1947 PG - 15 SN - 1863-2653 DO - 10.1007/s00429-022-02506-w UR - https://m2.mtmt.hu/api/publication/32863612 ID - 32863612 AB - The mirror technique adapted for electron microscopy allows correlating neuronal structures across the cutting plane of adjoining light microscopic sections which, however, have a limited thickness, typically less than 100 µm (Talapka et al. in Front Neuroanat, 2021, https://doi.org/10.3389/fnana.2021.652422 ). Here, we extend the mirror technique for tissue blocks in the millimeter range and demonstrate compatibility with serial block-face electron microscopy (SBEM). An essential step of the methodological improvement regards the recognition that unbound resin must be removed from the tissue surface to gain visibility of surface structures. To this, the tissue block was placed on absorbent paper during the curing process. In this way, neuronal cell bodies could be unequivocally identified using epi-illumination and confocal microscopy. Thus, the layout of cell bodies which were cut by the sectioning plane can be correlated with the layout of their complementary part in the adjoining section processed for immunohistochemistry. The modified mirror technique obviates the spatial limit in investigating synaptology of neurochemically identified structures such as neuronal processes, dendrites and axons. LA - English DB - MTMT ER - TY - CONF AU - Kocsis, Zsolt AU - Mohit, Srivastava AU - Cyril, Monier AU - Yves, Fregnac AU - Julian, ML Budd AU - Kisvárday, Zoltán TI - High-resolution retinotopic mapping using optical imaging of intrinsic signals in the cat primary visual cortex T2 - Neurotech Open Section - UD launch PY - 2021 SP - 1 UR - https://m2.mtmt.hu/api/publication/32236402 ID - 32236402 LA - English DB - MTMT ER - TY - CONF AU - Kocsis, Zsolt AU - Mohit, Srivastava AU - Kisvárday, Zoltán TI - High-Resolution Retinotopic Mapping with Intrinsic Signal Optical Imaging in the Cat's Primary Visual Cortex T2 - PhD Scientific Days 2021 PY - 2021 SP - 14 UR - https://m2.mtmt.hu/api/publication/32236275 ID - 32236275 LA - English DB - MTMT ER - TY - JOUR AU - Talapka, Petra AU - Kocsis, Zsolt AU - Marsi, Lívia Diána AU - Szarvas, Vera Etelka AU - Kisvárday, Zoltán TI - Application of the Mirror Technique for Three-Dimensional Electron Microscopy of Neurochemically Identified GABA-ergic Dendrites JF - FRONTIERS IN NEUROANATOMY J2 - FRONT NEUROANAT VL - 15 PY - 2021 PG - 15 SN - 1662-5129 DO - 10.3389/fnana.2021.652422 UR - https://m2.mtmt.hu/api/publication/31972476 ID - 31972476 AB - In the nervous system synaptic input arrives chiefly on dendrites and their type and distribution have been assumed pivotal in signal integration. We have developed an immunohistochemistry (IH)-correlated electron microscopy (EM) method – the “mirror” technique – by which synaptic input to entire dendrites of neurochemically identified interneurons (INs) can be mapped due preserving high-fidelity tissue ultrastructure. Hence, this approach allows quantitative assessment of morphometric parameters of synaptic inputs along the whole length of dendrites originating from the parent soma. The method exploits the fact that adjoining sections have truncated or cut cell bodies which appear on the common surfaces in a mirror fashion. In one of the sections the histochemical marker of the GABAergic subtype, calbindin was revealed in cell bodies whereas in the other section the remaining part of the very same cell bodies were subjected to serial section EM to trace and reconstruct the synaptology of entire dendrites. Here, we provide exemplary data on the synaptic coverage of two dendrites belonging to the same calbindin-D28K immunopositive IN and determine the spatial distribution of asymmetric and symmetric synapses, surface area and volume of the presynaptic boutons, morphometric parameters of synaptic vesicles, and area extent of the active zones. LA - English DB - MTMT ER - TY - JOUR AU - Déli, Éva Katalin AU - Peters, James AU - Kisvárday, Zoltán TI - The thermodynamics of cognition: A mathematical treatment JF - COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL J2 - CSBJ VL - 19 PY - 2021 SP - 784 EP - 793 PG - 10 SN - 2001-0370 DO - 10.1016/j.csbj.2021.01.008 UR - https://m2.mtmt.hu/api/publication/31935779 ID - 31935779 LA - English DB - MTMT ER - TY - CONF AU - Kocsis, Zsolt AU - Mohit, Srivastava AU - Julian, ML Budd AU - Cyril, Monier AU - Yves, Fregnac AU - Kisvárday, Zoltán TI - High-resolution retinotopic mapping with optical imaging of intrinsic signals in cat primary visual cortex T2 - IBRO Workshop PY - 2020 SP - 14 UR - https://m2.mtmt.hu/api/publication/31905631 ID - 31905631 LA - English DB - MTMT ER - TY - JOUR AU - Lódi, Mária AU - Bánhegyi, Viktor AU - Bódi, Beáta AU - Gyöngyösi, Alexandra AU - Kovács, Árpád AU - Árokszállási, Anita AU - Hamdani, Nazha AU - Fagyas, Miklós AU - Édes, István AU - Csanádi, Zoltán AU - Czuriga, István AU - Kisvárday, Zoltán AU - Lekli, István AU - Bay, Péter AU - Tóth, Attila AU - Papp, Zoltán AU - Czuriga, Dániel TI - Prophylactic, single-drug cardioprotection in a comparative, experimental study of doxorubicin-induced cardiomyopathy JF - JOURNAL OF TRANSLATIONAL MEDICINE J2 - J TRANSL MED VL - 18 PY - 2020 IS - 1 SN - 1479-5876 DO - 10.1186/s12967-020-02564-w UR - https://m2.mtmt.hu/api/publication/31621004 ID - 31621004 N1 - 296541 LA - English DB - MTMT ER - TY - JOUR AU - Déli, Éva Katalin AU - Kisvárday, Zoltán TI - The thermodynamic brain and the evolution of intellect: the role of mental energy JF - COGNITIVE NEURODYNAMICS J2 - COGN NEURODYN VL - 14 PY - 2020 IS - 6 SP - 743 EP - 756 PG - 14 SN - 1871-4080 DO - 10.1007/s11571-020-09637-y UR - https://m2.mtmt.hu/api/publication/31618887 ID - 31618887 LA - English DB - MTMT ER -