@article{MTMT:3287392,
	title = {Disturbed spermatogenic signaling in PACAP deficient mice.},
	url = {https://m2.mtmt.hu/api/publication/3287392},
	author = {Reglődi, Dóra and Cseh, Sándor and Somoskői, Bence and Fülöp, Balázs Dániel and Szentléleky, Eszter and Szegeczki, Vince and Kovacs, A and Varga, A and Kiss, Péter and Hashimoto, H and Tamás, Andrea and Bardosi, A and Sridharan, Manavalan and Bakó, Éva and Zákány, Róza and Juhász, Tamás},
	doi = {10.1530/REP-17-0470},
	journal-iso = {REPRODUCTION},
	journal = {REPRODUCTION},
	volume = {155},
	unique-id = {3287392},
	issn = {1470-1626},
	abstract = {PACAP is a neuropeptide with diverse functions in various organs, including reproductive system. It is present in the testis in high concentrations, and in addition to the stage-specific expression within the seminiferous tubules, PACAP affects spermatogenesis and the functions of Leydig and Sertoli cells. Mice lacking endogenous PACAP show reduced fertility, but the possibility of abnormalities in spermatogenic signaling has not yet been investigated. Therefore, we performed a detailed morphological analysis of spermatozoa, sperm motility, and investigated signaling pathways that play a role during spermatogenesis in knockout mice. No significant alterations were found in testicular morphology or motility of sperm in homo- and heterozygous PACAP deficient mice in spite of the moderately increased number of severely damaged sperms. However, we found robust changes in mRNA and/or protein expression of several factors that play an important role in spermatogenesis. Protein kinaseA expression was markedly reduced, while downstream phospho-ERK and p38 were elevated in knockout animals. Expression of major transcription factors, such as Sox9 and phospho-Sox9 was decreased, while that of Sox10, as a redundant factor, was increased in PACAP deficient mice. The reduced phospho-Sox9 expression was partly due to increased expression and activity of phosphatase PP2A in knockout mice. Targets of Sox transcription factors, such as Collagen type IV was reduced in knockout mice. In summary, our results show that lack of PACAP leads to disturbed signaling in spermatogenesis, which could be a factor responsible for reduced fertility in PACAP knockout mice, and further support the role of PACAP in reproduction.},
	year = {2018},
	eissn = {1741-7899},
	pages = {127-137}
}

@article{MTMT:2719815,
	title = {Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) Signalling Enhances Osteogenesis in UMR-106 Cell Line},
	url = {https://m2.mtmt.hu/api/publication/2719815},
	author = {Juhász, Tamás and Matta, Csaba and Katona, Éva and Szucs-Somogyi, Csilla and Takács, Roland Ádám and Hajdú, Tibor and Helgadottir, SL and Fodor, János and Csernoch, László and Tóth, Gábor and Bakó, Éva and Reglődi, Dóra and Tamás, Andrea and Zákány, Róza},
	doi = {10.1007/s12031-014-0389-1},
	journal-iso = {J MOL NEUROSCI},
	journal = {JOURNAL OF MOLECULAR NEUROSCIENCE},
	volume = {54},
	unique-id = {2719815},
	issn = {0895-8696},
	abstract = {Presence of the pituitary adenylate cyclase-activating polypeptide (PACAP) signalling has been proved in various peripheral tissues. PACAP can activate protein kinase A (PKA) signalling via binding to pituitary adenylate cyclase-activating polypeptide type I receptor (PAC1), vasoactive intestinal polypeptide receptor (VPAC) 1 or VPAC2 receptor. Since little is known about the role of this regulatory mechanism in bone formation, we aimed to investigate the effect of PACAP on osteogenesis of UMR-106 cells. PACAP 1-38 as an agonist and PACAP 6-38 as an antagonist of PAC1 were added to the culture medium. Surprisingly, both substances enhanced protein expressions of collagen type I, osterix and alkaline phosphatase, along with higher cell proliferation rate and an augmented mineralisation. Although expression of PKA was elevated, no alterations were detected in the expression, phosphorylation and nuclear presence of CREB, but increased nuclear appearance of Runx2, the key transcription factor of osteoblast differentiation, was shown. Both PACAPs increased the expressions of bone morphogenetic proteins (BMPs) 2, 4, 6, 7 and Smad1 proteins, as well as that of Sonic hedgehog, PATCH1 and Gli1. Data of our experiments indicate that activation of PACAP pathway enhances bone formation of UMR-106 cells and PKA, BMP and Hedgehog signalling pathways became activated. We also found that PACAP 6-38 did not act as an antagonist of PACAP signalling in UMR-106 cells.},
	year = {2014},
	eissn = {1559-1166},
	pages = {555-573},
	orcid-numbers = {Matta, Csaba/0000-0002-9678-7420}
}

@article{MTMT:2490249,
	title = {Mechanical loading stimulates chondrogenesis via the PKA/CREB-Sox9 and PP2A pathways in chicken micromass cultures},
	url = {https://m2.mtmt.hu/api/publication/2490249},
	author = {Juhász, Tamás and Matta, Csaba and Szucs-Somogyi, Csilla and Katona, Éva and Takács, Roland Ádám and Soha, Rudolf Ferenc and Szabó, István and Cserháti, Csaba and Sződy, Róbert and Karácsonyi, Zoltán and Bakó, Éva and Gergely, Pál and Zákány, Róza},
	doi = {10.1016/j.cellsig.2013.12.001},
	journal-iso = {CELL SIGNAL},
	journal = {CELLULAR SIGNALLING},
	volume = {26},
	unique-id = {2490249},
	issn = {0898-6568},
	year = {2014},
	eissn = {1873-3913},
	pages = {468-482},
	orcid-numbers = {Matta, Csaba/0000-0002-9678-7420; Szabó, István/0000-0002-4650-498X}
}

@article{MTMT:2053257,
	title = {Calcineurin regulates endothelial barrier function by interaction with and dephosphorylation of myosin phosphatase},
	url = {https://m2.mtmt.hu/api/publication/2053257},
	author = {Kolozsvári, Bernadett and Bakó, Éva and Bécsi, Bálint and Kiss, Andrea and Czikora, Ágnes and Tóth, Attila and Vámosi, György and Gergely, Pál and Erdődi, Ferenc},
	doi = {10.1093/cvr/cvs255},
	journal-iso = {CARDIOVASC RES},
	journal = {CARDIOVASCULAR RESEARCH},
	volume = {96},
	unique-id = {2053257},
	issn = {0008-6363},
	year = {2012},
	eissn = {1755-3245},
	pages = {494-503}
}

@article{MTMT:1754599,
	title = {Optimalized transient transfection of chondrogenic primary cell cultures},
	url = {https://m2.mtmt.hu/api/publication/1754599},
	author = {Juhász, Tamás and Matta, Csaba and Mészár, Zoltán and Nagy, Georgina and Szíjgyártó, Zsolt and Molnar, Z and Kolozsvari, B and Bakó, Éva and Zákány, Róza},
	doi = {10.2478/s11535-010-0053-x},
	journal-iso = {CENT EUR J BIOL},
	journal = {CENTRAL EUROPEAN JOURNAL OF BIOLOGY},
	volume = {5},
	unique-id = {1754599},
	issn = {1895-104X},
	abstract = {We aimed to find a transfection method which provides high efficiency with minimal cytotoxic and/or apoptotic effects for gene transfer into multilayer primary chondrogenic cell cultures. The pEGFP-C1 plasmid was introduced into the cell culture and the efficiency of transformation quantified by GFP fluorescence; the resulting nucleofection was effective but resulted in severe apoptosis. Two liposomal reagents designed to allow transfection into adherent cells did not deliver the plasmids sufficiently and cartilage formation did not occur. In addition, a third liposomal compound, recommended for transfection into either adherent or suspension cell cultures, lead to acceptable transfection efficiency but no cartilage formation. When an amphiphilic reagent was used however, there was acceptable transfection efficiency as well as cartilage formation. The viability of the cells which were transfected using the amphiphilic reagent remained unaffected but proliferation was severely diminished, particularly in the presence of GFP. In addition, the amount of cartilage decreased when GFP was expressed, despite unchanged levels of mRNAs of sox9 and aggrecan core protein, factors reflecting on the efficiency of chondrogenesis. Overexpression of both the constitutively active delta and gamma isoforms of catalytic subunit of calcineurin, a protein phosphatase described as a positive regulator of chondrogenesis, decreased protein level of Sox9 and subsequent cartilage formation. In conclusion, we found that amphiphilic reagent applied prior to the adhesion of cells provides a useful means to transfer plasmids to primary differentiating chondrogenic cells.},
	keywords = {PHOSPHATASE; EXPRESSION; IN-VITRO; CALCINEURIN; PROTEIN-KINASE; EFFICIENT; NUCLEOFECTION; DNA-TRANSFECTION; Cartilage differentiation; Cartilage differentiation; MEDIATED GENE-TRANSFER; Calcineurin overexpression; Transfection efficiency; Chondrifying primary cells; Mesenchymal cell culture},
	year = {2010},
	eissn = {1644-3632},
	pages = {572-584},
	orcid-numbers = {Matta, Csaba/0000-0002-9678-7420}
}

@article{MTMT:236671,
	title = {Role of calcineurin in thrombin-mediated endothelial cell contraction},
	url = {https://m2.mtmt.hu/api/publication/236671},
	author = {Kolozsvári, B and Szíjgyártó, Zsolt and Bay, Péter and Gergely, Pál and Verin, A and Garcia, JGN and Bakó, Éva},
	doi = {10.1002/cyto.a.20707},
	journal-iso = {CYTOM PART A},
	journal = {CYTOMETRY PART A},
	volume = {75},
	unique-id = {236671},
	issn = {1552-4922},
	year = {2009},
	eissn = {1552-4930},
	pages = {405-411}
}

@book{MTMT:1203931,
	title = {Laboratory practicals in medical chemistry},
	url = {https://m2.mtmt.hu/api/publication/1203931},
	author = {Bay, Péter and Bakó, Éva and Csortos, Csilla and Farkas, Ilona and Lontay, Beáta and Kókai, Endre},
	editor = {Viktor, Dombrádi},
	publisher = {DEOEC},
	unique-id = {1203931},
	year = {2007}
}

@book{MTMT:1203915,
	title = {Orvosi kémia laboratóriumi gyakorlatok},
	url = {https://m2.mtmt.hu/api/publication/1203915},
	author = {Bay, Péter and Bakó, Éva and Csortos, Csilla and Farkas, Ilona and Lontay, Beáta and Kókai, Endre},
	editor = {Dombrádi, Viktor},
	publisher = {DEOEC},
	unique-id = {1203915},
	year = {2007}
}

@CONFERENCE{MTMT:1379427,
	title = {Determination of immune complex bound soluble complement receptor-1, Fc receptor II and III in sera of patients with Systemic Lupus Erythematosus},
	url = {https://m2.mtmt.hu/api/publication/1379427},
	author = {Csípő, István and Kiss, E and Baráth, Sándor and Bakó, Éva and Zeher, M and Sipka, Sándor and Szegedi, G and Kavai, M},
	booktitle = {16th European Congress of Immunology},
	unique-id = {1379427},
	year = {2006},
	pages = {1}
}

@article{MTMT:1287813,
	title = {Soluble complement receptor 1 (CD35) bound to immune complexes in patients with systemic lupus erythematosus},
	url = {https://m2.mtmt.hu/api/publication/1287813},
	author = {Csípő, István and Kiss, Emese and Bakó, Éva and Szegedi, Gyula and Kávai, M},
	doi = {10.1002/art.21245},
	journal-iso = {ARTH RHEUM/AR C RES},
	journal = {ARTHRITIS AND RHEUMATISM},
	volume = {52},
	unique-id = {1287813},
	issn = {0004-3591},
	year = {2005},
	eissn = {1529-0131},
	pages = {2950-2951},
	orcid-numbers = {Kiss, Emese/0000-0002-5399-2379}
}