TY  - JOUR
AU  - Lengyel, Miklós
AU  - Erdélyi, Ferenc
AU  - Pergel, Enikő
AU  - Polonkáné Bálint, Ágnes
AU  - Dobolyi, Alice
AU  - Bozsaki, Peter
AU  - Dux, Mária
AU  - Király, Kornél P
AU  - Hegedűs, Tamás
AU  - Czirják, Gábor
AU  - Mátyus, Péter
AU  - Enyedi, Péter
TI  - Chemically Modified Derivatives of the Activator Compound Cloxyquin Exert Inhibitory Effect on TRESK (K2P18.1) Background Potassium Channel
JF  - MOLECULAR PHARMACOLOGY
J2  - MOL PHARMACOL
VL  - 95
PY  - 2019
IS  - 6
SP  - 652
EP  - 660
PG  - 9
SN  - 0026-895X
DO  - 10.1124/mol.118.115626
UR  - https://m2.mtmt.hu/api/publication/30654928
ID  - 30654928
AB  - Cloxyquin has been reported as a specific activator of TRESK (K2P18.1, TWIK-related spinal cord K+ channel) background potassium channel. In this study, we have synthetized chemically modified analogues of cloxyquin and tested their effects on TRESK and other K2P channels. The currents of murine K2P channels, expressed heterologously in Xenopus oocytes, were measured by two-electrode voltage clamp, whereas the native background K+ conductance of mouse dorsal root ganglion (DRG) neurons was examined by the whole-cell patch clamp method. Some of the analogues retained the activator character of the parent compound, but more interestingly, other derivatives inhibited mouse TRESK current. The inhibitor analogues (A2764 and A2793) exerted state-dependent effect. The degree of inhibition by 100 µM A2764 (77.8±1.5%, n=6) was larger in the activated state of TRESK (i.e. after calcineurin-dependent stimulation) than in the resting state of the channel (42.8±4.3% inhibition, n=7). The selectivity of the inhibitor compounds was tested on several K2P channels. A2793 inhibited TASK-1 (100 µM, 53.4±6%, n=5), while A2764 was more selective for TRESK, it only moderately influenced TREK-1 and TALK-1. The effect of A2764 was also examined on the background K+ currents of DRG neurons. A subpopulation of DRG neurons, prepared from wild-type animals, expressed background K+ currents sensitive to A2764, while the inhibitor did not affect the currents in the DRG neurons of TRESK-deficient mice. Accordingly, A2764 may prove to be useful for the identification of TRESK current in native cells, and for the investigation of the role of the channel in nociception and migraine.
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Mátyus, Péter
AU  - Polonkáné Bálint, Ágnes
AU  - Dunkel, Petra
AU  - Földi, Á
AU  - Ludányi, K
AU  - Bényei, Cs A
TI  - Aza-ring annelation via type 2 tert-amino effect: mechanism and scope
JF  - BOLETÍN DE LA SOCIEDAD QUÍMICA DE MÉXICO
J2  - B SOC QUIM MEX
VL  - 5
PY  - 2011
IS  - 3
SP  - 37
EP  - 37
PG  - 1
SN  - 1870-1809
UR  - https://m2.mtmt.hu/api/publication/2855891
ID  - 2855891
LA  - English
DB  - MTMT
ER  - 

TY  - GEN
AU  - Mátyus, Péter
AU  - Dunkel, Petra
AU  - Polonkáné Bálint, Ágnes
AU  - Földi, Á
AU  - Deme, Ruth
AU  - Gyires, Klára
AU  - Magyar, K
AU  - Tábi, T
AU  - Szökő, É
TI  - Semicarbazide-sensitive amine oxidase/vascular adhesion protein-1 inhibitors as novel anti-inflammatory agents
PY  - 2011
UR  - https://m2.mtmt.hu/api/publication/1753121
ID  - 1753121
LA  - English
DB  - MTMT
ER  - 

TY  - GEN
AU  - Földi, ÁA
AU  - Polonkáné Bálint, Ágnes
AU  - Drahos, László
AU  - Mátyus, Péter
TI  - Váratlan termékek képződése vinilcsoporttal szubsztituált tercier arilaminokból
PY  - 2010
UR  - https://m2.mtmt.hu/api/publication/2029634
ID  - 2029634
LA  - Hungarian
DB  - MTMT
ER  - 

TY  - GEN
AU  - Deme, Ruth
AU  - Polonkáné Bálint, Ágnes
AU  - Földi, ÁA
AU  - Dunkel, Petra
AU  - Mátyus, Péter
TI  - terc-amino effektus alkalmazása policiklusos vegyületek előállítására
PY  - 2010
UR  - https://m2.mtmt.hu/api/publication/2027325
ID  - 2027325
LA  - Hungarian
DB  - MTMT
ER  - 

TY  - GEN
AU  - Deme, Ruth
AU  - Dunkel, Petra
AU  - Polonkáné Bálint, Ágnes
AU  - Mátyus, Péter
TI  - Azocin és azecin gyűrűrendszerek előállítása a terc-amino effektus alkalmazásával
PY  - 2009
UR  - https://m2.mtmt.hu/api/publication/2027279
ID  - 2027279
N1  - [Poszter]
LA  - Hungarian
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Franck, P
AU  - Hostyn, S
AU  - Dajka-Halasz, B
AU  - Polonkáné Bálint, Ágnes
AU  - Monsieurs, K
AU  - Mátyus, Péter
AU  - Maes, BUW
TI  - Pd-catalyzed intramolecular direct arylations at high temperature
JF  - TETRAHEDRON
J2  - TETRAHEDRON
VL  - 64
PY  - 2008
IS  - 26
SP  - 6030
EP  - 6037
PG  - 8
SN  - 0040-4020
DO  - 10.1016/j.tet.2008.01.060
UR  - https://m2.mtmt.hu/api/publication/1344109
ID  - 1344109
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Polonkáné Bálint, Ágnes
AU  - Saraceno, C
AU  - Ludányi, Krisztina
AU  - Bényei, Attila Csaba
AU  - Mátyus, Péter
TI  - Novel Extensions of the tert-Amino Effect: Formation of Phenanthridines and Diarene-Fused Azocines from ortho-ortho′-Functionalized Biaryls
JF  - SYNLETT
J2  - SYNLETT
VL  - 2008
PY  - 2008
IS  - 18
SP  - 2846
EP  - 2850
PG  - 5
SN  - 0936-5214
DO  - 10.1055/s-0028-1083537
UR  - https://m2.mtmt.hu/api/publication/1189926
ID  - 1189926
N1  - Megjegyzés-22050677
Z9: 13
AB  - Phenanthridines and azocines fused to two benzene rings or one benzene
and one pyridazinone ring, which are otherwise difficult to access,
were prepared via two new extensions of the tert-amino effect. The
synthetic pathway includes three steps: i) Suzuki reaction of an
ortho-functionalized phenylboronic acid with ortho-disubstituted
benzenes or pyridazinones; ii) the Knoevenagel condensation reaction of
the biaryl aldehydes formed with active methylene compounds to obtain
vinyl derivatives or, through their cyclization, phenanthridines via a
tert-amino effect; and iii) thermal isomerization of vinyl or
phenanthridinium compounds to fused azocines via another type of
tert-amino effect.
LA  - English
DB  - MTMT
ER  - 

TY  - GEN
AU  - Polonkáné Bálint, Ágnes
AU  - Dunkel, Petra
AU  - Mátyus, P
TI  - Új típusú azocin és azecin gyűrűrendszerek előállítása új úton: a terc-amino effektus kiterjesztése
PY  - 2007
UR  - https://m2.mtmt.hu/api/publication/1344145
ID  - 1344145
N1  - [Előadás]
LA  - Hungarian
DB  - MTMT
ER  - 

TY  - GEN
AU  - Polonkáné Bálint, Ágnes
AU  - Saraceno, C
AU  - Czugler, Mátyás
AU  - Mátyus, Péter
TI  - Syntheses of dibenzazocines and a pyridazino-fused benzazocine by application of a new type of tert-amino effect
PY  - 2006
UR  - https://m2.mtmt.hu/api/publication/1344144
ID  - 1344144
N1  - [Előadás]
LA  - English
DB  - MTMT
ER  -